Downstream signaling of activated FGFR2

Pathway network for the Downstream signaling of activated FGFR2 SuperPath

Sources:

Reactome
QIAGEN

Pathways in the Downstream signaling of activated FGFR2 SuperPath

#	Name	Source	Genes
1	Downstream signaling of activated FGFR2	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 FRS3 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 PTPN11 SHC1 SOS1 (see all 30) (see less)
2	Downstream signaling of activated FGFR1	Reactome	FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FLRT1 FLRT2 FLRT3 FRS2 FRS3 GAB1 GRB2 HRAS KL KRAS NRAS PIK3CA PIK3R1 PLCG1 PTPN11 SHC1 SOS1 (see all 31) (see less)
3	Downstream signaling of activated FGFR4	Reactome	FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 FRS2 FRS3 GAB1 GRB2 HRAS KLB KRAS NRAS PIK3CA PIK3R1 PLCG1 PTPN11 SHC1 SOS1 (see all 27) (see less)
4	FRS-mediated FGFR2 signaling	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 FRS3 GRB2 HRAS KRAS NRAS PTPN11 SOS1 (see all 25) (see less)
5	Signaling by NTRK2 (TRKB)	Reactome	BDNF CDK5 CDK5R1 DOCK3 FRS2 FRS3 FYN GAB1 GRB2 GRIN2B HRAS KRAS NRAS NTF3 NTF4 NTRK2 PIK3CA PIK3R1 PLCG1 PTPN11 RAC1 SHC1 SOS1 SRC TIAM1 (see all 25) (see less)
6	Downstream signaling of activated FGFR3	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 FRS3 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 PTPN11 SHC1 SOS1 (see all 25) (see less)
7	FRS-mediated FGFR1 signaling	Reactome	FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FRS2 FRS3 GRB2 HRAS KL KRAS NRAS PTPN11 SOS1 (see all 23) (see less)
8	PI-3K cascade:FGFR2	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 GAB1 GRB2 PIK3CA PIK3R1 PTPN11 (see all 23) (see less)
9	SHC-mediated cascade:FGFR2	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 GRB2 HRAS KRAS NRAS SHC1 SOS1 (see all 23) (see less)
10	FRS-mediated FGFR4 signaling	Reactome	FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 FRS2 FRS3 GRB2 HRAS KLB KRAS NRAS PTPN11 SOS1 (see all 22) (see less)
11	Signaling by FGFR3 in disease	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 SOS1 (see all 22) (see less)
12	SHC-mediated cascade:FGFR1	Reactome	FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 GRB2 HRAS KL KRAS NRAS SHC1 SOS1 (see all 21) (see less)
13	PI-3K cascade:FGFR1	Reactome	FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FRS2 GAB1 GRB2 KL PIK3CA PIK3R1 PTPN11 (see all 21) (see less)
14	PI-3K cascade:FGFR4	Reactome	FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 FRS2 GAB1 GRB2 KLB PIK3CA PIK3R1 PTPN11 (see all 20) (see less)
15	SHC-mediated cascade:FGFR4	Reactome	FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 GRB2 HRAS KLB KRAS NRAS SHC1 SOS1 (see all 20) (see less)
16	FRS-mediated FGFR3 signaling	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 FRS3 GRB2 HRAS KRAS NRAS PTPN11 SOS1 (see all 20) (see less)
17	SHC-mediated cascade:FGFR3	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 GRB2 HRAS KRAS NRAS SHC1 SOS1 (see all 18) (see less)
18	Phospholipase C-mediated cascade; FGFR2	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 PLCG1 (see all 18) (see less)
19	PI-3K cascade:FGFR3	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 GAB1 GRB2 PIK3CA PIK3R1 PTPN11 (see all 18) (see less)
20	Activated point mutants of FGFR2	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 (see all 17) (see less)
21	Phospholipase C-mediated cascade: FGFR1	Reactome	FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 KL PLCG1 (see all 16) (see less)
22	Phospholipase C-mediated cascade; FGFR4	Reactome	FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 KLB PLCG1 (see all 15) (see less)
23	FGFR4 ligand binding and activation	Reactome	FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 KLB (see all 14) (see less)
24	FGFR2c ligand binding and activation	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR2 (see all 13) (see less)
25	Phospholipase C-mediated cascade; FGFR3	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 PLCG1 (see all 13) (see less)
26	Signaling by FGFR4 in disease	Reactome	FGFR4 FRS2 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 SOS1 (see all 11) (see less)
27	Activated NTRK2 signals through FRS2 and FRS3	Reactome	BDNF FRS2 FRS3 GRB2 HRAS KRAS NRAS NTF4 NTRK2 PTPN11 SOS1 (see all 11) (see less)
28	Activated NTRK2 signals through RAS	Reactome	BDNF GRB2 HRAS KRAS NRAS NTF4 NTRK2 SHC1 SOS1 (see all 9) (see less)
29	Activated NTRK2 signals through PI3K	Reactome	BDNF GAB1 GRB2 NTF4 NTRK2 PIK3CA PIK3R1 (see all 7) (see less)
30	Activated NTRK2 signals through FYN	Reactome	BDNF DOCK3 FYN GRIN2B NTRK2 RAC1 SRC (see all 7) (see less)
31	Activated NTRK2 signals through CDK5	Reactome	BDNF CDK5 CDK5R1 NTRK2 RAC1 TIAM1 (see all 6) (see less)
32	NTRK2 activates RAC1	Reactome	BDNF DOCK3 FYN NTRK2 RAC1
33	Activated NTRK2 signals through PLCG1	Reactome	BDNF NTF4 NTRK2 PLCG1
34	FGFR1c and Klotho ligand binding and activation	Reactome	FGF23 FGFR1 KL
35	betaKlotho-mediated ligand binding	Reactome	FGF19 FGFR4 KLB
36	BDNF activates NTRK2 (TRKB) signaling	Reactome	BDNF NTRK2
37	NTF3 activates NTRK2 (TRKB) signaling	Reactome	NTF3 NTRK2
38	NTF4 activates NTRK2 (TRKB) signaling	Reactome	NTF4 NTRK2
39	Inhibition of Ribosome Biogenesis by p19(ARF)	QIAGEN	RAC1
40	FGFR4 mutant receptor activation	Reactome	FGFR4

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGF23	Fibroblast Growth Factor 23	Protein Coding	25
2	FGF1	Fibroblast Growth Factor 1	Protein Coding	24
3	FGF2	Fibroblast Growth Factor 2	Protein Coding	24
4	FGF4	Fibroblast Growth Factor 4	Protein Coding	24
5	FGF8	Fibroblast Growth Factor 8	Protein Coding	24
6	FGF9	Fibroblast Growth Factor 9	Protein Coding	24
7	FGF20	Fibroblast Growth Factor 20	Protein Coding	24
8	FGF17	Fibroblast Growth Factor 17	Protein Coding	24
9	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	22
10	FGF18	Fibroblast Growth Factor 18	Protein Coding	19
11	FGF16	Fibroblast Growth Factor 16	Protein Coding	19
12	FGF5	Fibroblast Growth Factor 5	Protein Coding	18
13	FGF6	Fibroblast Growth Factor 6	Protein Coding	18
14	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	17
15	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	17
16	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	17
17	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	17
18	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	16
19	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	14
20	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	12
21	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	12
22	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	12
23	PLCG1	Phospholipase C Gamma 1	Protein Coding	12
24	FGF3	Fibroblast Growth Factor 3	Protein Coding	11
25	FGF10	Fibroblast Growth Factor 10	Protein Coding	11
26	FGF22	Fibroblast Growth Factor 22	Protein Coding	11
27	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	11
28	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	10
29	SHC1	SHC Adaptor Protein 1	Protein Coding	10
30	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	9
31	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	9
32	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	7
33	KLB	Klotho Beta	Protein Coding	7
34	FGF19	Fibroblast Growth Factor 19	Protein Coding	7
35	FGF7	Fibroblast Growth Factor 7	Protein Coding	6
36	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	6
37	KL	Klotho	Protein Coding	6
38	NTF4	Neurotrophin 4	Protein Coding	6
39	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	6
40	RAC1	Rac Family Small GTPase 1	Protein Coding	5
41	DOCK3	Dedicator Of Cytokinesis 3	Protein Coding	3
42	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
43	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
44	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	2
45	NTF3	Neurotrophin 3	Protein Coding	2
46	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
47	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	2
48	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	2
49	FLRT3	Fibronectin Leucine Rich Transmembrane Protein 3	Protein Coding	1
50	FLRT2	Fibronectin Leucine Rich Transmembrane Protein 2	Protein Coding	1
51	FLRT1	Fibronectin Leucine Rich Transmembrane Protein 1	Protein Coding	1

Disorders associated with Downstream signaling of activated FGFR2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bone development disease	Direct
2	Rasopathy	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	11.57
3	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	11.07
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	10.63
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	10.60
6	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	10.46
7	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	10.11
8	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	9.08
9	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, PTPN11	7.06
10	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, KL	7.01
11	Lung squamous cell carcinoma	Enrichment	FGFR3, KRAS, PIK3CA	6.96
12	Kallmann syndrome	Enrichment	FGF17, FGF8, FGFR1, FLRT3	6.72
13	Bladder cancer	Enrichment	FGFR3, HRAS, KRAS, PIK3CA	6.68
14	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.41
15	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	6.16
16	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	6.14
17	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	5.96
18	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.93
19	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	5.78
20	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	5.75
21	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	5.64
22	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	5.64
23	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.63
24	Spermatocytoma	Enrichment	FGFR3, HRAS	5.30
25	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2	5.30
26	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	5.09
27	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	5.09
28	Pilomyxoid astrocytoma	Enrichment	KRAS, NTRK2	5.09
29	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	5.09
30	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	5.05
31	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.96
32	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.90
33	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.90
34	Holoprosencephaly	Enrichment	FGF8, FGFR1	4.89
35	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1, SRC	4.74
36	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	4.71
37	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	4.67
38	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	4.57
39	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	4.41
40	Lynch syndrome	Enrichment	KRAS, PIK3CA	4.20
41	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, KLB, PTPN11	4.14
42	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	4.13
43	Gastric cancer	Enrichment	FGFR2, KRAS, PIK3CA	3.95
44	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	3.83
45	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	3.83
46	Glaucoma 1, open angle, o	Enrichment	NTF4	3.83
47	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	3.83
48	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	3.81
49	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	3.81
50	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	3.72
51	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	3.70
52	Lung cancer susceptibility 3	Enrichment	FGF10, KRAS	3.69
53	West syndrome	Enrichment	GRIN2B, NTRK2	3.67
54	Osteoglophonic dysplasia	Enrichment	FGFR1	3.66
55	Trigonocephaly 1	Enrichment	FGFR1	3.66
56	Tumoral calcinosis, hyperphosphatemic, familial, 3	Enrichment	KL	3.66
57	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	3.66
58	Hartsfield syndrome	Enrichment	FGFR1	3.66
59	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	3.66
60	Lung cancer	Enrichment	KRAS, PIK3CA	3.53
61	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.53
62	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.52
63	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	3.47
64	Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	Enrichment	DOCK3	3.43
65	Pfeiffer syndrome	Enrichment	FGFR1	3.35
66	Jackson-weiss syndrome	Enrichment	FGFR1	3.35
67	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	3.35
68	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	3.35
69	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	3.35
70	Macrodactyly	Enrichment	PIK3CA	3.29
71	Deafness, autosomal recessive 26	Enrichment	GAB1	3.29
72	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.29
73	Cowden syndrome 5	Enrichment	PIK3CA	3.29
74	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.29
75	Short syndrome	Enrichment	PIK3R1	3.29
76	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.29
77	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.29
78	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.29
79	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.29
80	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.29
81	Hypospadias	Enrichment	PIK3CA	3.29
82	Rare venous malformation	Enrichment	PIK3CA	3.29
83	Diaphragmatic eventration	Enrichment	PIK3CA	3.29
84	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.29
85	Rare combined vascular malformation	Enrichment	PIK3CA	3.29
86	Cavernous lymphangioma	Enrichment	PIK3CA	3.29
87	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.29
88	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.29
89	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.29
90	Macrodactyly of toe	Enrichment	PIK3CA	3.29
91	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	3.29
92	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	3.29
93	Thrombocytopenia 6	Enrichment	SRC	3.29
94	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	3.29
95	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	3.26
96	Endometrial cancer	Enrichment	FGFR2, PIK3CA	3.25
97	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	3.18
98	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	3.18
99	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	3.18
100	Oculoectodermal syndrome	Enrichment	KRAS	3.18
101	Noonan syndrome 4	Enrichment	SOS1	3.18
102	Melanosis, neurocutaneous	Enrichment	NRAS	3.18
103	Noonan syndrome 6	Enrichment	NRAS	3.18
104	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.18
105	Congenital pulmonary airway malformation	Enrichment	KRAS	3.18
106	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.18
107	Neurocutaneous melanocytosis	Enrichment	NRAS	3.18
108	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	3.18
109	Metachondromatosis	Enrichment	PTPN11	3.09
110	Leopard syndrome 1	Enrichment	PTPN11	3.09
111	Malignant astrocytoma	Enrichment	PTPN11	3.09
112	Scoliosis	Enrichment	GRIN2B, PTPN11	3.06
113	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	3.05
114	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	3.02
115	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	3.02
116	Apert syndrome	Enrichment	FGFR2	3.02
117	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	3.02
118	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	3.02
119	Metacarpal 4-5 fusion	Enrichment	FGF16	3.02
120	Familial isolated trichomegaly	Enrichment	FGF5	3.02
121	Multiple synostoses syndrome 3	Enrichment	FGF9	3.02
122	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	3.02
123	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	3.02
124	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	3.02
125	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	3.02
126	Hypochondroplasia	Enrichment	FGFR3	3.02
127	Thanatophoric dysplasia, type i	Enrichment	FGFR3	3.02
128	Muenke syndrome	Enrichment	FGFR3	3.02
129	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	3.02
130	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	3.02
131	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	3.02
132	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	3.02
133	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	3.02
134	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	3.02
135	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	3.02
136	Noonan syndrome 8	Enrichment	PIK3CA	2.99
137	Primary hypereosinophilic syndrome	Enrichment	FGFR1	2.96
138	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	2.93
139	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	2.93
140	Interstitial lung disease specific to childhood	Enrichment	FGF10	2.93
141	Fibromatosis, gingival, 1	Enrichment	SOS1	2.88
142	Costello syndrome	Enrichment	HRAS	2.88
143	Pulmonic stenosis	Enrichment	SOS1	2.88
144	Wooly hair nevus	Enrichment	HRAS	2.88
145	Congenital central hypoventilation syndrome	Enrichment	BDNF	2.88
146	Complex neurodevelopmental disorder	Enrichment	DOCK3, GRIN2B, TIAM1	2.83
147	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.81
148	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.81
149	Immunodeficiency 14	Enrichment	PIK3R1	2.81
150	Keratoacanthoma	Enrichment	PIK3CA	2.81
151	Hypophosphatemic rickets	Enrichment	FGF23	2.81
152	Werner syndrome	Enrichment	PTPN11	2.79
153	Trichomegaly	Enrichment	FGF5	2.72
154	Aural atresia, congenital	Enrichment	FGFR2	2.72
155	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.72
156	Split hand-foot malformation	Enrichment	FGFR2	2.72
157	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.72
158	Cervical cancer	Enrichment	FGFR3	2.72
159	Cervix carcinoma	Enrichment	FGFR3	2.72
160	Nuchal bleb, familial	Enrichment	SOS1	2.70
161	Langerhans cell histiocytosis	Enrichment	NRAS	2.70
162	Hypogonadotropic hypogonadism	Enrichment	FGFR1	2.70
163	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.69
164	Cerebrovascular disease	Enrichment	PIK3CA	2.69
165	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.69
166	Astigmatism	Enrichment	GRIN2B	2.69
167	Otodental dysplasia	Enrichment	FGF3	2.63
168	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.63
169	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	2.63
170	Oculootodental syndrome	Enrichment	FGF3	2.63
171	Tricuspid valve insufficiency	Enrichment	PTPN11	2.61
172	Myeloma, multiple	Enrichment	FGFR3, KRAS	2.61
173	Capillary malformations, congenital	Enrichment	PIK3CA	2.59
174	Hemimegalencephaly	Enrichment	PIK3CA	2.59
175	Sleep disorder	Enrichment	GRIN2B	2.59
176	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.58
177	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.58
178	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.58
179	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.58
180	Pilocytic astrocytoma	Enrichment	KRAS	2.58
181	Epidermolytic nevus	Enrichment	HRAS	2.58
182	Gingival fibromatosis	Enrichment	SOS1	2.58
183	Septooptic dysplasia	Enrichment	FGFR1	2.58
184	Crouzon syndrome	Enrichment	FGFR2	2.54
185	Achondroplasia	Enrichment	FGFR3	2.54
186	Larsen syndrome	Enrichment	FGFR3	2.54
187	Hamartoma	Enrichment	FGFR3	2.54
188	Testicular germ cell cancer	Enrichment	FGFR3	2.54
189	Testicular cancer	Enrichment	FGFR3	2.54
190	Ovarian cancer	Enrichment	KRAS, PIK3CA	2.54
191	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.51
192	Cowden syndrome 1	Enrichment	PIK3CA	2.51
193	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.51
194	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	2.51
195	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.49
196	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.49
197	Hypertelorism	Enrichment	FGFR2, PIK3CA	2.46
198	Thrombocytopenia	Enrichment	PTPN11, SRC	2.46
199	Gliosarcoma	Enrichment	FGFR1	2.45
200	Overgrowth syndrome	Enrichment	PIK3R1	2.44
201	Myelofibrosis	Enrichment	SRC	2.44
202	Giant cell glioblastoma	Enrichment	FGFR1	2.43
203	Saethre-chotzen syndrome	Enrichment	FGFR2	2.42
204	Multiple synostoses syndrome	Enrichment	FGF9	2.42
205	Glioma	Enrichment	FGFR2	2.42
206	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.42
207	Lymphoma	Enrichment	PTPN11	2.39
208	Spastic paraplegia, optic atrophy, and neuropathy	Enrichment	FLRT1	2.34
209	Hypogonadotropic hypogonadism 21 with or without anosmia	Enrichment	FLRT3	2.34
210	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.33
211	Cowden syndrome	Enrichment	PIK3CA	2.33
212	Hemifacial hyperplasia	Enrichment	FGFR2	2.32
213	Patent ductus arteriosus	Enrichment	PTPN11	2.31
214	Tooth agenesis	Enrichment	FGFR1	2.31
215	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	2.29
216	Split-hand/foot malformation 1	Enrichment	FGFR2	2.24
217	Testicular germ cell tumor	Enrichment	FGFR3	2.24
218	46,xy disorder of sex development	Enrichment	FGFR3	2.24
219	Meningioma	Enrichment	PIK3CA	2.21
220	Osteoporosis	Enrichment	SRC	2.14
221	Body mass index quantitative trait locus 11	Enrichment	BDNF	2.13
222	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	2.08
223	Renal agenesis, bilateral	Enrichment	FGF20	2.07
224	Aortic valve disease 1	Enrichment	SOS1	2.07
225	Protein-deficiency anemia	Enrichment	NRAS	2.07
226	Pectus excavatum	Enrichment	PTPN11	2.05
227	Specific learning disability	Enrichment	PTPN11	2.05
228	46,xy partial gonadal dysgenesis	Enrichment	SOS1	2.03
229	Meier-gorlin syndrome 1	Enrichment	FGFR2	2.02
230	Primary bone dysplasia	Enrichment	FGFR3	2.02
231	Epicanthus	Enrichment	PTPN11	2.01
232	Congenital long qt syndrome	Enrichment	PTPN11	2.01
233	Craniosynostosis	Enrichment	GRIN2B	1.99
234	Osteochondrodysplasia	Enrichment	FGFR3	1.98
235	Orofacial cleft 1	Enrichment	FGF10	1.98
236	Rhabdomyosarcoma	Enrichment	HRAS	1.98
237	Hepatocellular carcinoma	Enrichment	PIK3CA	1.95
238	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.94
239	Arteriovenous malformations of the brain	Enrichment	KRAS	1.90
240	Hydrocephalus	Enrichment	FGFR2	1.85
241	Septopreoptic holoprosencephaly	Enrichment	FGF8	1.85
242	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	1.85
243	Patent foramen ovale	Enrichment	PTPN11	1.84
244	Prostate cancer	Enrichment	PIK3CA	1.83
245	Alobar holoprosencephaly	Enrichment	FGF8	1.79
246	Pancreatic cancer	Enrichment	KRAS	1.78
247	Autism spectrum disorder	Enrichment	GRIN2B, PTPN11	1.77
248	Hepatoblastoma	Enrichment	FGFR3	1.70
249	Cerebral palsy	Enrichment	GRIN2B	1.70
250	Epilepsy	Enrichment	GRIN2B	1.69
251	Microcephaly	Enrichment	GRIN2B, PTPN11	1.67
252	Strabismus	Enrichment	PTPN11	1.66
253	Long qt syndrome 1	Enrichment	PTPN11	1.62
254	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIN2B	1.59
255	Connective tissue disease	Enrichment	FGFR3	1.52
256	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.46
257	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.44
258	Congenital nervous system abnormality	Enrichment	FGFR3	1.01
259	Nervous system disease	Enrichment	FGFR3	1.01
260	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Downstream signaling of activated FGFR2

Pathway Network for Downstream signaling of activated FGFR2

Pathway network for the Downstream signaling of activated FGFR2 SuperPath

Member Pathways for Downstream signaling of activated FGFR2

Pathways in the Downstream signaling of activated FGFR2 SuperPath

Associated Genes for Downstream signaling of activated FGFR2

Associated Disorders for Downstream signaling of activated FGFR2

Disorders associated with Downstream signaling of activated FGFR2 SuperPath

STRING Interaction Network for Downstream signaling of activated FGFR2

Sources for Downstream signaling of activated FGFR2