DNA damage response (only ATM dependent)

No Pathway Network information available for DNA damage response (only ATM dependent)

Pathways in the DNA damage response (only ATM dependent) SuperPath

#	Name	Source	Genes
1	DNA damage response (only ATM dependent)	WikiPathways	ABL1 APC ATM AXIN1 BAD BAK1 BAX BCL2 BCL2L11 BCL6 BIK CAT CCND1 CCND2 CCND3 CCNG2 CDC42 CDKN1A CDKN1B CTNNB1 DVL1 DVL2 DVL3 ERBB2 FASLG FOSL1 FOXO3 FRAT1 G6PC1 GRB2 GSK3B HMGB1 HRAS INSR IRS1 JUN KRAS LDLR LEF1 MAP3K1 MAP3K4 MAP3K7 MAPK1 MAPK10 MAPK8 MAPK9 MDM2 MLKL MYC NRAS PCK2 PDK1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLAU PMAIP1 PPP2R5C PPP2R5E PTEN RAC1 RAC2 RBL2 RHOA SCP2 SHC1 SMAD3 SMAD4 SOS1 SOS2 TCF7 TCF7L1 TCF7L2 TGFB1 TP53 TP73 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B (see all 101) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
2	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	1
3	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
4	CDC42	Cell Division Cycle 42	Protein Coding	1
5	WNT3A	Wnt Family Member 3A	Protein Coding	1
6	CCND3	Cyclin D3	Protein Coding	1
7	CCND2	Cyclin D2	Protein Coding	1
8	CAT	Catalase	Protein Coding	1
9	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
10	AXIN1	Axin 1	Protein Coding	1
11	WNT5B	Wnt Family Member 5B	Protein Coding	1
12	WNT10A	Wnt Family Member 10A	Protein Coding	1
13	WNT2B	Wnt Family Member 2B	Protein Coding	1
14	WNT11	Wnt Family Member 11	Protein Coding	1
15	WNT10B	Wnt Family Member 10B	Protein Coding	1
16	WNT7A	Wnt Family Member 7A	Protein Coding	1
17	WNT5A	Wnt Family Member 5A	Protein Coding	1
18	WNT3	Wnt Family Member 3	Protein Coding	1
19	WNT2	Wnt Family Member 2	Protein Coding	1
20	WNT1	Wnt Family Member 1	Protein Coding	1
21	TP73	Tumor Protein P73	Protein Coding	1
22	TP53	Tumor Protein P53	Protein Coding	1
23	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
24	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
25	TCF7	Transcription Factor 7	Protein Coding	1
26	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
27	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
28	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
29	SHC1	SHC Adaptor Protein 1	Protein Coding	1
30	SCP2	Sterol Carrier Protein 2	Protein Coding	1
31	BCL6	BCL6 Transcription Repressor	Protein Coding	1
32	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
33	CCND1	Cyclin D1	Protein Coding	1
34	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
35	RAC2	Rac Family Small GTPase 2	Protein Coding	1
36	RAC1	Rac Family Small GTPase 1	Protein Coding	1
37	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
38	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
39	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
40	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
41	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
42	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
43	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
44	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
45	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	1
46	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	1
47	WNT4	Wnt Family Member 4	Protein Coding	1
48	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
49	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
50	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
51	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
52	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
53	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
54	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
55	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
56	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
57	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
58	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	1
59	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
60	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
61	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
62	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
63	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
64	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
65	SMAD4	SMAD Family Member 4	Protein Coding	1
66	SMAD3	SMAD Family Member 3	Protein Coding	1
67	LDLR	Low Density Lipoprotein Receptor	Protein Coding	1
68	RHOA	Ras Homolog Family Member A	Protein Coding	1
69	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
70	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
71	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
72	INSR	Insulin Receptor	Protein Coding	1
73	FASLG	Fas Ligand	Protein Coding	1
74	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
75	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
76	HMGB1	High Mobility Group Box 1	Protein Coding	1
77	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
78	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	1
79	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
80	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
81	FOXO3	Forkhead Box O3	Protein Coding	1
82	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
83	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
84	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
85	CTNNB1	Catenin Beta 1	Protein Coding	1
86	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
87	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
88	BCL2L11	BCL2 Like 11	Protein Coding	1
89	MLKL	Mixed Lineage Kinase Domain Like Pseudokinase	Protein Coding	1
90	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
91	CCNG2	Cyclin G2	Protein Coding	1
92	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
93	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
94	WNT7B	Wnt Family Member 7B	Protein Coding	1
95	WNT6	Wnt Family Member 6	Protein Coding	1
96	BIK	BCL2 Interacting Killer	Protein Coding	1
97	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
98	WNT16	Wnt Family Member 16	Protein Coding	1
99	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
100	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
101	FRAT1	FRAT Regulator Of Wnt Signaling Pathway 1	Protein Coding	1

Disorders associated with DNA damage response (only ATM dependent) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	ATM, CDKN1A, CTNNB1, ERBB2, HRAS, KRAS, PIK3CA, PTEN, TP53	16.00
2	Colorectal cancer	Enrichment	APC, ATM, BAX, CCND1, CTNNB1, ERBB2, NRAS, PIK3CA, PIK3R1, SMAD4, TP53	10.51
3	Gallbladder cancer	Enrichment	CTNNB1, KRAS, PIK3CA, SMAD4, TP53	9.36
4	Gastric cancer	Enrichment	APC, ATM, ERBB2, KRAS, PIK3CA, PTEN, SMAD4, TP53	9.08
5	Ovarian cancer	Enrichment	APC, ATM, CDKN1B, CTNNB1, ERBB2, KRAS, MAP3K1, PIK3CA, PTEN, TP53	8.44
6	Lung non-small cell carcinoma	Enrichment	ERBB2, HRAS, KRAS, NRAS, PIK3CA	8.04
7	Breast cancer	Enrichment	APC, ATM, JUN, KRAS, PIK3CA, PTEN, SHC1, TP53	7.10
8	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.00
9	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1, PIK3CA, TP53	6.45
10	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, BCL6, MYC	6.40
11	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1, PIK3CA, TP53	6.31
12	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1, SOS2	6.20
13	Hereditary breast carcinoma	Enrichment	APC, ATM, KRAS, PIK3CA, PTEN, TP53	6.08
14	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1, SOS2	5.92
15	Lip and oral cavity carcinoma	Enrichment	ABL1, HRAS, PIK3CA, TP53	5.86
16	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.80
17	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3, WNT5A	5.80
18	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1, KRAS, NRAS	5.80
19	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3, WNT5A	5.80
20	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	5.43
21	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3, WNT5A	5.40
22	Cowden syndrome 1	Enrichment	LDLR, PIK3CA, PTEN	5.10
23	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3, WNT5A	5.10
24	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA, TP53	5.10
25	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS, PTEN	4.86
26	Leukemia, chronic myeloid	Enrichment	ABL1, KRAS, NRAS	4.86
27	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	4.86
28	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS, PTEN	4.86
29	Pancreatic cancer	Enrichment	ATM, KRAS, SMAD4, TP53	4.49
30	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	4.33
31	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.26
32	Intravascular large b-cell lymphoma	Enrichment	BCL2, BCL6	4.26
33	Immune system disease	Enrichment	CDC42, PIK3CD	4.26
34	Myeloma, multiple	Enrichment	ATM, CCND1, KRAS, PIK3R2, TP53	4.23
35	Prostate cancer	Enrichment	ATM, PIK3CA, PTEN, TP53	4.22
36	Lung cancer	Enrichment	ERBB2, FASLG, KRAS, PIK3CA	4.05
37	Lung cancer susceptibility 3	Enrichment	ERBB2, KRAS, TP53	3.86
38	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.79
39	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	3.79
40	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.79
41	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.79
42	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.79
43	Desmoid tumor	Enrichment	APC, CTNNB1	3.79
44	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.79
45	T-cell acute lymphoblastic leukemia	Enrichment	ABL1, BAX	3.79
46	Adenocarcinoma	Enrichment	ATM, TP53	3.79
47	Rhabdomyosarcoma	Enrichment	HRAS, PTEN, TP53	3.68
48	Small cell cancer of the lung	Enrichment	TP53, TP73	3.49
49	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.49
50	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2, PIK3R2	3.49
51	Mantle cell lymphoma	Enrichment	ATM, CCND1	3.49
52	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	3.49
53	Craniopharyngioma	Enrichment	APC, CTNNB1	3.49
54	Inherited cancer-predisposing syndrome	Enrichment	APC, ATM, CDKN1B, PTEN, SMAD4, TP53	3.35
55	Endometrial cancer	Enrichment	ATM, PIK3CA, PTEN	3.32
56	Hepatoblastoma	Enrichment	APC, CTNNB1, TP53	3.32
57	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3	3.27
58	Follicular lymphoma	Enrichment	BCL2, BCL6	3.27
59	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.27
60	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	3.27
61	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, KRAS, PTEN, TP53	3.13
62	Li-fraumeni syndrome	Enrichment	MDM2, TP53	3.09
63	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.09
64	Adrenocortical carcinoma	Enrichment	CTNNB1, TP53	3.09
65	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.09
66	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	2.95
67	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	2.95
68	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	2.95
69	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, TP53	2.95
70	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.90
71	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	2.83
72	Glioma susceptibility 1	Enrichment	ERBB2, TP53	2.83
73	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	2.72
74	Colonic benign neoplasm	Enrichment	APC, ATM	2.72
75	Cowden syndrome	Enrichment	PIK3CA, PTEN	2.72
76	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.62
77	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.62
78	Uterine corpus cancer	Enrichment	ATM, PTEN	2.54
79	Leukemia, acute myeloid	Enrichment	KRAS, NRAS, TP53	2.49
80	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.46
81	Meningioma	Enrichment	PIK3CA, PTEN	2.46
82	Type 2 diabetes mellitus	Enrichment	INSR, IRS1, TCF7L2	2.43
83	Medulloblastoma	Enrichment	APC, CTNNB1	2.33
84	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.33
85	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.27
86	Gliosarcoma	Enrichment	ATM, TP53	2.21
87	Giant cell glioblastoma	Enrichment	ATM, TP53	2.16
88	Macrodactyly	Enrichment	PIK3CA	2.13
89	Paget disease, extramammary	Enrichment	ERBB2	2.13
90	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.13
91	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.13
92	Donohue syndrome	Enrichment	INSR	2.13
93	Oculoectodermal syndrome	Enrichment	KRAS	2.13
94	Vacterl association with hydrocephalus	Enrichment	PTEN	2.13
95	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.13
96	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.13
97	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.13
98	Noonan syndrome 4	Enrichment	SOS1	2.13
99	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.13
100	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.13
101	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.13
102	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.13
103	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.13
104	Cowden syndrome 5	Enrichment	PIK3CA	2.13
105	Split-hand/foot malformation 6	Enrichment	WNT10B	2.13
106	Melanosis, neurocutaneous	Enrichment	NRAS	2.13
107	Noonan syndrome 9	Enrichment	SOS2	2.13
108	Caudal duplication anomaly	Enrichment	AXIN1	2.13
109	Noonan syndrome 6	Enrichment	NRAS	2.13
110	Tooth agenesis, selective, 8	Enrichment	WNT10B	2.13
111	46,xy sex reversal 6	Enrichment	MAP3K1	2.13
112	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.13
113	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.13
114	Accelerated tumor formation	Enrichment	MDM2	2.13
115	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.13
116	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.13
117	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.13
118	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.13
119	Noonan syndrome 13	Enrichment	MAPK1	2.13
120	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.13
121	Lessel-kubisch syndrome	Enrichment	MDM2	2.13
122	Short syndrome	Enrichment	PIK3R1	2.13
123	Bone marrow failure syndrome 5	Enrichment	TP53	2.13
124	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.13
125	Diarrhea 9	Enrichment	WNT2B	2.13
126	Papilloma of choroid plexus	Enrichment	TP53	2.13
127	Basal cell carcinoma 7	Enrichment	TP53	2.13
128	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.13
129	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.13
130	Anaplastic thyroid carcinoma	Enrichment	TP53	2.13
131	Papillary tumor of the pineal region	Enrichment	PTEN	2.13
132	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.13
133	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.13
134	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.13
135	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.13
136	Santos syndrome	Enrichment	WNT7A	2.13
137	Neuroendocrine tumor	Enrichment	CDKN1B	2.13
138	Acatalasemia	Enrichment	CAT	2.13
139	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.13
140	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.13
141	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.13
142	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	2.13
143	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.13
144	Endometrial serous adenocarcinoma	Enrichment	ATM	2.13
145	Glioma susceptibility 2	Enrichment	PTEN	2.13
146	Ductal carcinoma in situ	Enrichment	TP53	2.13
147	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.13
148	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.13
149	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.13
150	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.13
151	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.13
152	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.13
153	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.13
154	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.13
155	Adenoid ameloblastoma	Enrichment	CTNNB1	2.13
156	Heritable thoracic aortic disease	Enrichment	SMAD4	2.13
157	Hypospadias	Enrichment	PIK3CA	2.13
158	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.13
159	Congenital pulmonary airway malformation	Enrichment	KRAS	2.13
160	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.13
161	Choroid plexus cancer	Enrichment	TP53	2.13
162	Rare venous malformation	Enrichment	PIK3CA	2.13
163	Familial adenomatous polyposis	Enrichment	APC	2.13
164	Diaphragmatic eventration	Enrichment	PIK3CA	2.13
165	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.13
166	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.13
167	Nocarh syndrome	Enrichment	CDC42	2.13
168	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.13
169	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.13
170	Rare combined vascular malformation	Enrichment	PIK3CA	2.13
171	Cavernous lymphangioma	Enrichment	PIK3CA	2.13
172	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.13
173	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.13
174	Gardner syndrome	Enrichment	APC	2.13
175	5q22 microdeletion syndrome	Enrichment	APC	2.13
176	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.13
177	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.13
178	Attenuated familial adenomatous polyposis	Enrichment	APC	2.13
179	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.13
180	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.13
181	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.13
182	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.13
183	Macrodactyly of toe	Enrichment	PIK3CA	2.13
184	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.13
185	Neurocutaneous melanocytosis	Enrichment	NRAS	2.13
186	Microcystic stromal tumor	Enrichment	CTNNB1	2.13
187	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	2.06
188	Tooth agenesis	Enrichment	WNT10A, WNT10B	1.94
189	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, MYC	1.90
190	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.83
191	Burkitt lymphoma	Enrichment	MYC	1.83
192	Fibromatosis, gingival, 1	Enrichment	SOS1	1.83
193	Myhre syndrome	Enrichment	SMAD4	1.83
194	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.83
195	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.83
196	Camurati-engelmann disease 1	Enrichment	TGFB1	1.83
197	Costello syndrome	Enrichment	HRAS	1.83
198	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.83
199	Phosphoenolpyruvate carboxykinase deficiency, mitochondrial	Enrichment	PCK2	1.83
200	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.83
201	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.83
202	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.83
203	Quebec platelet disorder	Enrichment	PLAU	1.83
204	Cervical cancer	Enrichment	TP53	1.83
205	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.83
206	Pulmonic stenosis	Enrichment	SOS1	1.83
207	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.83
208	Tetraamelia syndrome 1	Enrichment	WNT3	1.83
209	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.83
210	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.83
211	Keratosis, seborrheic	Enrichment	PIK3CA	1.83
212	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.83
213	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.83
214	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.83
215	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3	1.83
216	Noonan syndrome 8	Enrichment	PIK3CA	1.83
217	Spermatogenic failure 17	Enrichment	PIK3C2G	1.83
218	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.83
219	Lymphoma, hodgkin, classic	Enrichment	TP53	1.83
220	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.83
221	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.83
222	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.83
223	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.83
224	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.83
225	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.83
226	Hyperlipoproteinemia, type iii	Enrichment	LDLR	1.83
227	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.83
228	Split hand-foot malformation	Enrichment	LEF1	1.83
229	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.83
230	Camurati-engelmann disease	Enrichment	TGFB1	1.83
231	Congenital fibrosarcoma	Enrichment	TP53	1.83
232	High grade glioma	Enrichment	ATM	1.83
233	Li-fraumeni syndrome 1	Enrichment	TP53	1.83
234	Sarcoma	Enrichment	TP53	1.83
235	Periampullary adenoma	Enrichment	APC	1.83
236	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.83
237	Cervix carcinoma	Enrichment	TP53	1.83
238	Hodgkin's lymphoma	Enrichment	TP53	1.83
239	T-cell prolymphocytic leukemia	Enrichment	ATM	1.83
240	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.83
241	Vacterl with hydrocephalus	Enrichment	PTEN	1.83
242	Teratoma	Enrichment	CTNNB1	1.83
243	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.83
244	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.83
245	Juvenile polyposis of infancy	Enrichment	PTEN	1.83
246	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.83
247	Wooly hair nevus	Enrichment	HRAS	1.83
248	Hypercholesterolemia, familial, 2	Enrichment	LDLR	1.65
249	Ataxia-telangiectasia	Enrichment	ATM	1.65
250	Juvenile polyposis syndrome	Enrichment	SMAD4	1.65
251	Polycythemia vera	Enrichment	ATM	1.65
252	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.65
253	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.65
254	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	1.65
255	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.65
256	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.65
257	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.65
258	Nuchal bleb, familial	Enrichment	SOS1	1.65
259	Langerhans cell histiocytosis	Enrichment	NRAS	1.65
260	Osteogenic sarcoma	Enrichment	TP53	1.65
261	Hypercholesterolemia, familial, 4	Enrichment	LDLR	1.65
262	Nasopharyngeal carcinoma	Enrichment	TP53	1.65
263	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.65
264	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.65
265	Anus, imperforate	Enrichment	CTNNB1	1.65
266	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.65
267	Koolen-de vries syndrome	Enrichment	ATM	1.65
268	Dedifferentiated liposarcoma	Enrichment	MDM2	1.65
269	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	1.65
270	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.65
271	Anaplastic astrocytoma	Enrichment	TP53	1.65
272	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.65
273	Squamous cell carcinoma	Enrichment	TP53	1.65
274	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.65
275	Bone osteosarcoma	Enrichment	TP53	1.65
276	Spermatocytoma	Enrichment	HRAS	1.65
277	Tetraamelia syndrome	Enrichment	WNT3	1.65
278	Respiratory failure	Enrichment	TP73	1.65
279	Colon adenocarcinoma	Enrichment	APC	1.65
280	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK2	1.65
281	Well-differentiated liposarcoma	Enrichment	MDM2	1.65
282	Keratoacanthoma	Enrichment	PIK3CA	1.65
283	Apc-associated polyposis conditions	Enrichment	APC	1.65
284	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.65
285	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.53
286	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.53
287	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.53
288	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.53
289	Glycogen storage disease ia	Enrichment	G6PC1	1.53
290	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.53
291	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.53
292	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.53
293	Pilomatrixoma	Enrichment	CTNNB1	1.53
294	Barrett esophagus	Enrichment	ERBB2	1.53
295	Alazami syndrome	Enrichment	CTNNB1	1.53
296	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.53
297	Ectodermal dysplasia	Enrichment	WNT10A	1.53
298	Cerebrovascular disease	Enrichment	PIK3CA	1.53
299	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.53
300	Aortic aneurysm	Enrichment	SMAD3	1.53
301	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.53
302	Pilocytic astrocytoma	Enrichment	KRAS	1.53
303	Epidermolytic nevus	Enrichment	HRAS	1.53
304	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.53
305	Primary hyperparathyroidism	Enrichment	CDKN1B	1.53
306	Glioma	Enrichment	PTEN	1.53
307	Gingival fibromatosis	Enrichment	SOS1	1.53
308	Oculomotor apraxia	Enrichment	ATM	1.53
309	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.53
310	Capillary malformations, congenital	Enrichment	PIK3CA	1.44
311	Alzheimer disease 2	Enrichment	PLAU	1.44
312	Hyperlipidemia, familial combined, 3	Enrichment	LDLR	1.44
313	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.44
314	Von hippel-lindau syndrome	Enrichment	CCND1	1.44
315	Rhabdomyosarcoma 2	Enrichment	TP53	1.44
316	Macrocephaly/autism syndrome	Enrichment	PTEN	1.44
317	Familial adenomatous polyposis 1	Enrichment	APC	1.44
318	Lymphoma	Enrichment	TP53	1.44
319	Glioblastoma	Enrichment	ATM	1.44
320	Hemangioma	Enrichment	PTEN	1.44
321	Hypoglycemia	Enrichment	G6PC1	1.44
322	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.44
323	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.44
324	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4	1.37
325	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.36
326	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.36
327	Split-hand/foot malformation 1	Enrichment	LEF1	1.36
328	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.36
329	Diarrhea	Enrichment	WNT2B	1.36
330	Lipid metabolism disorder	Enrichment	LDLR	1.36
331	Clear cell renal cell carcinoma	Enrichment	ATM	1.36
332	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.36
333	46,xy disorder of sex development	Enrichment	INSR	1.36
334	Esophageal cancer	Enrichment	TP53	1.29
335	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.29
336	Essential thrombocythemia	Enrichment	TP53	1.29
337	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.29
338	Pilomyxoid astrocytoma	Enrichment	KRAS	1.29
339	Overgrowth syndrome	Enrichment	PIK3R1	1.29
340	Moyamoya angiopathy	Enrichment	ABL1	1.29
341	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.24
342	Lennox-gastaut syndrome	Enrichment	MAPK10	1.24
343	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.24
344	Homozygous familial hypercholesterolemia	Enrichment	LDLR	1.24
345	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.24
346	Microcephaly	Enrichment	ABL1, CTNNB1, MAPK1	1.19
347	Coronary heart disease 5	Enrichment	LDLR	1.19
348	Loeys-dietz syndrome	Enrichment	SMAD3	1.19
349	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.19
350	Primary hyperaldosteronism	Enrichment	TP53	1.19
351	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.19
352	Lynch syndrome 1	Enrichment	ATM	1.14
353	Melanoma	Enrichment	PTEN	1.14
354	Familial colorectal cancer	Enrichment	TP53	1.14
355	Immune deficiency disease	Enrichment	ATM	1.10
356	Meningioma, familial	Enrichment	PTEN	1.10
357	Myelodysplastic syndrome	Enrichment	TP53	1.10
358	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.10
359	Glycogen storage disease	Enrichment	G6PC1	1.10
360	Familial colorectal cancer type x	Enrichment	ATM	1.10
361	Specific learning disability	Enrichment	MAPK1	1.10
362	Aortic valve disease 1	Enrichment	SOS1	1.03
363	Hypercholesterolemia, familial, 1	Enrichment	LDLR	1.03
364	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.03
365	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.03
366	Protein-deficiency anemia	Enrichment	NRAS	1.03
367	Nk-cell enteropathy	Enrichment	PIK3CB	1.03
368	Osteoporosis	Enrichment	WNT1	1.00
369	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.00
370	Heart disease	Enrichment	ABL1	1.00
371	Renal cell carcinoma, nonpapillary	Enrichment	ATM	0.97
372	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.97
373	Familial hypercholesterolemia	Enrichment	LDLR	0.97
374	Alzheimer disease, familial, 1	Enrichment	PLAU	0.92
375	Polycystic liver disease	Enrichment	CTNNB1	0.92
376	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.92
377	Heart, malformation of	Enrichment	MAPK1	0.90
378	Arteriovenous malformations of the brain	Enrichment	KRAS	0.88
379	Ehlers-danlos syndrome	Enrichment	SMAD3	0.88
380	Macs syndrome	Enrichment	WNT7B	0.86
381	Maturity-onset diabetes of the young	Enrichment	MLKL	0.86
382	Microphthalmia	Enrichment	WNT7B	0.82
383	Diamond-blackfan anemia 1	Enrichment	TP53	0.80
384	Brittle bone disorder	Enrichment	WNT1	0.80
385	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.75
386	Congenital nervous system abnormality	Enrichment	CTNNB1, PTEN	0.73
387	Nervous system disease	Enrichment	CTNNB1, PTEN	0.73
388	Hirschsprung disease 1	Enrichment	ERBB2	0.71
389	Cystic fibrosis	Enrichment	TGFB1	0.67
390	Connective tissue disease	Enrichment	SMAD3	0.67
391	Diamond-blackfan anemia	Enrichment	TP53	0.63
392	Thrombocytopenia	Enrichment	SMAD4	0.52
393	Hypertelorism	Enrichment	PIK3CA	0.49
394	Autism	Enrichment	TCF7L2	0.38
395	Autism spectrum disorder	Enrichment	PTEN	0.25
396	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA damage response (only ATM dependent)

Pathway Network for DNA damage response (only ATM dependent)

Member Pathways for DNA damage response (only ATM dependent)

Pathways in the DNA damage response (only ATM dependent) SuperPath

Associated Genes for DNA damage response (only ATM dependent)

Associated Disorders for DNA damage response (only ATM dependent)

Disorders associated with DNA damage response (only ATM dependent) SuperPath

STRING Interaction Network for DNA damage response (only ATM dependent)

Sources for DNA damage response (only ATM dependent)