Direct p53 effectors

No Pathway Network information available for Direct p53 effectors

Pathways in the Direct p53 effectors SuperPath

#	Name	Source	Genes
1	Direct p53 effectors	PubChem	AFP AIFM2 APAF1 APC ARID3A ATF3 BAK1 BAX BBC3 BCL2 BCL2L14 BCL6 BDKRB2 BID BNIP3L BTG2 CARM1 CASP1 CASP10 CASP6 CAV1 CCNB1 CCNG1 CCNK CD82 CDKN1A CEBPZ COL18A1 COP1 CSE1L CTSD CX3CL1 DDB2 DDIT4 DDX5 DGCR8 DKK1 DROSHA DUSP1 DUSP5 E2F1 EDN2 EGFR EPHA2 FAS FDXR FOXA1 GADD45A GDF15 GPX1 HDAC2 HGF HIC1 HTT IGFBP3 IRF5 JMY JUN KAT2A LIF MAP4K4 MCL1 MDM2 MET MLH1 MMP2 MSH2 NDRG1 NFYA NFYB NFYC NLRC4 PCBP4 PCNA PERP PIDD1 PLK3 PMAIP1 PML PMS2 POU4F1 POU4F2 PPM1J PRDM1 PRKAB1 PRMT1 PTEN PYCARD RB1 RCHY1 RGCC RNF144B RPS27L RRM2B S100A2 SCN3B SERPINB5 SERPINE1 SESN1 SFN SH2D1A SMARCA4 SNAI2 SP1 SPP1 STEAP3 TADA2B TAF9 TAP1 TFDP1 TGFA TIGAR TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TP53 TP53I3 TP53INP1 TP63 TP73 TRIAP1 TRRAP TSC2 TYRP1 VCAN VDR ZNF385A (see all 128) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CSE1L	Chromosome Segregation 1 Like	Protein Coding	1
2	CEBPZ	CCAAT Enhancer Binding Protein Zeta	Protein Coding	1
3	SERPINB5	Serpin Family B Member 5	Protein Coding	1
4	VCAN	Versican	Protein Coding	1
5	AFP	Alpha Fetoprotein	Protein Coding	1
6	SCN3B	Sodium Voltage-Gated Channel Beta Subunit 3	Protein Coding	1
7	RNF144B	Ring Finger Protein 144B	Protein Coding	1
8	PPM1J	Protein Phosphatase, Mg2+/Mn2+ Dependent 1J	Protein Coding	1
9	S100A2	S100 Calcium Binding Protein A2	Protein Coding	1
10	SESN1	Sestrin 1	Protein Coding	1
11	DUSP5	Dual Specificity Phosphatase 5	Protein Coding	1
12	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
13	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
14	SH2D1A	SH2 Domain Containing 1A	Protein Coding	1
15	GDF15	Growth Differentiation Factor 15	Protein Coding	1
16	EDN2	Endothelin 2	Protein Coding	1
17	EPHA2	EPH Receptor A2	Protein Coding	1
18	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	1
19	CD82	CD82 Molecule	Protein Coding	1
20	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
21	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
22	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
23	RPS27L	Ribosomal Protein S27 Like	Protein Coding	1
24	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	1
25	PYCARD	PYD And CARD Domain Containing	Protein Coding	1
26	IRF5	Interferon Regulatory Factor 5	Protein Coding	1
27	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	1
28	DROSHA	Drosha Ribonuclease III	Protein Coding	1
29	POU4F1	POU Class 4 Homeobox 1	Protein Coding	1
30	TP53INP1	Tumor Protein P53 Inducible Nuclear Protein 1	Protein Coding	1
31	STEAP3	STEAP3 Metalloreductase	Protein Coding	1
32	TP73	Tumor Protein P73	Protein Coding	1
33	POU4F2	POU Class 4 Homeobox 2	Protein Coding	1
34	TP63	Tumor Protein P63	Protein Coding	1
35	DGCR8	DGCR8 Microprocessor Complex Subunit	Protein Coding	1
36	BNIP3L	BCL2 Interacting Protein 3 Like	Protein Coding	1
37	TRIAP1	TP53 Regulated Inhibitor Of Apoptosis 1	Protein Coding	1
38	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
39	BTG2	BTG Anti-Proliferation Factor 2	Protein Coding	1
40	ARID3A	AT-Rich Interaction Domain 3A	Protein Coding	1
41	RGCC	Regulator Of Cell Cycle	Protein Coding	1
42	CCNG1	Cyclin G1	Protein Coding	1
43	JMY	Junction Mediating And Regulatory Protein, P53 Cofactor	Protein Coding	1
44	BCL2L14	BCL2 Like 14	Protein Coding	1
45	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	1
46	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	1
47	PLK3	Polo Like Kinase 3	Protein Coding	1
48	HTT	Huntingtin	Protein Coding	1
49	CASP1	Caspase 1	Protein Coding	1
50	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	1
51	CCNK	Cyclin K	Protein Coding	1
52	TIGAR	TP53 Induced Glycolysis Regulatory Phosphatase	Protein Coding	1
53	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
54	TFDP1	Transcription Factor Dp-1	Protein Coding	1
55	AIFM2	AIF Family Member 2	Protein Coding	1
56	PRDM1	PR/SET Domain 1	Protein Coding	1
57	TADA2B	Transcriptional Adaptor 2B	Protein Coding	1
58	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
59	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	1
60	ATF3	Activating Transcription Factor 3	Protein Coding	1
61	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
62	HIC1	HIC ZBTB Transcriptional Repressor 1	Protein Coding	1
63	BCL6	BCL6 Transcription Repressor	Protein Coding	1
64	PCBP4	Poly(RC) Binding Protein 4	Protein Coding	1
65	ZNF385A	Zinc Finger Protein 385A	Protein Coding	1
66	COP1	COP1 E3 Ubiquitin Ligase	Protein Coding	1
67	CASP10	Caspase 10	Protein Coding	1
68	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
69	PML	PML Nuclear Body Scaffold	Protein Coding	1
70	FOXA1	Forkhead Box A1	Protein Coding	1
71	DDX5	DEAD-Box Helicase 5	Protein Coding	1
72	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	1
73	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	1
74	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
75	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	1
76	CX3CL1	C-X3-C Motif Chemokine Ligand 1	Protein Coding	1
77	HGF	Hepatocyte Growth Factor	Protein Coding	1
78	CTSD	Cathepsin D	Protein Coding	1
79	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
80	RCHY1	Ring Finger And CHY Zinc Finger Domain Containing 1	Protein Coding	1
81	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
82	CASP6	Caspase 6	Protein Coding	1
83	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
84	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
85	BBC3	BCL2 Binding Component 3	Protein Coding	1
86	E2F1	E2F Transcription Factor 1	Protein Coding	1
87	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
88	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
89	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
90	TYRP1	Tyrosinase Related Protein 1	Protein Coding	1
91	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	1
92	FDXR	Ferredoxin Reductase	Protein Coding	1
93	NFYC	Nuclear Transcription Factor Y Subunit Gamma	Protein Coding	1
94	NFYB	Nuclear Transcription Factor Y Subunit Beta	Protein Coding	1
95	NFYA	Nuclear Transcription Factor Y Subunit Alpha	Protein Coding	1
96	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
97	MLH1	MutL Homolog 1	Protein Coding	1
98	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
99	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	1
100	CAV1	Caveolin 1	Protein Coding	1
101	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
102	COL18A1	Collagen Type XVIII Alpha 1 Chain	Protein Coding	1
103	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
104	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
105	SERPINE1	Serpin Family E Member 1	Protein Coding	1
106	SNAI2	Snail Family Transcriptional Repressor 2	Protein Coding	1
107	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
108	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
109	SP1	Sp1 Transcription Factor	Protein Coding	1
110	HDAC2	Histone Deacetylase 2	Protein Coding	1
111	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	1
112	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
113	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
114	TSC2	TSC Complex Subunit 2	Protein Coding	1
115	SFN	Stratifin	Protein Coding	1
116	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
117	VDR	Vitamin D Receptor	Protein Coding	1
118	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
119	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
120	CCNB1	Cyclin B1	Protein Coding	1
121	TP53	Tumor Protein P53	Protein Coding	1
122	GPX1	Glutathione Peroxidase 1	Protein Coding	1
123	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
124	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
125	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
126	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	1
127	MSH2	MutS Homolog 2	Protein Coding	1
128	BDKRB2	Bradykinin Receptor B2	Protein Coding	1

Disorders associated with Direct p53 effectors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited cancer-predisposing syndrome	Enrichment	APC, EGFR, MET, MLH1, MSH2, PMS2, PTEN, RB1, SMARCA4, TP53, TSC2	7.35
2	Gastric cancer	Enrichment	APC, CASP10, MLH1, MSH2, PMS2, PTEN, TP53	6.86
3	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN, TNFRSF10B, TP53	6.59
4	Ovarian cancer	Enrichment	APC, EGFR, MET, MSH2, PMS2, PTEN, RB1, TP53, TSC2	6.35
5	Hepatocellular carcinoma	Enrichment	APC, MET, PMS2, TP53, VDR	5.80
6	Small cell cancer of the lung	Enrichment	RB1, TP53, TP73	5.49
7	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, PMS2	5.49
8	Lynch syndrome 4	Enrichment	MSH2, PMS2, RB1	5.49
9	Breast cancer	Enrichment	APC, JUN, MLH1, MSH2, PMS2, PTEN, TP53	5.18
10	Bladder cancer	Enrichment	CDKN1A, EGFR, PTEN, RB1, TP53	5.16
11	Hereditary breast ovarian cancer syndrome	Enrichment	DROSHA, MLH1, MSH2, PMS2, PTEN, TP53	4.90
12	Rhabdomyosarcoma	Enrichment	MSH2, PMS2, PTEN, TP53	4.90
13	Colorectal cancer	Enrichment	APC, BAX, MET, MLH1, MSH2, PMS2, TP53	4.75
14	Endometrial cancer	Enrichment	MLH1, MSH2, PMS2, PTEN	4.40
15	Hereditary breast carcinoma	Enrichment	APC, MLH1, MSH2, PTEN, TP53	4.25
16	Muir-torre syndrome	Enrichment	MLH1, MSH2	4.05
17	Intravascular large b-cell lymphoma	Enrichment	BCL2, BCL6	4.05
18	Lynch syndrome 1	Enrichment	MLH1, MSH2, PMS2	4.03
19	Familial colorectal cancer	Enrichment	MLH1, MSH2, TP53	4.03
20	Lip and oral cavity carcinoma	Enrichment	EGFR, RB1, TP53	3.77
21	Lung cancer	Enrichment	EGFR, FAS, MET, MLH1	3.65
22	Osteogenic sarcoma	Enrichment	RB1, TP53	3.58
23	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, BCL6	3.58
24	Squamous cell carcinoma	Enrichment	RB1, TP53	3.58
25	Laryngeal squamous cell carcinoma	Enrichment	PTEN, TNFRSF10B	3.58
26	Bone osteosarcoma	Enrichment	RB1, TP53	3.58
27	Lung cancer susceptibility 3	Enrichment	EGFR, RB1, TP53	3.56
28	Lynch syndrome	Enrichment	MLH1, MSH2, PMS2	3.46
29	Gliosarcoma	Enrichment	EGFR, MSH2, TP53	3.38
30	Giant cell glioblastoma	Enrichment	EGFR, MSH2, TP53	3.30
31	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS	3.28
32	Diffuse large b-cell lymphoma	Enrichment	PMS2, PTEN, TP53	3.15
33	Follicular lymphoma	Enrichment	BCL2, BCL6	3.06
34	Lymphoma	Enrichment	PMS2, TP53	3.06
35	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.06
36	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1, IRF5	3.06
37	Hepatoblastoma	Enrichment	APC, MSH2, TP53	3.02
38	Li-fraumeni syndrome	Enrichment	MDM2, TP53	2.89
39	Cowden syndrome 1	Enrichment	EGFR, PTEN	2.89
40	Limited scleroderma	Enrichment	CAV1, IRF5	2.89
41	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, TP53	2.62
42	Adult hepatocellular carcinoma	Enrichment	TP53, TSC2	2.52
43	Colonic benign neoplasm	Enrichment	APC, MLH1	2.52
44	Uterine corpus cancer	Enrichment	MSH2, PTEN	2.34
45	Cataract	Enrichment	COL18A1, EPHA2	2.13
46	Rapp-hodgkin syndrome	Enrichment	TP63	2.03
47	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.03
48	Chiari malformation type i	Enrichment	DKK1	2.03
49	Vacterl association with hydrocephalus	Enrichment	PTEN	2.03
50	Split-hand/foot malformation 4	Enrichment	TP63	2.03
51	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.03
52	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.03
53	Deafness, autosomal recessive 39	Enrichment	HGF	2.03
54	Adult syndrome	Enrichment	TP63	2.03
55	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	2.03
56	Accelerated tumor formation	Enrichment	MDM2	2.03
57	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.03
58	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.03
59	Alpha-fetoprotein, hereditary persistence of	Enrichment	AFP	2.03
60	Lymphoproliferative syndrome, x-linked, 1	Enrichment	SH2D1A	2.03
61	Lessel-kubisch syndrome	Enrichment	MDM2	2.03
62	Hyperemesis gravidarum	Enrichment	GDF15	2.03
63	Bone marrow failure syndrome 5	Enrichment	TP53	2.03
64	Osteofibrous dysplasia	Enrichment	MET	2.03
65	Papilloma of choroid plexus	Enrichment	TP53	2.03
66	Basal cell carcinoma 7	Enrichment	TP53	2.03
67	Lynch syndrome 2	Enrichment	MLH1	2.03
68	Anaplastic thyroid carcinoma	Enrichment	TP53	2.03
69	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.03
70	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	2.03
71	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	2.03
72	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.03
73	Papillary tumor of the pineal region	Enrichment	PTEN	2.03
74	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.03
75	Limb-mammary syndrome	Enrichment	TP63	2.03
76	Deafness, autosomal recessive 97	Enrichment	MET	2.03
77	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	2.03
78	Systemic lupus erythematosus 10	Enrichment	IRF5	2.03
79	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.03
80	Autism 9	Enrichment	MET	2.03
81	Glutathione peroxidase deficiency	Enrichment	GPX1	2.03
82	Premature ovarian failure 21	Enrichment	TP63	2.03
83	Olmsted syndrome 2	Enrichment	PERP	2.03
84	Brugada syndrome 7	Enrichment	SCN3B	2.03
85	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.03
86	Alpha-fetoprotein deficiency	Enrichment	AFP	2.03
87	Inflammatory bowel disease 14	Enrichment	IRF5	2.03
88	Glioma susceptibility 2	Enrichment	PTEN	2.03
89	Ductal carcinoma in situ	Enrichment	TP53	2.03
90	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.03
91	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.03
92	Deafness, autosomal dominant 75	Enrichment	TRRAP	2.03
93	Orofacial cleft 8	Enrichment	TP63	2.03
94	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.03
95	Lopes-maciel-rodan syndrome	Enrichment	HTT	2.03
96	Mismatch repair cancer syndrome 4	Enrichment	PMS2	2.03
97	Intellectual developmental disorder with hypertelorism and distinctive facies	Enrichment	CCNK	2.03
98	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	2.03
99	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	2.03
100	Rectal benign neoplasm	Enrichment	MSH2	2.03
101	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.03
102	Trilateral retinoblastoma	Enrichment	RB1	2.03
103	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.03
104	Arthrogryposis, distal, type 11	Enrichment	MET	2.03
105	Rickets	Enrichment	VDR	2.03
106	Pituitary cancer	Enrichment	PMS2	2.03
107	Ascending colon cancer	Enrichment	MSH2	2.03
108	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.03
109	Tp63-related disorders	Enrichment	TP63	2.03
110	Choroid plexus cancer	Enrichment	TP53	2.03
111	Ovarian cyst	Enrichment	MSH2	2.03
112	Familial adenomatous polyposis	Enrichment	APC	2.03
113	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.03
114	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.03
115	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	2.03
116	Juvenile huntington disease	Enrichment	HTT	2.03
117	Gardner syndrome	Enrichment	APC	2.03
118	Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome	Enrichment	FDXR	2.03
119	5q22 microdeletion syndrome	Enrichment	APC	2.03
120	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.03
121	Attenuated familial adenomatous polyposis	Enrichment	APC	2.03
122	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	2.03
123	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	2.03
124	Lung oat cell carcinoma	Enrichment	RB1	2.03
125	Arteriovenous malformations of the brain	Enrichment	EGFR, MAP4K4	1.87
126	Fanconi renotubular syndrome 1	Enrichment	RRM2B	1.73
127	Burkitt lymphoma	Enrichment	PMS2	1.73
128	Wagner vitreoretinopathy	Enrichment	VCAN	1.73
129	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	1.73
130	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.73
131	Albinism, oculocutaneous, type iii	Enrichment	TYRP1	1.73
132	Cervical cancer	Enrichment	TP53	1.73
133	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	1.73
134	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	1.73
135	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	1.73
136	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.73
137	Piebald trait	Enrichment	SNAI2	1.73
138	Lymphangioleiomyomatosis	Enrichment	TSC2	1.73
139	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	1.73
140	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	1.73
141	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	1.73
142	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.73
143	Lymphoma, hodgkin, classic	Enrichment	TP53	1.73
144	Skin/hair/eye pigmentation, variation in, 11	Enrichment	TYRP1	1.73
145	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	1.73
146	Ataxia, intention tremor, and hypotonia syndrome, childhood-onset	Enrichment	POU4F1	1.73
147	Childhood hepatocellular carcinoma	Enrichment	MET	1.73
148	Bladder exstrophy	Enrichment	TP63	1.73
149	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	1.73
150	Lymphoproliferative syndrome	Enrichment	SH2D1A	1.73
151	Papillary renal cell carcinoma	Enrichment	MET	1.73
152	Pineoblastoma	Enrichment	DROSHA	1.73
153	Congenital fibrosarcoma	Enrichment	TP53	1.73
154	Li-fraumeni syndrome 1	Enrichment	TP53	1.73
155	Sarcoma	Enrichment	TP53	1.73
156	Glaucoma, primary closed-angle	Enrichment	COL18A1	1.73
157	Otosclerosis 12	Enrichment	SMARCA4	1.73
158	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.73
159	Periampullary adenoma	Enrichment	APC	1.73
160	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.73
161	Cervix carcinoma	Enrichment	TP53	1.73
162	Hodgkin's lymphoma	Enrichment	TP53	1.73
163	Fissured tongue	Enrichment	TP63	1.73
164	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	1.73
165	Wagner disease	Enrichment	VCAN	1.73
166	Vacterl with hydrocephalus	Enrichment	PTEN	1.73
167	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.73
168	Familial retinoblastoma	Enrichment	RB1	1.73
169	Juvenile polyposis of infancy	Enrichment	PTEN	1.73
170	Xeroderma pigmentosum group e	Enrichment	DDB2	1.73
171	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.73
172	Autoinflammatory disease	Enrichment	NLRC4, SH2D1A	1.67
173	Desmoid disease, hereditary	Enrichment	APC	1.55
174	Retinoblastoma	Enrichment	RB1	1.55
175	Tuberous sclerosis 1	Enrichment	TSC2	1.55
176	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.55
177	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.55
178	Osteoporosis, juvenile	Enrichment	DKK1	1.55
179	Nasopharyngeal carcinoma	Enrichment	TP53	1.55
180	Tuberous sclerosis 2	Enrichment	TSC2	1.55
181	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.55
182	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.55
183	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.55
184	Miller-dieker lissencephaly syndrome	Enrichment	HIC1	1.55
185	Cerebellar dysfunction with variable cognitive and behavioral abnormalities	Enrichment	POU4F1	1.55
186	Anus, imperforate	Enrichment	MAP4K4	1.55
187	Auditory neuropathy and optic atrophy	Enrichment	FDXR	1.55
188	Hypotrichosis 8	Enrichment	RB1	1.55
189	Multiple mitochondrial dysfunctions syndrome 9b	Enrichment	FDXR	1.55
190	Desmoid tumor	Enrichment	APC	1.55
191	Dedifferentiated liposarcoma	Enrichment	MDM2	1.55
192	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	1.55
193	Hamartoma	Enrichment	TSC2	1.55
194	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.55
195	Anaplastic astrocytoma	Enrichment	TP53	1.55
196	Xanthinuria, type ii	Enrichment	TSC2	1.55
197	Cellular ependymoma	Enrichment	MSH2	1.55
198	Tanycytic ependymoma	Enrichment	MSH2	1.55
199	Papillary ependymoma	Enrichment	MSH2	1.55
200	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.55
201	Adenocarcinoma	Enrichment	TP53	1.55
202	Respiratory failure	Enrichment	TP73	1.55
203	Idiopathic camptocormia	Enrichment	RRM2B	1.55
204	Colon adenocarcinoma	Enrichment	APC	1.55
205	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.55
206	Well-differentiated liposarcoma	Enrichment	MDM2	1.55
207	Clear cell ependymoma	Enrichment	MSH2	1.55
208	Renal cell carcinoma	Enrichment	MET	1.55
209	Vogt-koyanagi-harada disease	Enrichment	FAS	1.55
210	Apc-associated polyposis conditions	Enrichment	APC	1.55
211	Prostate cancer	Enrichment	PTEN, TP53	1.52
212	Huntington disease	Enrichment	HTT	1.43
213	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.43
214	Focal cortical dysplasia, type ii	Enrichment	TSC2	1.43
215	Mhc class i deficiency 1	Enrichment	TAP1	1.43
216	Lung sarcomatoid carcinoma	Enrichment	TP53	1.43
217	Mhc class i deficiency	Enrichment	TAP1	1.43
218	Tuberous sclerosis	Enrichment	TSC2	1.43
219	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.43
220	Craniopharyngioma	Enrichment	APC	1.43
221	Knobloch syndrome	Enrichment	COL18A1	1.43
222	Immunodeficiency by defective expression of mhc class i	Enrichment	TAP1	1.43
223	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.43
224	Isolated focal cortical dysplasia type ii	Enrichment	TSC2	1.43
225	Glioma	Enrichment	PTEN	1.43
226	Benign ependymoma	Enrichment	MSH2	1.43
227	Cleft lip and alveolus	Enrichment	TP63	1.43
228	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.43
229	Cataract 6, multiple types	Enrichment	EPHA2	1.33
230	Albinism, oculocutaneous, type ii	Enrichment	TYRP1	1.33
231	Kearns-sayre syndrome	Enrichment	RRM2B	1.33
232	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.33
233	Rhabdomyosarcoma 2	Enrichment	TP53	1.33
234	Macrocephaly/autism syndrome	Enrichment	PTEN	1.33
235	Knobloch syndrome 1	Enrichment	COL18A1	1.33
236	Breast-ovarian cancer, familial 2	Enrichment	PMS2	1.33
237	Familial adenomatous polyposis 1	Enrichment	APC	1.33
238	Glioblastoma	Enrichment	MSH2	1.33
239	Hemangioma	Enrichment	PTEN	1.33
240	Cleft upper lip	Enrichment	TP63	1.33
241	Hemimegalencephaly	Enrichment	PTEN	1.33
242	Aniridia	Enrichment	EPHA2	1.33
243	Systemic lupus erythematosus	Enrichment	IRF5, SPP1	1.28
244	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	RRM2B	1.26
245	Albinism, ocular, type i	Enrichment	TYRP1	1.26
246	Adrenocortical carcinoma	Enrichment	TP53	1.26
247	Breast adenocarcinoma	Enrichment	TP53	1.26
248	Lung squamous cell carcinoma	Enrichment	EGFR	1.26
249	Albinism	Enrichment	TYRP1	1.26
250	Esophageal cancer	Enrichment	TP53	1.19
251	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.19
252	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.19
253	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.19
254	Waardenburg syndrome, type 2e	Enrichment	SNAI2	1.19
255	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.19
256	Oculocutaneous albinism	Enrichment	TYRP1	1.19
257	Polycystic kidney disease 1	Enrichment	TSC2	1.19
258	Essential thrombocythemia	Enrichment	TP53	1.19
259	Gallbladder cancer	Enrichment	TP53	1.19
260	Follicular thyroid carcinoma	Enrichment	PTEN	1.19
261	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.19
262	Arthrogryposis, distal, type 1a	Enrichment	MET	1.14
263	Glioma susceptibility 1	Enrichment	TP53	1.14
264	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.14
265	Neuroblastoma	Enrichment	SMARCA4	1.14
266	Isolated split hand-split foot malformation	Enrichment	TP63	1.14
267	Early-onset posterior polar cataract	Enrichment	EPHA2	1.14
268	Sensorineural hearing loss	Enrichment	HGF, RRM2B	1.12
269	Rheumatoid arthritis	Enrichment	IRF5	1.09
270	Primary hyperaldosteronism	Enrichment	TP53	1.09
271	Ventricular septal defect	Enrichment	SMARCA4	1.09
272	Primary biliary cholangitis	Enrichment	IRF5	1.09
273	Cowden syndrome	Enrichment	PTEN	1.09
274	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	RRM2B	1.09
275	Leukemia, chronic lymphocytic	Enrichment	TP53	1.04
276	Stickler syndrome	Enrichment	VCAN	1.04
277	Melanoma	Enrichment	PTEN	1.04
278	Xeroderma pigmentosum, variant type	Enrichment	DDB2	1.00
279	Meningioma, familial	Enrichment	PTEN	1.00
280	Myelodysplastic syndrome	Enrichment	TP53	1.00
281	Cardiomyopathy, familial hypertrophic, 9	Enrichment	PMS2	1.00
282	Atrial heart septal defect	Enrichment	SMARCA4	1.00
283	Lung non-small cell carcinoma	Enrichment	EGFR	1.00
284	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.00
285	Interatrial communication	Enrichment	SMARCA4	1.00
286	Primary ovarian insufficiency	Enrichment	AFP, TP63	0.97
287	Meningioma	Enrichment	PTEN	0.97
288	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	0.94
289	Breast-ovarian cancer, familial 1	Enrichment	MSH2	0.94
290	Pulmonary disease, chronic obstructive	Enrichment	VDR	0.94
291	Acute promyelocytic leukemia	Enrichment	PML	0.94
292	Premature menopause	Enrichment	TP63	0.94
293	Medulloblastoma	Enrichment	APC	0.91
294	Cleft lip/palate	Enrichment	TP63	0.91
295	Coffin-siris syndrome 1	Enrichment	SMARCA4	0.88
296	Renal cell carcinoma, nonpapillary	Enrichment	MET	0.88
297	Familial hypercholesterolemia	Enrichment	SMARCA4	0.88
298	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	0.88
299	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.88
300	Male infertility with spermatogenesis disorder	Enrichment	TP63	0.88
301	Cleft palate, isolated	Enrichment	SMARCA4	0.83
302	Cataract 44	Enrichment	EPHA2	0.83
303	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	0.80
304	Early-onset nuclear cataract	Enrichment	EPHA2	0.80
305	Behcet syndrome	Enrichment	FAS	0.78
306	Cardiomyopathy, dilated, 1g	Enrichment	PMS2	0.72
307	Tooth agenesis	Enrichment	TGFA	0.72
308	Diamond-blackfan anemia 1	Enrichment	TP53	0.71
309	Familial atrial fibrillation	Enrichment	SCN3B	0.69
310	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	0.69
311	Pancreatic cancer	Enrichment	TP53	0.68
312	Brugada syndrome	Enrichment	SCN3B	0.66
313	Auditory neuropathy	Enrichment	FDXR	0.66
314	Severe covid-19	Enrichment	CASP10	0.62
315	Stargardt disease 1	Enrichment	COL18A1	0.61
316	Congenital nervous system abnormality	Enrichment	PTEN, TSC2	0.58
317	Nervous system disease	Enrichment	PTEN, TSC2	0.58
318	Autism spectrum disorder	Enrichment	PTEN, TSC2	0.56
319	Diamond-blackfan anemia	Enrichment	TP53	0.54
320	Cerebral palsy	Enrichment	SMARCA4	0.51
321	Leukemia, acute myeloid	Enrichment	TP53	0.50
322	Charcot-marie-tooth disease	Enrichment	NDRG1	0.49
323	West syndrome	Enrichment	TSC2	0.47
324	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TRRAP	0.41
325	Myeloma, multiple	Enrichment	TP53	0.38
326	Mitochondrial disease	Enrichment	RRM2B	0.25
327	Retinitis pigmentosa	Enrichment	COL18A1, RRM2B	0.22
328	Complex neurodevelopmental disorder	Enrichment	HTT	0.16
329	Hereditary retinal dystrophy	Enrichment	COL18A1, VCAN	0.12
330	Fundus dystrophy	Enrichment	COL18A1, VCAN	0.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Direct p53 effectors

Pathway Network for Direct p53 effectors

Member Pathways for Direct p53 effectors

Pathways in the Direct p53 effectors SuperPath

Associated Genes for Direct p53 effectors

Associated Disorders for Direct p53 effectors

Disorders associated with Direct p53 effectors SuperPath

STRING Interaction Network for Direct p53 effectors

Sources for Direct p53 effectors