DNA repair pathways, full network

Pathway network for the DNA repair pathways, full network SuperPath

Sources:

WikiPathways
Reactome
QIAGEN

Pathways in the DNA repair pathways, full network SuperPath

#	Name	Source	Genes
1	DNA repair pathways, full network	WikiPathways	APEX1 APEX2 ATM ATR BRCA1 BRCA2 BRIP1 CCNH CDK7 CENPS CENPX CETN2 CHEK1 CUL4A CUL4B DCLRE1C DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 EXO1 FAAP100 FAAP24 FAN1 FANCA FANCB FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM FEN1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AX HMGB1 LIG1 LIG3 LIG4 LOC105376156 MBD4 MGMT MLH1 MNAT1 MPG MRE11 MSH2 MSH3 MSH6 MUTYH NBN NEIL2 NEIL3 NHEJ1 NTHL1 OGG1 PALB2 PARP1 PARP2 PCNA PMS2 PNKP POLB POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLH POLI POLK POLL POLM PRKDC RAD23A RAD23B RAD50 RAD51 RAD51C RAD52 RAD54B RAP1A RBX1 REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 SMUG1 TDG TERF2 UNG USP1 WDR48 WRN XPA XPC XRCC1 XRCC4 XRCC5 XRCC6 (see all 119) (see less)
2	Nucleotide excision repair in xeroderma pigmentosum	WikiPathways	BRCA1 CCNH CDK7 CETN2 CHD1L CUL4A CUL4B DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 HMGN1 LIG1 LIG3 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLH POLK RAD23A RAD23B RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 SLX4 SLX4IP USP7 UVSSA XAB2 XPA XPC XRCC1 (see all 54) (see less)
3	Nucleotide excision repair	WikiPathways	CCNH CDK7 CETN2 CUL4A CUL4B DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 LIG1 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 RAD23A RAD23B RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 XPA XPC (see all 43) (see less)
4	Dual Incision in GG-NER	Reactome	CHD1L CUL4A CUL4B DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 PARP1 PARP2 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLK RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A UBA52 UBB UBC XPA (see all 41) (see less)
5	Nucleotide Excision Repair Pathway	QIAGEN	ERCC1 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 LIG1 LIG3 LIG4 PCNA POLD1 POLE POLR1A POLR2A POLR2B POLR2C RAD23B RFC1 RFC2 RFC3 RFC4 RFC5 RPA2 RPA3 XPA XPC (see all 28) (see less)
6	Mismatch Repair	Reactome	EXO1 LIG1 MLH1 MSH2 MSH3 MSH6 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 (see all 15) (see less)
7	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	Reactome	EXO1 LIG1 MLH1 MSH2 MSH3 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 (see all 14) (see less)
8	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	Reactome	EXO1 LIG1 MLH1 MSH2 MSH6 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 (see all 14) (see less)
9	Homologous recombination	WikiPathways	ATM BRCA2 MRE11 NBN POLD1 POLD2 POLD3 POLD4 RAD50 RAD51 RAD52 RAD54B RPA1 (see all 13) (see less)
10	Non-homologous end joining	WikiPathways	DCLRE1C LIG4 NHEJ1 POLL POLM PRKDC WRN XRCC4 XRCC5 XRCC6 (see all 10) (see less)
11	Diseases of Mismatch Repair (MMR)	Reactome	MLH1 MSH2 MSH3 MSH6 PMS2
12	Defective Mismatch Repair Associated With MSH2	Reactome	MSH2 MSH3 MSH6
13	Defective Mismatch Repair Associated With MSH6	Reactome	MSH2 MSH6
14	Defective Mismatch Repair Associated With MSH3	Reactome	MSH2 MSH3

Gene overlap in member pathways for DNA repair pathways, full network SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	9
2	RPA1	Replication Protein A1	Protein Coding	8
3	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	8
4	MSH2	MutS Homolog 2	Protein Coding	8
5	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	8
6	RPA3	Replication Protein A3	Protein Coding	8
7	RPA2	Replication Protein A2	Protein Coding	8
8	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	8
9	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	8
10	LIG1	DNA Ligase 1	Protein Coding	7
11	MSH3	MutS Homolog 3	Protein Coding	6
12	MSH6	MutS Homolog 6	Protein Coding	6
13	XPA	XPA, DNA Damage Recognition And Repair Factor	Protein Coding	5
14	RFC4	Replication Factor C Subunit 4	Protein Coding	5
15	RFC1	Replication Factor C Subunit 1	Protein Coding	5
16	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	5
17	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	5
18	MLH1	MutL Homolog 1	Protein Coding	5
19	ERCC4	ERCC Excision Repair 4, Endonuclease Catalytic Subunit	Protein Coding	5
20	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	5
21	RFC5	Replication Factor C Subunit 5	Protein Coding	5
22	RFC3	Replication Factor C Subunit 3	Protein Coding	5
23	RFC2	Replication Factor C Subunit 2	Protein Coding	5
24	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	5
25	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	5
26	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	5
27	RBX1	Ring-Box 1	Protein Coding	4
28	EXO1	Exonuclease 1	Protein Coding	4
29	CUL4A	Cullin 4A	Protein Coding	4
30	CUL4B	Cullin 4B	Protein Coding	4
31	XPC	XPC Complex Subunit, DNA Damage Recognition And Repair Factor	Protein Coding	4
32	RAD23B	RAD23 Nucleotide Excision Repair Protein B	Protein Coding	4
33	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	4
34	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	4
35	ERCC5	ERCC Excision Repair 5, Endonuclease	Protein Coding	4
36	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	4
37	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	4
38	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	4
39	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	4
40	ERCC8	ERCC Excision Repair 8, CSA Ubiquitin Ligase Complex Subunit	Protein Coding	4
41	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	4
42	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	4
43	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	4
44	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	4
45	CCNH	Cyclin H	Protein Coding	3
46	RAD23A	RAD23 Nucleotide Excision Repair Protein A	Protein Coding	3
47	POLK	DNA Polymerase Kappa	Protein Coding	3
48	LIG4	DNA Ligase 4	Protein Coding	3
49	CETN2	Centrin 2	Protein Coding	3
50	CDK7	Cyclin Dependent Kinase 7	Protein Coding	3
51	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	3
52	LIG3	DNA Ligase 3	Protein Coding	3
53	NHEJ1	Non-Homologous End Joining Factor 1	Protein Coding	2
54	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	2
55	XRCC4	X-Ray Repair Cross Complementing 4	Protein Coding	2
56	XRCC1	X-Ray Repair Cross Complementing 1	Protein Coding	2
57	WRN	WRN RecQ Like Helicase	Protein Coding	2
58	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	2
59	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	2
60	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	2
61	RAD52	RAD52 DNA Repair Protein	Protein Coding	2
62	RAD51	RAD51 Recombinase	Protein Coding	2
63	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	2
64	POLH	DNA Polymerase Eta	Protein Coding	2
65	ATM	ATM Serine/Threonine Kinase	Protein Coding	2
66	NBN	Nibrin	Protein Coding	2
67	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	2
68	RAD54B	RAD54 Homolog B	Protein Coding	2
69	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	2
70	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	2
71	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	2
72	PARP2	Poly(ADP-Ribose) Polymerase 2	Protein Coding	2
73	POLM	DNA Polymerase Mu	Protein Coding	2
74	POLL	DNA Polymerase Lambda	Protein Coding	2
75	CHD1L	Chromodomain Helicase DNA Binding Protein 1 Like	Protein Coding	2
76	TDG	Thymine DNA Glycosylase	Protein Coding	1
77	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
78	MPG	N-Methylpurine DNA Glycosylase	Protein Coding	1
79	NEIL2	Nei Like DNA Glycosylase 2	Protein Coding	1
80	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	1
81	MBD4	Methyl-CpG Binding Domain 4, DNA Glycosylase	Protein Coding	1
82	BRIP1	BRCA1 Interacting DNA Helicase 1	Protein Coding	1
83	PALB2	Partner And Localizer Of BRCA2	Protein Coding	1
84	UNG	Uracil DNA Glycosylase	Protein Coding	1
85	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	1
86	RAD51C	RAD51 Paralog C	Protein Coding	1
87	FANCM	FA Complementation Group M	Protein Coding	1
88	WDR48	WD Repeat Domain 48	Protein Coding	1
89	NEIL3	Nei Like DNA Glycosylase 3	Protein Coding	1
90	FANCI	FA Complementation Group I	Protein Coding	1
91	FANCL	FA Complementation Group L	Protein Coding	1
92	ATR	ATR Checkpoint Kinase	Protein Coding	1
93	POLB	DNA Polymerase Beta	Protein Coding	1
94	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	1
95	NTHL1	Nth Like DNA Glycosylase 1	Protein Coding	1
96	MUTYH	MutY DNA Glycosylase	Protein Coding	1
97	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	1
98	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
99	HMGB1	High Mobility Group Box 1	Protein Coding	1
100	H2AX	H2A.X Variant Histone	Protein Coding	1
101	FAN1	FANCD2 And FANCI Associated Nuclease 1	Protein Coding	1
102	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	1
103	FANCG	FA Complementation Group G	Protein Coding	1
104	FANCF	FA Complementation Group F	Protein Coding	1
105	FANCB	FA Complementation Group B	Protein Coding	1
106	FANCE	FA Complementation Group E	Protein Coding	1
107	FANCD2	FA Complementation Group D2	Protein Coding	1
108	FANCA	FA Complementation Group A	Protein Coding	1
109	PNKP	Polynucleotide Kinase 3''-Phosphatase	Protein Coding	1
110	CHEK1	Checkpoint Kinase 1	Protein Coding	1
111	FAAP24	FA Core Complex Associated Protein 24	Protein Coding	1
112	POLI	DNA Polymerase Iota	Protein Coding	1
113	LOC105376156	Uncharacterized LOC105376156	RNA Gene	1
114	FAAP100	FA Core Complex Associated Protein 100	Protein Coding	1
115	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	1
116	REV3L	REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit	Protein Coding	1
117	REV1	REV1 DNA Directed Polymerase	Protein Coding	1
118	CENPS	Centromere Protein S	Protein Coding	1
119	APEX2	Apurinic/Apyrimidinic Endodeoxyribonuclease 2	Protein Coding	1
120	CENPX	Centromere Protein X	Protein Coding	1
121	SLX4	SLX4 Structure-Specific Endonuclease Subunit	Protein Coding	1
122	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
123	UVSSA	UV Stimulated Scaffold Protein A	Protein Coding	1
124	HMGN1	High Mobility Group Nucleosome Binding Domain 1	Protein Coding	1
125	SLX4IP	SLX4 Interacting Protein	Protein Coding	1
126	XAB2	XPA Binding Protein 2~Name Same As:- HGNC:14337	Protein Coding	1
127	RPS27A	Ribosomal Protein S27a	Protein Coding	1
128	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
129	UBB	Ubiquitin B	Protein Coding	1
130	UBC	Ubiquitin C	Protein Coding	1
131	POLR1A	RNA Polymerase I Subunit A	Protein Coding	1
132	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
133	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
134	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1

Disorders associated with DNA repair pathways, full network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, FANCM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, RAD50, RAD51, RAD51C	16.00
2	Colorectal cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, FANCE, FANCI, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, POLD1, POLE, RAD54B, REV3L	16.00
3	Ovarian cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, ERCC2, ERCC3, ERCC4, ERCC5, FANCA, FANCD2, FANCE, FANCG, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, RAD50, RAD51C, WRN, XPA, XPC	16.00
4	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, BRIP1, ERCC4, FANCA, FANCB, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, PALB2, RAD51, RAD51C	16.00
5	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, ERCC4, FANCE, FANCG, NBN, PALB2, POLD1	16.00
6	Xeroderma pigmentosum, variant type	Enrichment	DDB2, ERCC2, ERCC3, ERCC4, ERCC5, POLH, XPA, XPC	16.00
7	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, BRIP1, MSH2, NBN, PALB2, RAD51C	16.00
8	Gastric cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, FANCI, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, RAD51C	16.00
9	Hereditary breast carcinoma	Enrichment	ATM, BRCA1, BRCA2, BRIP1, FANCM, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, RAD50, RAD51	16.00
10	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, MSH2, MSH6, PALB2, RAD51C	16.00
11	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, BRCA2, BRIP1, ERCC3, FANCA, FANCM, MBD4, MLH1, MRE11, MSH2, MSH3, MSH6, MUTYH, NBN, NTHL1, PALB2, PMS2, POLD1, POLE, RAD50, RAD51C	16.00
12	Lynch syndrome 1	Enrichment	MLH1, MSH2, MSH6, PMS2	11.70
13	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, BRCA2, BRIP1, FANCM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, RAD50, RAD51, RAD51C	11.64
14	Endometrial cancer	Enrichment	ATM, BRCA1, BRCA2, MLH1, MSH2, MSH3, MSH6, MUTYH, PMS2, RAD51C	11.44
15	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, MSH6, PMS2	10.68
16	Lynch syndrome	Enrichment	MLH1, MSH2, MSH6, PMS2	10.44
17	Lynch syndrome 4	Enrichment	MSH2, MSH6, PMS2	9.91
18	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3, ERCC4, ERCC5	9.42
19	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC1, ERCC2, ERCC5, ERCC6	8.88
20	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, MSH6, NBN, PALB2, POLK	8.35
21	Colonic benign neoplasm	Enrichment	ATM, MLH1, MRE11, MUTYH, PALB2	8.23
22	Rhabdomyosarcoma	Enrichment	MSH2, MSH6, PMS2	7.87
23	Familial colorectal cancer type x	Enrichment	ATM, BRCA2, MUTYH, POLD1, POLE	7.67
24	Uv-sensitive syndrome	Enrichment	ERCC6, ERCC8, UVSSA	7.22
25	Cockayne syndrome a	Enrichment	ERCC4, ERCC6, ERCC8	7.10
26	Muir-torre syndrome	Enrichment	MLH1, MSH2	6.96
27	Cockayne syndrome b	Enrichment	ERCC1, ERCC6, ERCC8	6.80
28	Cockayne syndrome	Enrichment	ERCC4, ERCC6, ERCC8	6.56
29	Lig4 syndrome	Enrichment	LIG4, XRCC4	6.31
30	Hepatoblastoma	Enrichment	BRCA2, ERCC2, ERCC5, FANCA, MSH2	6.06
31	Severe combined immunodeficiency	Enrichment	DCLRE1C, LIG4, NHEJ1	5.81
32	Trichothiodystrophy	Enrichment	ERCC2, ERCC3, GTF2H5	5.67
33	Xeroderma pigmentosum, complementation group a	Enrichment	XPA, XPC	5.39
34	Cockayne syndrome type 3	Enrichment	ERCC6, ERCC8	5.39
35	Familial colorectal cancer	Enrichment	MLH1, MSH2	5.31
36	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	5.29
37	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2, PMS2	5.19
38	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	4.91
39	Omenn syndrome	Enrichment	DCLRE1C, LIG4	4.66
40	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2, BRIP1	4.12
41	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	4.12
42	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	4.12
43	Neuroendocrine tumor of pancreas	Enrichment	BRCA2, PALB2	4.12
44	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2, ERCC2	3.95
45	Diffuse large b-cell lymphoma	Enrichment	BRCA2, NBN	3.84
46	Mismatch repair cancer syndrome 2	Enrichment	MSH2	3.83
47	Rectal benign neoplasm	Enrichment	MSH2	3.83
48	Ascending colon cancer	Enrichment	MSH2	3.83
49	Ovarian cyst	Enrichment	MSH2	3.83
50	Lung cancer	Enrichment	BRCA1, ERCC6, MLH1, PALB2	3.78
51	Hepatocellular carcinoma	Enrichment	NBN, RAD50	3.71
52	Mismatch repair cancer syndrome 3	Enrichment	MSH6	3.53
53	Gliosarcoma	Enrichment	ATM, MGMT, MSH2	3.47
54	Lynch syndrome 2	Enrichment	MLH1	3.43
55	Mismatch repair cancer syndrome 4	Enrichment	PMS2	3.43
56	Pituitary cancer	Enrichment	PMS2	3.43
57	Giant cell glioblastoma	Enrichment	ATM, MGMT, MSH2	3.39
58	Lynch syndrome 5	Enrichment	MSH6	3.35
59	Cellular ependymoma	Enrichment	MSH2	3.35
60	Tanycytic ependymoma	Enrichment	MSH2	3.35
61	Papillary ependymoma	Enrichment	MSH2	3.35
62	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	3.35
63	Colon adenocarcinoma	Enrichment	MSH6	3.35
64	Clear cell ependymoma	Enrichment	MSH2	3.35
65	Familial adenomatous polyposis 4	Enrichment	MSH3	3.35
66	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11, PNKP	3.34
67	Chordoma	Enrichment	BRCA2, PALB2	3.34
68	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	3.34
69	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	3.34
70	Gaucher disease, type i	Enrichment	MSH6	3.23
71	Benign ependymoma	Enrichment	MSH2	3.23
72	Burkitt lymphoma	Enrichment	PMS2	3.13
73	Glioblastoma	Enrichment	MSH2	3.13
74	Immunodeficiency 124, severe combined	Enrichment	NHEJ1	3.13
75	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	3.13
76	Microphthalmia/coloboma 13	Enrichment	NHEJ1	3.13
77	Fanconi anemia, complementation group d2	Enrichment	BRIP1, FANCD2	3.12
78	Colorectal cancer 10	Enrichment	POLD1	3.02
79	Glioma susceptibility 3	Enrichment	BRCA2	3.02
80	Mirror movements 2	Enrichment	RAD51	3.02
81	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	3.02
82	Fanconi anemia, complementation group r	Enrichment	RAD51	3.02
83	Immunodeficiency 120	Enrichment	POLD1	3.02
84	Pancreatic cancer 2	Enrichment	BRCA2	3.02
85	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	3.02
86	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	3.02
87	Endometrial serous adenocarcinoma	Enrichment	ATM	3.02
88	Immunodeficiency 122	Enrichment	POLD3	3.02
89	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.02
90	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.99
91	Immunodeficiency 96	Enrichment	LIG1	2.99
92	Clear cell renal cell carcinoma	Enrichment	ATM, OGG1	2.95
93	Myeloma, multiple	Enrichment	ATM, BRCA2	2.90
94	Chromosome 2q35 duplication syndrome	Enrichment	NHEJ1	2.83
95	Dubowitz syndrome	Enrichment	LIG4	2.83
96	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	2.83
97	Werner syndrome	Enrichment	WRN	2.83
98	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC4	2.83
99	Microcephalic primordial dwarfism-insulin resistance syndrome	Enrichment	XRCC4	2.83
100	Primary ovarian insufficiency	Enrichment	ERCC1, FANCA, NBN, RAD51C	2.75
101	Lymphoma	Enrichment	PMS2	2.73
102	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.72
103	High grade glioma	Enrichment	ATM	2.72
104	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.72
105	T-cell prolymphocytic leukemia	Enrichment	ATM	2.72
106	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.69
107	Cerebrooculofacioskeletal syndrome 4	Enrichment	ERCC1	2.69
108	Colorectal cancer 12	Enrichment	POLE	2.69
109	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	2.69
110	Xfe progeroid syndrome	Enrichment	ERCC4	2.69
111	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.69
112	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2, XRCC4	2.69
113	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	2.66
114	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	2.66
115	Isolated anophthalmia-microphthalmia syndrome	Enrichment	NHEJ1	2.66
116	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2, BRIP1	2.58
117	Leukemia, acute lymphoblastic 3	Enrichment	ERCC4, PALB2	2.58
118	Ataxia-telangiectasia	Enrichment	ATM	2.54
119	Nijmegen breakage syndrome	Enrichment	NBN	2.54
120	Polycythemia vera	Enrichment	ATM	2.54
121	Tumor predisposition syndrome 1	Enrichment	BRCA2	2.54
122	Koolen-de vries syndrome	Enrichment	ATM	2.54
123	Adenocarcinoma	Enrichment	ATM	2.54
124	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	2.54
125	Aicardi-goutieres syndrome 1	Enrichment	DCLRE1C	2.53
126	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	2.52
127	White-kernohan syndrome	Enrichment	DDB1	2.52
128	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	2.52
129	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	2.52
130	Xeroderma pigmentosum group b	Enrichment	ERCC3	2.52
131	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	2.52
132	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	2.52
133	Xeroderma pigmentosum group d	Enrichment	ERCC2	2.52
134	Isolated tracheo-esophageal fistula	Enrichment	BRCA2, BRIP1	2.48
135	Mirror movements 1	Enrichment	RAD51	2.42
136	Mantle cell lymphoma	Enrichment	ATM	2.42
137	Oculomotor apraxia	Enrichment	ATM	2.42
138	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.40
139	Fanconi anemia, complementation group p	Enrichment	SLX4	2.40
140	Infant-type hemispheric glioma	Enrichment	BRCA1	2.40
141	Uv-sensitive syndrome 3	Enrichment	UVSSA	2.40
142	Spinocerebellar ataxia, autosomal recessive 26	Enrichment	XRCC1	2.40
143	Primary peritoneal carcinoma	Enrichment	BRCA1	2.40
144	Cardiomyopathy, familial hypertrophic, 9	Enrichment	PMS2	2.39
145	Xeroderma pigmentosum, complementation group f	Enrichment	ERCC4	2.38
146	Xeroderma pigmentosum, complementation group c	Enrichment	XPC	2.38
147	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	2.38
148	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	2.38
149	Mitochondrial complex i deficiency, nuclear type 10	Enrichment	ERCC8	2.38
150	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	2.38
151	Fanconi anemia, complementation group q	Enrichment	ERCC4	2.38
152	Xeroderma pigmentosum group f	Enrichment	ERCC4	2.38
153	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	2.38
154	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	2.38
155	Xeroderma pigmentosum group c	Enrichment	XPC	2.38
156	Mitochondrial dna depletion syndrome 20	Enrichment	LIG3	2.38
157	Premature menopause	Enrichment	ERCC1, NBN	2.25
158	Kabuki syndrome 1	Enrichment	BRCA2	2.24
159	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	2.22
160	Intellectual developmental disorder, x-linked, syndromic, cabezas type	Enrichment	CUL4B	2.22
161	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	POLK	2.22
162	Pettigrew syndrome	Enrichment	CUL4B	2.22
163	Xeroderma pigmentosum group e	Enrichment	DDB2	2.22
164	Submucosal cleft palate	Enrichment	UBB	2.22
165	Cleft hard palate	Enrichment	UBB	2.22
166	De sanctis-cacchione syndrome	Enrichment	ERCC6	2.21
167	Xeroderma pigmentosum, complementation group g	Enrichment	ERCC5	2.21
168	Burn-mckeown syndrome	Enrichment	POLR1A	2.21
169	Uv-sensitive syndrome 1	Enrichment	ERCC6	2.21
170	Uv-sensitive syndrome 2	Enrichment	ERCC8	2.21
171	Cerebrooculofacioskeletal syndrome 3	Enrichment	ERCC5	2.21
172	Premature ovarian failure 11	Enrichment	ERCC6	2.21
173	Childhood apraxia of speech	Enrichment	RFC3	2.21
174	Xeroderma pigmentosum group g	Enrichment	ERCC5	2.21
175	Medulloblastoma	Enrichment	BRCA2, WRN	2.19
176	Pituitary stalk interruption syndrome	Enrichment	FANCA, FANCG	2.19
177	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.17
178	Renal cell carcinoma, nonpapillary	Enrichment	ATM, OGG1	2.13
179	Lymphoma, non-hodgkin, familial	Enrichment	RAD54B	2.12
180	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.10
181	Pancreatic cancer 4	Enrichment	BRCA1	2.10
182	Hao-fountain syndrome	Enrichment	USP7	2.10
183	Peritoneum cancer	Enrichment	BRCA1	2.10
184	Cardiomyopathy, dilated, 1g	Enrichment	PMS2	2.09
185	Hutchinson-gilford progeria syndrome	Enrichment	ERCC4	2.08
186	Deafness, autosomal recessive 1a	Enrichment	ERCC8	2.08
187	Macular degeneration, age-related, 5	Enrichment	ERCC6	2.08
188	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	2.08
189	Gjb2-related autosomal recessive nonsyndromic hearing loss	Enrichment	ERCC8	2.08
190	Polydactyly	Enrichment	BRCA2	2.07
191	Fanconi anemia, complementation group j	Enrichment	BRIP1	2.06
192	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.06
193	Melanoma, uveal 1	Enrichment	MBD4	2.06
194	Ataxia-oculomotor apraxia 4	Enrichment	PNKP	2.06
195	Seckel syndrome 1	Enrichment	ATR	2.06
196	Fanconi anemia, complementation group g	Enrichment	FANCG	2.06
197	Fanconi anemia, complementation group b	Enrichment	FANCB	2.06
198	Spermatogenic failure 28	Enrichment	FANCM	2.06
199	Premature ovarian failure 15	Enrichment	FANCM	2.06
200	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.06
201	Familial adenomatous polyposis 3	Enrichment	NTHL1	2.06
202	Fanconi anemia, complementation group l	Enrichment	FANCL	2.06
203	Autosomal recessive spastic paraplegia type 60	Enrichment	WDR48	2.06
204	Tumor predisposition syndrome 2	Enrichment	MBD4	2.06
205	Fanconi anemia, complementation group x	Enrichment	FAAP100	2.06
206	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.06
207	Basal cell carcinoma	Enrichment	PALB2	2.06
208	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.06
209	Uvula, bifid	Enrichment	UBB	2.04
210	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	2.04
211	Cleft soft palate	Enrichment	UBB	2.04
212	Wieacker-wolff syndrome	Enrichment	CCNH	2.02
213	Leukemia, chronic lymphocytic	Enrichment	ATM	2.02
214	Aplastic anemia	Enrichment	NBN	2.02
215	Cataract	Enrichment	WRN	1.99
216	Autosomal recessive cerebellar ataxia	Enrichment	ERCC4	1.99
217	Polyneuropathy	Enrichment	ERCC5	1.99
218	Immune deficiency disease	Enrichment	ATM	1.98
219	Leukemia, acute lymphoblastic	Enrichment	NBN	1.98
220	Combined immunodeficiency	Enrichment	POLD1	1.98
221	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.98
222	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.98
223	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2, BRIP1	1.93
224	Craniopharyngioma	Enrichment	ERCC2	1.92
225	Wilms tumor 1	Enrichment	BRCA2	1.85
226	Capillary malformations, congenital	Enrichment	CCNH	1.80
227	Ovarian germ cell cancer	Enrichment	FANCM	1.76
228	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	FANCL	1.76
229	Fanconi anemia, complementation group i	Enrichment	FANCI	1.76
230	Fanconi anemia, complementation group n	Enrichment	PALB2	1.76
231	Familial adenomatous polyposis 2	Enrichment	MUTYH	1.76
232	Charcot-marie-tooth disease, axonal, type 2b2	Enrichment	PNKP	1.76
233	Pancreatic cancer 3	Enrichment	PALB2	1.76
234	Ovarian cancer 1	Enrichment	BRIP1	1.76
235	Interstitial nephritis, karyomegalic	Enrichment	FAN1	1.76
236	Intellectual developmental disorder, x-linked, syndromic, pilorge type	Enrichment	FANCB	1.76
237	Fanconi anemia, complementation group e	Enrichment	FANCE	1.76
238	Charcot-marie-tooth disease type 2b2	Enrichment	PNKP	1.76
239	Microcephaly, seizures, and developmental delay	Enrichment	PNKP	1.76
240	Immunodeficiency with hyper-igm, type 5	Enrichment	UNG	1.76
241	Vacterl with hydrocephalus	Enrichment	FANCB	1.76
242	Malignant germ cell tumor of ovary	Enrichment	FANCM	1.76
243	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	LIG3	1.73
244	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.72
245	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.72
246	Hemangioma, capillary infantile	Enrichment	CCNH	1.72
247	Basal cell carcinoma 1	Enrichment	CCNH	1.72
248	Lissencephaly	Enrichment	NBN	1.70
249	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.66
250	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	1.66
251	Pectus excavatum	Enrichment	ERCC5	1.65
252	Retinoblastoma	Enrichment	FANCM	1.58
253	Spastic paraplegia 7, autosomal recessive	Enrichment	MUTYH	1.58
254	Breast-ovarian cancer, familial 3	Enrichment	RAD51C	1.58
255	Fanconi anemia, complementation group o	Enrichment	RAD51C	1.58
256	Breast-ovarian cancer, familial 5	Enrichment	PALB2	1.58
257	Fanconi anemia, complementation group f	Enrichment	FANCF	1.58
258	Hereditary site-specific ovarian cancer syndrome	Enrichment	RAD51C	1.58
259	Inflammatory bowel disease 1	Enrichment	ERCC2	1.57
260	Hypotrichosis simplex	Enrichment	ERCC2	1.57
261	Arteriovenous malformation	Enrichment	CCNH	1.55
262	Type 2 diabetes mellitus	Enrichment	WRN	1.52
263	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	1.50
264	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.46
265	Pilomatrixoma	Enrichment	MUTYH	1.46
266	Developmental and epileptic encephalopathy 12	Enrichment	PNKP	1.46
267	Vacterl association	Enrichment	FANCL	1.46
268	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.46
269	Cerebral palsy	Enrichment	BRCA2	1.43
270	Parkinson's disease	Enrichment	RFC1	1.41
271	Williams-beuren syndrome	Enrichment	RFC2	1.39
272	Moebius syndrome	Enrichment	REV3L	1.37
273	Vater/vacterl association	Enrichment	FANCL	1.37
274	Von hippel-lindau syndrome	Enrichment	FANCD2	1.37
275	Familial adenomatous polyposis 1	Enrichment	MUTYH	1.37
276	Corpus callosum, agenesis of	Enrichment	ERCC2	1.35
277	Isolated corpus callosum agenesis	Enrichment	ERCC2	1.35
278	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	1.35
279	Parkinson disease, late-onset	Enrichment	RFC1	1.31
280	Periventricular nodular heterotopia	Enrichment	BRCA1	1.26
281	Leukodystrophy	Enrichment	ERCC2	1.23
282	Mitochondrial dna depletion syndrome 4a	Enrichment	FANCI	1.22
283	Hereditary clear cell renal cell carcinoma	Enrichment	OGG1	1.22
284	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	ERCC8	1.12
285	Spastic ataxia	Enrichment	ERCC4	0.98
286	Microcephaly	Enrichment	NBN	0.95
287	Seckel syndrome	Enrichment	ATR	0.94
288	Male infertility with spermatogenesis disorder	Enrichment	FANCM	0.91
289	Isolated congenital microcephaly	Enrichment	PNKP	0.88
290	Melanoma, cutaneous malignant 1	Enrichment	MGMT	0.86
291	Early infantile developmental and epileptic encephalopathy	Enrichment	PNKP	0.83
292	Azoospermia	Enrichment	FANCM	0.79
293	Congenital nervous system abnormality	Enrichment	ERCC8	0.70
294	Nervous system disease	Enrichment	ERCC8	0.70
295	Leukemia, acute myeloid	Enrichment	FANCD2	0.53
296	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FANCM	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DNA repair pathways, full network

Pathway Network for DNA repair pathways, full network

Pathway network for the DNA repair pathways, full network SuperPath

Member Pathways for DNA repair pathways, full network

Pathways in the DNA repair pathways, full network SuperPath

Gene overlap in member pathways for DNA repair pathways, full network SuperPath

Associated Genes for DNA repair pathways, full network

Associated Disorders for DNA repair pathways, full network

Disorders associated with DNA repair pathways, full network SuperPath

STRING Interaction Network for DNA repair pathways, full network

Sources for DNA repair pathways, full network