DNA IR-double strand breaks and cellular response via ATM

Pathway network for the DNA IR-double strand breaks and cellular response via ATM SuperPath

Sources:

WikiPathways
PubChem
GeneGo (Thomson Reuters)

Pathways in the DNA IR-double strand breaks and cellular response via ATM SuperPath

#	Name	Source	Genes
1	DNA IR-double strand breaks and cellular response via ATM	WikiPathways	ABL1 ACTL6A APAF1 ATF2 ATM ATR BAK1 BAX BID BLM BRCA1 BRCA2 CASP3 CASP9 CDC25C CDK5 CDKN2A CHEK1 CHEK2 DCLRE1C E2F1 EXO1 FANCD2 H2AX HSF1 KAT5 LATS1 MCPH1 MDC1 MDM2 MRE11 NABP2 NBN PARP1 PCNA PRKDC RAD17 RAD50 RAD51 RAD52 RAD9A RASSF1 RIF1 RNF8 SMC1A SMC3 STK3 TERF2 TP53 TP53BP1 TP73 TRAF6 TRIM28 UPF1 YAP1 (see all 55) (see less)
2	ATM pathway	PubChem	ABL1 ABRAXAS1 ATM BID BLM BRCA1 CDC25A CDC25C CHEK2 COP1 CTBP1 DCLRE1C FANCD2 H2AX KAT5 MDC1 MDM2 MRE11 NBN RAD17 RAD50 RAD9A RBBP8 RNF8 SMC1A SMC3 TERF2 TOP3A TP53BP1 TRIM28 UBE2N UIMC1 XRCC4 YWHAB (see all 34) (see less)
3	DNA damage_DNA-damage-induced responses	GeneGo (Thomson Reuters)	ABL1 ATM ATR BRCA1 CHEK1 CHEK2 MDC1 PRKDC TP53 (see all 9) (see less)

Gene overlap in member pathways for DNA IR-double strand breaks and cellular response via ATM SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	3
2	CHEK2	Checkpoint Kinase 2	Protein Coding	3
3	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	3
4	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	3
5	ATM	ATM Serine/Threonine Kinase	Protein Coding	3
6	TRIM28	Tripartite Motif Containing 28	Protein Coding	2
7	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	2
8	CDC25C	Cell Division Cycle 25C	Protein Coding	2
9	FANCD2	FA Complementation Group D2	Protein Coding	2
10	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	2
11	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	2
12	RNF8	Ring Finger Protein 8	Protein Coding	2
13	TP53BP1	Tumor Protein P53 Binding Protein 1	Protein Coding	2
14	KAT5	Lysine Acetyltransferase 5	Protein Coding	2
15	BID	BH3 Interacting Domain Death Agonist	Protein Coding	2
16	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	2
17	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	2
18	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	2
19	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	2
20	BLM	BLM RecQ Like Helicase	Protein Coding	2
21	NBN	Nibrin	Protein Coding	2
22	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
23	H2AX	H2A.X Variant Histone	Protein Coding	2
24	ATR	ATR Checkpoint Kinase	Protein Coding	2
25	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	2
26	CHEK1	Checkpoint Kinase 1	Protein Coding	2
27	TP53	Tumor Protein P53	Protein Coding	2
28	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	2
29	RASSF1	Ras Association Domain Family Member 1	Protein Coding	1
30	NABP2	Nucleic Acid Binding Protein 2	Protein Coding	1
31	UPF1	UPF1 RNA Helicase And ATPase	Protein Coding	1
32	TP73	Tumor Protein P73	Protein Coding	1
33	MCPH1	Microcephalin 1	Protein Coding	1
34	HSF1	Heat Shock Transcription Factor 1	Protein Coding	1
35	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
36	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	1
37	STK3	Serine/Threonine Kinase 3	Protein Coding	1
38	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
39	ACTL6A	Actin Like 6A	Protein Coding	1
40	RIF1	Replication Timing Regulatory Factor 1	Protein Coding	1
41	RAD52	RAD52 DNA Repair Protein	Protein Coding	1
42	EXO1	Exonuclease 1	Protein Coding	1
43	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
44	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
45	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
46	E2F1	E2F Transcription Factor 1	Protein Coding	1
47	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
48	RAD51	RAD51 Recombinase	Protein Coding	1
49	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
50	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
51	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
52	CASP9	Caspase 9	Protein Coding	1
53	CASP3	Caspase 3	Protein Coding	1
54	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
55	ATF2	Activating Transcription Factor 2	Protein Coding	1
56	CDC25A	Cell Division Cycle 25A	Protein Coding	1
57	COP1	COP1 E3 Ubiquitin Ligase	Protein Coding	1
58	ABRAXAS1	Abraxas 1, BRCA1 A Complex Subunit	Protein Coding	1
59	UIMC1	Ubiquitin Interaction Motif Containing 1	Protein Coding	1
60	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
61	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
62	TOP3A	DNA Topoisomerase III Alpha	Protein Coding	1
63	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
64	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
65	XRCC4	X-Ray Repair Cross Complementing 4	Protein Coding	1

Disorders associated with DNA IR-double strand breaks and cellular response via ATM SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, CHEK2, MRE11, NBN, RAD50, RAD51, TP53	16.00
2	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, CDKN2A, CHEK2, NBN, TP53	16.00
3	Ovarian cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, CDKN2A, CHEK2, FANCD2, MRE11, NBN, RAD50, TP53	12.19
4	Hereditary breast carcinoma	Enrichment	ATM, BLM, BRCA1, BRCA2, CHEK2, NBN, RAD50, RAD51, TP53	10.92
5	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BLM, BRCA1, BRCA2, CHEK2, MRE11, NBN, RAD50, RAD51, TP53	10.92
6	Inherited cancer-predisposing syndrome	Enrichment	ATM, BLM, BRCA1, BRCA2, CDKN2A, CHEK2, MRE11, NBN, RAD50, TP53	9.90
7	Gastric cancer	Enrichment	ATM, BRCA1, BRCA2, CDKN2A, CHEK2, NBN, TP53	9.45
8	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, CHEK2, NBN	8.94
9	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, CHEK2, NBN, TP53	8.83
10	Li-fraumeni syndrome	Enrichment	CDKN2A, CHEK2, MDM2, TP53	8.44
11	Endometrial cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, CHEK2	7.75
12	Uterine corpus cancer	Enrichment	ATM, BRCA1, CHEK2	7.48
13	Colorectal cancer	Enrichment	ATM, BAX, BLM, BRCA1, BRCA2, CHEK2, TP53	7.26
14	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2, CDKN2A, TP53	7.00
15	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	6.41
16	Sarcoma	Enrichment	CHEK2, TP53	6.41
17	Diffuse large b-cell lymphoma	Enrichment	BRCA2, CHEK2, NBN, TP53	6.05
18	Osteogenic sarcoma	Enrichment	CHEK2, TP53	5.93
19	Adenocarcinoma	Enrichment	ATM, TP53	5.93
20	Bone osteosarcoma	Enrichment	CHEK2, TP53	5.93
21	Colonic benign neoplasm	Enrichment	ATM, CHEK2, MRE11	5.92
22	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A, TP53	5.66
23	Myeloma, multiple	Enrichment	ATM, BRCA2, LATS1, TP53, YAP1	5.53
24	Familial colorectal cancer type x	Enrichment	ATM, BRCA2, CHEK2	4.99
25	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, FANCD2, RAD51	4.94
26	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A, TP53	4.87
27	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	4.79
28	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	4.79
29	Lynch syndrome 1	Enrichment	ATM, CHEK2	4.76
30	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	4.76
31	Wilms tumor 1	Enrichment	BRCA2, CHEK2, TRIM28	4.56
32	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2, TP53	4.47
33	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.44
34	Gliosarcoma	Enrichment	ATM, TP53	4.33
35	T-cell acute lymphoblastic leukemia	Enrichment	ABL1, BAX	4.32
36	Giant cell glioblastoma	Enrichment	ATM, TP53	4.28
37	Wilms tumor 5	Enrichment	CHEK2, TRIM28	4.04
38	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	4.04
39	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	4.04
40	Small cell cancer of the lung	Enrichment	TP53, TP73	4.02
41	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	4.02
42	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	4.02
43	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	3.80
44	Lung cancer	Enrichment	BRCA1, CHEK2	3.72
45	Cornelia de lange syndrome 1	Enrichment	SMC1A, SMC3	3.66
46	Cornelia de lange syndrome	Enrichment	SMC1A, SMC3	3.66
47	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.62
48	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	3.18
49	Seckel syndrome 1	Enrichment	ATR	3.18
50	Bone marrow failure syndrome 5	Enrichment	TP53	3.18
51	Papilloma of choroid plexus	Enrichment	TP53	3.18
52	Basal cell carcinoma 7	Enrichment	TP53	3.18
53	Anaplastic thyroid carcinoma	Enrichment	TP53	3.18
54	Infant-type hemispheric glioma	Enrichment	BRCA1	3.18
55	Tumor predisposition syndrome 4	Enrichment	CHEK2	3.18
56	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	3.18
57	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	3.18
58	Endometrial serous adenocarcinoma	Enrichment	ATM	3.18
59	Ductal carcinoma in situ	Enrichment	TP53	3.18
60	Leiomyosarcoma	Enrichment	CHEK2	3.18
61	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.18
62	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.18
63	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.18
64	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	3.18
65	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.18
66	Choroid plexus cancer	Enrichment	TP53	3.18
67	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.18
68	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	3.18
69	Primary peritoneal carcinoma	Enrichment	BRCA1	3.18
70	Melanoma	Enrichment	CDKN2A, CHEK2	3.15
71	Leukemia, acute lymphoblastic	Enrichment	CDKN2A, NBN	3.06
72	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.88
73	Cervical cancer	Enrichment	TP53	2.88
74	Lymphoma, hodgkin, classic	Enrichment	TP53	2.88
75	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.88
76	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.88
77	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.88
78	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.88
79	Pancreatic cancer 4	Enrichment	BRCA1	2.88
80	Congenital fibrosarcoma	Enrichment	TP53	2.88
81	High grade glioma	Enrichment	ATM	2.88
82	Cervix carcinoma	Enrichment	TP53	2.88
83	Hodgkin's lymphoma	Enrichment	TP53	2.88
84	T-cell prolymphocytic leukemia	Enrichment	ATM	2.88
85	Peritoneum cancer	Enrichment	BRCA1	2.88
86	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.88
87	Ataxia-telangiectasia	Enrichment	ATM	2.70
88	Polycythemia vera	Enrichment	ATM	2.70
89	Nasopharyngeal carcinoma	Enrichment	TP53	2.70
90	Koolen-de vries syndrome	Enrichment	ATM	2.70
91	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.70
92	Anaplastic astrocytoma	Enrichment	TP53	2.70
93	Squamous cell carcinoma	Enrichment	TP53	2.70
94	Bloom syndrome	Enrichment	BLM	2.60
95	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.60
96	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.60
97	Seckel syndrome 2	Enrichment	RBBP8	2.60
98	Accelerated tumor formation	Enrichment	MDM2	2.60
99	Lessel-kubisch syndrome	Enrichment	MDM2	2.60
100	Jawad syndrome	Enrichment	RBBP8	2.60
101	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.60
102	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5	Enrichment	TOP3A	2.60
103	Wilms tumor 7	Enrichment	TRIM28	2.60
104	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.58
105	Mantle cell lymphoma	Enrichment	ATM	2.58
106	Lung sarcomatoid carcinoma	Enrichment	TP53	2.58
107	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.58
108	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.58
109	Hemoglobin c disease	Enrichment	CHEK2	2.58
110	Oculomotor apraxia	Enrichment	ATM	2.58
111	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	2.58
112	Hepatoblastoma	Enrichment	BRCA2, TP53	2.49
113	Rhabdomyosarcoma 2	Enrichment	TP53	2.48
114	Lymphoma	Enrichment	TP53	2.48
115	Glioblastoma	Enrichment	ATM	2.48
116	Acute megakaryocytic leukemia	Enrichment	TP53	2.48
117	Microcephaly	Enrichment	ABL1, NBN, SMC1A	2.45
118	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A	2.41
119	Clear cell renal cell carcinoma	Enrichment	ATM	2.40
120	Breast adenocarcinoma	Enrichment	TP53	2.40
121	Torticollis	Enrichment	ACTL6A	2.39
122	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.39
123	Glioma susceptibility 3	Enrichment	BRCA2	2.39
124	Mirror movements 2	Enrichment	RAD51	2.39
125	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.39
126	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.39
127	Fanconi anemia, complementation group r	Enrichment	RAD51	2.39
128	Pancreatic cancer 2	Enrichment	BRCA2	2.39
129	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.39
130	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.39
131	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.39
132	Esophageal cancer	Enrichment	TP53	2.33
133	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.33
134	Leukemia, chronic myeloid	Enrichment	ABL1	2.33
135	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.33
136	Essential thrombocythemia	Enrichment	TP53	2.33
137	Gallbladder cancer	Enrichment	TP53	2.33
138	Moyamoya angiopathy	Enrichment	ABL1	2.33
139	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.30
140	Lig4 syndrome	Enrichment	XRCC4	2.30
141	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	2.30
142	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.30
143	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.30
144	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TP53BP1	2.30
145	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC4	2.30
146	Microcephaly, growth restriction, and increased sister chromatid exchange 2	Enrichment	TOP3A	2.30
147	Microcephaly and chorioretinopathy 3	Enrichment	TP53BP1	2.30
148	Microcephalic primordial dwarfism-insulin resistance syndrome	Enrichment	XRCC4	2.30
149	Glioma susceptibility 1	Enrichment	TP53	2.28
150	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.28
151	Adult hepatocellular carcinoma	Enrichment	TP53	2.22
152	Primary hyperaldosteronism	Enrichment	TP53	2.22
153	Familial colorectal cancer	Enrichment	TP53	2.18
154	Immune deficiency disease	Enrichment	ATM	2.14
155	Myelodysplastic syndrome	Enrichment	TP53	2.14
156	Nijmegen breakage syndrome	Enrichment	NBN	2.12
157	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	2.12
158	Dedifferentiated liposarcoma	Enrichment	MDM2	2.12
159	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	2.12
160	Well-differentiated liposarcoma	Enrichment	MDM2	2.12
161	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.09
162	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.09
163	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	2.09
164	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.09
165	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.09
166	Lymphatic malformation 10	Enrichment	MCPH1	2.09
167	Malignant peritoneal mesothelioma	Enrichment	LATS1	2.09
168	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	2.09
169	Nk-cell enteropathy	Enrichment	CHEK2	2.07
170	Lung cancer susceptibility 3	Enrichment	TP53	2.03
171	Periventricular nodular heterotopia	Enrichment	BRCA1	2.03
172	Seckel syndrome	Enrichment	ATR	2.03
173	Heart disease	Enrichment	ABL1	2.03
174	Primary ovarian insufficiency	Enrichment	CHEK2, NBN	2.02
175	Renal cell carcinoma, nonpapillary	Enrichment	ATM	2.00
176	Lynch syndrome	Enrichment	CHEK2	2.00
177	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.00
178	Erythrocytosis, familial, 2	Enrichment	FANCD2	2.00
179	Aicardi-goutieres syndrome 1	Enrichment	DCLRE1C	2.00
180	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	TP53BP1	2.00
181	Leukemia, acute myeloid	Enrichment	FANCD2, TP53	1.94
182	Right atrial isomerism	Enrichment	UPF1	1.92
183	Congenital heart defects, multiple types, 6	Enrichment	UPF1	1.92
184	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.92
185	Arthrogryposis multiplex congenita 6	Enrichment	RIF1	1.92
186	Umbilical hernia	Enrichment	ACTL6A	1.92
187	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.92
188	Respiratory failure	Enrichment	TP73	1.92
189	Fanconi anemia, complementation group d2	Enrichment	FANCD2	1.90
190	Von hippel-lindau syndrome	Enrichment	FANCD2	1.90
191	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.83
192	Diamond-blackfan anemia 1	Enrichment	TP53	1.82
193	Mirror movements 1	Enrichment	RAD51	1.79
194	Nemaline myopathy 2	Enrichment	RIF1	1.79
195	Chordoma	Enrichment	BRCA2	1.79
196	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	1.79
197	Ciliary dyskinesia, primary, 22	Enrichment	RASSF1	1.79
198	Transposition of the great arteries	Enrichment	UPF1	1.79
199	Isolated growth hormone deficiency, type ia	Enrichment	XRCC4	1.70
200	Rett syndrome, congenital variant	Enrichment	SMC1A	1.70
201	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.70
202	Microcephaly 1, primary, autosomal recessive	Enrichment	MCPH1	1.70
203	Diamond-blackfan anemia	Enrichment	TP53	1.63
204	Kabuki syndrome 1	Enrichment	BRCA2	1.62
205	Inguinal hernia	Enrichment	ACTL6A	1.62
206	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.62
207	Omenn syndrome	Enrichment	DCLRE1C	1.61
208	Aplastic anemia	Enrichment	NBN	1.61
209	Gastroesophageal reflux	Enrichment	ACTL6A	1.50
210	Premature menopause	Enrichment	NBN	1.49
211	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	1.44
212	Polydactyly	Enrichment	BRCA2	1.44
213	Nemaline myopathy	Enrichment	RIF1	1.40
214	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	1.40
215	Polycystic liver disease	Enrichment	CDC25A	1.38
216	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.38
217	Atrial heart septal defect	Enrichment	ACTL6A	1.36
218	Interatrial communication	Enrichment	ACTL6A	1.36
219	Semilobar holoprosencephaly	Enrichment	SMC1A	1.35
220	Lissencephaly	Enrichment	NBN	1.29
221	Microphthalmia/coloboma 12	Enrichment	YAP1	1.29
222	Medulloblastoma	Enrichment	BRCA2	1.26
223	Coloboma of macula	Enrichment	YAP1	1.23
224	Isolated congenital microcephaly	Enrichment	MCPH1	1.20
225	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.18
226	Congenital nervous system abnormality	Enrichment	MCPH1, SMC1A	1.16
227	Nervous system disease	Enrichment	MCPH1, SMC1A	1.16
228	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	1.13
229	Severe combined immunodeficiency	Enrichment	DCLRE1C	1.10
230	Complex neurodevelopmental disorder	Enrichment	ACTL6A, UPF1	1.05
231	Muscular dystrophy	Enrichment	RIF1	1.03
232	Strabismus	Enrichment	UPF1	0.98
233	Primary autosomal recessive microcephaly	Enrichment	MCPH1	0.91
234	Cerebral palsy	Enrichment	BRCA2	0.83
235	Hypertelorism	Enrichment	UPF1	0.72
236	Mitochondrial disease	Enrichment	TOP3A	0.71
237	Autism spectrum disorder	Enrichment	SMC3	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA IR-double strand breaks and cellular response via ATM

Pathway Network for DNA IR-double strand breaks and cellular response via ATM

Pathway network for the DNA IR-double strand breaks and cellular response via ATM SuperPath

Member Pathways for DNA IR-double strand breaks and cellular response via ATM

Pathways in the DNA IR-double strand breaks and cellular response via ATM SuperPath

Gene overlap in member pathways for DNA IR-double strand breaks and cellular response via ATM SuperPath

Associated Genes for DNA IR-double strand breaks and cellular response via ATM

Associated Disorders for DNA IR-double strand breaks and cellular response via ATM

Disorders associated with DNA IR-double strand breaks and cellular response via ATM SuperPath

STRING Interaction Network for DNA IR-double strand breaks and cellular response via ATM

Sources for DNA IR-double strand breaks and cellular response via ATM