DNA Damage Reversal

Sources:

#	Name	Source	Genes
1	DNA Damage Reversal	Reactome	ALKBH2 ALKBH3 ALKBH5 ASCC1 ASCC2 ASCC3 FTO MGMT (see all 8) (see less)
2	Reversal of alkylation damage by DNA dioxygenases	Reactome	ALKBH2 ALKBH3 ALKBH5 ASCC1 ASCC2 ASCC3 FTO (see all 7) (see less)
3	ALKBH3 mediated reversal of alkylation damage	Reactome	ALKBH3 ASCC1 ASCC2 ASCC3
4	Direct reversal repair	WikiPathways	ALKBH2 ALKBH3 MGMT
5	ALKBH2 mediated reversal of alkylation damage	Reactome	ALKBH2
6	MGMT-mediated DNA damage reversal	Reactome	MGMT

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALKBH2	AlkB Homolog 2, Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	4
2	ALKBH3	AlkB Homolog 3, Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	4
3	ASCC3	Activating Signal Cointegrator 1 Complex Subunit 3	Protein Coding	3
4	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	3
5	ASCC1	Activating Signal Cointegrator 1 Complex Subunit 1	Protein Coding	3
6	ASCC2	Activating Signal Cointegrator 1 Complex Subunit 2	Protein Coding	3
7	ALKBH5	AlkB Homolog 5, RNA Demethylase	Protein Coding	2
8	FTO	FTO Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spinal muscular atrophy with congenital bone fractures 2	Enrichment	ASCC1	3.53
2	Intellectual developmental disorder, autosomal recessive 81	Enrichment	ASCC3	3.53
3	Growth retardation, developmental delay, and facial dysmorphism	Enrichment	FTO	3.29
4	Body mass index quantitative trait locus 14	Enrichment	FTO	3.29
5	Prenatal-onset spinal muscular atrophy with congenital bone fractures	Enrichment	ASCC1	3.23
6	Barrett esophagus	Enrichment	ASCC1	2.93
7	Gliosarcoma	Enrichment	MGMT	2.93
8	Melanoma, cutaneous malignant 1	Enrichment	MGMT	2.90
9	Giant cell glioblastoma	Enrichment	MGMT	2.90
10	Congenital myopathy	Enrichment	ASCC3	2.25
11	Centronuclear myopathy	Enrichment	ASCC1	2.21
12	Fetal akinesia deformation sequence 1	Enrichment	ASCC1	1.96
13	Distal arthrogryposis	Enrichment	ASCC1	1.91
14	Body mass index quantitative trait locus 11	Enrichment	FTO	1.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for DNA Damage Reversal