Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Pathway network for the Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

Sources:

PharmGKB
WikiPathways

Pathways in the Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

#	Name	Source	Genes
1	Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)	PharmGKB	ALDH1A1 ALDH2 COMT DDC MAOA MAOB TH (see all 7) (see less)
2	Dopamine metabolism	WikiPathways	COMT DDC MAOA MAOB NQO1 PPP2CA PPP2CB PRKACA PRKACB PRKACG SOD1 TH TYR (see all 13) (see less)
3	Disulfiram Pathway, Pharmacodynamics (Serotonergic neuron)	PharmGKB	ADH1B ALDH1A1 ALDH2 DDC MAOA MAOB SULT1A1 TPH2 UGT1A6 (see all 9) (see less)

Gene overlap in member pathways for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAOA	Monoamine Oxidase A	Protein Coding	3
2	MAOB	Monoamine Oxidase B	Protein Coding	3
3	DDC	Dopa Decarboxylase	Protein Coding	3
4	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	2
5	TH	Tyrosine Hydroxylase	Protein Coding	2
6	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	2
7	COMT	Catechol-O-Methyltransferase	Protein Coding	2
8	TYR	Tyrosinase	Protein Coding	1
9	SOD1	Superoxide Dismutase 1	Protein Coding	1
10	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
11	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
12	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
13	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
14	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
15	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
16	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
17	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	1
18	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	1
19	TPH2	Tryptophan Hydroxylase 2	Protein Coding	1

Disorders associated with Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alcohol dependence	Enrichment	ADH1B, ALDH2	5.23
2	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	4.52
3	Brunner syndrome	Enrichment	MAOA	3.29
4	Alcohol sensitivity, acute	Enrichment	ALDH2	3.29
5	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	3.29
6	Albinism, oculocutaneous, type ib	Enrichment	TYR	3.02
7	Skin/hair/eye pigmentation, variation in, 3	Enrichment	TYR	3.02
8	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	3.02
9	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	3.02
10	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	3.02
11	Minimal pigment oculocutaneous albinism type 1	Enrichment	TYR	3.02
12	Hypopigmentation of the skin	Enrichment	TYR	3.02
13	Segawa syndrome, autosomal recessive	Enrichment	TH	2.99
14	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.99
15	Amed syndrome, digenic	Enrichment	ALDH2	2.99
16	Major affective disorder 1	Enrichment	TPH2	2.88
17	Dystonia, dopa-responsive	Enrichment	TH	2.81
18	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.72
19	Albinism, oculocutaneous, type ia	Enrichment	TYR	2.72
20	Melanoma, cutaneous malignant 8	Enrichment	TYR	2.72
21	Fibrolamellar carcinoma	Enrichment	PRKACA	2.72
22	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.72
23	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.72
24	Major depressive disorder	Enrichment	TPH2	2.48
25	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	2.32
26	Albinism, ocular, type i	Enrichment	TYR	2.24
27	Albinism	Enrichment	TYR	2.24
28	Digeorge syndrome	Enrichment	COMT	2.21
29	Crigler-najjar syndrome, type i	Enrichment	UGT1A6	2.18
30	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A6	2.18
31	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A6	2.18
32	Crigler-najjar syndrome, type ii	Enrichment	UGT1A6	2.18
33	Waardenburg syndrome, type 2e	Enrichment	TYR	2.17
34	Oculocutaneous albinism	Enrichment	TYR	2.17
35	Motor neuron disease	Enrichment	SOD1	2.17
36	Gilbert syndrome	Enrichment	UGT1A6	2.14
37	Bilirubin metabolic disorder	Enrichment	UGT1A6	2.14
38	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	2.02
39	Optic nerve disease	Enrichment	TYR	2.02
40	Rasopathy	Enrichment	DDC	1.87
41	Myopia	Enrichment	TYR	1.85
42	Dystonia	Enrichment	TH	1.75
43	Skin disease	Enrichment	TYR	1.68
44	Bardet-biedl syndrome	Enrichment	COMT	1.67
45	Strabismus	Enrichment	TYR	1.59
46	Schizophrenia	Enrichment	COMT	1.52
47	Eye disease	Enrichment	TYR	1.48
48	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	1.27
49	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Pathway Network for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Pathway network for the Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

Member Pathways for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Pathways in the Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

Gene overlap in member pathways for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

Associated Genes for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Associated Disorders for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Disorders associated with Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) SuperPath

STRING Interaction Network for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)

Sources for Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron)