DNA Damage

No Pathway Network information available for DNA Damage

Pathways in the DNA Damage SuperPath

#	Name	Source	Genes
1	DNA Damage	Cell Signaling Technology	ACD ADD1 ALKBH7 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANP32A APEX1 APTX ARPP19 ATM ATR ATRAID ATRIP AURKA AURKB AURKC BABAM1 BABAM2 BLM BORA BRCA1 BRCA2 BRCC3 BRD2 BRIP1 BRSK1 BRSK2 BUB1B BUB3 CABIN1 CAD CCAR2 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNF CCNH CCP110 CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC27 CDC37 CDC45 CDC6 CDC7 CDC73 CDCA2 CDIP1 CDK1 CDK10 CDK11B CDK12 CDK16 CDK2 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2C CDT1 CEND1 CENPA CENPE CENPF CENPI CENPT CEP55 CHEK1 CHEK2 CHFR CIP2A CIRBP CKAP5 CLASP2 CLSPN COPS5 CSNK1A1 CSNK2A1 CUEDC2 DCLRE1C DCTN1 DDB1 DDB2 DDIT4 DDX3X DMAP1 DPYD DTX3L DYRK2 E2F1 EAPP ENSA ERCC1 ERCC2 ERCC3 ERCC4 ERCC6L FANCA FANCB FANCD2 FEN1 FOS FOSB FOXK2 FOXM1 GADD45A GMNN GSTP1 H2AX H3C1 HCFC1 HELQ HIPK2 HJURP HUS1 INCENP JUNB KAT5 KIF11 LATS1 LATS2 LIG4 LMNA MAD2L1 MAPRE1 MASTL MCM2 MCM3 MCM4 MCM7 MCPH1 MDM2 MEX3C MGMT MIS18A MKI67 MLH1 MRE11 MSH2 MSH6 MUTYH NAA10 NBN NCAPD3 NEK7 NHEJ1 NPM1 NTMT1 NUDT1 NUMA1 ORC1 ORC2 ORC6 OTUB1 PARG PAXX PBK PCM1 PCNA PHB1 PHLDA3 PIN1 PKMYT1 PLK1 PLK2 PLK3 PNKP POLG POLH POLR2A PPM1D PPP1CA PPP2CA PPP2R1A PPP2R2A PPP5C PRIM1 PRIM2 PRKDC PTPA PTPN12 PTPRA PTTG1 PWWP3A RAD17 RAD18 RAD21 RAD23A RAD23B RAD50 RAD51 RAD54L RAD9A RB1 RBBP8 RBL2 RBMX RCC1 RCC2 RCHY1 RECQL RECQL4 RECQL5 RIF1 RNF2 RPA1 RPA2 RRM1 S100A6 SESN2 SFN SKP2 SLK SMARCA4 SMARCA5 SMARCAL1 SMC1A SMC2 SMC3 SMC4 SMG1 SPART STAG2 TACC3 TDP1 TERF2 TERF2IP TFAP2C TFCP2 TIGAR TLK1 TMPO TOP1 TOP2A TOPBP1 TP53 TP53BP1 TP63 TP73 TPT1 TPX2 TRIB2 TRIM28 TRIM29 TRRAP TTK TYMS UBE2A UBE2B UBE2C UBE2N UBE2S UBE2T UIMC1 USP1 USP10 USP2 USP4 UVRAG VCP VIM VRK1 VRK3 WAPL WEE1 WRN WWOX XPA XPC XRCC1 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HC1 (see all 296) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
2	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
3	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
4	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
5	SFN	Stratifin	Protein Coding	1
6	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
7	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
8	TP53BP1	Tumor Protein P53 Binding Protein 1	Protein Coding	1
9	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	1
10	ADD1	Adducin 1	Protein Coding	1
11	ALKBH7	AlkB Homolog 7	Protein Coding	1
12	ANP32A	Acidic Nuclear Phosphoprotein 32 Family Member A	Protein Coding	1
13	TFAP2C	Transcription Factor AP-2 Gamma	Protein Coding	1
14	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	1
15	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	1
16	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	1
17	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	1
18	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
19	ATRAID	All-Trans Retinoic Acid Induced Differentiation Factor	Protein Coding	1
20	APTX	Aprataxin	Protein Coding	1
21	ARPP19	CAMP Regulated Phosphoprotein 19	Protein Coding	1
22	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	1
23	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
24	ATR	ATR Checkpoint Kinase	Protein Coding	1
25	ATRIP	ATR Interacting Protein	Protein Coding	1
26	AURKA	Aurora Kinase A	Protein Coding	1
27	AURKB	Aurora Kinase B	Protein Coding	1
28	AURKC	Aurora Kinase C	Protein Coding	1
29	BLM	BLM RecQ Like Helicase	Protein Coding	1
30	BORA	BORA Aurora Kinase A Activator	Protein Coding	1
31	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
32	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
33	BRCC3	BRCA1/BRCA2-Containing Complex Subunit 3	Protein Coding	1
34	BRD2	Bromodomain Containing 2	Protein Coding	1
35	BABAM2	BRISC And BRCA1 A Complex Member 2	Protein Coding	1
36	BRIP1	BRCA1 Interacting DNA Helicase 1	Protein Coding	1
37	BRSK1	BR Serine/Threonine Kinase 1	Protein Coding	1
38	BRSK2	BR Serine/Threonine Kinase 2	Protein Coding	1
39	BUB1B	BUB1 Mitotic Checkpoint Serine/Threonine Kinase B	Protein Coding	1
40	BUB3	BUB3 Mitotic Checkpoint Protein	Protein Coding	1
41	CABIN1	Calcineurin Binding Protein 1	Protein Coding	1
42	CAD	Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase	Protein Coding	1
43	CCNA2	Cyclin A2	Protein Coding	1
44	CCNB1	Cyclin B1	Protein Coding	1
45	CCND1	Cyclin D1	Protein Coding	1
46	CCND2	Cyclin D2	Protein Coding	1
47	CCND3	Cyclin D3	Protein Coding	1
48	CCNE1	Cyclin E1	Protein Coding	1
49	CCNE2	Cyclin E2	Protein Coding	1
50	CCNF	Cyclin F	Protein Coding	1
51	CCNH	Cyclin H	Protein Coding	1
52	CDC16	Cell Division Cycle 16	Protein Coding	1
53	CDC20	Cell Division Cycle 20	Protein Coding	1
54	CDC23	Cell Division Cycle 23	Protein Coding	1
55	CDC25A	Cell Division Cycle 25A	Protein Coding	1
56	CDC25B	Cell Division Cycle 25B	Protein Coding	1
57	CDC25C	Cell Division Cycle 25C	Protein Coding	1
58	CDC27	Cell Division Cycle 27	Protein Coding	1
59	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	1
60	CDC45	Cell Division Cycle 45	Protein Coding	1
61	CDC6	Cell Division Cycle 6	Protein Coding	1
62	CDC7	Cell Division Cycle 7	Protein Coding	1
63	CDC73	Cell Division Cycle 73	Protein Coding	1
64	CDCA2	Cell Division Cycle Associated 2	Protein Coding	1
65	CDIP1	Cell Death Inducing P53 Target 1	Protein Coding	1
66	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
67	CDK10	Cyclin Dependent Kinase 10	Protein Coding	1
68	CDK11B	Cyclin Dependent Kinase 11B	Protein Coding	1
69	CDK12	Cyclin Dependent Kinase 12	Protein Coding	1
70	CDK16	Cyclin Dependent Kinase 16	Protein Coding	1
71	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
72	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
73	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
74	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
75	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
76	CDK8	Cyclin Dependent Kinase 8	Protein Coding	1
77	CDK9	Cyclin Dependent Kinase 9	Protein Coding	1
78	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	1
79	CDT1	Chromatin Licensing And DNA Replication Factor 1	Protein Coding	1
80	CEND1	Cell Cycle Exit And Neuronal Differentiation 1	Protein Coding	1
81	CENPA	Centromere Protein A	Protein Coding	1
82	CENPE	Centromere Protein E	Protein Coding	1
83	CENPF	Centromere Protein F	Protein Coding	1
84	CENPI	Centromere Protein I	Protein Coding	1
85	CENPT	Centromere Protein T	Protein Coding	1
86	CEP55	Centrosomal Protein 55	Protein Coding	1
87	CHFR	Checkpoint With Forkhead And Ring Finger Domains	Protein Coding	1
88	CHEK1	Checkpoint Kinase 1	Protein Coding	1
89	CHEK2	Checkpoint Kinase 2	Protein Coding	1
90	CIP2A	Cellular Inhibitor Of PP2A	Protein Coding	1
91	CIRBP	Cold Inducible RNA Binding Protein	Protein Coding	1
92	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
93	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
94	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	1
95	CLASP2	Cytoplasmic Linker Associated Protein 2	Protein Coding	1
96	CLSPN	Claspin	Protein Coding	1
97	COPS5	COP9 Signalosome Subunit 5	Protein Coding	1
98	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	1
99	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
100	CUEDC2	CUE Domain Containing 2	Protein Coding	1
101	CCAR2	Cell Cycle And Apoptosis Regulator 2	Protein Coding	1
102	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	1
103	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
104	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
105	DDX3X	DEAD-Box Helicase 3 X-Linked	Protein Coding	1
106	DMAP1	DNA Methyltransferase 1 Associated Protein 1	Protein Coding	1
107	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
108	DPYD	Dihydropyrimidine Dehydrogenase	Protein Coding	1
109	DTX3L	Deltex E3 Ubiquitin Ligase 3L	Protein Coding	1
110	DCTN1	Dynactin Subunit 1	Protein Coding	1
111	DYRK2	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2	Protein Coding	1
112	E2F1	E2F Transcription Factor 1	Protein Coding	1
113	EAPP	E2F Associated Phosphoprotein	Protein Coding	1
114	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	1
115	ENSA	Endosulfine Alpha	Protein Coding	1
116	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	1
117	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	1
118	ERCC4	ERCC Excision Repair 4, Endonuclease Catalytic Subunit	Protein Coding	1
119	FANCA	FA Complementation Group A	Protein Coding	1
120	FANCB	FA Complementation Group B	Protein Coding	1
121	FANCD2	FA Complementation Group D2	Protein Coding	1
122	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	1
123	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
124	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
125	FOXK2	Forkhead Box K2	Protein Coding	1
126	FOXM1	Forkhead Box M1	Protein Coding	1
127	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
128	GMNN	Geminin DNA Replication Inhibitor	Protein Coding	1
129	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
130	H2AX	H2A.X Variant Histone	Protein Coding	1
131	H3C1	H3 Clustered Histone 1	Protein Coding	1
132	HCFC1	Host Cell Factor C1	Protein Coding	1
133	HELQ	Helicase, POLQ Like	Protein Coding	1
134	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	1
135	HJURP	Holliday Junction Recognition Protein	Protein Coding	1
136	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	1
137	INCENP	Inner Centromere Protein	Protein Coding	1
138	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
139	MKI67	Marker Of Proliferation Ki-67	Protein Coding	1
140	KIF11	Kinesin Family Member 11	Protein Coding	1
141	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
142	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
143	LMNA	Lamin A/C	Protein Coding	1
144	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	1
145	LATS2	Large Tumor Suppressor Kinase 2	Protein Coding	1
146	LIG4	DNA Ligase 4	Protein Coding	1
147	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	1
148	MASTL	Microtubule Associated Serine/Threonine Kinase Like	Protein Coding	1
149	MCM2	Minichromosome Maintenance Complex Component 2	Protein Coding	1
150	MCM3	Minichromosome Maintenance Complex Component 3	Protein Coding	1
151	MCM4	Minichromosome Maintenance Complex Component 4	Protein Coding	1
152	MCM7	Minichromosome Maintenance Complex Component 7	Protein Coding	1
153	MCPH1	Microcephalin 1	Protein Coding	1
154	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
155	NTMT1	N-Terminal Xaa-Pro-Lys N-Methyltransferase 1	Protein Coding	1
156	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	1
157	MIS18A	MIS18 Kinetochore Protein A	Protein Coding	1
158	MLH1	MutL Homolog 1	Protein Coding	1
159	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
160	MSH2	MutS Homolog 2	Protein Coding	1
161	MSH6	MutS Homolog 6	Protein Coding	1
162	PWWP3A	PWWP Domain Containing 3A, DNA Repair Factor	Protein Coding	1
163	MUTYH	MutY DNA Glycosylase	Protein Coding	1
164	PKMYT1	Protein Kinase, Membrane Associated Tyrosine/Threonine 1	Protein Coding	1
165	NAA10	N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit	Protein Coding	1
166	BABAM1	BRISC And BRCA1 A Complex Member 1	Protein Coding	1
167	NBN	Nibrin	Protein Coding	1
168	NCAPD3	Non-SMC Condensin II Complex Subunit D3	Protein Coding	1
169	NEK7	NIMA Related Kinase 7	Protein Coding	1
170	NHEJ1	Non-Homologous End Joining Factor 1	Protein Coding	1
171	ZC3HC1	Zinc Finger C3HC-Type Containing 1	Protein Coding	1
172	NPM1	Nucleophosmin 1	Protein Coding	1
173	NUDT1	Nudix Hydrolase 1	Protein Coding	1
174	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	1
175	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	1
176	ORC2	Origin Recognition Complex Subunit 2	Protein Coding	1
177	ORC6	Origin Recognition Complex Subunit 6	Protein Coding	1
178	OTUB1	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1	Protein Coding	1
179	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
180	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
181	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
182	TP53	Tumor Protein P53	Protein Coding	1
183	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	1
184	TP63	Tumor Protein P63	Protein Coding	1
185	TP73	Tumor Protein P73	Protein Coding	1
186	PARG	Poly(ADP-Ribose) Glycohydrolase	Protein Coding	1
187	PAXX	PAXX Non-Homologous End Joining Factor	Protein Coding	1
188	PBK	PDZ Binding Kinase	Protein Coding	1
189	PCM1	Pericentriolar Material 1	Protein Coding	1
190	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
191	PHB1	Prohibitin 1	Protein Coding	1
192	PHLDA3	Pleckstrin Homology Like Domain Family A Member 3	Protein Coding	1
193	ERCC6L	ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase	Protein Coding	1
194	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	1
195	PLK1	Polo Like Kinase 1	Protein Coding	1
196	PLK2	Polo Like Kinase 2	Protein Coding	1
197	PLK3	Polo Like Kinase 3	Protein Coding	1
198	PNKP	Polynucleotide Kinase 3''-Phosphatase	Protein Coding	1
199	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	1
200	POLH	DNA Polymerase Eta	Protein Coding	1
201	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
202	PPM1D	Protein Phosphatase, Mg2+/Mn2+ Dependent 1D	Protein Coding	1
203	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1
204	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
205	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
206	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
207	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
208	PPP5C	Protein Phosphatase 5 Catalytic Subunit	Protein Coding	1
209	PRIM2	DNA Primase Subunit 2	Protein Coding	1
210	PRIM1	DNA Primase Subunit 1	Protein Coding	1
211	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	1
212	PTPRA	Protein Tyrosine Phosphatase Receptor Type A	Protein Coding	1
213	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	1
214	RAD18	RAD18 E3 Ubiquitin Protein Ligase	Protein Coding	1
215	RAD21	RAD21 Cohesin Complex Component	Protein Coding	1
216	RAD23A	RAD23 Nucleotide Excision Repair Protein A	Protein Coding	1
217	RAD23B	RAD23 Nucleotide Excision Repair Protein B	Protein Coding	1
218	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
219	RAD51	RAD51 Recombinase	Protein Coding	1
220	RAD54L	RAD54 Like	Protein Coding	1
221	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
222	UIMC1	Ubiquitin Interaction Motif Containing 1	Protein Coding	1
223	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
224	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
225	RBMX	RNA Binding Motif Protein X-Linked	Protein Coding	1
226	RCC1	Regulator Of Chromosome Condensation 1	Protein Coding	1
227	RCHY1	Ring Finger And CHY Zinc Finger Domain Containing 1	Protein Coding	1
228	RECQL	RecQ Like Helicase	Protein Coding	1
229	RECQL4	RecQ Like Helicase 4	Protein Coding	1
230	RECQL5	RecQ Like Helicase 5	Protein Coding	1
231	RPA2	Replication Protein A2	Protein Coding	1
232	RIF1	Replication Timing Regulatory Factor 1	Protein Coding	1
233	MEX3C	Mex-3 RNA Binding Family Member C	Protein Coding	1
234	RNF2	Ring Finger Protein 2	Protein Coding	1
235	RPA1	Replication Protein A1	Protein Coding	1
236	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	1
237	S100A6	S100 Calcium Binding Protein A6	Protein Coding	1
238	PTTG1	PTTG1 Regulator Of Sister Chromatid Separation, Securin	Protein Coding	1
239	SESN2	Sestrin 2	Protein Coding	1
240	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
241	SLK	STE20 Like Kinase	Protein Coding	1
242	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
243	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	1
244	SMARCAL1	SNF2 Related Chromatin Remodeling Annealing Helicase 1	Protein Coding	1
245	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
246	SMC2	Structural Maintenance Of Chromosomes 2	Protein Coding	1
247	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	1
248	SMC4	Structural Maintenance Of Chromosomes 4	Protein Coding	1
249	SMG1	SMG1 Nonsense Mediated MRNA Decay Associated PI3K Related Kinase	Protein Coding	1
250	SPART	Spartin	Protein Coding	1
251	STAG2	STAG2 Cohesin Complex Component	Protein Coding	1
252	TACC3	Transforming Acidic Coiled-Coil Containing Protein 3	Protein Coding	1
253	RCC2	Regulator Of Chromosome Condensation 2	Protein Coding	1
254	TDP1	Tyrosyl-DNA Phosphodiesterase 1	Protein Coding	1
255	TERF2IP	TERF2 Interacting Protein	Protein Coding	1
256	TFCP2	Transcription Factor CP2	Protein Coding	1
257	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
258	TIGAR	TP53 Induced Glycolysis Regulatory Phosphatase	Protein Coding	1
259	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
260	TLK1	Tousled Like Kinase 1	Protein Coding	1
261	TMPO	Thymopoietin	Protein Coding	1
262	TOP1	DNA Topoisomerase I	Protein Coding	1
263	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	1
264	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	1
265	TPT1	Tumor Protein, Translationally-Controlled 1	Protein Coding	1
266	TPX2	TPX2 Microtubule Nucleation Factor	Protein Coding	1
267	TRIB2	Tribbles Pseudokinase 2	Protein Coding	1
268	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	1
269	TRIM29	Tripartite Motif Containing 29	Protein Coding	1
270	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	1
271	TTK	TTK Protein Kinase	Protein Coding	1
272	TYMS	Thymidylate Synthetase	Protein Coding	1
273	UBE2A	Ubiquitin Conjugating Enzyme E2 A	Protein Coding	1
274	UBE2B	Ubiquitin Conjugating Enzyme E2 B	Protein Coding	1
275	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	1
276	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
277	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	1
278	UBE2T	Ubiquitin Conjugating Enzyme E2 T	Protein Coding	1
279	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	1
280	USP10	Ubiquitin Specific Peptidase 10	Protein Coding	1
281	USP2	Ubiquitin Specific Peptidase 2	Protein Coding	1
282	USP4	Ubiquitin Specific Peptidase 4	Protein Coding	1
283	UVRAG	UV Radiation Resistance Associated	Protein Coding	1
284	VCP	Valosin Containing Protein	Protein Coding	1
285	VIM	Vimentin	Protein Coding	1
286	VRK1	VRK Serine/Threonine Kinase 1	Protein Coding	1
287	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	1
288	WAPL	WAPL Cohesin Release Factor	Protein Coding	1
289	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	1
290	WRN	WRN RecQ Like Helicase	Protein Coding	1
291	WWOX	WW Domain Containing Oxidoreductase	Protein Coding	1
292	XPA	XPA, DNA Damage Recognition And Repair Factor	Protein Coding	1
293	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	1
294	XPC	XPC Complex Subunit, DNA Damage Recognition And Repair Factor	Protein Coding	1
295	XRCC1	X-Ray Repair Cross Complementing 1	Protein Coding	1
296	YY1	YY1 Transcription Factor	Protein Coding	1

Disorders associated with DNA Damage SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ovarian cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, BUB1B, CDKN1B, CDKN2A, CHEK2, ERCC2, ERCC3, ERCC4, FANCA, FANCD2, MRE11, MSH2, MSH6, MUTYH, NBN, PPM1D, RAD50, RB1, RECQL4, TP53, WRN, XPA, XPC	11.26
2	Hereditary breast carcinoma	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, CDC73, CHEK2, MLH1, MSH2, MSH6, MUTYH, NBN, PPM1D, RAD50, RAD51, RAD54L, TP53	11.11
3	Breast cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, CDC73, CHEK2, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PHB1, PPM1D, RAD50, RAD51, RAD54L, TP53	11.09
4	Gastric cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CDK4, CDKN2A, CHEK2, MLH1, MSH2, MSH6, MUTYH, NBN, TP53	10.80
5	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, CHEK2, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PLK2, RAD50, RAD51, RECQL, TP53, VRK1	10.79
6	Inherited cancer-predisposing syndrome	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, CDC73, CDK4, CDKN1B, CDKN2A, CHEK2, ERCC3, FANCA, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, RAD50, RB1, RECQL, RECQL4, SMARCA4, TP53	10.71
7	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CDKN2A, CHEK2, ERCC4, NBN, RBBP8, TP53	10.29
8	Endometrial cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, CHEK2, MLH1, MSH2, MSH6, MUTYH	9.62
9	Meier-gorlin syndrome 1	Enrichment	CDC45, CDC6, CDT1, GMNN, MCM7, ORC1, ORC6	9.59
10	Colorectal cancer	Enrichment	ATM, AURKA, BLM, BRCA1, BRCA2, BRIP1, BUB1B, CCND1, CHEK2, MLH1, MSH2, MSH6, MUTYH, PTPN12, TP53	9.25
11	Xeroderma pigmentosum, variant type	Enrichment	DDB2, ERCC2, ERCC3, ERCC4, POLH, XPA, XPC	9.17
12	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CHEK2, MSH2, MSH6	9.17
13	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CHEK2, MSH2, NBN	8.47
14	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, BRIP1, ERCC4, FANCA, FANCB, FANCD2, RAD51, UBE2T	7.37
15	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2, CDKN1A, CDKN2A, ERCC2, RB1, TP53	6.87
16	Myeloma, multiple	Enrichment	ATM, AURKA, BRCA2, CCND1, CDKN2C, H3C1, LATS1, LIG4, RECQL4, TP53	6.51
17	Colonic benign neoplasm	Enrichment	ATM, CHEK2, MLH1, MRE11, MUTYH	6.25
18	Histiocytoid hemangioma	Enrichment	FOS, FOSB, LMNA, VIM	5.96
19	Lynch syndrome 1	Enrichment	ATM, CHEK2, MLH1, MSH2, MSH6	5.96
20	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, CHEK2, MSH6, NBN, TP53	5.64
21	Li-fraumeni syndrome	Enrichment	CDKN2A, CHEK2, MDM2, TP53	5.49
22	Hepatoblastoma	Enrichment	BRCA2, ERCC2, FANCA, MSH2, RECQL4, TP53	5.37
23	Multiple endocrine neoplasia, type i	Enrichment	CDC73, CDKN1A, CDKN1B, CDKN2C	5.13
24	Seckel syndrome	Enrichment	ATR, ATRIP, CENPE, PRIM1, RBBP8	5.09
25	Osteogenic sarcoma	Enrichment	CHEK2, RB1, TP53	4.99
26	Bone osteosarcoma	Enrichment	CHEK2, RB1, TP53	4.99
27	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2, MSH2, MSH6, TP53	4.77
28	Gliosarcoma	Enrichment	ATM, MGMT, MSH2, TACC3, TP53	4.77
29	Melanoma, cutaneous malignant 1	Enrichment	ACD, CDK4, CDKN2A, MGMT, TERF2IP	4.62
30	Giant cell glioblastoma	Enrichment	ATM, MGMT, MSH2, TACC3, TP53	4.62
31	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	APTX, MRE11, PNKP	4.39
32	Small cell cancer of the lung	Enrichment	RB1, TP53, TP73	4.39
33	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, MSH6	4.39
34	Lynch syndrome 4	Enrichment	MSH2, MSH6, RB1	4.39
35	Familial colorectal cancer	Enrichment	MLH1, MSH2, MUTYH, TP53	4.38
36	Familial colorectal cancer type x	Enrichment	ATM, BRCA2, CHEK2, MUTYH	4.19
37	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3, ERCC4	4.00
38	Lynch syndrome	Enrichment	CHEK2, MLH1, MSH2, MSH6	3.60
39	Primary ovarian insufficiency	Enrichment	CHEK2, ERCC1, FANCA, NBN, POLG, RAD54L, TP63	3.55
40	Muir-torre syndrome	Enrichment	MLH1, MSH2	3.32
41	Xeroderma pigmentosum, complementation group a	Enrichment	XPA, XPC	3.32
42	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2, BRIP1	3.32
43	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	3.32
44	Sarcoma	Enrichment	CHEK2, TP53	3.32
45	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	3.32
46	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	3.32
47	Malignant peritoneal mesothelioma	Enrichment	LATS1, LATS2	3.32
48	Primary autosomal recessive microcephaly	Enrichment	CDK6, CENPE, MCM7, MCPH1, NCAPD3	3.23
49	Diffuse large b-cell lymphoma	Enrichment	BRCA2, CHEK2, NBN, TP53	3.18
50	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	3.11
51	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	ADD1, BRCA2, BRIP1	3.11
52	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	3.11
53	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	2.96
54	Isolated tracheo-esophageal fistula	Enrichment	ADD1, BRCA2, BRIP1	2.96
55	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	CENPT, HCFC1	2.85
56	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	2.85
57	Squamous cell carcinoma	Enrichment	RB1, TP53	2.85
58	Adenocarcinoma	Enrichment	ATM, TP53	2.85
59	Colon adenocarcinoma	Enrichment	MSH6, RAD54L	2.85
60	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	2.85
61	Microcephaly	Enrichment	DDX3X, KIF11, MCM7, NBN, SMARCA5, SMARCAL1, SMC1A, SPART, YWHAG	2.83
62	Lip and oral cavity carcinoma	Enrichment	CDKN2A, RB1, TP53	2.71
63	Premature menopause	Enrichment	ERCC1, NBN, TP63	2.60
64	Hutchinson-gilford progeria syndrome	Enrichment	ERCC4, LMNA	2.56
65	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	2.56
66	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	2.56
67	Aicardi-goutieres syndrome 1	Enrichment	ATRIP, DCLRE1C	2.56
68	Mantle cell lymphoma	Enrichment	ATM, CCND1	2.56
69	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	2.56
70	Lung cancer susceptibility 3	Enrichment	CDK12, RB1, TP53	2.50
71	Wilms tumor 1	Enrichment	BRCA2, CHEK2, TRIM28	2.41
72	Fanconi anemia, complementation group d2	Enrichment	BRIP1, FANCD2	2.34
73	Von hippel-lindau syndrome	Enrichment	CCND1, FANCD2	2.34
74	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	2.34
75	Glioblastoma	Enrichment	ATM, MSH2	2.34
76	Isolated congenital microcephaly	Enrichment	MCPH1, PNKP, SMARCAL1	2.33
77	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC1, ERCC2	2.17
78	Wilms tumor 5	Enrichment	CHEK2, TRIM28	2.17
79	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	2.17
80	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	2.17
81	Esophageal atresia/tracheoesophageal fistula	Enrichment	ADD1, BRCA2, BRIP1	2.11
82	Esophageal cancer	Enrichment	TP53, WWOX	2.03
83	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	2.03
84	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	1.93
85	Glioma susceptibility 1	Enrichment	H3C1, TP53	1.91
86	Lymphoma, non-hodgkin, familial	Enrichment	RAD54L, TP53	1.91
87	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B, BUB3	1.91
88	Trichothiodystrophy	Enrichment	ERCC2, ERCC3	1.81
89	Omenn syndrome	Enrichment	DCLRE1C, LIG4	1.72
90	Melanoma	Enrichment	CDKN2A, CHEK2	1.72
91	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	1.66
92	Rapp-hodgkin syndrome	Enrichment	TP63	1.66
93	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	1.66
94	Perry syndrome	Enrichment	DCTN1	1.66
95	Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development	Enrichment	KIF11	1.66
96	Bloom syndrome	Enrichment	BLM	1.66
97	Intellectual developmental disorder, x-linked, syndromic, gustavson type	Enrichment	RBMX	1.66
98	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	1.66
99	Rapadilino syndrome	Enrichment	RECQL4	1.66
100	Holoprosencephaly 13, x-linked	Enrichment	STAG2	1.66
101	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	1.66
102	Split-hand/foot malformation 4	Enrichment	TP63	1.66
103	Seckel syndrome 2	Enrichment	RBBP8	1.66
104	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	1.66
105	Cerebrooculofacioskeletal syndrome 4	Enrichment	ERCC1	1.66
106	Immunodeficiency 124, severe combined	Enrichment	NHEJ1	1.66
107	Melanoma, cutaneous malignant 3	Enrichment	CDK4	1.66
108	Fanconi anemia, complementation group j	Enrichment	BRIP1	1.66
109	Parathyroid carcinoma	Enrichment	CDC73	1.66
110	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	1.66
111	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	1.66
112	Hyperparathyroidism 2 with jaw tumors	Enrichment	CDC73	1.66
113	Glioma susceptibility 3	Enrichment	BRCA2	1.66
114	Adult syndrome	Enrichment	TP63	1.66
115	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	1.66
116	Ataxia-oculomotor apraxia 4	Enrichment	PNKP	1.66
117	Seckel syndrome 1	Enrichment	ATR	1.66
118	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	1.66
119	Mirror movements 2	Enrichment	RAD51	1.66
120	Schimke immunoosseous dysplasia	Enrichment	SMARCAL1	1.66
121	Fanconi anemia, complementation group t	Enrichment	UBE2T	1.66
122	Meier-gorlin syndrome 3	Enrichment	ORC6	1.66
123	Accelerated tumor formation	Enrichment	MDM2	1.66
124	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	1.66
125	Premature chromatid separation trait	Enrichment	BUB1B	1.66
126	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	1.66
127	Corpus callosum, agenesis of, with facial anomalies and robin sequence	Enrichment	DDX3X	1.66
128	Luo-schoch-yamamoto syndrome	Enrichment	RNF2	1.66
129	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	1.66
130	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	1.66
131	Fanconi anemia, complementation group r	Enrichment	RAD51	1.66
132	White-kernohan syndrome	Enrichment	DDB1	1.66
133	Fanconi anemia, complementation group b	Enrichment	FANCB	1.66
134	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	1.66
135	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	1.66
136	Recon progeroid syndrome	Enrichment	RECQL	1.66
137	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	1.66
138	Lessel-kubisch syndrome	Enrichment	MDM2	1.66
139	Mullegama-klein-martinez syndrome	Enrichment	STAG2	1.66
140	Bone marrow failure syndrome 5	Enrichment	TP53	1.66
141	Spastic paraplegia 20, autosomal recessive	Enrichment	SPART	1.66
142	Frontotemporal dementia and/or amyotrophic lateral sclerosis 5	Enrichment	CCNF	1.66
143	Meier-gorlin syndrome 4	Enrichment	CDT1	1.66
144	Intellectual developmental disorder, x-linked, syndromic, nascimento type	Enrichment	UBE2A	1.66
145	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	1.66
146	Intellectual developmental disorder, x-linked, syndromic, snijders blok type	Enrichment	DDX3X	1.66
147	Papilloma of choroid plexus	Enrichment	TP53	1.66
148	Anisometropia	Enrichment	MCM7	1.66
149	Basal cell carcinoma 7	Enrichment	TP53	1.66
150	Lynch syndrome 2	Enrichment	MLH1	1.66
151	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	1.66
152	Anaplastic thyroid carcinoma	Enrichment	TP53	1.66
153	Infant-type hemispheric glioma	Enrichment	BRCA1	1.66
154	Pancreatic cancer 2	Enrichment	BRCA2	1.66
155	Syndromic x-linked intellectual disability nascimento type	Enrichment	UBE2A	1.66
156	Jawad syndrome	Enrichment	RBBP8	1.66
157	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	1.66
158	Houge-janssens syndrome 2	Enrichment	PPP2R1A	1.66
159	Tumor predisposition syndrome 4	Enrichment	CHEK2	1.66
160	Limb-mammary syndrome	Enrichment	TP63	1.66
161	Immunodeficiency 54	Enrichment	MCM4	1.66
162	Deafness, autosomal dominant 70	Enrichment	MCM2	1.66
163	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1	Enrichment	TDP1	1.66
164	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	1.66
165	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	1.66
166	Xeroderma pigmentosum group b	Enrichment	ERCC3	1.66
167	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	1.66
168	Xfe progeroid syndrome	Enrichment	ERCC4	1.66
169	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	1.66
170	Neuroendocrine tumor	Enrichment	CDKN1B	1.66
171	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	1.66
172	Mungan syndrome	Enrichment	RAD21	1.66
173	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	1.66
174	Premature ovarian failure 21	Enrichment	TP63	1.66
175	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	1.66
176	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	1.66
177	Endometrial serous adenocarcinoma	Enrichment	ATM	1.66
178	Cdc73-related disorders	Enrichment	CDC73	1.66
179	Ductal carcinoma in situ	Enrichment	TP53	1.66
180	Meier-gorlin syndrome 5	Enrichment	CDC6	1.66
181	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	1.66
182	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	1.66
183	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	1.66
184	Ovarian small cell carcinoma	Enrichment	SMARCA4	1.66
185	Deafness, autosomal dominant 75	Enrichment	TRRAP	1.66
186	Orofacial cleft 8	Enrichment	TP63	1.66
187	Mismatch repair cancer syndrome 2	Enrichment	MSH2	1.66
188	Microcephaly 13, primary, autosomal recessive	Enrichment	CENPE	1.66
189	Ddx3x-related neurodevelopmental disorder	Enrichment	DDX3X	1.66
190	Atypical werner syndrome	Enrichment	LMNA	1.66
191	Xq25 microduplication syndrome	Enrichment	STAG2	1.66
192	Meier-gorlin syndrome 6	Enrichment	GMNN	1.66
193	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	1.66
194	Meier-gorlin syndrome 7	Enrichment	CDC45	1.66
195	Microcephaly 22, primary, autosomal recessive	Enrichment	NCAPD3	1.66
196	Jansen-de vries syndrome	Enrichment	PPM1D	1.66
197	Short stature and microcephaly with genital anomalies	Enrichment	CENPT	1.66
198	Leiomyosarcoma	Enrichment	CHEK2	1.66
199	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	1.66
200	Spinocerebellar ataxia, autosomal recessive 26	Enrichment	XRCC1	1.66
201	Multisystem proteinopathy	Enrichment	VCP	1.66
202	Rectal benign neoplasm	Enrichment	MSH2	1.66
203	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.66
204	Neuronopathy, distal hereditary motor, autosomal recessive 10	Enrichment	VRK1	1.66
205	Trilateral retinoblastoma	Enrichment	RB1	1.66
206	Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome	Enrichment	BRCC3	1.66
207	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.66
208	Cdkn2a cancer predisposition	Enrichment	CDKN2A	1.66
209	B-lymphoblastic leukemia/lymphoma with etv6-runx1	Enrichment	RECQL4	1.66
210	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	1.66
211	Mandibuloacral dysplasia	Enrichment	LMNA	1.66
212	Atrioventricular block	Enrichment	LMNA	1.66
213	Ascending colon cancer	Enrichment	MSH2	1.66
214	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.66
215	Breast ductal carcinoma	Enrichment	RAD54L	1.66
216	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	1.66
217	Tp63-related disorders	Enrichment	TP63	1.66
218	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	1.66
219	B-cell non-hodgkin lymphoma	Enrichment	ATM	1.66
220	Choroid plexus cancer	Enrichment	TP53	1.66
221	Ovarian cyst	Enrichment	MSH2	1.66
222	Undifferentiated pleomorphic sarcoma	Enrichment	RECQL4	1.66
223	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	1.66
224	Wilms tumor 7	Enrichment	TRIM28	1.66
225	Childhood myocerebrohepatopathy spectrum	Enrichment	POLG	1.66
226	Xeroderma pigmentosum group d	Enrichment	ERCC2	1.66
227	Esophagus squamous cell carcinoma	Enrichment	WWOX	1.66
228	Microphthalmia/coloboma 13	Enrichment	NHEJ1	1.66
229	Malignant fibrous histiocytoma	Enrichment	RECQL4	1.66
230	Infection-induced acute-onset axonal neuropathy	Enrichment	RCC1	1.66
231	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.66
232	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	1.66
233	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	1.66
234	Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome	Enrichment	CDKN1C	1.66
235	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	1.66
236	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	1.66
237	Premature aging	Enrichment	VIM	1.66
238	Microcephaly-complex motor and sensory axonal neuropathy syndrome	Enrichment	VRK1	1.66
239	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	1.66
240	Spinocerebellar ataxia with epilepsy	Enrichment	POLG	1.66
241	Recessive mitochondrial ataxia syndrome	Enrichment	POLG	1.66
242	X-linked intellectual disability-hypotonia-movement disorder syndrome	Enrichment	DDX3X	1.66
243	Primary peritoneal carcinoma	Enrichment	BRCA1	1.66
244	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	1.66
245	1p21.3 microdeletion syndrome	Enrichment	DPYD	1.66
246	Laminopathy	Enrichment	LMNA	1.66
247	Lung oat cell carcinoma	Enrichment	RB1	1.66
248	Leukemia, acute lymphoblastic	Enrichment	CDKN2A, NBN	1.64
249	Acute promyelocytic leukemia	Enrichment	NPM1, NUMA1	1.50
250	Nk-cell enteropathy	Enrichment	AURKB, CHEK2	1.50
251	Lung cancer	Enrichment	BRCA1, CHEK2, MLH1	1.49
252	Severe combined immunodeficiency	Enrichment	DCLRE1C, LIG4, NHEJ1	1.46
253	Medulloblastoma	Enrichment	BRCA2, WRN	1.44
254	Male infertility with spermatogenesis disorder	Enrichment	AURKC, TP63	1.38
255	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.36
256	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	1.36
257	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.36
258	Baller-gerold syndrome	Enrichment	RECQL4	1.36
259	Stromme syndrome	Enrichment	CENPF	1.36
260	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	CEP55	1.36
261	Chromosome 2q35 duplication syndrome	Enrichment	NHEJ1	1.36
262	Microcephaly and chorioretinopathy, autosomal recessive, 1	Enrichment	KIF11	1.36
263	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.36
264	Ogden syndrome	Enrichment	NAA10	1.36
265	Microphthalmia, syndromic 1	Enrichment	NAA10	1.36
266	Ebstein anomaly	Enrichment	CDK8	1.36
267	Xeroderma pigmentosum, complementation group f	Enrichment	ERCC4	1.36
268	Xeroderma pigmentosum, complementation group c	Enrichment	XPC	1.36
269	Moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism	Enrichment	BRCC3	1.36
270	Cervical cancer	Enrichment	TP53	1.36
271	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.36
272	Rothmund-thomson syndrome, type 2	Enrichment	RECQL4	1.36
273	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	1.36
274	Intellectual developmental disorder, x-linked, syndromic, shashi type	Enrichment	RBMX	1.36
275	Fanconi anemia, complementation group i	Enrichment	POLG	1.36
276	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	1.36
277	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.36
278	Hyperparathyroidism 1	Enrichment	CDC73	1.36
279	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.36
280	Pontocerebellar hypoplasia, type 1a	Enrichment	VRK1	1.36
281	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.36
282	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.36
283	Familial adenomatous polyposis 2	Enrichment	MUTYH	1.36
284	Developmental and epileptic encephalopathy 28	Enrichment	WWOX	1.36
285	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	CDKN1C	1.36
286	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.36
287	Dubowitz syndrome	Enrichment	LIG4	1.36
288	Charcot-marie-tooth disease, axonal, type 2b2	Enrichment	PNKP	1.36
289	Developmental and epileptic encephalopathy 50	Enrichment	CAD	1.36
290	Lig4 syndrome	Enrichment	LIG4	1.36
291	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.36
292	Lymphoma, hodgkin, classic	Enrichment	TP53	1.36
293	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.36
294	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	WWOX	1.36
295	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	1.36
296	Encephalopathy, acute, infection-induced 10	Enrichment	TPT1	1.36
297	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	1.36
298	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	1.36
299	Restrictive dermopathy 2	Enrichment	LMNA	1.36
300	Gabriele-de vries syndrome	Enrichment	YY1	1.36
301	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.36
302	Dystonia 30	Enrichment	PTPRA	1.36
303	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.36
304	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1	Enrichment	POLG	1.36
305	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.36
306	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.36
307	Werner syndrome	Enrichment	WRN	1.36
308	Pancreatic cancer 4	Enrichment	BRCA1	1.36
309	Ovarian cancer 1	Enrichment	BRIP1	1.36
310	Intellectual developmental disorder, x-linked, syndromic, pilorge type	Enrichment	FANCB	1.36
311	Bladder exstrophy	Enrichment	TP63	1.36
312	Fanconi anemia, complementation group q	Enrichment	ERCC4	1.36
313	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	1.36
314	Microcephaly and chorioretinopathy 1	Enrichment	KIF11	1.36
315	Kala-azar 2	Enrichment	GSTP1	1.36
316	Charcot-marie-tooth disease type 2b2	Enrichment	PNKP	1.36
317	Microcephaly, seizures, and developmental delay	Enrichment	PNKP	1.36
318	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TP53BP1	1.36
319	Xeroderma pigmentosum group f	Enrichment	ERCC4	1.36
320	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.36
321	Cataract 30	Enrichment	VIM	1.36
322	Syndromic x-linked intellectual disability shashi type	Enrichment	RBMX	1.36
323	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.36
324	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	1.36
325	Al kaissi syndrome	Enrichment	CDK10	1.36
326	Congenital fibrosarcoma	Enrichment	TP53	1.36
327	High grade glioma	Enrichment	ATM	1.36
328	Fanconi anemia, complementation group d1	Enrichment	BRCA2	1.36
329	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.36
330	Otosclerosis 12	Enrichment	SMARCA4	1.36
331	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.36
332	Cervix carcinoma	Enrichment	TP53	1.36
333	Hodgkin's lymphoma	Enrichment	TP53	1.36
334	Insulinoma	Enrichment	YY1	1.36
335	T-cell prolymphocytic leukemia	Enrichment	ATM	1.36
336	Methylmalonic aciduria and homocystinuria, cbll type	Enrichment	CENPT	1.36
337	Polg-related disorders	Enrichment	POLG	1.36
338	Autosomal recessive progressive external ophthalmoplegia	Enrichment	POLG	1.36
339	Acute myeloid leukemia without maturation	Enrichment	NPM1	1.36
340	Dyskeratosis congenita, digenic	Enrichment	TYMS	1.36
341	Mismatch repair cancer syndrome 3	Enrichment	MSH6	1.36
342	Congenital pontocerebellar hypoplasia type 1	Enrichment	VRK1	1.36
343	Xeroderma pigmentosum group c	Enrichment	XPC	1.36
344	Lymphatic malformation 10	Enrichment	MCPH1	1.36
345	Fissured tongue	Enrichment	TP63	1.36
346	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.36
347	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	1.36
348	Peritoneum cancer	Enrichment	BRCA1	1.36
349	Lymphomatoid papulosis	Enrichment	NPM1	1.36
350	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	1.36
351	Microcephaly and chorioretinopathy 3	Enrichment	TP53BP1	1.36
352	Familial partial lipodystrophy	Enrichment	LMNA	1.36
353	Vacterl with hydrocephalus	Enrichment	FANCB	1.36
354	Familial retinoblastoma	Enrichment	RB1	1.36
355	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.36
356	Xeroderma pigmentosum group e	Enrichment	DDB2	1.36
357	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.36
358	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	1.36
359	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	1.36
360	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	1.36
361	Leukemia, acute myeloid	Enrichment	FANCD2, NPM1, TP53	1.25
362	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	1.24
363	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA, VCP	1.20
364	Dyskeratosis congenita	Enrichment	NPM1, TYMS	1.20
365	Retinoblastoma	Enrichment	RB1	1.19
366	Ataxia-telangiectasia	Enrichment	ATM	1.19
367	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP	1.19
368	Nijmegen breakage syndrome	Enrichment	NBN	1.19
369	Polycythemia vera	Enrichment	ATM	1.19
370	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	1.19
371	Restrictive dermopathy 1	Enrichment	LMNA	1.19
372	Dihydropyrimidine dehydrogenase deficiency	Enrichment	DPYD	1.19
373	Chilblain lupus 1	Enrichment	ATRIP	1.19
374	Spastic paraplegia 7, autosomal recessive	Enrichment	MUTYH	1.19
375	Nasopharyngeal carcinoma	Enrichment	TP53	1.19
376	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.19
377	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	1.19
378	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.19
379	Dyskeratosis congenita, autosomal dominant 6	Enrichment	ACD	1.19
380	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.19
381	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.19
382	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.19
383	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.19
384	Lynch syndrome 5	Enrichment	MSH6	1.19
385	Pontocerebellar hypoplasia, type 1b	Enrichment	VRK1	1.19
386	Arthrogryposis multiplex congenita 6	Enrichment	RIF1	1.19
387	Hypotrichosis 8	Enrichment	RB1	1.19
388	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	1.19
389	Koolen-de vries syndrome	Enrichment	ATM	1.19
390	Wieacker-wolff syndrome	Enrichment	CCNH	1.19
391	Chilblain lupus	Enrichment	ATRIP	1.19
392	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.19
393	Anaplastic astrocytoma	Enrichment	TP53	1.19
394	Cellular ependymoma	Enrichment	MSH2	1.19
395	Tanycytic ependymoma	Enrichment	MSH2	1.19
396	Papillary ependymoma	Enrichment	MSH2	1.19
397	Parathyroid adenoma	Enrichment	CDC73	1.19
398	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.19
399	Restrictive dermopathy	Enrichment	LMNA	1.19
400	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	1.19
401	Familial isolated hyperparathyroidism	Enrichment	CDC73	1.19
402	Respiratory failure	Enrichment	TP73	1.19
403	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	1.19
404	Idiopathic camptocormia	Enrichment	POLG	1.19
405	Isolated anophthalmia-microphthalmia syndrome	Enrichment	NHEJ1	1.19
406	Clear cell ependymoma	Enrichment	MSH2	1.19
407	Congenital nervous system abnormality	Enrichment	MCPH1, PNKP, POLG, SMC1A, WWOX	1.08
408	Nervous system disease	Enrichment	MCPH1, PNKP, POLG, SMC1A, WWOX	1.08
409	Mirror movements 1	Enrichment	RAD51	1.07
410	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	1.07
411	Gaucher disease, type i	Enrichment	MSH6	1.07
412	Cystinuria	Enrichment	CENPF	1.07
413	Nemaline myopathy 2	Enrichment	RIF1	1.07
414	Chordoma	Enrichment	BRCA2	1.07
415	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.07
416	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.07
417	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.07
418	Astigmatism	Enrichment	MCM7	1.07
419	Microtia-anotia	Enrichment	LMNA	1.07
420	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	1.07
421	Pilomatrixoma	Enrichment	MUTYH	1.07
422	Ciliary dyskinesia, primary, 29	Enrichment	CENPF	1.07
423	Developmental and epileptic encephalopathy 12	Enrichment	PNKP	1.07
424	Congenital generalized lipodystrophy	Enrichment	FOS	1.07
425	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.07
426	Enophthalmos	Enrichment	MCM7	1.07
427	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.07
428	Lung sarcomatoid carcinoma	Enrichment	TP53	1.07
429	Generalized epilepsy	Enrichment	POLG	1.07
430	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.07
431	Craniopharyngioma	Enrichment	ERCC2	1.07
432	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.07
433	Hemoglobin c disease	Enrichment	CHEK2	1.07
434	Charcot-marie-tooth hereditary neuropathy	Enrichment	VRK1	1.07
435	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	TP53BP1	1.07
436	Sick sinus syndrome	Enrichment	LMNA	1.07
437	Silver-russell syndrome due to a point mutation	Enrichment	CDKN1C	1.07
438	Primary hyperparathyroidism	Enrichment	CDKN1B	1.07
439	Benign ependymoma	Enrichment	MSH2	1.07
440	Cleft lip and alveolus	Enrichment	TP63	1.07
441	Thrombotic microangiopathy	Enrichment	ATRIP	1.07
442	Oculomotor apraxia	Enrichment	ATM	1.07
443	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.07
444	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.07
445	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, DDX3X	1.05
446	Autosomal dominant non-syndromic intellectual disability	Enrichment	BRSK2, PPM1D, YWHAZ	1.02
447	Muscular dystrophy	Enrichment	LMNA, RIF1	1.02
448	Developmental and epileptic encephalopathy 1	Enrichment	CAD, WWOX	0.99
449	Capillary malformations, congenital	Enrichment	CCNH	0.98
450	Dementia, lewy body	Enrichment	VCP	0.98
451	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP	0.98
452	Cockayne syndrome a	Enrichment	ERCC4	0.98
453	Microcephaly 1, primary, autosomal recessive	Enrichment	MCPH1	0.98
454	Rhabdomyosarcoma 2	Enrichment	TP53	0.98
455	Atrioventricular septal defect	Enrichment	SMARCAL1	0.98
456	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B	0.98
457	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	Enrichment	POLG	0.98
458	Familial adenomatous polyposis 1	Enrichment	MUTYH	0.98
459	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	0.98
460	Autosomal recessive cerebellar ataxia	Enrichment	ERCC4	0.98
461	Lymphoma	Enrichment	TP53	0.98
462	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	0.98
463	Acute myeloid leukemia with maturation	Enrichment	NPM1	0.98
464	Spinal muscular atrophy	Enrichment	VRK1	0.98
465	Vascular dementia	Enrichment	ATRIP	0.98
466	Acute megakaryocytic leukemia	Enrichment	TP53	0.98
467	Cleft upper lip	Enrichment	TP63	0.98
468	Autosomal thrombocytopenia with normal platelets	Enrichment	MASTL	0.98
469	Genetic motor neuron disease	Enrichment	DCTN1	0.98
470	Farsightedness	Enrichment	MCM7	0.98
471	Endometrial stromal sarcoma	Enrichment	YWHAE	0.98
472	Cockayne syndrome b	Enrichment	ERCC1	0.91
473	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	0.91
474	Kabuki syndrome 1	Enrichment	BRCA2	0.91
475	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	0.91
476	Machado-joseph disease	Enrichment	POLG	0.91
477	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	POLG	0.91
478	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	0.91
479	Hemangioma, capillary infantile	Enrichment	CCNH	0.91
480	Mitochondrial dna depletion syndrome 1	Enrichment	POLG	0.91
481	Basal cell carcinoma 1	Enrichment	CCNH	0.91
482	Pontocerebellar hypoplasia, type 1e	Enrichment	VRK1	0.91
483	Mitochondrial dna depletion syndrome	Enrichment	POLG	0.91
484	Clear cell renal cell carcinoma	Enrichment	ATM	0.91
485	Hoyeraal-hreidarsson syndrome	Enrichment	ACD	0.91
486	Breast adenocarcinoma	Enrichment	TP53	0.91
487	Lung squamous cell carcinoma	Enrichment	CDKN2A	0.91
488	Kidney clear cell sarcoma	Enrichment	YWHAE	0.91
489	Syndromic rod-cone dystrophy	Enrichment	KIF11	0.91
490	Severe covid-19	Enrichment	CENPF, RECQL4	0.88
491	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CCNF, DCTN1, VCP	0.88
492	Bethlem myopathy 1a	Enrichment	LMNA	0.84
493	Mitochondrial dna depletion syndrome 4a	Enrichment	POLG	0.84
494	Squamous cell carcinoma, head and neck	Enrichment	TP53	0.84
495	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	0.84
496	Renal cell carcinoma, papillary, 1	Enrichment	ATM	0.84
497	Essential thrombocythemia	Enrichment	TP53	0.84
498	Cockayne syndrome	Enrichment	ERCC4	0.84
499	Gallbladder cancer	Enrichment	TP53	0.84
500	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	0.84
501	Spermatogenic failure 5	Enrichment	AURKC	0.79
502	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2	0.79
503	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	0.79
504	Ewing sarcoma	Enrichment	SMARCA5	0.79
505	Rett syndrome, congenital variant	Enrichment	SMC1A	0.79
506	Mitochondrial dna depletion syndrome 4b	Enrichment	POLG	0.79
507	Congenital muscular dystrophy	Enrichment	LMNA	0.79
508	Neuroblastoma	Enrichment	SMARCA4	0.79
509	Myocarditis	Enrichment	LMNA	0.79
510	Isolated split hand-split foot malformation	Enrichment	TP63	0.79
511	Inflammatory bowel disease 1	Enrichment	ERCC2	0.74
512	Polydactyly	Enrichment	BRCA2	0.74
513	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	0.74
514	Leukemia, acute lymphoblastic 3	Enrichment	ERCC4	0.74
515	Arteriovenous malformation	Enrichment	CCNH	0.74
516	Adult hepatocellular carcinoma	Enrichment	TP53	0.74
517	Progressive non-fluent aphasia	Enrichment	VCP	0.74
518	Primary hyperaldosteronism	Enrichment	TP53	0.74
519	Ventricular septal defect	Enrichment	SMARCA4	0.74
520	Autosomal dominant cerebellar ataxia	Enrichment	POLG	0.74
521	Hypotrichosis simplex	Enrichment	ERCC2	0.74
522	Behavioral variant of frontotemporal dementia	Enrichment	VCP	0.74
523	Juvenile amyotrophic lateral sclerosis	Enrichment	VRK1	0.74
524	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	POLG	0.74
525	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	0.70
526	Cataract 30, multiple types	Enrichment	VIM	0.70
527	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	0.70
528	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	0.70
529	Aplastic anemia	Enrichment	NBN	0.70
530	Aicardi-goutieres syndrome	Enrichment	ATRIP	0.70
531	Nemaline myopathy	Enrichment	RIF1	0.70
532	Cerebral palsy	Enrichment	BRCA2, SMARCA4	0.68
533	Immune deficiency disease	Enrichment	ATM	0.67
534	Frontotemporal dementia 1	Enrichment	DCTN1	0.67
535	Myelodysplastic syndrome	Enrichment	TP53	0.67
536	Atrial heart septal defect	Enrichment	SMARCA4	0.67
537	Interatrial communication	Enrichment	SMARCA4	0.67
538	Specific learning disability	Enrichment	YWHAG	0.67
539	Epilepsy	Enrichment	APTX, WWOX	0.66
540	Charcot-marie-tooth disease	Enrichment	DCTN1, LMNA	0.65
541	Cardiac conduction defect	Enrichment	LMNA	0.63
542	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	0.63
543	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	0.63
544	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	0.63
545	Diaphragmatic hernia, congenital	Enrichment	CDK8	0.60
546	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	0.60
547	Alzheimer's disease	Enrichment	VCP	0.60
548	Oligospermia	Enrichment	CDK16	0.60
549	Periventricular nodular heterotopia	Enrichment	BRCA1	0.58
550	Heart disease	Enrichment	RECQL4	0.58
551	Cataract	Enrichment	WRN	0.58
552	Cleft lip/palate	Enrichment	TP63	0.58
553	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	0.58
554	Pituitary stalk interruption syndrome	Enrichment	FANCA	0.58
555	46,xy partial gonadal dysgenesis	Enrichment	WWOX	0.58
556	Coffin-siris syndrome 1	Enrichment	SMARCA4	0.55
557	Renal cell carcinoma, nonpapillary	Enrichment	ATM	0.55
558	Corpus callosum, agenesis of	Enrichment	ERCC2	0.55
559	Atypical hemolytic-uremic syndrome	Enrichment	SMARCAL1	0.55
560	Familial hypercholesterolemia	Enrichment	SMARCA4	0.55
561	Isolated corpus callosum agenesis	Enrichment	ERCC2	0.55
562	Rare genetic intellectual disability	Enrichment	DDX3X	0.55
563	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	0.55
564	Complex neurodevelopmental disorder	Enrichment	CDK8, CSNK2A1, PPP2CA, RNF2	0.54
565	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DDX3X	0.53
566	Hydrocephalus, congenital, 1	Enrichment	CDK8	0.53
567	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	0.53
568	Alzheimer disease, familial, 1	Enrichment	VCP	0.50
569	Hypertension, essential	Enrichment	ADD1	0.50
570	Cleft palate, isolated	Enrichment	SMARCA4	0.50
571	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	0.50
572	Polycystic liver disease	Enrichment	CDC25A	0.50
573	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	0.50
574	Alobar holoprosencephaly	Enrichment	STAG2	0.50
575	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MCM2, TRRAP	0.50
576	Familial isolated dilated cardiomyopathy	Enrichment	LMNA, TMPO	0.49
577	Beckwith-wiedemann syndrome	Enrichment	CDKN1C	0.48
578	Heart, malformation of	Enrichment	CDK8	0.48
579	Pontocerebellar hypoplasia	Enrichment	VRK1	0.48
580	Neuromuscular disease	Enrichment	LMNA	0.48
581	Early infantile developmental and epileptic encephalopathy	Enrichment	PNKP	0.48
582	Undetermined early-onset epileptic encephalopathy	Enrichment	WWOX, YWHAG	0.46
583	Williams-beuren syndrome	Enrichment	CDKN1C	0.45
584	Leukodystrophy	Enrichment	ERCC2	0.45
585	Focal segmental glomerulosclerosis	Enrichment	SMARCAL1	0.45
586	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	0.43
587	Lissencephaly	Enrichment	NBN	0.43
588	Microphthalmia	Enrichment	MCM7	0.41
589	Diamond-blackfan anemia 1	Enrichment	TP53	0.40
590	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	0.39
591	Brugada syndrome	Enrichment	LMNA	0.36
592	Strabismus	Enrichment	SPART	0.35
593	Differentiated thyroid carcinoma	Enrichment	PCM1	0.33
594	Long qt syndrome	Enrichment	LMNA	0.30
595	Peripheral nervous system disease	Enrichment	LMNA	0.30
596	Neuropathy	Enrichment	LMNA	0.30
597	Nephronophthisis	Enrichment	INCENP	0.29
598	Left ventricular noncompaction	Enrichment	LMNA	0.27
599	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1	0.26
600	Diamond-blackfan anemia	Enrichment	TP53	0.26
601	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	POLG	0.25
602	Systemic lupus erythematosus	Enrichment	ATRIP	0.24
603	Benign epilepsy with centrotemporal spikes	Enrichment	WWOX	0.22
604	Type 2 diabetes mellitus	Enrichment	WRN	0.22
605	Hereditary spastic paraplegia	Enrichment	POLG	0.22
606	Centralopathic epilepsy	Enrichment	WWOX	0.21
607	Nephrotic syndrome	Enrichment	SMARCAL1	0.21
608	Hypertrophic cardiomyopathy	Enrichment	POLG	0.21
609	West syndrome	Enrichment	WWOX	0.21
610	Body mass index quantitative trait locus 11	Enrichment	POLG	0.17
611	Spastic ataxia	Enrichment	ERCC4	0.16
612	Autism spectrum disorder	Enrichment	CSNK2A1, SMC3	0.16
613	Leigh syndrome, nuclear	Enrichment	POLG	0.11
614	Dilated cardiomyopathy	Enrichment	LMNA	0.08
615	Mitochondrial disease	Enrichment	POLG	0.07
616	Hereditary retinal dystrophy	Enrichment	ATRIP, KIF11	0.01
617	Fundus dystrophy	Enrichment	ATRIP, KIF11	0.01
618	Retinitis pigmentosa	Enrichment	KIF11	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA Damage

Pathway Network for DNA Damage

Member Pathways for DNA Damage

Pathways in the DNA Damage SuperPath

Associated Genes for DNA Damage

Associated Disorders for DNA Damage

Disorders associated with DNA Damage SuperPath

STRING Interaction Network for DNA Damage

Sources for DNA Damage