DNA IR-damage and cellular response via ATR

No Pathway Network information available for DNA IR-damage and cellular response via ATR

Pathways in the DNA IR-damage and cellular response via ATR SuperPath

#	Name	Source	Genes
1	DNA IR-damage and cellular response via ATR	WikiPathways	ABRAXAS1 ATM ATR ATRIP BARD1 BCL6 BRCA1 BRCA2 BRCC3 BRIP1 CDC25C CDC45 CDK1 CDK2 CEP164 CHEK1 CHEK2 CLK2 CLSPN DCLRE1A E2F1 EEF1E1 EXO1 FANCA FANCD2 FANCI FEN1 FOXM1 H2AX HERC2 HUS1 IKBKG MCM2 MCPH1 MDC1 MDM2 MLH1 MRE11 MSH2 NBN PALB2 PARP1 PCNA PLK1 PML POLB POLN PPM1D PRKDC RAD1 RAD17 RAD50 RAD51 RAD52 RAD9A RBBP8 RECQL RECQL4 RECQL5 RFWD3 RMI1 RPA1 RPA2 SEM1 SMARCAL1 SMARCC2 SMC1A SP1 TDP1 TOP3A TOPBP1 TP53 TP53BP1 TRIM28 UBE2D3 UIMC1 UPF1 USP1 WRN XPA XRCC5 (see all 81) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMARCAL1	SNF2 Related Chromatin Remodeling Annealing Helicase 1	Protein Coding	1
2	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
3	RFWD3	Ring Finger And WD Repeat Domain 3	Protein Coding	1
4	RECQL5	RecQ Like Helicase 5	Protein Coding	1
5	RECQL4	RecQ Like Helicase 4	Protein Coding	1
6	RECQL	RecQ Like Helicase	Protein Coding	1
7	TDP1	Tyrosyl-DNA Phosphodiesterase 1	Protein Coding	1
8	CLK2	CDC Like Kinase 2	Protein Coding	1
9	DCLRE1A	DNA Cross-Link Repair 1A	Protein Coding	1
10	UPF1	UPF1 RNA Helicase And ATPase	Protein Coding	1
11	PPM1D	Protein Phosphatase, Mg2+/Mn2+ Dependent 1D	Protein Coding	1
12	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	1
13	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
14	BCL6	BCL6 Transcription Repressor	Protein Coding	1
15	MCPH1	Microcephalin 1	Protein Coding	1
16	FOXM1	Forkhead Box M1	Protein Coding	1
17	MCM2	Minichromosome Maintenance Complex Component 2	Protein Coding	1
18	CDC45	Cell Division Cycle 45	Protein Coding	1
19	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
20	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
21	CDC25C	Cell Division Cycle 25C	Protein Coding	1
22	PML	PML Nuclear Body Scaffold	Protein Coding	1
23	FANCI	FA Complementation Group I	Protein Coding	1
24	FANCA	FA Complementation Group A	Protein Coding	1
25	FANCD2	FA Complementation Group D2	Protein Coding	1
26	POLN	DNA Polymerase Nu	Protein Coding	1
27	XPA	XPA, DNA Damage Recognition And Repair Factor	Protein Coding	1
28	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
29	RAD52	RAD52 DNA Repair Protein	Protein Coding	1
30	RMI1	RecQ Mediated Genome Instability 1	Protein Coding	1
31	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	1
32	PALB2	Partner And Localizer Of BRCA2	Protein Coding	1
33	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	1
34	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	1
35	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	1
36	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	1
37	WRN	WRN RecQ Like Helicase	Protein Coding	1
38	EXO1	Exonuclease 1	Protein Coding	1
39	ATRIP	ATR Interacting Protein	Protein Coding	1
40	HERC2	HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
41	ABRAXAS1	Abraxas 1, BRCA1 A Complex Subunit	Protein Coding	1
42	UIMC1	Ubiquitin Interaction Motif Containing 1	Protein Coding	1
43	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	1
44	BRCC3	BRCA1/BRCA2-Containing Complex Subunit 3	Protein Coding	1
45	TP53BP1	Tumor Protein P53 Binding Protein 1	Protein Coding	1
46	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	1
47	CHEK2	Checkpoint Kinase 2	Protein Coding	1
48	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	1
49	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	1
50	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
51	CLSPN	Claspin	Protein Coding	1
52	E2F1	E2F Transcription Factor 1	Protein Coding	1
53	BRIP1	BRCA1 Interacting DNA Helicase 1	Protein Coding	1
54	EEF1E1	Eukaryotic Translation Elongation Factor 1 Epsilon 1	Protein Coding	1
55	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
56	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
57	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
58	MLH1	MutL Homolog 1	Protein Coding	1
59	TOP3A	DNA Topoisomerase III Alpha	Protein Coding	1
60	RPA2	Replication Protein A2	Protein Coding	1
61	RPA1	Replication Protein A1	Protein Coding	1
62	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
63	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
64	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
65	RAD51	RAD51 Recombinase	Protein Coding	1
66	NBN	Nibrin	Protein Coding	1
67	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
68	SP1	Sp1 Transcription Factor	Protein Coding	1
69	CEP164	Centrosomal Protein 164	Protein Coding	1
70	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
71	PLK1	Polo Like Kinase 1	Protein Coding	1
72	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
73	H2AX	H2A.X Variant Histone	Protein Coding	1
74	ATR	ATR Checkpoint Kinase	Protein Coding	1
75	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
76	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
77	CHEK1	Checkpoint Kinase 1	Protein Coding	1
78	TP53	Tumor Protein P53	Protein Coding	1
79	MSH2	MutS Homolog 2	Protein Coding	1
80	POLB	DNA Polymerase Beta	Protein Coding	1
81	ATM	ATM Serine/Threonine Kinase	Protein Coding	1

Disorders associated with DNA IR-damage and cellular response via ATR SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ovarian cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, FANCA, FANCD2, MRE11, MSH2, NBN, PALB2, PPM1D, RAD50, RECQL4, TP53, WRN, XPA	16.00
2	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CHEK2, NBN, PALB2, RBBP8, TP53	16.00
3	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MLH1, MSH2, NBN, PALB2, PPM1D, RAD50, RAD51, TP53	11.90
4	Breast cancer	Enrichment	ABRAXAS1, ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MLH1, MRE11, MSH2, NBN, PALB2, PPM1D, RAD50, RAD51, TP53	11.38
5	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CHEK2, MSH2, NBN, PALB2	11.18
6	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, BRIP1, FANCA, FANCD2, FANCI, PALB2, RAD51, RFWD3	11.12
7	Inherited cancer-predisposing syndrome	Enrichment	ABRAXAS1, ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, FANCA, MLH1, MRE11, MSH2, NBN, PALB2, RAD50, RECQL, RECQL4, TP53	10.92
8	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MLH1, MRE11, MSH2, NBN, PALB2, RAD50, RAD51, RECQL, TP53	10.89
9	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, FANCI, MLH1, MSH2, NBN, PALB2, TP53	10.71
10	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CHEK2, MSH2, PALB2	10.71
11	Colorectal cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, CHEK2, FANCI, MLH1, MSH2, PALB2, RMI1, TP53	10.67
12	Endometrial cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, CHEK2, MLH1, MSH2	10.60
13	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, CHEK2, NBN, PALB2, TP53	9.52
14	Colonic benign neoplasm	Enrichment	ATM, CHEK2, MLH1, MRE11, PALB2	9.07
15	Lynch syndrome 1	Enrichment	ATM, CHEK2, MLH1, MSH2, PALB2	8.78
16	Hepatoblastoma	Enrichment	BARD1, BRCA2, FANCA, MSH2, RECQL4, TP53	8.72
17	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2, MSH2, TP53	5.69
18	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	5.39
19	Diffuse large b-cell lymphoma	Enrichment	BRCA2, CHEK2, NBN, TP53	5.37
20	Myeloma, multiple	Enrichment	ATM, BARD1, BRCA2, RECQL4, TP53	4.70
21	Familial colorectal cancer	Enrichment	MLH1, MSH2, TP53	4.62
22	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2, TP53	4.60
23	Familial colorectal cancer type x	Enrichment	ATM, BRCA2, CHEK2	4.49
24	Muir-torre syndrome	Enrichment	MLH1, MSH2	4.45
25	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2, BRIP1	4.45
26	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.45
27	Sarcoma	Enrichment	CHEK2, TP53	4.45
28	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	4.45
29	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	4.45
30	Neuroendocrine tumor of pancreas	Enrichment	BRCA2, PALB2	4.45
31	Lung cancer	Enrichment	BRCA1, CHEK2, MLH1, PALB2	4.43
32	Seckel syndrome	Enrichment	ATR, ATRIP, RBBP8	4.15
33	Wilms tumor 1	Enrichment	BRCA2, CHEK2, TRIM28	4.05
34	Lynch syndrome	Enrichment	CHEK2, MLH1, MSH2	4.05
35	Osteogenic sarcoma	Enrichment	CHEK2, TP53	3.98
36	Adenocarcinoma	Enrichment	ATM, TP53	3.98
37	Bone osteosarcoma	Enrichment	CHEK2, TP53	3.98
38	Gliosarcoma	Enrichment	ATM, MSH2, TP53	3.96
39	Giant cell glioblastoma	Enrichment	ATM, MSH2, TP53	3.88
40	Chordoma	Enrichment	BRCA2, PALB2	3.68
41	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2	3.68
42	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	3.68
43	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	3.68
44	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	3.68
45	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	3.54
46	Fanconi anemia, complementation group d2	Enrichment	BRIP1, FANCD2	3.46
47	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	3.46
48	Glioblastoma	Enrichment	ATM, MSH2	3.46
49	Wilms tumor 5	Enrichment	CHEK2, TRIM28	3.28
50	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2, BRIP1	2.91
51	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	2.81
52	Isolated tracheo-esophageal fistula	Enrichment	BRCA2, BRIP1	2.81
53	Medulloblastoma	Enrichment	BRCA2, WRN	2.51
54	Isolated congenital microcephaly	Enrichment	MCPH1, SMARCAL1	2.40
55	Primary ovarian insufficiency	Enrichment	CHEK2, FANCA, NBN	2.28
56	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2, BRIP1	2.25
57	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.22
58	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.22
59	Rapadilino syndrome	Enrichment	RECQL4	2.22
60	Incontinentia pigmenti	Enrichment	IKBKG	2.22
61	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.22
62	Seckel syndrome 2	Enrichment	RBBP8	2.22
63	Fanconi anemia, complementation group j	Enrichment	BRIP1	2.22
64	Glioma susceptibility 3	Enrichment	BRCA2	2.22
65	Seckel syndrome 1	Enrichment	ATR	2.22
66	Mirror movements 2	Enrichment	RAD51	2.22
67	Schimke immunoosseous dysplasia	Enrichment	SMARCAL1	2.22
68	Accelerated tumor formation	Enrichment	MDM2	2.22
69	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.22
70	Fanconi anemia, complementation group r	Enrichment	RAD51	2.22
71	Recon progeroid syndrome	Enrichment	RECQL	2.22
72	Lessel-kubisch syndrome	Enrichment	MDM2	2.22
73	Bone marrow failure syndrome 5	Enrichment	TP53	2.22
74	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.22
75	Papilloma of choroid plexus	Enrichment	TP53	2.22
76	Basal cell carcinoma 7	Enrichment	TP53	2.22
77	Lynch syndrome 2	Enrichment	MLH1	2.22
78	Anaplastic thyroid carcinoma	Enrichment	TP53	2.22
79	Infant-type hemispheric glioma	Enrichment	BRCA1	2.22
80	Pancreatic cancer 2	Enrichment	BRCA2	2.22
81	Jawad syndrome	Enrichment	RBBP8	2.22
82	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.22
83	Deafness, autosomal dominant 70	Enrichment	MCM2	2.22
84	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1	Enrichment	TDP1	2.22
85	Fanconi anemia, complementation group w	Enrichment	RFWD3	2.22
86	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.22
87	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.22
88	Intellectual developmental disorder, autosomal recessive 38	Enrichment	HERC2	2.22
89	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.22
90	Nephronophthisis 15	Enrichment	CEP164	2.22
91	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.22
92	Endometrial serous adenocarcinoma	Enrichment	ATM	2.22
93	Ductal carcinoma in situ	Enrichment	TP53	2.22
94	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.22
95	Meier-gorlin syndrome 7	Enrichment	CDC45	2.22
96	Jansen-de vries syndrome	Enrichment	PPM1D	2.22
97	Leiomyosarcoma	Enrichment	CHEK2	2.22
98	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5	Enrichment	TOP3A	2.22
99	Rectal benign neoplasm	Enrichment	MSH2	2.22
100	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.22
101	Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome	Enrichment	BRCC3	2.22
102	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.22
103	B-lymphoblastic leukemia/lymphoma with etv6-runx1	Enrichment	RECQL4	2.22
104	Ascending colon cancer	Enrichment	MSH2	2.22
105	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.22
106	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.22
107	Basal cell carcinoma	Enrichment	PALB2	2.22
108	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.22
109	Choroid plexus cancer	Enrichment	TP53	2.22
110	Ovarian cyst	Enrichment	MSH2	2.22
111	Undifferentiated pleomorphic sarcoma	Enrichment	RECQL4	2.22
112	Wilms tumor 7	Enrichment	TRIM28	2.22
113	Malignant fibrous histiocytoma	Enrichment	RECQL4	2.22
114	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.22
115	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.22
116	Primary peritoneal carcinoma	Enrichment	BRCA1	2.22
117	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.92
118	Baller-gerold syndrome	Enrichment	RECQL4	1.92
119	Skin/hair/eye pigmentation, variation in, 1	Enrichment	HERC2	1.92
120	Moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism	Enrichment	BRCC3	1.92
121	Cervical cancer	Enrichment	TP53	1.92
122	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.92
123	Immunodeficiency 33	Enrichment	IKBKG	1.92
124	Rothmund-thomson syndrome, type 2	Enrichment	RECQL4	1.92
125	Fanconi anemia, complementation group i	Enrichment	FANCI	1.92
126	Fanconi anemia, complementation group n	Enrichment	PALB2	1.92
127	Pancreatic cancer 3	Enrichment	PALB2	1.92
128	Lymphoma, hodgkin, classic	Enrichment	TP53	1.92
129	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	1.92
130	Xeroderma pigmentosum, complementation group a	Enrichment	XPA	1.92
131	Coffin-siris syndrome 8	Enrichment	SMARCC2	1.92
132	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.92
133	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.92
134	Werner syndrome	Enrichment	WRN	1.92
135	Intravascular large b-cell lymphoma	Enrichment	BCL6	1.92
136	Pancreatic cancer 4	Enrichment	BRCA1	1.92
137	Ovarian cancer 1	Enrichment	BRIP1	1.92
138	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TP53BP1	1.92
139	Congenital fibrosarcoma	Enrichment	TP53	1.92
140	High grade glioma	Enrichment	ATM	1.92
141	Fanconi anemia, complementation group d1	Enrichment	BRCA2	1.92
142	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	1.92
143	Cervix carcinoma	Enrichment	TP53	1.92
144	Hodgkin's lymphoma	Enrichment	TP53	1.92
145	T-cell prolymphocytic leukemia	Enrichment	ATM	1.92
146	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.92
147	Microcephaly, growth restriction, and increased sister chromatid exchange 2	Enrichment	TOP3A	1.92
148	Lymphatic malformation 10	Enrichment	MCPH1	1.92
149	Peritoneum cancer	Enrichment	BRCA1	1.92
150	Microcephaly and chorioretinopathy 3	Enrichment	TP53BP1	1.92
151	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.92
152	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.92
153	Right atrial isomerism	Enrichment	UPF1	1.75
154	Ataxia-telangiectasia	Enrichment	ATM	1.75
155	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP	1.75
156	Nijmegen breakage syndrome	Enrichment	NBN	1.75
157	Polycythemia vera	Enrichment	ATM	1.75
158	Chilblain lupus 1	Enrichment	ATRIP	1.75
159	Nasopharyngeal carcinoma	Enrichment	TP53	1.75
160	Congenital heart defects, multiple types, 6	Enrichment	UPF1	1.75
161	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.75
162	Breast-ovarian cancer, familial 5	Enrichment	PALB2	1.75
163	Koolen-de vries syndrome	Enrichment	ATM	1.75
164	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.75
165	Dedifferentiated liposarcoma	Enrichment	MDM2	1.75
166	Chilblain lupus	Enrichment	ATRIP	1.75
167	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.75
168	Anaplastic astrocytoma	Enrichment	TP53	1.75
169	Squamous cell carcinoma	Enrichment	TP53	1.75
170	Cellular ependymoma	Enrichment	MSH2	1.75
171	Tanycytic ependymoma	Enrichment	MSH2	1.75
172	Papillary ependymoma	Enrichment	MSH2	1.75
173	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.75
174	Well-differentiated liposarcoma	Enrichment	MDM2	1.75
175	Clear cell ependymoma	Enrichment	MSH2	1.75
176	Mirror movements 1	Enrichment	RAD51	1.63
177	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.63
178	Small cell cancer of the lung	Enrichment	TP53	1.63
179	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.63
180	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.63
181	Aicardi-goutieres syndrome 1	Enrichment	ATRIP	1.63
182	Lynch syndrome 4	Enrichment	MSH2	1.63
183	Mantle cell lymphoma	Enrichment	ATM	1.63
184	Lung sarcomatoid carcinoma	Enrichment	TP53	1.63
185	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.63
186	Hemoglobin c disease	Enrichment	CHEK2	1.63
187	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	TP53BP1	1.63
188	Transposition of the great arteries	Enrichment	UPF1	1.63
189	Benign ependymoma	Enrichment	MSH2	1.63
190	Thrombotic microangiopathy	Enrichment	ATRIP	1.63
191	Oculomotor apraxia	Enrichment	ATM	1.63
192	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.63
193	Leukemia, acute myeloid	Enrichment	FANCD2, TP53	1.62
194	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP	1.53
195	Von hippel-lindau syndrome	Enrichment	FANCD2	1.53
196	Microcephaly 1, primary, autosomal recessive	Enrichment	MCPH1	1.53
197	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.53
198	Rhabdomyosarcoma 2	Enrichment	TP53	1.53
199	Atrioventricular septal defect	Enrichment	SMARCAL1	1.53
200	Follicular lymphoma	Enrichment	BCL6	1.53
201	Lymphoma	Enrichment	TP53	1.53
202	Vascular dementia	Enrichment	ATRIP	1.53
203	Acute megakaryocytic leukemia	Enrichment	TP53	1.53
204	Kabuki syndrome 1	Enrichment	BRCA2	1.45
205	Wiedemann-steiner syndrome	Enrichment	SMC1A	1.45
206	Adrenocortical carcinoma	Enrichment	TP53	1.45
207	Clear cell renal cell carcinoma	Enrichment	ATM	1.45
208	Breast adenocarcinoma	Enrichment	TP53	1.45
209	Microcephaly	Enrichment	NBN, SMARCAL1, SMC1A	1.43
210	Esophageal cancer	Enrichment	TP53	1.39
211	Prader-willi syndrome	Enrichment	HERC2	1.39
212	Mitochondrial dna depletion syndrome 4a	Enrichment	FANCI	1.39
213	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.39
214	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.39
215	Essential thrombocythemia	Enrichment	TP53	1.39
216	Gallbladder cancer	Enrichment	TP53	1.39
217	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.39
218	Glioma susceptibility 1	Enrichment	TP53	1.33
219	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2	1.33
220	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.33
221	Rett syndrome, congenital variant	Enrichment	SMC1A	1.33
222	Isolated split hand-split foot malformation	Enrichment	SEM1	1.33
223	Cornelia de lange syndrome 1	Enrichment	SMC1A	1.28
224	Polydactyly	Enrichment	BRCA2	1.28
225	Coronary heart disease 5	Enrichment	IKBKG	1.28
226	Leukemia, acute lymphoblastic 3	Enrichment	PALB2	1.28
227	Adult hepatocellular carcinoma	Enrichment	TP53	1.28
228	Primary hyperaldosteronism	Enrichment	TP53	1.28
229	Cornelia de lange syndrome	Enrichment	SMC1A	1.28
230	Meier-gorlin syndrome 1	Enrichment	CDC45	1.24
231	Aplastic anemia	Enrichment	NBN	1.24
232	Aicardi-goutieres syndrome	Enrichment	ATRIP	1.24
233	Melanoma	Enrichment	CHEK2	1.24
234	Immune deficiency disease	Enrichment	ATM	1.20
235	Xeroderma pigmentosum, variant type	Enrichment	XPA	1.20
236	Leukemia, acute lymphoblastic	Enrichment	NBN	1.20
237	Myelodysplastic syndrome	Enrichment	TP53	1.20
238	Lip and oral cavity carcinoma	Enrichment	TP53	1.16
239	Senior-loken syndrome 1	Enrichment	CEP164	1.13
240	Acute promyelocytic leukemia	Enrichment	PML	1.13
241	Premature menopause	Enrichment	NBN	1.13
242	Nk-cell enteropathy	Enrichment	CHEK2	1.13
243	Lung cancer susceptibility 3	Enrichment	TP53	1.09
244	Periventricular nodular heterotopia	Enrichment	BRCA1	1.09
245	Heart disease	Enrichment	RECQL4	1.09
246	Cataract	Enrichment	WRN	1.09
247	Pituitary stalk interruption syndrome	Enrichment	FANCA	1.09
248	Coffin-siris syndrome 1	Enrichment	SMARCC2	1.07
249	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.07
250	Atypical hemolytic-uremic syndrome	Enrichment	SMARCAL1	1.07
251	Semilobar holoprosencephaly	Enrichment	SMC1A	0.99
252	Focal segmental glomerulosclerosis	Enrichment	SMARCAL1	0.95
253	Lissencephaly	Enrichment	NBN	0.93
254	Diamond-blackfan anemia 1	Enrichment	TP53	0.89
255	Malaria	Enrichment	IKBKG	0.89
256	Congenital nervous system abnormality	Enrichment	MCPH1, SMC1A	0.88
257	Nervous system disease	Enrichment	MCPH1, SMC1A	0.88
258	Strabismus	Enrichment	UPF1	0.83
259	Severe covid-19	Enrichment	RECQL4	0.80
260	Primary autosomal recessive microcephaly	Enrichment	MCPH1	0.76
261	Diamond-blackfan anemia	Enrichment	TP53	0.71
262	Systemic lupus erythematosus	Enrichment	ATRIP	0.68
263	Cerebral palsy	Enrichment	BRCA2	0.68
264	Type 2 diabetes mellitus	Enrichment	WRN	0.65
265	Nephrotic syndrome	Enrichment	SMARCAL1	0.64
266	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPM1D	0.59
267	Hypertelorism	Enrichment	UPF1	0.57
268	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MCM2	0.57
269	Mitochondrial disease	Enrichment	TOP3A	0.39
270	Hereditary retinal dystrophy	Enrichment	ATRIP, CEP164	0.28
271	Fundus dystrophy	Enrichment	ATRIP, CEP164	0.28
272	Complex neurodevelopmental disorder	Enrichment	UPF1	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA IR-damage and cellular response via ATR

Pathway Network for DNA IR-damage and cellular response via ATR

Member Pathways for DNA IR-damage and cellular response via ATR

Pathways in the DNA IR-damage and cellular response via ATR SuperPath

Associated Genes for DNA IR-damage and cellular response via ATR

Associated Disorders for DNA IR-damage and cellular response via ATR

Disorders associated with DNA IR-damage and cellular response via ATR SuperPath

STRING Interaction Network for DNA IR-damage and cellular response via ATR

Sources for DNA IR-damage and cellular response via ATR