Disulfiram Pathway, Pharmacodynamics (Cocaine and Ethanol PK)
No Pathway Network information available for Disulfiram Pathway, Pharmacodynamics (Cocaine and Ethanol PK)
Pathways in the Disulfiram Pathway, Pharmacodynamics (Cocaine and Ethanol PK) SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Disulfiram Pathway, Pharmacodynamics (Cocaine and Ethanol PK) | PharmGKB | |
| 2 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | SLC6A5 | Solute Carrier Family 6 Member 5 | Protein Coding | 2 |
| 2 | BCHE | Butyrylcholinesterase | Protein Coding | 1 |
| 3 | ALDH2 | Aldehyde Dehydrogenase 2 Family Member | Protein Coding | 1 |
| 4 | SLC6A3 | Solute Carrier Family 6 Member 3 | Protein Coding | 1 |
| 5 | SLC6A4 | Solute Carrier Family 6 Member 4 | Protein Coding | 1 |
| 6 | CES2 | Carboxylesterase 2 | Protein Coding | 1 |
| 7 | CYP3A4 | Cytochrome P450 Family 3 Subfamily A Member 4 | Protein Coding | 1 |
| 8 | CES1 | Carboxylesterase 1 | Protein Coding | 1 |
| 9 | ADH1B | Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide | Protein Coding | 1 |
| 10 | ADH4 | Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide | Protein Coding | 1 |
Disorders associated with Disulfiram Pathway, Pharmacodynamics (Cocaine and Ethanol PK) SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Alcohol dependence | Enrichment | ADH1B, ALDH2 | 5.14 |
| 2 | Hyperekplexia 3 | Enrichment | SLC6A5 | 4.13 |
| 3 | Hyperekplexia | Enrichment | SLC6A5 | 3.43 |
| 4 | Drug metabolism, altered, ces1-related | Enrichment | CES1 | 3.13 |
| 5 | Alcohol sensitivity, acute | Enrichment | ALDH2 | 3.13 |
| 6 | Parkinsonism-dystonia 1, infantile-onset | Enrichment | SLC6A3 | 3.13 |
| 7 | Butyrylcholinesterase deficiency | Enrichment | BCHE | 3.13 |
| 8 | Vitamin d-dependent rickets, type 3 | Enrichment | CYP3A4 | 3.13 |
| 9 | Classic dopamine transporter deficiency syndrome | Enrichment | SLC6A3 | 3.13 |
| 10 | Parkinsonism-dystonia, infantile | Enrichment | SLC6A3 | 3.13 |
| 11 | Obsessive-compulsive disorder | Enrichment | SLC6A4 | 2.83 |
| 12 | Amed syndrome, digenic | Enrichment | ALDH2 | 2.83 |
| 13 | Tobacco addiction | Enrichment | SLC6A3 | 2.53 |
| 14 | Anxiety | Enrichment | SLC6A4 | 2.35 |
