Downstream signaling in naïve CD8+ T cells

No Pathway Network information available for Downstream signaling in naïve CD8+ T cells

Pathways in the Downstream signaling in naïve CD8+ T cells SuperPath

#	Name	Source	Genes
1	Downstream signaling in naïve CD8+ T cells	PubChem	B2M BRAF CD247 CD3D CD3E CD3G CD8A CD8B EGR1 EGR4 ELK1 EOMES FASLG FOS FOSL1 GZMB HLA-A IFNAR1 IFNAR2 IFNG IL2 IL2RA IL2RB IL2RG JUN JUNB MAP2K1 MAPK3 MAPK8 MAPK9 NFATC1 NFATC2 PIK3CA PRF1 PRKCA PRKCB PRKCE PRKCQ PTPN7 RAF1 STAT4 TNF TNFRSF18 TNFRSF4 TNFRSF9 (see all 45) (see less)
2	Ras signaling in the CD4+ TCR pathway	PubChem	BRAF ELK1 FOS MAP2K1 MAP3K8 MAPK3 PRKCA PRKCB PTPN7 RAF1 (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTPN7	Protein Tyrosine Phosphatase Non-Receptor Type 7	Protein Coding	2
2	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
3	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
4	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
5	PRKCA	Protein Kinase C Alpha	Protein Coding	2
6	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
7	PRKCB	Protein Kinase C Beta	Protein Coding	2
8	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
9	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
10	EGR4	Early Growth Response 4	Protein Coding	1
11	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
12	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
13	CD247	CD247 Molecule	Protein Coding	1
14	EOMES	Eomesodermin	Protein Coding	1
15	PRF1	Perforin 1	Protein Coding	1
16	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	1
17	TNFRSF9	TNF Receptor Superfamily Member 9	Protein Coding	1
18	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
19	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
20	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
21	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
22	CD8A	CD8 Subunit Alpha	Protein Coding	1
23	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
24	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
25	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	1
26	IFNG	Interferon Gamma	Protein Coding	1
27	IL2	Interleukin 2	Protein Coding	1
28	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
29	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
30	CD8B	CD8 Subunit Beta	Protein Coding	1
31	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
32	B2M	Beta-2-Microglobulin	Protein Coding	1
33	FASLG	Fas Ligand	Protein Coding	1
34	EGR1	Early Growth Response 1	Protein Coding	1
35	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
36	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
37	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
38	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
39	GZMB	Granzyme B	Protein Coding	1
40	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
41	TNF	Tumor Necrosis Factor	Protein Coding	1
42	PRKCQ	Protein Kinase C Theta	Protein Coding	1
43	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
44	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	1
45	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
46	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1

Disorders associated with Downstream signaling in naïve CD8+ T cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, IL2RB, STAT4	8.44
2	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, IL2RB, STAT4	8.44
3	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.47
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, RAF1	6.88
5	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, RAF1	6.29
6	Rasopathy	Enrichment	BRAF, MAP2K1, RAF1	6.13
7	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	5.83
8	Lymphoma, non-hodgkin, familial	Enrichment	B2M, BRAF, PRF1	5.72
9	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	5.53
10	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	5.53
11	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	5.53
12	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G	5.39
13	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1, PIK3CA	5.26
14	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	4.99
15	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	4.86
16	Idiopathic aplastic anemia	Enrichment	IFNG, PRF1	3.97
17	Lung cancer	Enrichment	BRAF, FASLG, PIK3CA	3.80
18	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.65
19	Gallbladder cancer	Enrichment	BRAF, PIK3CA	3.65
20	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.42
21	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.32
22	Aplastic anemia	Enrichment	IFNG, PRF1	3.32
23	Lip and oral cavity carcinoma	Enrichment	BRAF, PIK3CA	3.16
24	Noonan syndrome 5	Enrichment	RAF1	3.13
25	Melorheostosis, isolated	Enrichment	MAP2K1	3.13
26	Noonan syndrome 7	Enrichment	BRAF	3.13
27	Leopard syndrome 3	Enrichment	BRAF	3.13
28	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	3.13
29	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.13
30	Lymphangioma	Enrichment	BRAF	3.13
31	Phace association	Enrichment	BRAF	3.13
32	Melorheostosis	Enrichment	MAP2K1	3.13
33	Leopard syndrome 2	Enrichment	RAF1	3.13
34	Trigonitis	Enrichment	RAF1	3.13
35	Syringocystadenoma papilliferum	Enrichment	BRAF	3.13
36	Ganglioglioma	Enrichment	BRAF	3.13
37	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.13
38	Phace syndrome	Enrichment	BRAF	3.13
39	Classic hairy cell leukemia	Enrichment	BRAF	3.13
40	Pulmonic stenosis	Enrichment	BRAF	2.83
41	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	2.82
42	Breast cancer	Enrichment	IL2, JUN, PIK3CA	2.71
43	Ataxia-telangiectasia	Enrichment	BRAF	2.66
44	Tethered spinal cord syndrome	Enrichment	BRAF	2.66
45	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.53
46	Congenital generalized lipodystrophy	Enrichment	FOS	2.53
47	Craniopharyngioma	Enrichment	BRAF	2.53
48	Newborn respiratory distress syndrome	Enrichment	BRAF	2.53
49	Macrodactyly	Enrichment	PIK3CA	2.48
50	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.48
51	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.48
52	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.48
53	Immunodeficiency 16	Enrichment	TNFRSF4	2.48
54	Cowden syndrome 5	Enrichment	PIK3CA	2.48
55	Immunodeficiency 116	Enrichment	CD8A	2.48
56	Immunodeficiency 43	Enrichment	B2M	2.48
57	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.48
58	Immunodeficiency 69	Enrichment	IFNG	2.48
59	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.48
60	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.48
61	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.48
62	Immunodeficiency 18	Enrichment	CD3E	2.48
63	Systemic lupus erythematosus 11	Enrichment	STAT4	2.48
64	Dialysis-related amyloidosis	Enrichment	B2M	2.48
65	Immunodeficiency 25	Enrichment	CD247	2.48
66	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.48
67	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.48
68	Birdshot chorioretinopathy	Enrichment	HLA-A	2.48
69	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.48
70	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.48
71	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.48
72	Immunodeficiency 109 with lymphoproliferation	Enrichment	TNFRSF9	2.48
73	Hypospadias	Enrichment	PIK3CA	2.48
74	Rare venous malformation	Enrichment	PIK3CA	2.48
75	Diaphragmatic eventration	Enrichment	PIK3CA	2.48
76	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.48
77	Immunodeficiency 19	Enrichment	CD3D	2.48
78	Rare combined vascular malformation	Enrichment	PIK3CA	2.48
79	Cavernous lymphangioma	Enrichment	PIK3CA	2.48
80	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.48
81	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.48
82	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.48
83	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.48
84	Macrodactyly of toe	Enrichment	PIK3CA	2.48
85	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	2.48
86	Histiocytoid hemangioma	Enrichment	FOS	2.43
87	Wilms tumor 5	Enrichment	BRAF	2.35
88	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	2.29
89	Noonan syndrome 3	Enrichment	RAF1	2.29
90	Follicular thyroid carcinoma	Enrichment	BRAF	2.29
91	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.18
92	Primary hyperaldosteronism	Enrichment	BRAF	2.18
93	Ventricular septal defect	Enrichment	BRAF	2.18
94	Severe cutaneous adverse reaction	Enrichment	HLA-A	2.18
95	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.18
96	Keratosis, seborrheic	Enrichment	PIK3CA	2.18
97	Immunodeficiency 45	Enrichment	IFNAR2	2.18
98	Noonan syndrome 8	Enrichment	PIK3CA	2.18
99	Immunodeficiency 127	Enrichment	TNF	2.18
100	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.18
101	Immunodeficiency 17	Enrichment	CD3G	2.18
102	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.18
103	Melanoma	Enrichment	BRAF	2.13
104	Systemic lupus erythematosus	Enrichment	STAT4, TNF	2.13
105	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.00
106	Tuberous sclerosis 1	Enrichment	IFNG	2.00
107	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.00
108	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.00
109	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.00
110	Psoriatic arthritis	Enrichment	TNF	2.00
111	Hepatitis c virus	Enrichment	IFNG	2.00
112	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.00
113	Tuberous sclerosis 2	Enrichment	IFNG	2.00
114	Migraine without aura	Enrichment	TNF	2.00
115	Immunodeficiency 44	Enrichment	IFNAR2	2.00
116	Keratoacanthoma	Enrichment	PIK3CA	2.00
117	Lung cancer susceptibility 3	Enrichment	BRAF	1.99
118	Wilms tumor 1	Enrichment	BRAF	1.96
119	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.90
120	Dandy-walker syndrome	Enrichment	BRAF	1.90
121	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.88
122	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.88
123	Hepatitis b	Enrichment	IFNAR2	1.88
124	Cerebrovascular disease	Enrichment	PIK3CA	1.88
125	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.88
126	Cerebral malaria	Enrichment	TNF	1.88
127	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M	1.88
128	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.88
129	Arteriovenous malformations of the brain	Enrichment	BRAF	1.86
130	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.86
131	Capillary malformations, congenital	Enrichment	PIK3CA	1.78
132	Amyloidosis, hereditary systemic 2	Enrichment	B2M	1.78
133	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.78
134	Vascular dementia	Enrichment	TNF	1.78
135	Hemimegalencephaly	Enrichment	PIK3CA	1.78
136	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.76
137	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.70
138	Cowden syndrome 1	Enrichment	PIK3CA	1.70
139	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.70
140	Breast adenocarcinoma	Enrichment	PIK3CA	1.70
141	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.70
142	Differentiated thyroid carcinoma	Enrichment	BRAF	1.67
143	Nevus, epidermal	Enrichment	PIK3CA	1.64
144	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.62
145	Left ventricular noncompaction	Enrichment	RAF1	1.59
146	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.53
147	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.53
148	Cowden syndrome	Enrichment	PIK3CA	1.53
149	Omenn syndrome	Enrichment	IL2RG	1.49
150	Colorectal cancer	Enrichment	BRAF, PIK3CA	1.47
151	Asthma	Enrichment	TNF	1.44
152	Combined immunodeficiency	Enrichment	IL2RG	1.44
153	Ichthyosis	Enrichment	IL2RB	1.44
154	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.44
155	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.44
156	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.42
157	Meningioma	Enrichment	PIK3CA	1.41
158	Myeloma, multiple	Enrichment	BRAF	1.39
159	Alzheimer's disease	Enrichment	TNF	1.37
160	Lynch syndrome	Enrichment	PIK3CA	1.31
161	Human immunodeficiency virus type 1	Enrichment	IFNG	1.24
162	Behcet syndrome	Enrichment	STAT4	1.21
163	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.17
164	Endometrial cancer	Enrichment	PIK3CA	1.17
165	Hepatocellular carcinoma	Enrichment	PIK3CA	1.15
166	Multisystem inflammatory syndrome in children	Enrichment	IFNAR2	1.15
167	Malaria	Enrichment	TNF	1.13
168	Autoinflammatory disease	Enrichment	PRF1	1.12
169	Autism spectrum disorder	Enrichment	MAP2K1	1.11
170	Bladder cancer	Enrichment	PIK3CA	1.04
171	Prostate cancer	Enrichment	PIK3CA	1.04
172	Severe covid-19	Enrichment	HLA-A	1.04
173	Gastric cancer	Enrichment	PIK3CA	0.88
174	Hereditary breast carcinoma	Enrichment	PIK3CA	0.87
175	Hypertelorism	Enrichment	PIK3CA	0.80
176	Ovarian cancer	Enrichment	PIK3CA	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Downstream signaling in naïve CD8+ T cells

Pathway Network for Downstream signaling in naïve CD8+ T cells

Member Pathways for Downstream signaling in naïve CD8+ T cells

Pathways in the Downstream signaling in naïve CD8+ T cells SuperPath

Associated Genes for Downstream signaling in naïve CD8+ T cells

Associated Disorders for Downstream signaling in naïve CD8+ T cells

Disorders associated with Downstream signaling in naïve CD8+ T cells SuperPath

STRING Interaction Network for Downstream signaling in naïve CD8+ T cells

Sources for Downstream signaling in naïve CD8+ T cells