Diuretics Pathway, Pharmacodynamics

No Pathway Network information available for Diuretics Pathway, Pharmacodynamics

Pathways in the Diuretics Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Diuretics Pathway, Pharmacodynamics	PharmGKB	ADD1 ARNT ARRB2 ATP1A1 BSND CLCNKA CLCNKB FXYD2 GRK2 GRK3 KCNJ1 MAPK1 MAPK3 NEDD4L OXSR1 PPP2CA PRKAA2 PRKCE SCNN1A SCNN1B SCNN1G SGK1 SLC12A1 SLC12A3 STK39 WNK1 WNK3 WNK4 ZEB1 (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	WNK1	WNK Lysine Deficient Protein Kinase 1	Protein Coding	1
2	SCNN1A	Sodium Channel Epithelial 1 Subunit Alpha	Protein Coding	1
3	SCNN1B	Sodium Channel Epithelial 1 Subunit Beta	Protein Coding	1
4	SCNN1G	Sodium Channel Epithelial 1 Subunit Gamma	Protein Coding	1
5	WNK3	WNK Lysine Deficient Protein Kinase 3	Protein Coding	1
6	SLC12A1	Solute Carrier Family 12 Member 1	Protein Coding	1
7	SLC12A3	Solute Carrier Family 12 Member 3	Protein Coding	1
8	ARRB2	Arrestin Beta 2	Protein Coding	1
9	KCNJ1	Potassium Inwardly Rectifying Channel Subfamily J Member 1	Protein Coding	1
10	ATP1A1	ATPase Na+/K+ Transporting Subunit Alpha 1	Protein Coding	1
11	FXYD2	FXYD Domain Containing Ion Transport Regulator 2	Protein Coding	1
12	NEDD4L	NEDD4 Like E3 Ubiquitin Protein Ligase	Protein Coding	1
13	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
15	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
16	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
17	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
18	ADD1	Adducin 1	Protein Coding	1
19	CLCNKA	Chloride Voltage-Gated Channel Ka	Protein Coding	1
20	CLCNKB	Chloride Voltage-Gated Channel Kb	Protein Coding	1
21	STK39	Serine/Threonine Kinase 39	Protein Coding	1
22	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
23	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
24	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
25	WNK4	WNK Lysine Deficient Protein Kinase 4	Protein Coding	1
26	BSND	Barttin CLCNK Type Accessory Subunit Beta	Protein Coding	1
27	OXSR1	Oxidative Stress Responsive Kinase 1	Protein Coding	1
28	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	1
29	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	1

Disorders associated with Diuretics Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bartter disease	Enrichment	BSND, CLCNKB, KCNJ1, SLC12A1, SLC12A3	10.76
2	Liddle syndrome 1	Enrichment	SCNN1A, SCNN1B, SCNN1G	8.06
3	Pseudohypoaldosteronism, type ib1, autosomal recessive	Enrichment	SCNN1A, SCNN1B, SCNN1G	8.06
4	Bartter syndrome type 4	Enrichment	BSND, CLCNKA, CLCNKB	8.06
5	Idiopathic bronchiectasis	Enrichment	SCNN1A, SCNN1B, SCNN1G	7.45
6	Bartter syndrome, type 4b, neonatal, with sensorineural deafness	Enrichment	CLCNKA, CLCNKB	4.58
7	Gitelman syndrome	Enrichment	CLCNKB, SLC12A3	4.36
8	Bartter syndrome, type 2, antenatal	Enrichment	KCNJ1	2.67
9	Bartter syndrome, type 4a, neonatal, with sensorineural deafness	Enrichment	BSND	2.67
10	Bronchiectasis with or without elevated sweat chloride 2	Enrichment	SCNN1A	2.67
11	Bronchiectasis with or without elevated sweat chloride 3	Enrichment	SCNN1G	2.67
12	Pseudohypoaldosteronism, type iib	Enrichment	WNK4	2.67
13	Noonan syndrome 13	Enrichment	MAPK1	2.67
14	Pseudohypoaldosteronism, type ib2, autosomal recessive	Enrichment	SCNN1B	2.67
15	Liddle syndrome 2	Enrichment	SCNN1G	2.67
16	Prieto syndrome	Enrichment	WNK3	2.67
17	Liddle syndrome 3	Enrichment	SCNN1A	2.67
18	Pseudohypoaldosteronism, type iic	Enrichment	WNK1	2.67
19	Bartter disease type 4a	Enrichment	BSND	2.67
20	Periventricular nodular heterotopia 7	Enrichment	NEDD4L	2.67
21	Pseudohypoaldosteronism, type ib3, autosomal recessive	Enrichment	SCNN1G	2.67
22	Motor stereotypies	Enrichment	WNK3	2.67
23	Hypomagnesemia 2, renal	Enrichment	FXYD2	2.37
24	Polymyoclonus, infantile	Enrichment	SCNN1B	2.37
25	Bartter syndrome, type 3	Enrichment	CLCNKB	2.37
26	Bartter syndrome, type 1, antenatal	Enrichment	SLC12A1	2.37
27	Charcot-marie-tooth disease, axonal, type 2dd	Enrichment	ATP1A1	2.37
28	Hypomagnesemia, seizures, and impaired intellectual development 2	Enrichment	ATP1A1	2.37
29	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.37
30	Pseudohypoaldosteronism	Enrichment	SCNN1A	2.37
31	Hypokalemia	Enrichment	SLC12A3	2.37
32	Sleep apnea	Enrichment	WNK3	2.37
33	Laryngomalacia	Enrichment	WNK3	2.19
34	Osteopetrosis, autosomal dominant 1	Enrichment	CLCNKB	2.19
35	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	2.19
36	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	2.19
37	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	NEDD4L	2.19
38	Intraocular pressure quantitative trait locus	Enrichment	ZEB1	2.19
39	Deafness, autosomal recessive	Enrichment	BSND, CLCNKA	2.10
40	Autosomal recessive nonsyndromic deafness	Enrichment	BSND, CLCNKA	2.09
41	Neuropathy, hereditary sensory and autonomic, type iia	Enrichment	WNK1	2.07
42	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.07
43	Hereditary sensory and autonomic neuropathy type 2	Enrichment	WNK1	2.07
44	Corneal dystrophy	Enrichment	ZEB1	2.07
45	Fuchs' endothelial dystrophy	Enrichment	ZEB1	1.97
46	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	1.89
47	Epilepsy, familial focal, with variable foci 1	Enrichment	CLCNKB	1.83
48	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	BSND, CLCNKA	1.81
49	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	ADD1	1.72
50	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	SCNN1B	1.72
51	Nephrocalcinosis	Enrichment	SLC12A1	1.67
52	Nephrolithiasis	Enrichment	SLC12A1	1.67
53	Isolated tracheo-esophageal fistula	Enrichment	ADD1	1.67
54	Specific learning disability	Enrichment	MAPK1	1.63
55	Periventricular nodular heterotopia	Enrichment	NEDD4L	1.53
56	Hypertension, essential	Enrichment	ADD1	1.45
57	Heart, malformation of	Enrichment	MAPK1	1.42
58	Esophageal atresia/tracheoesophageal fistula	Enrichment	ADD1	1.40
59	Jeune thoracic dystrophy	Enrichment	GRK2	1.28
60	Brugada syndrome	Enrichment	SCNN1A	1.27
61	Asphyxiating thoracic dystrophy	Enrichment	GRK2	1.23
62	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	1.17
63	Sensorineural hearing loss	Enrichment	CLCNKA	1.01
64	Myeloma, multiple	Enrichment	SGK1	0.95
65	Autism	Enrichment	WNK3	0.84
66	Microcephaly	Enrichment	MAPK1	0.63
67	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Diuretics Pathway, Pharmacodynamics

Pathway Network for Diuretics Pathway, Pharmacodynamics

Member Pathways for Diuretics Pathway, Pharmacodynamics

Pathways in the Diuretics Pathway, Pharmacodynamics SuperPath

Associated Genes for Diuretics Pathway, Pharmacodynamics

Associated Disorders for Diuretics Pathway, Pharmacodynamics

Disorders associated with Diuretics Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Diuretics Pathway, Pharmacodynamics

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