DNA Methylation and Transcriptional Repression

No Pathway Network information available for DNA Methylation and Transcriptional Repression

Pathways in the DNA Methylation and Transcriptional Repression SuperPath

#	Name	Source	Genes
1	DNA Methylation and Transcriptional Repression	QIAGEN	CHD4 DNMT1 DNMT3A DNMT3B HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 MBD2 MBD3 MECP2 RBBP4 RBBP7 SAP18 SAP30 SIN3A TRDMT1 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	1
2	DNMT1	DNA Methyltransferase 1	Protein Coding	1
3	TRDMT1	TRNA Aspartic Acid Methyltransferase 1	Protein Coding	1
4	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	1
5	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	1
6	HDAC1	Histone Deacetylase 1	Protein Coding	1
7	HDAC10	Histone Deacetylase 10	Protein Coding	1
8	HDAC11	Histone Deacetylase 11	Protein Coding	1
9	HDAC2	Histone Deacetylase 2	Protein Coding	1
10	HDAC3	Histone Deacetylase 3	Protein Coding	1
11	HDAC5	Histone Deacetylase 5	Protein Coding	1
12	HDAC6	Histone Deacetylase 6	Protein Coding	1
13	HDAC7	Histone Deacetylase 7	Protein Coding	1
14	HDAC8	Histone Deacetylase 8	Protein Coding	1
15	HDAC9	Histone Deacetylase 9	Protein Coding	1
16	MBD2	Methyl-CpG Binding Domain Protein 2	Protein Coding	1
17	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	1
18	MECP2	Methyl-CpG Binding Protein 2	Protein Coding	1
19	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
20	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
21	SAP18	Sin3A Associated Protein 18	Protein Coding	1
22	SAP30	Sin3A Associated Protein 30	Protein Coding	1
23	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1

Disorders associated with DNA Methylation and Transcriptional Repression SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.77
2	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.77
3	Facial hypertrichosis	Enrichment	MECP2	2.77
4	Intellectual developmental disorder, x-linked, syndromic, lubs type	Enrichment	MECP2	2.77
5	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.77
6	Autism x-linked 3	Enrichment	MECP2	2.77
7	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.77
8	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	2.77
9	Syndromic x-linked intellectual disability lubs type	Enrichment	MECP2	2.77
10	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.77
11	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	2.47
12	Encephalopathy, neonatal severe, due to mecp2 mutations	Enrichment	MECP2	2.47
13	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.47
14	Syndactyly, type iii	Enrichment	HDAC8	2.47
15	Intellectual developmental disorder, x-linked, syndromic 13	Enrichment	MECP2	2.47
16	Wilson-turner syndrome	Enrichment	HDAC8	2.47
17	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	2.47
18	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.47
19	X-linked intellectual disability-psychosis-macroorchidism syndrome	Enrichment	MECP2	2.47
20	Witteveen-kolk syndrome	Enrichment	SIN3A	2.47
21	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	2.47
22	Progressive bulbar palsy	Enrichment	MECP2	2.47
23	Bruxism	Enrichment	MECP2	2.47
24	Laryngomalacia	Enrichment	MECP2	2.29
25	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	2.29
26	Sick sinus syndrome	Enrichment	MECP2	2.17
27	Myeloproliferative neoplasm	Enrichment	DNMT3A	2.07
28	Glioblastoma	Enrichment	DNMT3A	2.07
29	Angelman syndrome	Enrichment	MECP2	1.99
30	Facioscapulohumeral muscular dystrophy 1	Enrichment	DNMT3B	1.99
31	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B	1.99
32	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	1.99
33	Rett syndrome	Enrichment	MECP2	1.93
34	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	1.93
35	Focal epilepsy	Enrichment	MECP2	1.93
36	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.87
37	Rett syndrome, congenital variant	Enrichment	MECP2	1.87
38	Congenital nervous system abnormality	Enrichment	DNMT3A, MECP2	1.86
39	Nervous system disease	Enrichment	DNMT3A, MECP2	1.86
40	Autism spectrum disorder	Enrichment	DNMT3A, MECP2	1.84
41	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.82
42	Cornelia de lange syndrome	Enrichment	HDAC8	1.82
43	Melanoma	Enrichment	DNMT3A	1.77
44	Microcephaly	Enrichment	HDAC8, MECP2	1.74
45	Atrial heart septal defect	Enrichment	HDAC8	1.73
46	Interatrial communication	Enrichment	HDAC8	1.73
47	Specific learning disability	Enrichment	DNMT3A	1.73
48	Stereotypic movement disorder	Enrichment	MECP2	1.66
49	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.63
50	Rare genetic intellectual disability	Enrichment	DNMT3A	1.60
51	Gliosarcoma	Enrichment	DNMT3A	1.57
52	Giant cell glioblastoma	Enrichment	DNMT3A	1.55
53	Polycystic kidney disease	Enrichment	HDAC8	1.52
54	Diffuse large b-cell lymphoma	Enrichment	DNMT3A	1.50
55	Attention deficit-hyperactivity disorder	Enrichment	MECP2	1.44
56	Dystonia	Enrichment	MECP2	1.24
57	Non-syndromic x-linked intellectual disability	Enrichment	MECP2	1.23
58	Systemic lupus erythematosus	Enrichment	MECP2	1.19
59	Leukemia, acute myeloid	Enrichment	DNMT3A	1.18
60	Epilepsy	Enrichment	MECP2	1.18
61	Body mass index quantitative trait locus 11	Enrichment	DNMT3A	1.09
62	Spastic ataxia	Enrichment	DNMT1	1.06
63	Myeloma, multiple	Enrichment	DNMT3A	1.04
64	Autism	Enrichment	MECP2	0.94

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA Methylation and Transcriptional Repression

Pathway Network for DNA Methylation and Transcriptional Repression

Member Pathways for DNA Methylation and Transcriptional Repression

Pathways in the DNA Methylation and Transcriptional Repression SuperPath

Associated Genes for DNA Methylation and Transcriptional Repression

Associated Disorders for DNA Methylation and Transcriptional Repression

Disorders associated with DNA Methylation and Transcriptional Repression SuperPath

STRING Interaction Network for DNA Methylation and Transcriptional Repression

Sources for DNA Methylation and Transcriptional Repression