Diseases of Immune System

Pathway network for the Diseases of Immune System SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Diseases of Immune System SuperPath

#	Name	Source	Genes
1	Diseases of Immune System	Reactome	BTK CD14 CD36 CHUK FGA FGB FGG HMGB1 IKBKB IKBKG IRAK4 LY96 MYD88 NFKB1 NFKB2 NFKBIA RELA S100A1 S100A8 S100A9 TICAM1 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TRAF3 UNC93B1 (see all 32) (see less)
2	Diseases associated with the TLR signaling cascade	Reactome	BTK CD14 CD36 CHUK FGA FGB FGG HMGB1 IKBKB IKBKG IRAK4 LY96 MYD88 NFKB1 NFKB2 NFKBIA RELA S100A1 S100A8 S100A9 TICAM1 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TRAF3 UNC93B1 (see all 32) (see less)
3	Toll-like receptor signaling related to MyD88	WikiPathways	CHUK IKBKB IKBKE IKBKG IRAK1 IRAK4 IRF3 IRF7 MAPK1 MYD88 NFKB1 NFKB2 REL RELA RELB TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TOLLIP TRAF3 TRAF6 (see all 31) (see less)
4	Endogenous TLR signaling	PubChem	BGN CD14 CHUK HMGB1 HSPD1 IKBKB IKBKG IRAK1 IRAK2 IRAK4 LY96 MYD88 RHOA S100A8 S100A9 SFTPA1 TICAM1 TIRAP TLR1 TLR2 TLR3 TLR4 TLR6 VCAN (see all 24) (see less)
5	Regulation of TLR by endogenous ligand	Reactome	APOB CD14 CD36 FGA FGB FGG GSDMD GSDME HMGB1 LBP LY96 S100A1 S100A8 S100A9 SFTPA1 SFTPA2 SFTPD TLR1 TLR2 TLR4 TLR6 TLR7 (see all 22) (see less)
6	IRAK4 deficiency (TLR2/4)	Reactome	BTK CD14 CD36 FGA FGB FGG HMGB1 IRAK4 LY96 MYD88 S100A1 S100A8 S100A9 TIRAP TLR1 TLR2 TLR4 TLR6 (see all 18) (see less)
7	MyD88 deficiency (TLR2/4)	Reactome	BTK CD14 CD36 FGA FGB FGG HMGB1 LY96 MYD88 S100A1 S100A8 S100A9 TIRAP TLR1 TLR2 TLR4 TLR6 (see all 17) (see less)
8	IRAK4 deficiency (TLR5)	Reactome	IRAK4 MYD88 TLR10 TLR5
9	Transfer of LPS from LBP carrier to CD14	Reactome	CD14 LBP
10	MyD88 deficiency (TLR5)	Reactome	MYD88 TLR5

Gene overlap in member pathways for Diseases of Immune System SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	8
2	TLR6	Toll Like Receptor 6	Protein Coding	7
3	TLR1	Toll Like Receptor 1	Protein Coding	7
4	TLR2	Toll Like Receptor 2	Protein Coding	7
5	TLR4	Toll Like Receptor 4	Protein Coding	7
6	CD14	CD14 Molecule	Protein Coding	7
7	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	6
8	LY96	Lymphocyte Antigen 96	Protein Coding	6
9	HMGB1	High Mobility Group Box 1	Protein Coding	6
10	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	6
11	S100A8	S100 Calcium Binding Protein A8	Protein Coding	6
12	S100A9	S100 Calcium Binding Protein A9	Protein Coding	6
13	FGA	Fibrinogen Alpha Chain	Protein Coding	5
14	FGB	Fibrinogen Beta Chain	Protein Coding	5
15	FGG	Fibrinogen Gamma Chain	Protein Coding	5
16	S100A1	S100 Calcium Binding Protein A1	Protein Coding	5
17	TLR5	Toll Like Receptor 5	Protein Coding	5
18	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	5
19	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
20	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	4
21	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
22	TLR7	Toll Like Receptor 7	Protein Coding	4
23	BTK	Bruton Tyrosine Kinase	Protein Coding	4
24	TLR3	Toll Like Receptor 3	Protein Coding	4
25	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	4
26	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
27	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
28	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
29	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	3
30	TLR10	Toll Like Receptor 10	Protein Coding	3
31	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
32	UNC93B1	Unc-93B1 Regulator Of TLR Signaling	Protein Coding	2
33	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
34	SFTPA1	Surfactant Protein A1	Protein Coding	2
35	LBP	Lipopolysaccharide Binding Protein	Protein Coding	2
36	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
37	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
38	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
39	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
40	TLR9	Toll Like Receptor 9	Protein Coding	1
41	TLR8	Toll Like Receptor 8	Protein Coding	1
42	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
43	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
44	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	1
45	TBK1	TANK Binding Kinase 1	Protein Coding	1
46	TOLLIP	Toll Interacting Protein	Protein Coding	1
47	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
48	BGN	Biglycan	Protein Coding	1
49	VCAN	Versican	Protein Coding	1
50	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
51	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	1
52	RHOA	Ras Homolog Family Member A	Protein Coding	1
53	GSDME	Gasdermin E	Protein Coding	1
54	APOB	Apolipoprotein B	Protein Coding	1
55	SFTPD	Surfactant Protein D	Protein Coding	1
56	SFTPA2	Surfactant Protein A2	Protein Coding	1
57	GSDMD	Gasdermin D	Protein Coding	1

Disorders associated with Diseases of Immune System SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immune deficiency disease	Direct
2	Herpes simplex virus encephalitis	Enrichment	TBK1, TICAM1, TLR3, TRAF3	9.89
3	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	8.43
4	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	8.43
5	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	8.43
6	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.83
7	Multisystem inflammatory syndrome in children	Enrichment	IRF3, TLR3, TLR6, TRAF3	6.80
8	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	5.52
9	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	5.52
10	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.98
11	Interstitial lung disease 2	Enrichment	SFTPA1, SFTPA2	3.47
12	Malaria	Enrichment	IKBKG, TIRAP	3.13
13	Leprosy 3	Enrichment	TLR2	2.79
14	Coronary heart disease 7	Enrichment	CD36	2.79
15	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.79
16	Leprosy 5	Enrichment	TLR1	2.79
17	Interstitial lung disease 1	Enrichment	SFTPA1	2.79
18	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.79
19	X-linked immunodeficiency 74	Enrichment	TLR7	2.79
20	Systemic lupus erythematosus 17	Enrichment	TLR7	2.79
21	Deafness, autosomal dominant 5	Enrichment	GSDME	2.79
22	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.79
23	Macular degeneration, age-related, 10	Enrichment	TLR4	2.79
24	Congenital fibrinogen deficiency	Enrichment	FGG	2.79
25	Incontinentia pigmenti	Enrichment	IKBKG	2.75
26	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.75
27	Immunodeficiency 68	Enrichment	MYD88	2.75
28	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.75
29	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.75
30	Bacteremia 1	Enrichment	TIRAP	2.75
31	Fetal encasement syndrome	Enrichment	CHUK	2.75
32	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.75
33	Immunodeficiency 15b	Enrichment	IKBKB	2.75
34	Immunodeficiency 15a	Enrichment	IKBKB	2.75
35	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.75
36	Meester-loeys syndrome	Enrichment	BGN	2.75
37	Spastic paraplegia 13, autosomal dominant	Enrichment	HSPD1	2.75
38	Immunodeficiency 67	Enrichment	IRAK4	2.75
39	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.75
40	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.75
41	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.75
42	Waldenstram macroglobulinemia	Enrichment	MYD88	2.75
43	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.75
44	Legionnaire disease	Enrichment	TLR5	2.64
45	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.64
46	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.64
47	Noonan syndrome 13	Enrichment	MAPK1	2.64
48	Immunodeficiency 92	Enrichment	REL	2.64
49	Systemic lupus erythematosus 1	Enrichment	TLR5	2.64
50	Immunodeficiency 132a	Enrichment	TRAF3	2.64
51	Immunodeficiency 132b	Enrichment	TRAF3	2.64
52	Immunodeficiency 39	Enrichment	IRF7	2.64
53	Melioidosis	Enrichment	TLR5	2.64
54	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.64
55	Corticobasal syndrome	Enrichment	TBK1	2.64
56	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.64
57	Immunodeficiency 53	Enrichment	RELB	2.64
58	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.64
59	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.49
60	Leprosy 1	Enrichment	TLR6	2.49
61	Hypobetalipoproteinemia	Enrichment	APOB	2.49
62	Wagner vitreoretinopathy	Enrichment	VCAN	2.45
63	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	BGN	2.45
64	Leukodystrophy, hypomyelinating, 4	Enrichment	HSPD1	2.45
65	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.45
66	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.45
67	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.45
68	Wagner disease	Enrichment	VCAN	2.45
69	Systemic lupus erythematosus	Enrichment	IRAK1, TLR7	2.45
70	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
71	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.34
72	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.34
73	Rela fusion-positive ependymoma	Enrichment	RELA	2.34
74	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.34
75	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
76	Hypercholesterolemia, familial, 2	Enrichment	APOB	2.31
77	Blood platelet disease	Enrichment	CD36	2.19
78	Cerebral malaria	Enrichment	CD36	2.19
79	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	2.16
80	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.15
81	Hyperlipidemia, familial combined, 3	Enrichment	APOB	2.09
82	Amyloidosis, hereditary systemic 2	Enrichment	FGA	2.09
83	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.05
84	Anemia, autoimmune hemolytic	Enrichment	TLR8	2.04
85	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.04
86	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.04
87	Hemihyperplasia, isolated	Enrichment	RHOA	1.98
88	Thrombophilia due to thrombin defect	Enrichment	FGA	1.95
89	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.94
90	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.89
91	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.89
92	Rheumatoid arthritis	Enrichment	TLR1	1.84
93	Coronary heart disease 5	Enrichment	APOB	1.84
94	Motor neuron disease	Enrichment	TBK1	1.80
95	Stickler syndrome	Enrichment	VCAN	1.76
96	Progressive non-fluent aphasia	Enrichment	TBK1	1.69
97	Hypercholesterolemia, familial, 1	Enrichment	APOB	1.68
98	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.65
99	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
100	Familial hypercholesterolemia	Enrichment	APOB	1.62
101	Specific learning disability	Enrichment	MAPK1	1.60
102	Behcet syndrome	Enrichment	TLR4	1.52
103	Human immunodeficiency virus type 1	Enrichment	TLR3	1.50
104	Diffuse large b-cell lymphoma	Enrichment	MYD88	1.48
105	Leukodystrophy	Enrichment	HSPD1	1.46
106	Heart, malformation of	Enrichment	MAPK1	1.39
107	Severe combined immunodeficiency	Enrichment	IKBKB	1.25
108	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	BGN	1.12
109	Thrombocytopenia	Enrichment	FGG	1.12
110	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GSDME	1.09
111	Rare genetic deafness	Enrichment	GSDME	0.92
112	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.90
113	Colorectal cancer	Enrichment	TLR2	0.88
114	Microcephaly	Enrichment	MAPK1	0.61
115	Hereditary retinal dystrophy	Enrichment	VCAN	0.39
116	Fundus dystrophy	Enrichment	VCAN	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Diseases of Immune System

Pathway Network for Diseases of Immune System

Pathway network for the Diseases of Immune System SuperPath

Member Pathways for Diseases of Immune System

Pathways in the Diseases of Immune System SuperPath

Gene overlap in member pathways for Diseases of Immune System SuperPath

Associated Genes for Diseases of Immune System

Associated Disorders for Diseases of Immune System

Disorders associated with Diseases of Immune System SuperPath

STRING Interaction Network for Diseases of Immune System

Sources for Diseases of Immune System