DNA Double Strand Break Response

Pathway network for the DNA Double Strand Break Response SuperPath

Sources:

Reactome

Pathways in the DNA Double Strand Break Response SuperPath

#	Name	Source	Genes
1	DNA Double Strand Break Response	Reactome	ABL1 ABRAXAS1 APBB1 ATM BABAM1 BABAM2 BAP1 BARD1 BAZ1B BRCA1 BRCC3 CHEK2 EYA1 EYA2 EYA3 EYA4 H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HERC2 KAT5 KDM4A KDM4B KPNA2 MAPK8 MDC1 MRE11 NBN NSD2 PIAS4 PPP5C RAD50 RNF168 RNF8 RPS27A SMARCA5 SUMO1 TP53 TP53BP1 UBA52 UBB UBC UBE2I UBE2N UBE2V2 UBXN1 UIMC1 (see all 78) (see less)
2	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Reactome	ABL1 ABRAXAS1 APBB1 ATM BABAM1 BABAM2 BAP1 BARD1 BAZ1B BRCA1 BRCC3 CHEK2 EYA1 EYA2 EYA3 EYA4 H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HERC2 KAT5 KDM4A KDM4B MAPK8 MDC1 MRE11 NBN NSD2 PIAS4 PPP5C RAD50 RNF168 RNF8 RPS27A SMARCA5 SUMO1 TP53 TP53BP1 UBA52 UBB UBC UBE2I UBE2N UBE2V2 UBXN1 UIMC1 (see all 77) (see less)
3	Nonhomologous End-Joining (NHEJ)	Reactome	ABRAXAS1 ATM BABAM1 BABAM2 BARD1 BRCA1 BRCC3 DCLRE1C H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HERC2 KAT5 LIG4 MDC1 MRE11 NBN NHEJ1 NSD2 PAXIP1 PIAS4 POLL POLM PRKDC RAD50 RIF1 RNF168 RNF8 TDP1 TDP2 TP53BP1 UBE2N UBE2V2 UIMC1 XRCC4 XRCC5 XRCC6 (see all 68) (see less)
4	Sensing of DNA Double Strand Breaks	Reactome	ATM KAT5 KPNA2 MRE11 NBN RAD50 (see all 6) (see less)

Gene overlap in member pathways for DNA Double Strand Break Response SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	4
2	KAT5	Lysine Acetyltransferase 5	Protein Coding	4
3	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	4
4	NBN	Nibrin	Protein Coding	4
5	ATM	ATM Serine/Threonine Kinase	Protein Coding	4
6	H4C16	H4 Histone 16	Protein Coding	3
7	H2BC26	H2B Clustered Histone 26	Protein Coding	3
8	RNF168	Ring Finger Protein 168	Protein Coding	3
9	H2BC1	H2B Clustered Histone 1	Protein Coding	3
10	BABAM1	BRISC And BRCA1 A Complex Member 1	Protein Coding	3
11	H2AX	H2A.X Variant Histone	Protein Coding	3
12	H2BC5	H2B Clustered Histone 5	Protein Coding	3
13	H2BC3	H2B Clustered Histone 3	Protein Coding	3
14	PIAS4	Protein Inhibitor Of Activated STAT 4	Protein Coding	3
15	UIMC1	Ubiquitin Interaction Motif Containing 1	Protein Coding	3
16	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	3
17	H4C15	H4 Clustered Histone 15	Protein Coding	3
18	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	3
19	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	3
20	TP53BP1	Tumor Protein P53 Binding Protein 1	Protein Coding	3
21	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	3
22	UBE2V2	Ubiquitin Conjugating Enzyme E2 V2	Protein Coding	3
23	NSD2	Nuclear Receptor Binding SET Domain Protein 2	Protein Coding	3
24	BRCC3	BRCA1/BRCA2-Containing Complex Subunit 3	Protein Coding	3
25	H3-4	H3.4 Histone, Cluster Member	Protein Coding	3
26	H4C9	H4 Clustered Histone 9	Protein Coding	3
27	H2BC8	H2B Clustered Histone 8	Protein Coding	3
28	H2BC13	H2B Clustered Histone 13	Protein Coding	3
29	H2BC15	H2B Clustered Histone 15	Protein Coding	3
30	H2BC14	H2B Clustered Histone 14	Protein Coding	3
31	H2BC7	H2B Clustered Histone 7	Protein Coding	3
32	H2BC6	H2B Clustered Histone 6	Protein Coding	3
33	H2BC9	H2B Clustered Histone 9	Protein Coding	3
34	H2BC10	H2B Clustered Histone 10	Protein Coding	3
35	H2BC4	H2B Clustered Histone 4	Protein Coding	3
36	H2BC17	H2B Clustered Histone 17	Protein Coding	3
37	H2BC21	H2B Clustered Histone 21	Protein Coding	3
38	H4C1	H4 Clustered Histone 1	Protein Coding	3
39	H4C4	H4 Clustered Histone 4	Protein Coding	3
40	H4C6	H4 Clustered Histone 6	Protein Coding	3
41	H4C12	H4 Clustered Histone 12	Protein Coding	3
42	H4C11	H4 Clustered Histone 11	Protein Coding	3
43	H4C3	H4 Clustered Histone 3	Protein Coding	3
44	H4C8	H4 Clustered Histone 8	Protein Coding	3
45	H4C2	H4 Clustered Histone 2	Protein Coding	3
46	H4C5	H4 Clustered Histone 5	Protein Coding	3
47	H4C13	H4 Clustered Histone 13	Protein Coding	3
48	H4C14	H4 Clustered Histone 14	Protein Coding	3
49	ABRAXAS1	Abraxas 1, BRCA1 A Complex Subunit	Protein Coding	3
50	H2BC12	H2B Clustered Histone 12	Protein Coding	3
51	HERC2	HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	3
52	H2BC11	H2B Clustered Histone 11	Protein Coding	3
53	RNF8	Ring Finger Protein 8	Protein Coding	3
54	BABAM2	BRISC And BRCA1 A Complex Member 2	Protein Coding	3
55	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	3
56	CHEK2	Checkpoint Kinase 2	Protein Coding	2
57	EYA4	EYA Transcriptional Coactivator And Phosphatase 4	Protein Coding	2
58	EYA1	EYA Transcriptional Coactivator And Phosphatase 1	Protein Coding	2
59	EYA2	EYA Transcriptional Coactivator And Phosphatase 2	Protein Coding	2
60	EYA3	EYA Transcriptional Coactivator And Phosphatase 3	Protein Coding	2
61	KDM4B	Lysine Demethylase 4B	Protein Coding	2
62	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	2
63	APBB1	Amyloid Beta Precursor Protein Binding Family B Member 1	Protein Coding	2
64	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	2
65	UBXN1	UBX Domain Protein 1	Protein Coding	2
66	PPP5C	Protein Phosphatase 5 Catalytic Subunit	Protein Coding	2
67	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
68	RPS27A	Ribosomal Protein S27a	Protein Coding	2
69	TP53	Tumor Protein P53	Protein Coding	2
70	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
71	UBB	Ubiquitin B	Protein Coding	2
72	UBC	Ubiquitin C	Protein Coding	2
73	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	2
74	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	2
75	BAP1	BRCA1 Associated Deubiquitinase 1	Protein Coding	2
76	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	2
77	BAZ1B	Bromodomain Adjacent To Zinc Finger Domain 1B	Protein Coding	2
78	KDM4A	Lysine Demethylase 4A	Protein Coding	2
79	PAXIP1	PAX Interacting Protein 1	Protein Coding	1
80	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
81	POLL	DNA Polymerase Lambda	Protein Coding	1
82	POLM	DNA Polymerase Mu	Protein Coding	1
83	LIG4	DNA Ligase 4	Protein Coding	1
84	TDP2	Tyrosyl-DNA Phosphodiesterase 2	Protein Coding	1
85	RIF1	Replication Timing Regulatory Factor 1	Protein Coding	1
86	TDP1	Tyrosyl-DNA Phosphodiesterase 1	Protein Coding	1
87	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
88	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	1
89	XRCC4	X-Ray Repair Cross Complementing 4	Protein Coding	1
90	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
91	NHEJ1	Non-Homologous End Joining Factor 1	Protein Coding	1

Disorders associated with DNA Double Strand Break Response SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ABRAXAS1, ATM, BARD1, BRCA1, CHEK2, MRE11, NBN, RAD50, TP53	9.47
2	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BRCA1, CHEK2, MRE11, NBN, RAD50, TP53	9.14
3	Inherited cancer-predisposing syndrome	Enrichment	ABRAXAS1, ATM, BAP1, BARD1, BRCA1, CHEK2, MRE11, NBN, RAD50, TP53	8.47
4	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BRCA1, CHEK2, NBN, RAD50, TP53	8.33
5	Ovarian cancer	Enrichment	ATM, MRE11, NBN, RAD50	7.37
6	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.92
7	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, CHEK2, NBN, TP53	6.85
8	Pancreatic cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	6.60
9	Prostate cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	6.26
10	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, CHEK2, NBN	6.18
11	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	6.01
12	Endometrial cancer	Enrichment	ATM, BARD1, BRCA1, CHEK2	5.27
13	Colonic benign neoplasm	Enrichment	ATM, MRE11	5.23
14	Lig4 syndrome	Enrichment	LIG4, XRCC4	4.61
15	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.61
16	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.61
17	Uterine corpus cancer	Enrichment	ATM, BRCA1, CHEK2	4.55
18	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.50
19	Sarcoma	Enrichment	CHEK2, TP53	4.50
20	Hepatocellular carcinoma	Enrichment	NBN, RAD50	4.43
21	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.13
22	Osteogenic sarcoma	Enrichment	CHEK2, TP53	4.02
23	Adenocarcinoma	Enrichment	ATM, TP53	4.02
24	Bone osteosarcoma	Enrichment	CHEK2, TP53	4.02
25	Diffuse large b-cell lymphoma	Enrichment	CHEK2, NBN, TP53	3.80
26	Myeloma, multiple	Enrichment	ATM, BAP1, BARD1, TP53	3.55
27	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	3.35
28	Endometrial serous adenocarcinoma	Enrichment	ATM	3.35
29	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.35
30	Li-fraumeni syndrome	Enrichment	CHEK2, TP53	3.33
31	Clear cell renal cell carcinoma	Enrichment	ATM, BAP1	3.33
32	Bladder cancer	Enrichment	ATM, BRCA1, TP53	3.24
33	Severe combined immunodeficiency	Enrichment	DCLRE1C, LIG4, NHEJ1	3.23
34	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, TP53	3.18
35	Complex neurodevelopmental disorder	Enrichment	BAP1, H4C3, H4C5, H4C9, KDM4B	3.16
36	Glioma susceptibility 1	Enrichment	BAP1, TP53	3.06
37	Ewing sarcoma	Enrichment	BAP1, SMARCA5	3.06
38	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	3.05
39	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	3.05
40	High grade glioma	Enrichment	ATM	3.05
41	T-cell prolymphocytic leukemia	Enrichment	ATM	3.05
42	Omenn syndrome	Enrichment	DCLRE1C, LIG4	2.96
43	Ataxia-telangiectasia	Enrichment	ATM	2.88
44	Nijmegen breakage syndrome	Enrichment	NBN	2.88
45	Polycythemia vera	Enrichment	ATM	2.88
46	Koolen-de vries syndrome	Enrichment	ATM	2.88
47	Lynch syndrome 1	Enrichment	ATM, CHEK2	2.86
48	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	2.86
49	Colorectal cancer	Enrichment	ATM, BRCA1, CHEK2, TP53	2.83
50	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	2.77
51	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.75
52	Mantle cell lymphoma	Enrichment	ATM	2.75
53	Oculomotor apraxia	Enrichment	ATM	2.75
54	Lip and oral cavity carcinoma	Enrichment	ABL1, TP53	2.69
55	Glioblastoma	Enrichment	ATM	2.66
56	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.51
57	Renal cell carcinoma, nonpapillary	Enrichment	ATM, BAP1	2.50
58	Rhabdomyosarcoma	Enrichment	BRCA1, TP53	2.44
59	Gliosarcoma	Enrichment	ATM, TP53	2.44
60	Giant cell glioblastoma	Enrichment	ATM, TP53	2.39
61	Aplastic anemia	Enrichment	NBN	2.35
62	Immune deficiency disease	Enrichment	ATM	2.31
63	Leukemia, acute lymphoblastic	Enrichment	NBN	2.31
64	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.30
65	Immunodeficiency 124, severe combined	Enrichment	NHEJ1	2.30
66	Spinocerebellar ataxia, autosomal recessive 23	Enrichment	TDP2	2.30
67	Infant-type hemispheric glioma	Enrichment	BRCA1	2.30
68	Riddle syndrome	Enrichment	RNF168	2.30
69	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1	Enrichment	TDP1	2.30
70	Intellectual developmental disorder, autosomal recessive 38	Enrichment	HERC2	2.30
71	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.30
72	Rauch-steindl syndrome	Enrichment	NSD2	2.30
73	Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome	Enrichment	BRCC3	2.30
74	Microphthalmia/coloboma 13	Enrichment	NHEJ1	2.30
75	Primary peritoneal carcinoma	Enrichment	BRCA1	2.30
76	Melanoma, uveal 2	Enrichment	BAP1	2.25
77	Otofaciocervical syndrome 1	Enrichment	EYA1	2.25
78	Bone marrow failure syndrome 5	Enrichment	TP53	2.25
79	Orofacial cleft 10	Enrichment	SUMO1	2.25
80	Papilloma of choroid plexus	Enrichment	TP53	2.25
81	Basal cell carcinoma 7	Enrichment	TP53	2.25
82	Anaplastic thyroid carcinoma	Enrichment	TP53	2.25
83	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.25
84	Ductal carcinoma in situ	Enrichment	TP53	2.25
85	Leiomyosarcoma	Enrichment	CHEK2	2.25
86	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.25
87	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.25
88	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.25
89	Choroid plexus cancer	Enrichment	TP53	2.25
90	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.25
91	Premature menopause	Enrichment	NBN	2.24
92	Hepatoblastoma	Enrichment	BARD1, TP53	2.21
93	Lissencephaly	Enrichment	NBN	2.03
94	Chromosome 2q35 duplication syndrome	Enrichment	NHEJ1	2.00
95	Skin/hair/eye pigmentation, variation in, 1	Enrichment	HERC2	2.00
96	Moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism	Enrichment	BRCC3	2.00
97	Macroglossia	Enrichment	NSD2	2.00
98	Dubowitz syndrome	Enrichment	LIG4	2.00
99	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	2.00
100	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.00
101	Pancreatic cancer 4	Enrichment	BRCA1	2.00
102	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TP53BP1	2.00
103	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC4	2.00
104	Inflammatory breast carcinoma	Enrichment	BRCA1	2.00
105	Fissured tongue	Enrichment	NSD2	2.00
106	Peritoneum cancer	Enrichment	BRCA1	2.00
107	Bilateral breast cancer	Enrichment	BRCA1	2.00
108	Microcephaly and chorioretinopathy 3	Enrichment	TP53BP1	2.00
109	Microcephalic primordial dwarfism-insulin resistance syndrome	Enrichment	XRCC4	2.00
110	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.95
111	Cervical cancer	Enrichment	TP53	1.95
112	Lymphoma, hodgkin, classic	Enrichment	TP53	1.95
113	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	1.95
114	Intellectual developmental disorder, autosomal dominant 65	Enrichment	KDM4B	1.95
115	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.95
116	Branchiootic syndrome	Enrichment	EYA1	1.95
117	Congenital fibrosarcoma	Enrichment	TP53	1.95
118	Branchiootic syndrome 1	Enrichment	EYA1	1.95
119	Ocular melanoma	Enrichment	BAP1	1.95
120	Cervix carcinoma	Enrichment	TP53	1.95
121	Hodgkin's lymphoma	Enrichment	TP53	1.95
122	Kury-isidor syndrome	Enrichment	BAP1	1.95
123	Otofaciocervical syndrome	Enrichment	EYA1	1.95
124	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.95
125	Submucosal cleft palate	Enrichment	UBB	1.95
126	Cleft hard palate	Enrichment	UBB	1.95
127	Lung cancer	Enrichment	BRCA1, CHEK2	1.85
128	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	1.82
129	Arthrogryposis multiplex congenita 6	Enrichment	RIF1	1.82
130	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	1.82
131	Isolated anophthalmia-microphthalmia syndrome	Enrichment	NHEJ1	1.82
132	Mesothelioma, malignant	Enrichment	BAP1	1.77
133	Uvula, bifid	Enrichment	UBB	1.77
134	Niemann-pick disease, type a	Enrichment	APBB1	1.77
135	Deafness, autosomal dominant 10	Enrichment	EYA4	1.77
136	Cardiomyopathy, dilated, 1j	Enrichment	EYA4	1.77
137	Cleft soft palate	Enrichment	UBB	1.77
138	Niemann-pick disease, type b	Enrichment	APBB1	1.77
139	Nasopharyngeal carcinoma	Enrichment	TP53	1.77
140	Tumor predisposition syndrome 1	Enrichment	BAP1	1.77
141	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.77
142	Anaplastic astrocytoma	Enrichment	TP53	1.77
143	Squamous cell carcinoma	Enrichment	TP53	1.77
144	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.77
145	Bap1 tumor predisposition syndrome	Enrichment	BAP1	1.77
146	Nemaline myopathy 2	Enrichment	RIF1	1.70
147	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.70
148	Cholangiocarcinoma	Enrichment	BRCA1	1.70
149	Aicardi-goutieres syndrome 1	Enrichment	DCLRE1C	1.70
150	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	TP53BP1	1.70
151	Branchiooculofacial syndrome	Enrichment	EYA1	1.65
152	Small cell cancer of the lung	Enrichment	TP53	1.65
153	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.65
154	Lung sarcomatoid carcinoma	Enrichment	TP53	1.65
155	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.65
156	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.65
157	Hemoglobin c disease	Enrichment	CHEK2	1.65
158	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.61
159	Hypoglycemia	Enrichment	NSD2	1.61
160	Primary ovarian insufficiency	Enrichment	NBN	1.59
161	Niemann-pick disease, type c1	Enrichment	APBB1	1.55
162	Rhabdomyosarcoma 2	Enrichment	TP53	1.55
163	Lymphoma	Enrichment	TP53	1.55
164	Niemann-pick disease	Enrichment	APBB1	1.55
165	Acute megakaryocytic leukemia	Enrichment	TP53	1.55
166	Wolf-hirschhorn syndrome	Enrichment	NSD2	1.53
167	Microcephaly	Enrichment	ABL1, NBN, SMARCA5	1.48
168	Melanoma, uveal	Enrichment	BAP1	1.47
169	Branchiootorenal syndrome 1	Enrichment	EYA1	1.47
170	Wilms tumor 5	Enrichment	CHEK2	1.47
171	Adrenocortical carcinoma	Enrichment	TP53	1.47
172	Breast adenocarcinoma	Enrichment	TP53	1.47
173	Prader-willi syndrome	Enrichment	HERC2	1.46
174	Esophageal cancer	Enrichment	TP53	1.41
175	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.41
176	Leukemia, chronic myeloid	Enrichment	ABL1	1.41
177	Branchiootorenal syndrome	Enrichment	EYA1	1.41
178	Essential thrombocythemia	Enrichment	TP53	1.41
179	Gallbladder cancer	Enrichment	TP53	1.41
180	Moyamoya angiopathy	Enrichment	ABL1	1.41
181	Isolated growth hormone deficiency, type ia	Enrichment	XRCC4	1.40
182	Ventricular septal defect	Enrichment	NSD2	1.35
183	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.35
184	Nemaline myopathy	Enrichment	RIF1	1.31
185	Adult hepatocellular carcinoma	Enrichment	TP53	1.30
186	Primary hyperaldosteronism	Enrichment	TP53	1.30
187	Renal agenesis, bilateral	Enrichment	EYA1	1.30
188	Melanoma	Enrichment	CHEK2	1.26
189	Familial colorectal cancer	Enrichment	TP53	1.26
190	Myelodysplastic syndrome	Enrichment	TP53	1.22
191	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	NSD2	1.20
192	Clubfoot	Enrichment	NSD2	1.20
193	Protein-deficiency anemia	Enrichment	NSD2	1.20
194	Meningioma	Enrichment	BAP1	1.18
195	Periventricular nodular heterotopia	Enrichment	BRCA1	1.17
196	Nk-cell enteropathy	Enrichment	CHEK2	1.15
197	Rare genetic deafness	Enrichment	EYA1, EYA4	1.13
198	Lung cancer susceptibility 3	Enrichment	TP53	1.12
199	Heart disease	Enrichment	ABL1	1.12
200	Wilms tumor 1	Enrichment	CHEK2	1.09
201	Lynch syndrome	Enrichment	CHEK2	1.09
202	Syndromic intellectual disability	Enrichment	NSD2	1.09
203	Melanoma, cutaneous malignant 1	Enrichment	BAP1	1.03
204	Williams-beuren syndrome	Enrichment	BAZ1B	0.97
205	Focal segmental glomerulosclerosis	Enrichment	EYA1	0.97
206	Muscular dystrophy	Enrichment	RIF1	0.94
207	Tooth agenesis	Enrichment	SUMO1	0.93
208	Diamond-blackfan anemia 1	Enrichment	TP53	0.91
209	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	0.91
210	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.79
211	Diamond-blackfan anemia	Enrichment	TP53	0.73
212	Non-syndromic genetic deafness	Enrichment	EYA4	0.73
213	Hypertrophic cardiomyopathy	Enrichment	NSD2	0.71
214	Leukemia, acute myeloid	Enrichment	TP53	0.69
215	Nonsyndromic hearing loss	Enrichment	EYA4	0.67
216	Thrombocytopenia	Enrichment	NSD2	0.67
217	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	EYA4	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA Double Strand Break Response

Pathway Network for DNA Double Strand Break Response

Pathway network for the DNA Double Strand Break Response SuperPath

Member Pathways for DNA Double Strand Break Response

Pathways in the DNA Double Strand Break Response SuperPath

Gene overlap in member pathways for DNA Double Strand Break Response SuperPath

Associated Genes for DNA Double Strand Break Response

Associated Disorders for DNA Double Strand Break Response

Disorders associated with DNA Double Strand Break Response SuperPath

STRING Interaction Network for DNA Double Strand Break Response

Sources for DNA Double Strand Break Response