Diseases of hemostasis

Pathway network for the Diseases of hemostasis SuperPath

Sources:

Reactome
WikiPathways
R&D Systems
QIAGEN
PubChem

Pathways in the Diseases of hemostasis SuperPath

#	Name	Source	Genes
1	Diseases of hemostasis	Reactome	ADAMTS13 COL1A1 COL1A2 F10 F11 F12 F2 F8 F9 GGCX GP1BA GP1BB GP5 GP9 KLKB1 SERPING1 TPST1 TPST2 VWF (see all 19) (see less)
2	Complement and coagulation cascades	WikiPathways	A2M BDKRB1 C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4B C5AR1 C6 C7 C8G C9 CD46 CD55 CFB CFD CFH CFI CLTC CLU CPB2 CR1 CR2 F10 F12 F13B F2 F2R F3 F5 F7 F8 F9 FGB KLKB1 KNG1 LMAN1 MASP1 MASP2 PLAT PLAU PLAUR PLG PROC PROS1 SERPINA1 SERPINA5 SERPINC1 SERPIND1 SERPINE1 SERPINF2 SERPING1 TFPI THBD VWF (see all 59) (see less)
3	Formation of Fibrin Clot (Clotting Cascade)	Reactome	A2M C1QBP CD177 F10 F11 F12 F13A1 F13B F2 F2R F3 F5 F7 F8 F9 FGA FGB FGG GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PF4 PF4V1 PRCP PROC PROCR PROS1 PRTN3 SERPINA5 SERPINC1 SERPIND1 SERPINE2 SERPING1 TFPI THBD VWF (see all 39) (see less)
4	Blood Coagulation Signaling Pathways	R&D Systems	A2M COL4A1 F10 F11 F12 F2 F3 F5 F7 F8 F9 FGB GP1BA GP5 GP6 GP9 KLKB1 KNG1 PLAT PLAU PLG PROC PROS1 SERPINA5 SERPINB2 SERPINC1 SERPIND1 SERPINE1 SERPINF2 TFPI TFPI2 THBD VWF (see all 33) (see less)
5	Intrinsic Pathway of Fibrin Clot Formation	Reactome	A2M C1QBP F10 F11 F12 F2 F8 F9 GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PRCP PROC PROS1 SERPINA5 SERPINC1 SERPIND1 SERPINE2 SERPING1 VWF (see all 23) (see less)
6	Common Pathway of Fibrin Clot Formation	Reactome	CD177 F10 F13A1 F13B F2 F2R F5 F8 FGA FGB FGG PF4 PF4V1 PROC PROCR PROS1 PRTN3 SERPINA5 SERPINC1 SERPIND1 SERPINE2 THBD (see all 22) (see less)
7	Blood clotting cascade	WikiPathways	F10 F11 F12 F13B F2 F3 F5 F7 F8 F9 FGA FGB FGG KLK1 KLKB1 PLAT PLAU PLG SERPINB2 SERPINE1 SERPINF2 VWF (see all 22) (see less)
8	Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	Reactome	F10 F11 F12 F2 F8 F9 GGCX GP1BA GP1BB GP5 GP9 KLKB1 SERPING1 TPST1 TPST2 VWF (see all 16) (see less)
9	Extrinsic Prothrombin Activation Pathway	QIAGEN	F10 F12 F13A1 F13B F2 F3 F5 F7 FGA FGB FGG PROC PROS1 SERPINC1 TFPI THBD (see all 16) (see less)
10	Defective factor IX causes hemophilia B	Reactome	F10 F11 F8 F9 GGCX GP1BA GP1BB GP5 GP9 (see all 9) (see less)
11	Defective factor VIII causes hemophilia A	Reactome	F10 F2 F8 F9 TPST1 TPST2 VWF (see all 7) (see less)
12	Defective F9 activation	Reactome	F11 F9 GP1BA GP1BB GP5 GP9 (see all 6) (see less)
13	Extrinsic Pathway of Fibrin Clot Formation	Reactome	F10 F3 F7 F9 TFPI
14	Defective F8 sulfation at Y1699	Reactome	F8 TPST1 TPST2
15	Defective factor XII causes hereditary angioedema	Reactome	F12 F2 KLKB1
16	Defective F8 cleavage by thrombin	Reactome	F2 F8 VWF
17	Defective gamma-carboxylation of F9	Reactome	F9 GGCX
18	Defective F8 binding to von Willebrand factor	Reactome	F8 VWF
19	Thrombin/protease-activated receptor (PAR) pathway	PubChem	F2
20	Defective F9 secretion	Reactome	F9

Gene overlap in member pathways for Diseases of hemostasis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	F2	Coagulation Factor II, Thrombin	Protein Coding	13
2	F8	Coagulation Factor VIII	Protein Coding	13
3	F9	Coagulation Factor IX	Protein Coding	13
4	F10	Coagulation Factor X	Protein Coding	12
5	VWF	Von Willebrand Factor	Protein Coding	10
6	F12	Coagulation Factor XII	Protein Coding	9
7	F11	Coagulation Factor XI	Protein Coding	8
8	KLKB1	Kallikrein B1	Protein Coding	8
9	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	7
10	GP5	Glycoprotein V Platelet	Protein Coding	7
11	GP9	Glycoprotein IX Platelet	Protein Coding	7
12	GP1BB	Glycoprotein Ib Platelet Subunit Beta	Protein Coding	6
13	PROS1	Protein S	Protein Coding	6
14	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	6
15	SERPINC1	Serpin Family C Member 1	Protein Coding	6
16	FGB	Fibrinogen Beta Chain	Protein Coding	6
17	F7	Coagulation Factor VII	Protein Coding	6
18	F5	Coagulation Factor V	Protein Coding	6
19	F3	Coagulation Factor III, Tissue Factor	Protein Coding	6
20	SERPING1	Serpin Family G Member 1	Protein Coding	5
21	THBD	Thrombomodulin	Protein Coding	5
22	TFPI	Tissue Factor Pathway Inhibitor	Protein Coding	5
23	SERPINA5	Serpin Family A Member 5	Protein Coding	5
24	SERPIND1	Serpin Family D Member 1	Protein Coding	5
25	F13B	Coagulation Factor XIII B Chain	Protein Coding	5
26	GGCX	Gamma-Glutamyl Carboxylase	Protein Coding	4
27	TPST2	Tyrosylprotein Sulfotransferase 2	Protein Coding	4
28	TPST1	Tyrosylprotein Sulfotransferase 1	Protein Coding	4
29	KNG1	Kininogen 1	Protein Coding	4
30	A2M	Alpha-2-Macroglobulin	Protein Coding	4
31	FGA	Fibrinogen Alpha Chain	Protein Coding	4
32	FGG	Fibrinogen Gamma Chain	Protein Coding	4
33	SERPINF2	Serpin Family F Member 2	Protein Coding	3
34	PLG	Plasminogen	Protein Coding	3
35	PLAU	Plasminogen Activator, Urokinase	Protein Coding	3
36	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	3
37	SERPINE1	Serpin Family E Member 1	Protein Coding	3
38	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	3
39	F13A1	Coagulation Factor XIII A Chain	Protein Coding	3
40	SERPINE2	Serpin Family E Member 2	Protein Coding	3
41	PROCR	Protein C Receptor	Protein Coding	2
42	PF4	Platelet Factor 4	Protein Coding	2
43	PF4V1	Platelet Factor 4 Variant 1	Protein Coding	2
44	PRCP	Prolylcarboxypeptidase	Protein Coding	2
45	PRTN3	Proteinase 3	Protein Coding	2
46	CD177	CD177 Molecule	Protein Coding	2
47	C1QBP	Complement C1q Binding Protein	Protein Coding	2
48	SERPINB2	Serpin Family B Member 2	Protein Coding	2
49	ADAMTS13	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13	Protein Coding	1
50	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
51	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
52	C9	Complement C9	Protein Coding	1
53	C8G	Complement C8 Gamma Chain	Protein Coding	1
54	C7	Complement C7	Protein Coding	1
55	C6	Complement C6	Protein Coding	1
56	C5AR1	Complement C5a Receptor 1	Protein Coding	1
57	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	1
58	C3	Complement C3	Protein Coding	1
59	C2	Complement C2	Protein Coding	1
60	C1S	Complement C1s	Protein Coding	1
61	C1R	Complement C1r	Protein Coding	1
62	C1QC	Complement C1q C Chain	Protein Coding	1
63	C1QB	Complement C1q B Chain	Protein Coding	1
64	C1QA	Complement C1q A Chain	Protein Coding	1
65	CFB	Complement Factor B	Protein Coding	1
66	BDKRB1	Bradykinin Receptor B1	Protein Coding	1
67	MASP1	MBL Associated Serine Protease 1	Protein Coding	1
68	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
69	SERPINA1	Serpin Family A Member 1	Protein Coding	1
70	CD46	CD46 Molecule	Protein Coding	1
71	LMAN1	Lectin, Mannose Binding 1	Protein Coding	1
72	CFI	Complement Factor I	Protein Coding	1
73	CFH	Complement Factor H	Protein Coding	1
74	CFD	Complement Factor D	Protein Coding	1
75	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	1
76	CR2	Complement C3d Receptor 2	Protein Coding	1
77	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	1
78	CPB2	Carboxypeptidase B2	Protein Coding	1
79	CLTC	Clathrin Heavy Chain	Protein Coding	1
80	CLU	Clusterin	Protein Coding	1
81	MASP2	MBL Associated Serine Protease 2	Protein Coding	1
82	C3AR1	Complement C3a Receptor 1	Protein Coding	1
83	GP6	Glycoprotein VI Platelet	Protein Coding	1
84	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
85	TFPI2	Tissue Factor Pathway Inhibitor 2	Protein Coding	1
86	KLK1	Kallikrein 1	Protein Coding	1

Disorders associated with Diseases of hemostasis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	C1 inhibitor deficiency	Direct
2	Factor viii deficiency	Direct
3	Hemophilia b	Direct
4	Hereditary angioedema	Direct
5	Thrombophilia	Direct
6	Thrombocytopenia	Enrichment	F10, F11, F8, FGG, GP1BA, GP1BB, GP9, PROS1, THBD, VWF	16.00
7	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3, CD46, CFB, CFH, CFI, THBD	10.61
8	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1QA, C1QB, C1QC, C1R, C1S, C2, C4B	10.56
9	Thrombophilia due to thrombin defect	Enrichment	F13A1, F13B, F2, FGA	10.18
10	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	8.87
11	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	8.87
12	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	8.87
13	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	8.27
14	Immunodeficiency due to a late component of complement deficiency	Enrichment	C6, C7, C8G, C9	7.95
15	Bernard-soulier syndrome	Enrichment	GP1BA, GP1BB, GP9	7.37
16	Angioedema, hereditary, 1	Enrichment	F12, PLG, SERPING1	7.11
17	C1q deficiency 1	Enrichment	C1QA, C1QB, C1QC	7.11
18	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH	7.11
19	Hellp syndrome	Enrichment	CD46, CFH, CFI	6.51
20	Atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH, CFI	6.37
21	Factor xiii deficiency	Enrichment	F13A1, F13B	5.88
22	Cerebral palsy	Enrichment	COL4A1, F2, F8, PROC	5.65
23	Angioedema	Enrichment	F12, SERPING1	5.56
24	Cerebral sinovenous thrombosis	Enrichment	F2, F5	5.41
25	Factor x deficiency	Enrichment	F10, F11	5.12
26	Congenital factor x deficiency	Enrichment	F10, F11	5.12
27	Hemophilia a	Enrichment	F8, F9	4.82
28	Macular degeneration, age-related, 14	Enrichment	C2, CFB	4.73
29	De novo thrombotic microangiopathy after kidney transplantation	Enrichment	CFH, CFI	4.73
30	Periodontal ehlers-danlos syndrome	Enrichment	C1R, C1S	4.73
31	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	GP1BA, GP1BB	4.39
32	Ehlers-danlos syndrome, periodontal type, 1	Enrichment	C1R, C1S	4.25
33	Ehlers-danlos syndrome, periodontal type, 2	Enrichment	C1R, C1S	4.25
34	Familial drusen	Enrichment	CFH, CFI	4.25
35	Stroke, ischemic	Enrichment	F2, F5	4.23
36	Prothrombin deficiency, congenital	Enrichment	F2	4.13
37	Pregnancy loss, recurrent 2	Enrichment	F2	4.13
38	Prothrombin deficiency	Enrichment	F2	4.13
39	Autosomal dominant macrothrombocytopenia	Enrichment	GP1BA, GP1BB	3.91
40	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1, CFH	3.73
41	Systemic lupus erythematosus 16	Enrichment	C1QA, C1R	3.73
42	Myocardial infarction	Enrichment	F13A1, F7	3.53
43	Factor vii deficiency	Enrichment	F7	3.43
44	Warfarin sensitivity, x-linked	Enrichment	F9	3.43
45	Thrombophilia, x-linked, due to factor ix defect	Enrichment	F9	3.43
46	Hemophilia b leyden	Enrichment	F9	3.43
47	Congenital factor vii deficiency	Enrichment	F7	3.43
48	Thrombophilia due to protein c deficiency, autosomal dominant	Enrichment	PROC	2.93
49	Angioedema, hereditary, 3	Enrichment	F12	2.93
50	Hemolytic uremic syndrome, atypical 6	Enrichment	THBD	2.93
51	Thrombophilia due to protein s deficiency, autosomal dominant	Enrichment	PROS1	2.93
52	Factor v deficiency	Enrichment	F5	2.93
53	Thrombophilia due to protein s deficiency, autosomal recessive	Enrichment	PROS1	2.93
54	Thrombophilia due to activated protein c resistance	Enrichment	F5	2.93
55	Thrombophilia due to protein c deficiency, autosomal recessive	Enrichment	PROC	2.93
56	Antithrombin iii deficiency	Enrichment	SERPINC1	2.93
57	Factor xiii, b subunit, deficiency of	Enrichment	F13B	2.93
58	Thrombophilia due to thrombomodulin defect	Enrichment	THBD	2.93
59	Factor xiii, a subunit, deficiency of	Enrichment	F13A1	2.93
60	Protein s deficiency	Enrichment	PROS1	2.93
61	Factor v atlanta bleeding disorder	Enrichment	F5	2.93
62	Congenital fibrinogen deficiency	Enrichment	FGG	2.93
63	Factor v leiden thrombophilia	Enrichment	F5	2.93
64	Severe hereditary thrombophilia due to congenital protein c deficiency	Enrichment	PROC	2.93
65	Protein c deficiency	Enrichment	PROC	2.93
66	Urticaria	Enrichment	F12	2.93
67	Factor v amsterdam bleeding disorder	Enrichment	F5	2.93
68	Hereditary thrombophilia due to congenital protein s deficiency	Enrichment	PROS1	2.93
69	F12-associated cold autoinflammatory syndrome	Enrichment	F12	2.93
70	Thrombophilia, x-linked, due to factor viii defect	Enrichment	F8	2.79
71	Von willebrand disease, type 1	Enrichment	VWF	2.79
72	Alpha-2-plasmin inhibitor deficiency	Enrichment	SERPINF2	2.79
73	Prekallikrein deficiency	Enrichment	KLKB1	2.79
74	Von willebrand disease, type 2	Enrichment	VWF	2.79
75	Angioedema, hereditary, 4	Enrichment	PLG	2.79
76	Von willebrand disease, type 3	Enrichment	VWF	2.79
77	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.79
78	Von willebrand's disease	Enrichment	VWF	2.79
79	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.79
80	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.79
81	Inherited prekallikrein deficiency	Enrichment	KLKB1	2.79
82	Bernard-soulier syndrome, type a2, autosomal dominant	Enrichment	GP1BA	2.77
83	Complement component 4, partial deficiency of	Enrichment	SERPING1	2.77
84	High molecular weight kininogen deficiency	Enrichment	KNG1	2.77
85	Nonarteritic anterior ischemic optic neuropathy	Enrichment	GP1BA	2.77
86	Von willebrand disease, platelet-type	Enrichment	GP1BA	2.77
87	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.77
88	Angioedema, hereditary, 6	Enrichment	KNG1	2.77
89	Bernard-soulier syndrome type a2	Enrichment	GP1BA	2.77
90	Hereditary angioedema with c1inh deficiency	Enrichment	SERPING1	2.77
91	Cholesteatoma, congenital	Enrichment	F13B	2.63
92	Factor xii deficiency	Enrichment	F12	2.63
93	Bleeding disorder, east texas type	Enrichment	F5	2.63
94	Cholesteatoma	Enrichment	F13B	2.63
95	Bleeding disorder, platelet-type, 11	Enrichment	GP6	2.61
96	Porencephaly	Enrichment	COL4A1	2.61
97	Col4a1-related disorders	Enrichment	COL4A1	2.61
98	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	2.61
99	Surfactant metabolism dysfunction, pulmonary, 3	Enrichment	F8	2.49
100	Plasminogen deficiency, type i	Enrichment	PLG	2.49
101	Quebec platelet disorder	Enrichment	PLAU	2.49
102	Kallikrein, decreased urinary activity of	Enrichment	KLK1	2.49
103	Factor xi deficiency	Enrichment	F11	2.49
104	3mc syndrome 1	Enrichment	MASP1	2.36
105	Complement component 2 deficiency	Enrichment	C2	2.36
106	Basal laminar drusen	Enrichment	CFH	2.36
107	Complement component 7 deficiency	Enrichment	C7	2.36
108	Hemolytic uremic syndrome, atypical 4	Enrichment	CFB	2.36
109	Complement factor d deficiency	Enrichment	CFD	2.36
110	Macular degeneration, age-related, 4	Enrichment	CFH	2.36
111	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.36
112	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	Enrichment	CD55	2.36
113	Blood group, cromer system	Enrichment	CD55	2.36
114	Macular degeneration, age-related, 15	Enrichment	C9	2.36
115	Hemolytic uremic syndrome, atypical 3	Enrichment	CFI	2.36
116	Macular degeneration, age-related, 13	Enrichment	CFI	2.36
117	C1q deficiency 3	Enrichment	C1QC	2.36
118	Complement factor h deficiency	Enrichment	CFH	2.36
119	Complement factor i deficiency	Enrichment	CFI	2.36
120	Complement component 4b deficiency	Enrichment	C4B	2.36
121	Masp2 deficiency	Enrichment	MASP2	2.36
122	Hemolytic uremic syndrome, atypical 2	Enrichment	CD46	2.36
123	Alpha-1-antitrypsin deficiency	Enrichment	SERPINA1	2.36
124	Macular degeneration, age-related, 9	Enrichment	C3	2.36
125	Complement component 9 deficiency	Enrichment	C9	2.36
126	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.36
127	Complement factor b deficiency	Enrichment	CFB	2.36
128	Complement component 3 deficiency	Enrichment	C3	2.36
129	C1q deficiency 2	Enrichment	C1QB	2.36
130	Hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation	Enrichment	SERPINA1	2.36
131	Membranoproliferative glomerulonephritis	Enrichment	C3	2.36
132	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.36
133	Protein-losing enteropathy	Enrichment	CD55	2.36
134	Genetic hemolytic uremic syndrome	Enrichment	CFH	2.36
135	Immunodeficiency due to masp-2 deficiency	Enrichment	MASP2	2.36
136	Recurrent neisseria infections due to factor d deficiency	Enrichment	CFD	2.36
137	Immunodeficiency with factor h anomaly	Enrichment	CFH	2.36
138	Budd-chiari syndrome	Enrichment	F5	2.33
139	Pregnancy loss, recurrent 1	Enrichment	F5	2.33
140	Heparin cofactor ii deficiency	Enrichment	SERPIND1	2.31
141	Periventricular nodular heterotopia 1	Enrichment	VWF	2.31
142	Amyloidosis, hereditary systemic 2	Enrichment	FGA	2.23
143	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	2.19
144	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	KNG1	2.17
145	Retinal arteries, tortuosity of	Enrichment	COL4A1	2.14
146	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	2.14
147	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	2.14
148	Alzheimer disease 2	Enrichment	PLAU	2.09
149	Cystic fibrosis	Enrichment	PLG, SERPINA1	2.07
150	Cyclic neutropenia	Enrichment	CFD	2.06
151	Immunodeficiency, common variable, 2	Enrichment	CR2	2.06
152	Complement component c1s deficiency	Enrichment	C1S	2.06
153	Complement component 6 deficiency	Enrichment	C6	2.06
154	Immunodeficiency, common variable, 7	Enrichment	CR2	2.06
155	Nephrotic syndrome, type 7	Enrichment	CFH	2.06
156	Combined deficiency of factor v and factor viii	Enrichment	LMAN1	2.06
157	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	2.03
158	Granulomatosis with polyangiitis	Enrichment	PRTN3	2.01
159	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1	2.01
160	Schizencephaly	Enrichment	COL4A1	2.01
161	Familial porencephaly	Enrichment	COL4A1	1.92
162	Systemic lupus erythematosus	Enrichment	C4B, CR2	1.91
163	Bilirubin metabolic disorder	Enrichment	F12	1.89
164	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	CFD	1.89
165	Factor v and factor viii, combined deficiency of, 1	Enrichment	LMAN1	1.89
166	Intellectual developmental disorder, x-linked 109	Enrichment	SERPINA1	1.89
167	Systemic lupus erythematosus 9	Enrichment	CR2	1.89
168	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.89
169	Anterior segment dysgenesis 5	Enrichment	COL4A1	1.84
170	Hemorrhage, intracerebral	Enrichment	COL4A1	1.84
171	Keratoconus	Enrichment	COL4A1	1.84
172	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.76
173	Thrombotic microangiopathy	Enrichment	CD46	1.76
174	Hypertension	Enrichment	F12	1.73
175	Digeorge syndrome	Enrichment	GP1BB	1.70
176	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	MASP2	1.67
177	C3 glomerulopathy	Enrichment	CFH	1.67
178	Peters-plus syndrome	Enrichment	COL4A1	1.62
179	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.59
180	3mc syndrome	Enrichment	MASP1	1.59
181	Alzheimer disease, familial, 1	Enrichment	PLAU	1.56
182	Noonan syndrome 3	Enrichment	CLTC	1.52
183	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.52
184	Walker-warburg syndrome	Enrichment	COL4A1	1.47
185	Severe covid-19	Enrichment	F13B	1.47
186	Corpus callosum, agenesis of	Enrichment	COL4A1	1.44
187	Anterior segment dysgenesis	Enrichment	COL4A1	1.44
188	Isolated corpus callosum agenesis	Enrichment	COL4A1	1.44
189	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1	1.44
190	Pulmonary disease, chronic obstructive	Enrichment	SERPINA1	1.26
191	Chronic kidney disease	Enrichment	CFH	1.26
192	Ehlers-danlos syndrome	Enrichment	C1R	1.10
193	Cakut	Enrichment	COL4A1	1.10
194	Malaria	Enrichment	CR1	1.02
195	Mitochondrial disease	Enrichment	C1QBP	0.86
196	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	0.71
197	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC	0.66
198	Microcephaly	Enrichment	COL4A1	0.59
199	Hereditary retinal dystrophy	Enrichment	CFH	0.14
200	Fundus dystrophy	Enrichment	CFH	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Diseases of hemostasis

Pathway Network for Diseases of hemostasis

Pathway network for the Diseases of hemostasis SuperPath

Member Pathways for Diseases of hemostasis

Pathways in the Diseases of hemostasis SuperPath

Gene overlap in member pathways for Diseases of hemostasis SuperPath

Associated Genes for Diseases of hemostasis

Associated Disorders for Diseases of hemostasis

Disorders associated with Diseases of hemostasis SuperPath

STRING Interaction Network for Diseases of hemostasis

Sources for Diseases of hemostasis