Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

No Pathway Network information available for Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

Pathways in the Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics	PharmGKB	ACO1 AKR1A1 AKR1C3 ATP2A2 ATP5F1A ATP5F1B ATP5F1C ATP5F1CP1 ATP5F1D ATP5F1E ATP5ME ATP5PB ATP5PD CBR1 CBR3 CYBA CYCS NCF4 NOS1 NOS2 NOS3 RAC2 RYR2 TOP2B (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RYR2	Ryanodine Receptor 2	Protein Coding	1
2	RAC2	Rac Family Small GTPase 2	Protein Coding	1
3	TOP2B	DNA Topoisomerase II Beta	Protein Coding	1
4	ATP5PD	ATP Synthase Peripheral Stalk Subunit D	Protein Coding	1
5	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	1
6	CBR1	Carbonyl Reductase 1	Protein Coding	1
7	CBR3	Carbonyl Reductase 3	Protein Coding	1
8	ATP5F1D	ATP Synthase F1 Subunit Delta	Protein Coding	1
9	ATP5F1E	ATP Synthase F1 Subunit Epsilon	Protein Coding	1
10	ATP5PB	ATP Synthase Peripheral Stalk-Membrane Subunit B	Protein Coding	1
11	ATP5ME	ATP Synthase Membrane Subunit E	Protein Coding	1
12	ACO1	Aconitase 1	Protein Coding	1
13	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
14	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
15	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
16	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	1
17	ATP5F1A	ATP Synthase F1 Subunit Alpha	Protein Coding	1
18	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	1
19	ATP5F1B	ATP Synthase F1 Subunit Beta	Protein Coding	1
20	ATP5F1C	ATP Synthase F1 Subunit Gamma	Protein Coding	1
21	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	1
22	CYCS	Cytochrome C, Somatic	Protein Coding	1
23	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
24	ATP5F1CP1	ATP Synthase F1 Subunit Gamma Pseudogene 1	Pseudogene	1

Disorders associated with Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Isolated atp synthase deficiency	Enrichment	ATP5F1A, ATP5F1D, ATP5F1E	6.57
2	Chronic granulomatous disease	Enrichment	CYBA, NCF4	3.97
3	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.75
4	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.75
5	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.75
6	B-cell immunodeficiency, distal limb anomalies, and urogenital malformations	Enrichment	TOP2B	2.75
7	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.75
8	Mitochondrial complex v deficiency, nuclear type 4b	Enrichment	ATP5F1A	2.75
9	Thrombocytopenia 4	Enrichment	CYCS	2.75
10	Combined oxidative phosphorylation deficiency 22	Enrichment	ATP5F1A	2.75
11	Mitochondrial complex v deficiency, nuclear type 4a	Enrichment	ATP5F1A	2.75
12	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.75
13	Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2	Enrichment	ATP5F1B	2.75
14	Rhabdomyolysis 2	Enrichment	ATP2A2	2.75
15	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.75
16	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.75
17	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.75
18	Acrokeratosis verruciformis	Enrichment	ATP2A2	2.45
19	Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome	Enrichment	RYR2	2.45
20	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	2.45
21	Ventricular tachycardia, catecholaminergic polymorphic, 2	Enrichment	RYR2	2.45
22	Darier-white disease	Enrichment	ATP2A2	2.28
23	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	2.28
24	Mitochondrial complex iv deficiency, nuclear type 5	Enrichment	ATP5F1A	2.28
25	Retinitis pigmentosa 40	Enrichment	ATP5ME	2.28
26	Mitochondrial complex v deficiency, nuclear type 5	Enrichment	ATP5F1D	2.28
27	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	2.28
28	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	RYR2	2.15
29	Mitochondrial complex v deficiency, nuclear type 3	Enrichment	ATP5F1E	2.15
30	Idiopathic achalasia	Enrichment	NOS1	2.15
31	Paroxysmal familial ventricular fibrillation	Enrichment	RYR2	2.15
32	Alzheimer disease 2	Enrichment	NOS3	2.05
33	Albinism, oculocutaneous, type ii	Enrichment	ATP5ME	2.05
34	Pre-eclampsia	Enrichment	NOS3	2.05
35	Heart conduction disease	Enrichment	RYR2	2.05
36	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	2.05
37	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	RYR2	1.98
38	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	RYR2	1.85
39	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	RYR2	1.85
40	Stroke, ischemic	Enrichment	NOS3	1.76
41	Cardiac conduction defect	Enrichment	RYR2	1.68
42	Lactic acidosis	Enrichment	ATP5F1A	1.68
43	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	RYR2	1.68
44	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	RYR2	1.68
45	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	RYR2	1.61
46	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	RYR2	1.55
47	Alzheimer disease, familial, 1	Enrichment	NOS3	1.53
48	Hypertension, essential	Enrichment	NOS3	1.53
49	Malaria	Enrichment	NOS2	1.40
50	Long qt syndrome	Enrichment	RYR2	1.27
51	Left ventricular noncompaction	Enrichment	RYR2	1.22
52	Thrombocytopenia	Enrichment	CYCS	1.09
53	Primary ovarian insufficiency	Enrichment	NOS3	1.00
54	Mitochondrial disease	Enrichment	ATP5F1D	0.84
55	Autism spectrum disorder	Enrichment	TOP2B	0.75
56	Retinitis pigmentosa	Enrichment	ATP5ME	0.50
57	Hereditary retinal dystrophy	Enrichment	ATP5ME	0.39
58	Fundus dystrophy	Enrichment	ATP5ME	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

Pathway Network for Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

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Pathways in the Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics SuperPath

Associated Genes for Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

Associated Disorders for Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

Disorders associated with Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics SuperPath

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