Digestion and absorption

Sources:

#	Name	Source	Genes
1	Digestion and absorption	Reactome	ALPI AMY1A AMY1B AMY1C AMY2A AMY2B CEL CHIA CHIT1 CLPS GUCA2A GUCA2B GUCY2C LCT LIPF MGAM NPC1L1 PIR PNLIP PNLIPRP1 PNLIPRP2 PNLIPRP3 RSC1A1 SI SLC2A2 SLC2A5 SLC5A1 TREH (see all 28) (see less)
2	Digestion	Reactome	ALPI AMY1A AMY1B AMY1C AMY2A AMY2B CEL CHIA CHIT1 CLPS GUCA2A GUCA2B GUCY2C LCT LIPF MGAM PIR PNLIP PNLIPRP1 PNLIPRP2 PNLIPRP3 SI TREH (see all 23) (see less)
3	Digestion of dietary carbohydrate	Reactome	AMY1A AMY1B AMY1C AMY2A AMY2B CHIA CHIT1 LCT MGAM SI TREH (see all 11) (see less)
4	Digestion of dietary lipid	Reactome	CEL CLPS LIPF PNLIP PNLIPRP1 PNLIPRP2 PNLIPRP3 (see all 7) (see less)
5	Intestinal absorption	Reactome	NPC1L1 RSC1A1 SLC2A2 SLC2A5 SLC5A1
6	Intestinal hexose absorption	Reactome	RSC1A1 SLC2A2 SLC2A5 SLC5A1
7	Intestinal saccharidase deficiencies	Reactome	LCT SI
8	Intestinal lipid absorption	Reactome	NPC1L1
9	Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)	Reactome	SLC5A1
10	Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)	Reactome	SLC2A2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LCT	Lactase	Protein Coding	4
2	SI	Sucrase-Isomaltase	Protein Coding	4
3	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	4
4	SLC5A1	Solute Carrier Family 5 Member 1	Protein Coding	4
5	CEL	Carboxyl Ester Lipase	Protein Coding	3
6	CHIT1	Chitinase 1	Protein Coding	3
7	TREH	Trehalase	Protein Coding	3
8	PNLIPRP3	Pancreatic Lipase Related Protein 3	Protein Coding	3
9	CLPS	Colipase	Protein Coding	3
10	CHIA	Chitinase Acidic	Protein Coding	3
11	AMY1A	Amylase Alpha 1A	Protein Coding	3
12	AMY1B	Amylase Alpha 1B	Protein Coding	3
13	AMY1C	Amylase Alpha 1C	Protein Coding	3
14	AMY2A	Amylase Alpha 2A	Protein Coding	3
15	AMY2B	Amylase Alpha 2B	Protein Coding	3
16	NPC1L1	NPC1 Like Intracellular Cholesterol Transporter 1	Protein Coding	3
17	PNLIP	Pancreatic Lipase	Protein Coding	3
18	PNLIPRP1	Pancreatic Lipase Related Protein 1	Protein Coding	3
19	PNLIPRP2	Pancreatic Lipase Related Protein 2 (Gene/Pseudogene)	Protein Coding	3
20	RSC1A1	Regulator Of Solute Carriers 1	Protein Coding	3
21	SLC2A5	Solute Carrier Family 2 Member 5	Protein Coding	3
22	LIPF	Lipase F, Gastric Type	Protein Coding	3
23	MGAM	Maltase-Glucoamylase	Protein Coding	3
24	ALPI	Alkaline Phosphatase, Intestinal	Protein Coding	2
25	GUCA2A	Guanylate Cyclase Activator 2A	Protein Coding	2
26	GUCA2B	Guanylate Cyclase Activator 2B	Protein Coding	2
27	GUCY2C	Guanylate Cyclase 2C	Protein Coding	2
28	PIR	Pirin	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Intestinal disaccharidase deficiency	Direct
2	Glucose intolerance	Direct
3	Renal tubular transport disease	Direct
4	Low density lipoprotein cholesterol level quantitative trait locus 7	Enrichment	NPC1L1	4.13
5	Glucose/galactose malabsorption	Enrichment	SLC5A1	3.53
6	Maturity-onset diabetes of the young, type 8, with exocrine dysfunction	Enrichment	CEL	3.29
7	Pancreatic lipase deficiency	Enrichment	PNLIP	3.29
8	Pancreatic triacylglycerol lipase deficiency	Enrichment	PNLIP	3.29
9	Fanconi-bickel syndrome	Enrichment	SLC2A2	3.23
10	Sucrase-isomaltase deficiency, congenital	Enrichment	SI	3.09
11	Lactase deficiency, congenital	Enrichment	LCT	3.09
12	Trehalase deficiency	Enrichment	TREH	3.09
13	Chitotriosidase deficiency	Enrichment	CHIT1	3.09
14	Renal glucosuria	Enrichment	SLC5A1	2.93
15	Alpi-related inflammatory bowel disease	Enrichment	ALPI	2.77
16	Duodenal atresia	Enrichment	GUCY2C	2.47
17	Diarrhea 6	Enrichment	GUCY2C	2.47
18	Congenital diarrhea 6	Enrichment	GUCY2C	2.47
19	Intestinal obstruction in the newborn due to guanylate cyclase 2c deficiency	Enrichment	GUCY2C	2.47
20	Congenital long qt syndrome	Enrichment	SLC2A2	2.45
21	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	GUCY2C	2.29
22	Meconium ileus	Enrichment	GUCY2C	2.17
23	Long qt syndrome 1	Enrichment	SLC2A2	2.05
24	Maturity-onset diabetes of the young	Enrichment	CEL	1.99
25	Type 2 diabetes mellitus	Enrichment	SLC2A2	1.91

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Digestion and absorption