DNA-PK pathway in nonhomologous end joining

No Pathway Network information available for DNA-PK pathway in nonhomologous end joining

Pathways in the DNA-PK pathway in nonhomologous end joining SuperPath

#	Name	Source	Genes
1	DNA-PK pathway in nonhomologous end joining	PubChem	APLF APTX DCLRE1C DNTT LIG4 NHEJ1 PNKP POLL POLM PRKDC XRCC4 XRCC5 XRCC6 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APLF	Aprataxin And PNKP Like Factor	Protein Coding	1
2	DNTT	DNA Nucleotidylexotransferase	Protein Coding	1
3	POLL	DNA Polymerase Lambda	Protein Coding	1
4	APTX	Aprataxin	Protein Coding	1
5	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	1
6	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
7	NHEJ1	Non-Homologous End Joining Factor 1	Protein Coding	1
8	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
9	LIG4	DNA Ligase 4	Protein Coding	1
10	PNKP	Polynucleotide Kinase 3''-Phosphatase	Protein Coding	1
11	XRCC4	X-Ray Repair Cross Complementing 4	Protein Coding	1
12	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
13	POLM	DNA Polymerase Mu	Protein Coding	1

Disorders associated with DNA-PK pathway in nonhomologous end joining SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lig4 syndrome	Enrichment	LIG4, XRCC4	6.07
2	Severe combined immunodeficiency	Enrichment	DCLRE1C, LIG4, NHEJ1	5.43
3	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	APTX, PNKP	5.29
4	Omenn syndrome	Enrichment	DCLRE1C, LIG4	4.42
5	Immunodeficiency 124, severe combined	Enrichment	NHEJ1	3.02
6	Ataxia-oculomotor apraxia 4	Enrichment	PNKP	3.02
7	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	3.02
8	Microphthalmia/coloboma 13	Enrichment	NHEJ1	3.02
9	Chromosome 2q35 duplication syndrome	Enrichment	NHEJ1	2.72
10	Dubowitz syndrome	Enrichment	LIG4	2.72
11	Charcot-marie-tooth disease, axonal, type 2b2	Enrichment	PNKP	2.72
12	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	2.72
13	Charcot-marie-tooth disease type 2b2	Enrichment	PNKP	2.72
14	Microcephaly, seizures, and developmental delay	Enrichment	PNKP	2.72
15	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC4	2.72
16	Microcephalic primordial dwarfism-insulin resistance syndrome	Enrichment	XRCC4	2.72
17	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	2.54
18	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	2.54
19	Isolated anophthalmia-microphthalmia syndrome	Enrichment	NHEJ1	2.54
20	Aicardi-goutieres syndrome 1	Enrichment	DCLRE1C	2.42
21	Developmental and epileptic encephalopathy 12	Enrichment	PNKP	2.42
22	Isolated growth hormone deficiency, type ia	Enrichment	XRCC4	2.12
23	Isolated congenital microcephaly	Enrichment	PNKP	1.82
24	Early infantile developmental and epileptic encephalopathy	Enrichment	PNKP	1.77
25	Epilepsy	Enrichment	APTX	1.42
26	Myeloma, multiple	Enrichment	LIG4	1.28
27	Congenital nervous system abnormality	Enrichment	PNKP	1.01
28	Nervous system disease	Enrichment	PNKP	1.01

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA-PK pathway in nonhomologous end joining

Pathway Network for DNA-PK pathway in nonhomologous end joining

Member Pathways for DNA-PK pathway in nonhomologous end joining

Pathways in the DNA-PK pathway in nonhomologous end joining SuperPath

Associated Genes for DNA-PK pathway in nonhomologous end joining

Associated Disorders for DNA-PK pathway in nonhomologous end joining

Disorders associated with DNA-PK pathway in nonhomologous end joining SuperPath

STRING Interaction Network for DNA-PK pathway in nonhomologous end joining

Sources for DNA-PK pathway in nonhomologous end joining