Dopaminergic neurogenesis

No Pathway Network information available for Dopaminergic neurogenesis

Pathways in the Dopaminergic neurogenesis SuperPath

#	Name	Source	Genes
1	Dopaminergic neurogenesis	WikiPathways	ALDH1A1 ASCL1 CDKN1C DDC EN1 EN2 FGF8 FOXA2 GBX2 GLI1 GLI2 LMX1A LMX1B MSX1 NEUROD1 NEUROG2 NKX2-2 NKX6-1 NR4A2 OTX2 PITX3 RET SHH SLC18A2 SLC6A3 SOX2 STAT3 TGFB1 TH WNT1 (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	WNT1	Wnt Family Member 1	Protein Coding	1
2	TH	Tyrosine Hydroxylase	Protein Coding	1
3	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
4	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
5	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
6	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	1
7	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	1
8	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
9	RET	Ret Proto-Oncogene	Protein Coding	1
10	PITX3	Paired Like Homeodomain 3	Protein Coding	1
11	OTX2	Orthodenticle Homeobox 2	Protein Coding	1
12	NR4A2	Nuclear Receptor Subfamily 4 Group A Member 2	Protein Coding	1
13	NKX6-1	NK6 Homeobox 1	Protein Coding	1
14	NEUROD1	Neuronal Differentiation 1	Protein Coding	1
15	MSX1	Msh Homeobox 1	Protein Coding	1
16	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	1
17	LMX1B	LIM Homeobox Transcription Factor 1 Beta	Protein Coding	1
18	LMX1A	LIM Homeobox Transcription Factor 1 Alpha	Protein Coding	1
19	FOXA2	Forkhead Box A2	Protein Coding	1
20	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
21	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
22	GBX2	Gastrulation Brain Homeobox 2	Protein Coding	1
23	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
24	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
25	EN2	Engrailed Homeobox 2	Protein Coding	1
26	EN1	Engrailed Homeobox 1	Protein Coding	1
27	DDC	Dopa Decarboxylase	Protein Coding	1
28	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	1
29	NEUROG2	Neurogenin 2	Protein Coding	1
30	NKX2-2	NK2 Homeobox 2	Protein Coding	1

Disorders associated with Dopaminergic neurogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Combined pituitary hormone deficiency	Enrichment	FOXA2, GLI2, OTX2	6.27
2	Septooptic dysplasia	Enrichment	OTX2, SHH, SOX2	5.67
3	Septopreoptic holoprosencephaly	Enrichment	FGF8, GLI2, SHH	5.36
4	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8, GLI2, SHH	5.36
5	Microform holoprosencephaly	Enrichment	FGF8, GLI2, SHH	5.27
6	Lobar holoprosencephaly	Enrichment	FGF8, GLI2, SHH	5.27
7	Alobar holoprosencephaly	Enrichment	FGF8, GLI2, SHH	5.19
8	Semilobar holoprosencephaly	Enrichment	FGF8, GLI2, SHH	5.11
9	Macs syndrome	Enrichment	OTX2, SHH, SOX2	4.96
10	Haddad syndrome	Enrichment	ASCL1, RET	4.55
11	Nanophthalmos	Enrichment	OTX2, SOX2	3.59
12	Microphthalmia	Enrichment	OTX2, SOX2	2.97
13	Holoprosencephaly 3	Enrichment	SHH	2.66
14	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.66
15	Focal segmental glomerulosclerosis 10	Enrichment	LMX1B	2.66
16	Maturity-onset diabetes of the young, type 6	Enrichment	NEUROD1	2.66
17	Nail-patella syndrome	Enrichment	LMX1B	2.66
18	Microphthalmia/coloboma 5	Enrichment	SHH	2.66
19	Polydactyly, preaxial i	Enrichment	GLI1	2.66
20	Culler-jones syndrome	Enrichment	GLI2	2.66
21	Endove syndrome, limb-brain type	Enrichment	EN1	2.66
22	Polydactyly, postaxial, type a8	Enrichment	GLI1	2.66
23	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.66
24	Microphthalmia, syndromic 5	Enrichment	OTX2	2.66
25	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.66
26	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	2.66
27	Holoprosencephaly 9	Enrichment	GLI2	2.66
28	Pituitary hormone deficiency, combined, 6	Enrichment	OTX2	2.66
29	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	2.66
30	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.66
31	Lipoid nephrosis	Enrichment	LMX1B	2.66
32	Intellectual developmental disorder with language impairment and early-onset dopa-responsive dystonia-parkinsonism	Enrichment	NR4A2	2.66
33	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	2.66
34	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	2.66
35	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.66
36	Thyroid cancer	Enrichment	RET	2.66
37	Congenital cataract-anterior segment dysgenesis syndrome	Enrichment	PITX3	2.66
38	Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome	Enrichment	CDKN1C	2.66
39	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	2.66
40	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.66
41	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.66
42	Gastrointestinal system disease	Enrichment	RET	2.66
43	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.66
44	Multiple endocrine neoplasia	Enrichment	RET	2.66
45	Camurati-engelmann disease 1	Enrichment	TGFB1	2.35
46	Agnathia-otocephaly complex	Enrichment	OTX2	2.35
47	Cataract 11, multiple types	Enrichment	PITX3	2.35
48	Anterior segment dysgenesis 1	Enrichment	PITX3	2.35
49	Segawa syndrome, autosomal recessive	Enrichment	TH	2.35
50	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.35
51	Solitary median maxillary central incisor	Enrichment	SHH	2.35
52	Orofacial cleft 5	Enrichment	MSX1	2.35
53	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	CDKN1C	2.35
54	White-sutton syndrome	Enrichment	GLI2	2.35
55	Witkop syndrome	Enrichment	MSX1	2.35
56	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.35
57	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.35
58	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.35
59	Camurati-engelmann disease	Enrichment	TGFB1	2.35
60	Deafness, autosomal dominant 7	Enrichment	LMX1A	2.35
61	Medullary thyroid carcinoma	Enrichment	RET	2.35
62	9q33.3q34.11 microdeletion syndrome	Enrichment	LMX1B	2.35
63	Postaxial polydactyly type b	Enrichment	GLI1	2.35
64	Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion	Enrichment	NR4A2	2.35
65	Isolated radial hemimelia	Enrichment	SHH	2.35
66	Sensorineural hearing loss	Enrichment	LMX1A, RET	2.30
67	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.18
68	Dystonia, dopa-responsive	Enrichment	TH	2.18
69	Thyroid carcinoma, familial medullary	Enrichment	RET	2.18
70	Syndactyly, type iv	Enrichment	SHH	2.18
71	Osteoporosis, juvenile	Enrichment	WNT1	2.18
72	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.18
73	Hyper ige syndrome	Enrichment	STAT3	2.18
74	Gingival overgrowth	Enrichment	RET	2.18
75	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.18
76	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	NR4A2	2.18
77	Butterfly-shaped pigment dystrophy	Enrichment	OTX2	2.18
78	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, GLI2	2.17
79	Polydactyly, preaxial ii	Enrichment	SHH	2.05
80	Microphthalmia, syndromic 3	Enrichment	SOX2	2.05
81	Schizencephaly	Enrichment	SHH	2.05
82	Developmental and epileptic encephalopathy 4	Enrichment	LMX1B	2.05
83	Tobacco addiction	Enrichment	SLC6A3	2.05
84	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	2.05
85	Silver-russell syndrome due to a point mutation	Enrichment	CDKN1C	2.05
86	Cleft lip and alveolus	Enrichment	MSX1	2.05
87	Multiple endocrine neoplasia, type iia	Enrichment	RET	1.96
88	Holoprosencephaly	Enrichment	FGF8	1.96
89	Cleft upper lip	Enrichment	MSX1	1.96
90	Holoprosencephaly 1	Enrichment	FGF8	1.88
91	Anxiety	Enrichment	OTX2	1.88
92	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.88
93	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.88
94	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.88
95	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.76
96	Hypothyroidism	Enrichment	RET	1.76
97	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.76
98	Early-onset posterior polar cataract	Enrichment	PITX3	1.76
99	Tooth agenesis, selective, 1	Enrichment	MSX1	1.70
100	Ellis-van creveld syndrome	Enrichment	GLI1	1.70
101	Congenital central hypoventilation syndrome	Enrichment	RET	1.70
102	Renal agenesis, bilateral	Enrichment	RET	1.70
103	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.58
104	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.55
105	Acute promyelocytic leukemia	Enrichment	STAT3	1.55
106	Osteoporosis	Enrichment	WNT1	1.52
107	Pheochromocytoma	Enrichment	RET	1.52
108	Cleft lip/palate	Enrichment	MSX1	1.52
109	46,xy partial gonadal dysgenesis	Enrichment	OTX2	1.52
110	Polydactyly, postaxial, type a1	Enrichment	GLI1	1.49
111	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.49
112	Beckwith-wiedemann syndrome	Enrichment	CDKN1C	1.41
113	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF8	1.41
114	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.38
115	Parkinson's disease	Enrichment	NR4A2	1.38
116	Williams-beuren syndrome	Enrichment	CDKN1C	1.36
117	Maturity-onset diabetes of the young	Enrichment	NEUROD1	1.36
118	Craniosynostosis	Enrichment	GLI2	1.36
119	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.34
120	Hepatocellular carcinoma	Enrichment	RET	1.32
121	Tooth agenesis	Enrichment	MSX1	1.32
122	Brittle bone disorder	Enrichment	WNT1	1.30
123	Kallmann syndrome	Enrichment	FGF8	1.30
124	Parkinson disease, late-onset	Enrichment	NR4A2	1.29
125	Tetralogy of fallot	Enrichment	RET	1.25
126	Rasopathy	Enrichment	DDC	1.25
127	Hirschsprung disease 1	Enrichment	RET	1.21
128	Differentiated thyroid carcinoma	Enrichment	RET	1.21
129	Cystic fibrosis	Enrichment	TGFB1	1.16
130	Dystonia	Enrichment	TH	1.13
131	Epilepsy	Enrichment	NR4A2	1.07
132	Type 2 diabetes mellitus	Enrichment	NEUROD1	1.05
133	Nephrotic syndrome	Enrichment	LMX1B	1.04
134	Hereditary breast carcinoma	Enrichment	RET	1.03
135	Hypertelorism	Enrichment	RET	0.96
136	Autism	Enrichment	SHH	0.83
137	Breast cancer	Enrichment	RET	0.81
138	Colorectal cancer	Enrichment	RET	0.76
139	Leber plus disease	Enrichment	OTX2	0.72
140	Ovarian cancer	Enrichment	RET	0.70
141	Autism spectrum disorder	Enrichment	NR4A2	0.67
142	Complex neurodevelopmental disorder	Enrichment	NR4A2	0.62
143	Inherited cancer-predisposing syndrome	Enrichment	RET	0.59
144	Hereditary retinal dystrophy	Enrichment	NEUROD1	0.32
145	Fundus dystrophy	Enrichment	NEUROD1	0.32

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Dopaminergic neurogenesis

Pathway Network for Dopaminergic neurogenesis

Member Pathways for Dopaminergic neurogenesis

Pathways in the Dopaminergic neurogenesis SuperPath

Associated Genes for Dopaminergic neurogenesis

Associated Disorders for Dopaminergic neurogenesis

Disorders associated with Dopaminergic neurogenesis SuperPath

STRING Interaction Network for Dopaminergic neurogenesis

Sources for Dopaminergic neurogenesis