DNA damage_ATM/ATR regulation of G1/S checkpoint

No Pathway Network information available for DNA damage_ATM/ATR regulation of G1/S checkpoint

Pathways in the DNA damage_ATM/ATR regulation of G1/S checkpoint SuperPath

#	Name	Source	Genes
1	DNA damage_ATM/ATR regulation of G1/S checkpoint	GeneGo (Thomson Reuters)	ATM ATR ATRIP BARD1 BLM BRCA1 CCNA1 CCNA2 CCND1 CCND2 CCND3 CCNE1 CDC25A CDK2 CDK4 CDKN1A CHEK1 CHEK2 CLSPN FANCD2 FANCL GADD45A GADD45B MDC1 MDM2 MYC NBN NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PCNA RAD9A RAD9B REL RELA RELB SMC1A TP53 UBA52 UBB UBC USP1 (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
2	ATR	ATR Checkpoint Kinase	Protein Coding	1
3	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	1
4	CCND1	Cyclin D1	Protein Coding	1
5	BLM	BLM RecQ Like Helicase	Protein Coding	1
6	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
7	CCNA2	Cyclin A2	Protein Coding	1
8	CCND2	Cyclin D2	Protein Coding	1
9	CCND3	Cyclin D3	Protein Coding	1
10	CCNE1	Cyclin E1	Protein Coding	1
11	CDC25A	Cell Division Cycle 25A	Protein Coding	1
12	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
13	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
14	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
15	CHEK1	Checkpoint Kinase 1	Protein Coding	1
16	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
17	FANCD2	FA Complementation Group D2	Protein Coding	1
18	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
19	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
20	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
21	NBN	Nibrin	Protein Coding	1
22	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
23	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
24	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
25	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
26	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
27	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
28	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
29	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
30	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
31	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
32	TP53	Tumor Protein P53	Protein Coding	1
33	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
34	UBB	Ubiquitin B	Protein Coding	1
35	UBC	Ubiquitin C	Protein Coding	1
36	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	1
37	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
38	CCNA1	Cyclin A1	Protein Coding	1
39	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	1
40	CHEK2	Checkpoint Kinase 2	Protein Coding	1
41	FANCL	FA Complementation Group L	Protein Coding	1
42	CLSPN	Claspin	Protein Coding	1
43	ATRIP	ATR Interacting Protein	Protein Coding	1
44	RAD9B	RAD9 Checkpoint Clamp Component B	Protein Coding	1

Disorders associated with DNA damage_ATM/ATR regulation of G1/S checkpoint SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, CDK4, CHEK2, NBN, TP53	10.16
2	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BLM, BRCA1, CHEK2, NBN, TP53	10.09
3	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, CHEK2, NBN, TP53	9.37
4	Ovarian cancer	Enrichment	ATM, BARD1, BLM, BRCA1, CHEK2, FANCD2, NBN, TP53	9.00
5	Breast cancer	Enrichment	ATM, BARD1, BLM, BRCA1, CHEK2, NBN, TP53	8.41
6	Endometrial cancer	Enrichment	ATM, BARD1, BLM, BRCA1, CHEK2	8.26
7	Inherited cancer-predisposing syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, CDK4, CHEK2, NBN, TP53	8.07
8	Pancreatic cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	7.84
9	Prostate cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	7.50
10	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, CHEK2, NBN	7.17
11	Colorectal cancer	Enrichment	ATM, BLM, BRCA1, CCND1, CHEK2, TP53	6.47
12	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	6.20
13	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, TP53	5.67
14	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	5.42
15	Uterine corpus cancer	Enrichment	ATM, BRCA1, CHEK2	5.29
16	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.99
17	Sarcoma	Enrichment	CHEK2, TP53	4.99
18	Gliosarcoma	Enrichment	ATM, NFKBIA, TP53	4.76
19	Giant cell glioblastoma	Enrichment	ATM, NFKBIA, TP53	4.68
20	Diffuse large b-cell lymphoma	Enrichment	CHEK2, NBN, TP53	4.53
21	Osteogenic sarcoma	Enrichment	CHEK2, TP53	4.51
22	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.51
23	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	4.51
24	Adenocarcinoma	Enrichment	ATM, TP53	4.51
25	Bone osteosarcoma	Enrichment	CHEK2, TP53	4.51
26	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	4.51
27	Myeloma, multiple	Enrichment	ATM, BARD1, CCND1, TP53	4.50
28	Mantle cell lymphoma	Enrichment	ATM, CCND1	4.21
29	Von hippel-lindau syndrome	Enrichment	CCND1, FANCD2	3.99
30	Fanconi anemia, complementation group a	Enrichment	BRCA1, FANCD2, FANCL	3.71
31	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.67
32	Colonic benign neoplasm	Enrichment	ATM, CHEK2	3.44
33	Lynch syndrome 1	Enrichment	ATM, CHEK2	3.34
34	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.26
35	Seckel syndrome	Enrichment	ATR, ATRIP	3.04
36	Rhabdomyosarcoma	Enrichment	BRCA1, TP53	2.92
37	Hepatoblastoma	Enrichment	BARD1, TP53	2.68
38	Hepatocellular carcinoma	Enrichment	NBN, TP53	2.64
39	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.49
40	Bloom syndrome	Enrichment	BLM	2.49
41	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.49
42	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.49
43	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.49
44	Seckel syndrome 1	Enrichment	ATR	2.49
45	Accelerated tumor formation	Enrichment	MDM2	2.49
46	Immunodeficiency 92	Enrichment	REL	2.49
47	Lessel-kubisch syndrome	Enrichment	MDM2	2.49
48	Bone marrow failure syndrome 5	Enrichment	TP53	2.49
49	Papilloma of choroid plexus	Enrichment	TP53	2.49
50	Basal cell carcinoma 7	Enrichment	TP53	2.49
51	Anaplastic thyroid carcinoma	Enrichment	TP53	2.49
52	Infant-type hemispheric glioma	Enrichment	BRCA1	2.49
53	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.49
54	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.49
55	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.49
56	Endometrial serous adenocarcinoma	Enrichment	ATM	2.49
57	Ductal carcinoma in situ	Enrichment	TP53	2.49
58	Fanconi anemia, complementation group l	Enrichment	FANCL	2.49
59	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.49
60	Immunodeficiency 53	Enrichment	RELB	2.49
61	Leiomyosarcoma	Enrichment	CHEK2	2.49
62	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.49
63	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.49
64	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.49
65	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.49
66	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.49
67	Choroid plexus cancer	Enrichment	TP53	2.49
68	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.49
69	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.49
70	Primary peritoneal carcinoma	Enrichment	BRCA1	2.49
71	Lung cancer	Enrichment	BRCA1, CHEK2	2.32
72	Burkitt lymphoma	Enrichment	MYC	2.19
73	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.19
74	Cervical cancer	Enrichment	TP53	2.19
75	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.19
76	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	FANCL	2.19
77	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.19
78	Lymphoma, hodgkin, classic	Enrichment	TP53	2.19
79	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.19
80	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.19
81	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.19
82	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.19
83	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.19
84	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.19
85	Pancreatic cancer 4	Enrichment	BRCA1	2.19
86	Rela fusion-positive ependymoma	Enrichment	RELA	2.19
87	Congenital fibrosarcoma	Enrichment	TP53	2.19
88	High grade glioma	Enrichment	ATM	2.19
89	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.19
90	Cervix carcinoma	Enrichment	TP53	2.19
91	Hodgkin's lymphoma	Enrichment	TP53	2.19
92	T-cell prolymphocytic leukemia	Enrichment	ATM	2.19
93	Inflammatory breast carcinoma	Enrichment	BRCA1	2.19
94	Peritoneum cancer	Enrichment	BRCA1	2.19
95	Bilateral breast cancer	Enrichment	BRCA1	2.19
96	Common variable immunodeficiency 12	Enrichment	NFKB1	2.19
97	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.19
98	Submucosal cleft palate	Enrichment	UBB	2.19
99	Cleft hard palate	Enrichment	UBB	2.19
100	Leukemia, acute myeloid	Enrichment	FANCD2, TP53	2.13
101	Ataxia-telangiectasia	Enrichment	ATM	2.01
102	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP	2.01
103	Nijmegen breakage syndrome	Enrichment	NBN	2.01
104	Polycythemia vera	Enrichment	ATM	2.01
105	Uvula, bifid	Enrichment	UBB	2.01
106	Chilblain lupus 1	Enrichment	ATRIP	2.01
107	Cleft soft palate	Enrichment	UBB	2.01
108	Koolen-de vries syndrome	Enrichment	ATM	2.01
109	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.01
110	Chilblain lupus	Enrichment	ATRIP	2.01
111	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.01
112	Anaplastic astrocytoma	Enrichment	TP53	2.01
113	Squamous cell carcinoma	Enrichment	TP53	2.01
114	Small cell cancer of the lung	Enrichment	TP53	1.89
115	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.89
116	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.89
117	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.89
118	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	1.89
119	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.89
120	Cholangiocarcinoma	Enrichment	BRCA1	1.89
121	Aicardi-goutieres syndrome 1	Enrichment	ATRIP	1.89
122	Lung sarcomatoid carcinoma	Enrichment	TP53	1.89
123	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.89
124	Hemoglobin c disease	Enrichment	CHEK2	1.89
125	Vacterl association	Enrichment	FANCL	1.89
126	Thrombotic microangiopathy	Enrichment	ATRIP	1.89
127	Oculomotor apraxia	Enrichment	ATM	1.89
128	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.89
129	Primary ovarian insufficiency	Enrichment	CHEK2, NBN	1.81
130	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP	1.79
131	Fanconi anemia, complementation group d2	Enrichment	FANCD2	1.79
132	Vater/vacterl association	Enrichment	FANCL	1.79
133	Rhabdomyosarcoma 2	Enrichment	TP53	1.79
134	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.79
135	Lymphoma	Enrichment	TP53	1.79
136	Glioblastoma	Enrichment	ATM	1.79
137	Vascular dementia	Enrichment	ATRIP	1.79
138	Acute megakaryocytic leukemia	Enrichment	TP53	1.79
139	Wilms tumor 5	Enrichment	CHEK2	1.71
140	Wiedemann-steiner syndrome	Enrichment	SMC1A	1.71
141	Adrenocortical carcinoma	Enrichment	TP53	1.71
142	Clear cell renal cell carcinoma	Enrichment	ATM	1.71
143	Breast adenocarcinoma	Enrichment	TP53	1.71
144	Esophageal cancer	Enrichment	TP53	1.65
145	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.65
146	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.65
147	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.65
148	Essential thrombocythemia	Enrichment	TP53	1.65
149	Gallbladder cancer	Enrichment	TP53	1.65
150	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.65
151	Glioma susceptibility 1	Enrichment	TP53	1.59
152	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.59
153	Rett syndrome, congenital variant	Enrichment	SMC1A	1.59
154	Cornelia de lange syndrome 1	Enrichment	SMC1A	1.54
155	Adult hepatocellular carcinoma	Enrichment	TP53	1.54
156	Primary hyperaldosteronism	Enrichment	TP53	1.54
157	Cornelia de lange syndrome	Enrichment	SMC1A	1.54
158	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.50
159	Aplastic anemia	Enrichment	NBN	1.50
160	Aicardi-goutieres syndrome	Enrichment	ATRIP	1.50
161	Melanoma	Enrichment	CHEK2	1.50
162	Familial colorectal cancer	Enrichment	TP53	1.50
163	Immune deficiency disease	Enrichment	ATM	1.45
164	Leukemia, acute lymphoblastic	Enrichment	NBN	1.45
165	Myelodysplastic syndrome	Enrichment	TP53	1.45
166	Lip and oral cavity carcinoma	Enrichment	TP53	1.42
167	Neural tube defects	Enrichment	RAD9B	1.38
168	Premature menopause	Enrichment	NBN	1.38
169	Nk-cell enteropathy	Enrichment	CHEK2	1.38
170	Lung cancer susceptibility 3	Enrichment	TP53	1.35
171	Periventricular nodular heterotopia	Enrichment	BRCA1	1.35
172	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.32
173	Wilms tumor 1	Enrichment	CHEK2	1.32
174	Lynch syndrome	Enrichment	CHEK2	1.32
175	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.27
176	Polycystic liver disease	Enrichment	CDC25A	1.27
177	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.27
178	Semilobar holoprosencephaly	Enrichment	SMC1A	1.25
179	Microcephaly	Enrichment	NBN, SMC1A	1.22
180	Lissencephaly	Enrichment	NBN	1.18
181	Diamond-blackfan anemia 1	Enrichment	TP53	1.14
182	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.14
183	Diamond-blackfan anemia	Enrichment	TP53	0.96
184	Systemic lupus erythematosus	Enrichment	ATRIP	0.92
185	Congenital nervous system abnormality	Enrichment	SMC1A	0.53
186	Nervous system disease	Enrichment	SMC1A	0.53
187	Hereditary retinal dystrophy	Enrichment	ATRIP	0.21
188	Fundus dystrophy	Enrichment	ATRIP	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA damage_ATM/ATR regulation of G1/S checkpoint

Pathway Network for DNA damage_ATM/ATR regulation of G1/S checkpoint

Member Pathways for DNA damage_ATM/ATR regulation of G1/S checkpoint

Pathways in the DNA damage_ATM/ATR regulation of G1/S checkpoint SuperPath

Associated Genes for DNA damage_ATM/ATR regulation of G1/S checkpoint

Associated Disorders for DNA damage_ATM/ATR regulation of G1/S checkpoint

Disorders associated with DNA damage_ATM/ATR regulation of G1/S checkpoint SuperPath

STRING Interaction Network for DNA damage_ATM/ATR regulation of G1/S checkpoint

Sources for DNA damage_ATM/ATR regulation of G1/S checkpoint