DNA damage_NHEJ mechanisms of DSBs repair

No Pathway Network information available for DNA damage_NHEJ mechanisms of DSBs repair

Pathways in the DNA damage_NHEJ mechanisms of DSBs repair SuperPath

#	Name	Source	Genes
1	DNA damage_NHEJ mechanisms of DSBs repair	GeneGo (Thomson Reuters)	BRCA1 CSNK2A1 CSNK2A2 CSNK2B DCLRE1C FEN1 LIG4 MRE11 NBN PNKP POLM PRKDC RAD50 SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 WRN XRCC4 XRCC5 XRCC6 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
2	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
3	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
4	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
5	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	1
6	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
7	LIG4	DNA Ligase 4	Protein Coding	1
8	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
9	NBN	Nibrin	Protein Coding	1
10	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
11	WRN	WRN RecQ Like Helicase	Protein Coding	1
12	XRCC4	X-Ray Repair Cross Complementing 4	Protein Coding	1
13	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
14	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
15	PNKP	Polynucleotide Kinase 3''-Phosphatase	Protein Coding	1
16	SIRT2	Sirtuin 2	Protein Coding	1
17	SIRT5	Sirtuin 5	Protein Coding	1
18	SIRT4	Sirtuin 4	Protein Coding	1
19	SIRT3	Sirtuin 3	Protein Coding	1
20	SIRT1	Sirtuin 1	Protein Coding	1
21	POLM	DNA Polymerase Mu	Protein Coding	1
22	SIRT7	Sirtuin 7	Protein Coding	1
23	SIRT6	Sirtuin 6	Protein Coding	1
24	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	1

Disorders associated with DNA damage_NHEJ mechanisms of DSBs repair SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ovarian cancer	Enrichment	BRCA1, MRE11, NBN, RAD50, WRN	6.10
2	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1, MRE11, NBN, RAD50	5.62
3	Lig4 syndrome	Enrichment	LIG4, XRCC4	5.52
4	Breast cancer	Enrichment	BRCA1, MRE11, NBN, RAD50	5.07
5	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11, PNKP	4.75
6	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.75
7	Hereditary breast carcinoma	Enrichment	BRCA1, NBN, RAD50	4.21
8	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, MRE11, NBN, RAD50	4.11
9	Omenn syndrome	Enrichment	DCLRE1C, LIG4	3.87
10	Breast-ovarian cancer, familial 1	Enrichment	BRCA1, NBN	3.64
11	Hepatocellular carcinoma	Enrichment	NBN, RAD50	3.17
12	Pancreatic cancer	Enrichment	BRCA1, NBN	3.06
13	Prostate cancer	Enrichment	BRCA1, NBN	2.93
14	Severe combined immunodeficiency	Enrichment	DCLRE1C, LIG4	2.81
15	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.75
16	Ataxia-oculomotor apraxia 4	Enrichment	PNKP	2.75
17	Infant-type hemispheric glioma	Enrichment	BRCA1	2.75
18	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.75
19	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.75
20	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.75
21	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.75
22	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.75
23	Primary peritoneal carcinoma	Enrichment	BRCA1	2.75
24	Gastric cancer	Enrichment	BRCA1, NBN	2.59
25	Dubowitz syndrome	Enrichment	LIG4	2.45
26	Charcot-marie-tooth disease, axonal, type 2b2	Enrichment	PNKP	2.45
27	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	2.45
28	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.45
29	Werner syndrome	Enrichment	WRN	2.45
30	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	2.45
31	Pancreatic cancer 4	Enrichment	BRCA1	2.45
32	Charcot-marie-tooth disease type 2b2	Enrichment	PNKP	2.45
33	Microcephaly, seizures, and developmental delay	Enrichment	PNKP	2.45
34	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC4	2.45
35	Inflammatory breast carcinoma	Enrichment	BRCA1	2.45
36	Peritoneum cancer	Enrichment	BRCA1	2.45
37	Bilateral breast cancer	Enrichment	BRCA1	2.45
38	Microcephalic primordial dwarfism-insulin resistance syndrome	Enrichment	XRCC4	2.45
39	Primary ovarian insufficiency	Enrichment	NBN, SIRT6	2.32
40	Prognathism, mandibular	Enrichment	CSNK2B	2.28
41	Nijmegen breakage syndrome	Enrichment	NBN	2.28
42	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	2.28
43	Renu syndrome	Enrichment	SIRT4	2.28
44	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	2.28
45	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	2.15
46	Cholangiocarcinoma	Enrichment	BRCA1	2.15
47	Aicardi-goutieres syndrome 1	Enrichment	DCLRE1C	2.15
48	Developmental and epileptic encephalopathy 12	Enrichment	PNKP	2.15
49	Enophthalmos	Enrichment	CSNK2B	2.15
50	Syndactyly	Enrichment	CSNK2B	2.15
51	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	2.05
52	Isolated growth hormone deficiency, type ia	Enrichment	XRCC4	1.85
53	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B	1.80
54	Colonic benign neoplasm	Enrichment	MRE11	1.80
55	Aplastic anemia	Enrichment	NBN	1.76
56	Leukemia, acute lymphoblastic	Enrichment	NBN	1.71
57	Uterine corpus cancer	Enrichment	BRCA1	1.71
58	Premature menopause	Enrichment	NBN	1.64
59	Medulloblastoma	Enrichment	WRN	1.61
60	Periventricular nodular heterotopia	Enrichment	BRCA1	1.61
61	Cataract	Enrichment	WRN	1.61
62	Rhabdomyosarcoma	Enrichment	BRCA1	1.55
63	Isolated congenital microcephaly	Enrichment	PNKP	1.55
64	Early infantile developmental and epileptic encephalopathy	Enrichment	PNKP	1.50
65	Diffuse large b-cell lymphoma	Enrichment	NBN	1.48
66	Endometrial cancer	Enrichment	BRCA1	1.44
67	Lissencephaly	Enrichment	NBN	1.44
68	Bladder cancer	Enrichment	BRCA1	1.30
69	Lung cancer	Enrichment	BRCA1	1.26
70	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.22
71	Type 2 diabetes mellitus	Enrichment	WRN	1.14
72	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	1.07
73	Myeloma, multiple	Enrichment	LIG4	1.02
74	Colorectal cancer	Enrichment	BRCA1	0.84
75	Congenital nervous system abnormality	Enrichment	PNKP	0.77
76	Nervous system disease	Enrichment	PNKP	0.77
77	Microcephaly	Enrichment	NBN	0.71
78	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA damage_NHEJ mechanisms of DSBs repair

Pathway Network for DNA damage_NHEJ mechanisms of DSBs repair

Member Pathways for DNA damage_NHEJ mechanisms of DSBs repair

Pathways in the DNA damage_NHEJ mechanisms of DSBs repair SuperPath

Associated Genes for DNA damage_NHEJ mechanisms of DSBs repair

Associated Disorders for DNA damage_NHEJ mechanisms of DSBs repair

Disorders associated with DNA damage_NHEJ mechanisms of DSBs repair SuperPath

STRING Interaction Network for DNA damage_NHEJ mechanisms of DSBs repair

Sources for DNA damage_NHEJ mechanisms of DSBs repair