DNA Damage Induced 14-3-3Sigma Signaling

No Pathway Network information available for DNA Damage Induced 14-3-3Sigma Signaling

Pathways in the DNA Damage Induced 14-3-3Sigma Signaling SuperPath

#	Name	Source	Genes
1	DNA Damage Induced 14-3-3Sigma Signaling	QIAGEN	ATM ATR BRCA1 CCNB1 CCNB2 CCNB3 CCNE1 CCNE2 CDK1 CDK2 HUS1 RAD1 RAD17 RAD9A SFN TP53 YWHAE YWHAG YWHAQ (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
2	ATR	ATR Checkpoint Kinase	Protein Coding	1
3	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
4	CCNB1	Cyclin B1	Protein Coding	1
5	CCNB2	Cyclin B2	Protein Coding	1
6	CCNB3	Cyclin B3	Protein Coding	1
7	CCNE1	Cyclin E1	Protein Coding	1
8	CCNE2	Cyclin E2	Protein Coding	1
9	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
10	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
11	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	1
12	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	1
13	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	1
14	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
15	SFN	Stratifin	Protein Coding	1
16	TP53	Tumor Protein P53	Protein Coding	1
17	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
18	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
19	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1

Disorders associated with DNA Damage Induced 14-3-3Sigma Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pancreatic cancer	Enrichment	ATM, BRCA1, TP53	5.28
2	Adenocarcinoma	Enrichment	ATM, TP53	5.25
3	Bladder cancer	Enrichment	ATM, BRCA1, TP53	5.08
4	Prostate cancer	Enrichment	ATM, BRCA1, TP53	5.08
5	Gastric cancer	Enrichment	ATM, BRCA1, TP53	4.56
6	Hereditary breast carcinoma	Enrichment	ATM, BRCA1, TP53	4.53
7	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, TP53	4.23
8	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	4.08
9	Uterine corpus cancer	Enrichment	ATM, BRCA1	3.99
10	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1	3.84
11	Breast cancer	Enrichment	ATM, BRCA1, TP53	3.83
12	Rhabdomyosarcoma	Enrichment	BRCA1, TP53	3.66
13	Gliosarcoma	Enrichment	ATM, TP53	3.66
14	Colorectal cancer	Enrichment	ATM, BRCA1, TP53	3.64
15	Giant cell glioblastoma	Enrichment	ATM, TP53	3.60
16	Ovarian cancer	Enrichment	ATM, BRCA1, TP53	3.45
17	Endometrial cancer	Enrichment	ATM, BRCA1	3.42
18	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, TP53	3.11
19	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.85
20	Seckel syndrome 1	Enrichment	ATR	2.85
21	Bone marrow failure syndrome 5	Enrichment	TP53	2.85
22	Papilloma of choroid plexus	Enrichment	TP53	2.85
23	Basal cell carcinoma 7	Enrichment	TP53	2.85
24	Anaplastic thyroid carcinoma	Enrichment	TP53	2.85
25	Infant-type hemispheric glioma	Enrichment	BRCA1	2.85
26	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.85
27	Endometrial serous adenocarcinoma	Enrichment	ATM	2.85
28	Ductal carcinoma in situ	Enrichment	TP53	2.85
29	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.85
30	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.85
31	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.85
32	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.85
33	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.85
34	Choroid plexus cancer	Enrichment	TP53	2.85
35	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.85
36	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.85
37	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.85
38	Primary peritoneal carcinoma	Enrichment	BRCA1	2.85
39	Myeloma, multiple	Enrichment	ATM, TP53	2.56
40	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.55
41	Cervical cancer	Enrichment	TP53	2.55
42	Lymphoma, hodgkin, classic	Enrichment	TP53	2.55
43	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.55
44	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.55
45	Pancreatic cancer 4	Enrichment	BRCA1	2.55
46	Congenital fibrosarcoma	Enrichment	TP53	2.55
47	High grade glioma	Enrichment	ATM	2.55
48	Li-fraumeni syndrome 1	Enrichment	TP53	2.55
49	Sarcoma	Enrichment	TP53	2.55
50	Cervix carcinoma	Enrichment	TP53	2.55
51	Hodgkin's lymphoma	Enrichment	TP53	2.55
52	T-cell prolymphocytic leukemia	Enrichment	ATM	2.55
53	Inflammatory breast carcinoma	Enrichment	BRCA1	2.55
54	Peritoneum cancer	Enrichment	BRCA1	2.55
55	Bilateral breast cancer	Enrichment	BRCA1	2.55
56	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.55
57	Ataxia-telangiectasia	Enrichment	ATM	2.38
58	Polycythemia vera	Enrichment	ATM	2.38
59	Osteogenic sarcoma	Enrichment	TP53	2.38
60	Nasopharyngeal carcinoma	Enrichment	TP53	2.38
61	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	2.38
62	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	2.38
63	Koolen-de vries syndrome	Enrichment	ATM	2.38
64	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.38
65	Anaplastic astrocytoma	Enrichment	TP53	2.38
66	Squamous cell carcinoma	Enrichment	TP53	2.38
67	Bone osteosarcoma	Enrichment	TP53	2.38
68	Small cell cancer of the lung	Enrichment	TP53	2.25
69	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.25
70	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	2.25
71	Cholangiocarcinoma	Enrichment	BRCA1	2.25
72	Mantle cell lymphoma	Enrichment	ATM	2.25
73	Lung sarcomatoid carcinoma	Enrichment	TP53	2.25
74	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.25
75	Pregnancy loss, recurrent 1	Enrichment	CCNB3	2.25
76	Oculomotor apraxia	Enrichment	ATM	2.25
77	Rhabdomyosarcoma 2	Enrichment	TP53	2.16
78	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	2.16
79	Lymphoma	Enrichment	TP53	2.16
80	Glioblastoma	Enrichment	ATM	2.16
81	Acute megakaryocytic leukemia	Enrichment	TP53	2.16
82	Endometrial stromal sarcoma	Enrichment	YWHAE	2.16
83	Li-fraumeni syndrome	Enrichment	TP53	2.08
84	Adrenocortical carcinoma	Enrichment	TP53	2.08
85	Clear cell renal cell carcinoma	Enrichment	ATM	2.08
86	Breast adenocarcinoma	Enrichment	TP53	2.08
87	Kidney clear cell sarcoma	Enrichment	YWHAE	2.08
88	Esophageal cancer	Enrichment	TP53	2.01
89	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.01
90	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.01
91	Essential thrombocythemia	Enrichment	TP53	2.01
92	Gallbladder cancer	Enrichment	TP53	2.01
93	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.01
94	Glioma susceptibility 1	Enrichment	TP53	1.95
95	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.95
96	Adult hepatocellular carcinoma	Enrichment	TP53	1.90
97	Primary hyperaldosteronism	Enrichment	TP53	1.90
98	Colonic benign neoplasm	Enrichment	ATM	1.90
99	Lynch syndrome 1	Enrichment	ATM	1.86
100	Familial colorectal cancer	Enrichment	TP53	1.86
101	Immune deficiency disease	Enrichment	ATM	1.82
102	Myelodysplastic syndrome	Enrichment	TP53	1.82
103	Familial colorectal cancer type x	Enrichment	ATM	1.82
104	Specific learning disability	Enrichment	YWHAG	1.82
105	Lip and oral cavity carcinoma	Enrichment	TP53	1.78
106	Lung cancer susceptibility 3	Enrichment	TP53	1.71
107	Periventricular nodular heterotopia	Enrichment	BRCA1	1.71
108	Seckel syndrome	Enrichment	ATR	1.71
109	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.68
110	Diffuse large b-cell lymphoma	Enrichment	TP53	1.58
111	Hepatoblastoma	Enrichment	TP53	1.54
112	Hepatocellular carcinoma	Enrichment	TP53	1.52
113	Diamond-blackfan anemia 1	Enrichment	TP53	1.50
114	Lung cancer	Enrichment	BRCA1	1.36
115	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.32
116	Diamond-blackfan anemia	Enrichment	TP53	1.31
117	Leukemia, acute myeloid	Enrichment	TP53	1.26
118	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	1.12
119	Microcephaly	Enrichment	YWHAG	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA Damage Induced 14-3-3Sigma Signaling

Pathway Network for DNA Damage Induced 14-3-3Sigma Signaling

Member Pathways for DNA Damage Induced 14-3-3Sigma Signaling

Pathways in the DNA Damage Induced 14-3-3Sigma Signaling SuperPath

Associated Genes for DNA Damage Induced 14-3-3Sigma Signaling

Associated Disorders for DNA Damage Induced 14-3-3Sigma Signaling

Disorders associated with DNA Damage Induced 14-3-3Sigma Signaling SuperPath

STRING Interaction Network for DNA Damage Induced 14-3-3Sigma Signaling

Sources for DNA Damage Induced 14-3-3Sigma Signaling