Doxorubicin Pathway, Pharmacokinetics

No Pathway Network information available for Doxorubicin Pathway, Pharmacokinetics

Pathways in the Doxorubicin Pathway, Pharmacokinetics SuperPath

#	Name	Source	Genes
1	Doxorubicin Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC1 ABCC2 ABCG2 AKR1A1 AKR1C3 CAT CBR1 CBR3 GPX1 NDUFS2 NDUFS3 NDUFS7 NOS1 NOS2 NOS3 NQO1 POR RALBP1 SLC22A16 SOD1 XDH (see all 22) (see less)
2	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics	PharmGKB	ABCB1 ABCC1 ABCC2 ABCG2 CAT ERCC2 GPX1 MLH1 MSH2 NFKB1 NOS3 NQO1 RALBP1 SLC22A16 SOD1 TOP2A TP53 XDH (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	XDH	Xanthine Dehydrogenase	Protein Coding	2
2	GPX1	Glutathione Peroxidase 1	Protein Coding	2
3	SOD1	Superoxide Dismutase 1	Protein Coding	2
4	RALBP1	RalA Binding Protein 1	Protein Coding	2
5	CAT	Catalase	Protein Coding	2
6	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
7	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	2
8	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	2
9	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	2
10	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	2
11	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2
12	SLC22A16	Solute Carrier Family 22 Member 16	Protein Coding	2
13	POR	Cytochrome P450 Oxidoreductase	Protein Coding	1
14	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	1
15	CBR1	Carbonyl Reductase 1	Protein Coding	1
16	CBR3	Carbonyl Reductase 3	Protein Coding	1
17	NDUFS2	NADH:Ubiquinone Oxidoreductase Core Subunit S2	Protein Coding	1
18	NDUFS3	NADH:Ubiquinone Oxidoreductase Core Subunit S3	Protein Coding	1
19	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
20	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	1
21	NDUFS7	NADH:Ubiquinone Oxidoreductase Core Subunit S7	Protein Coding	1
22	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
23	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	1
24	TP53	Tumor Protein P53	Protein Coding	1
25	MLH1	MutL Homolog 1	Protein Coding	1
26	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
27	MSH2	MutS Homolog 2	Protein Coding	1
28	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	1

Disorders associated with Doxorubicin Pathway, Pharmacokinetics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial colorectal cancer	Enrichment	MLH1, MSH2, TP53	6.63
2	Muir-torre syndrome	Enrichment	MLH1, MSH2	5.78
3	Hepatoblastoma	Enrichment	ERCC2, MSH2, TP53	5.59
4	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2	5.00
5	Gastric cancer	Enrichment	MLH1, MSH2, TP53	4.63
6	Hereditary breast carcinoma	Enrichment	MLH1, MSH2, TP53	4.60
7	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NDUFS2, NDUFS3, NDUFS7	4.52
8	Hereditary breast ovarian cancer syndrome	Enrichment	MLH1, MSH2, TP53	4.31
9	Lynch syndrome 1	Enrichment	MLH1, MSH2	4.13
10	Breast cancer	Enrichment	MLH1, MSH2, TP53	3.90
11	Lynch syndrome	Enrichment	MLH1, MSH2	3.76
12	Colorectal cancer	Enrichment	MLH1, MSH2, TP53	3.71
13	Rhabdomyosarcoma	Enrichment	MSH2, TP53	3.70
14	Gliosarcoma	Enrichment	MSH2, TP53	3.70
15	Giant cell glioblastoma	Enrichment	MSH2, TP53	3.65
16	Ovarian cancer	Enrichment	ERCC2, MSH2, TP53	3.52
17	Endometrial cancer	Enrichment	MLH1, MSH2	3.46
18	Inherited cancer-predisposing syndrome	Enrichment	MLH1, MSH2, TP53	3.18
19	Bladder cancer	Enrichment	ERCC2, TP53	3.18
20	Colchicine resistance	Enrichment	ABCB1	2.88
21	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.88
22	Encephalopathy, acute transient	Enrichment	ABCB1	2.88
23	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.88
24	Bone marrow failure syndrome 5	Enrichment	TP53	2.88
25	Papilloma of choroid plexus	Enrichment	TP53	2.88
26	Basal cell carcinoma 7	Enrichment	TP53	2.88
27	Lynch syndrome 2	Enrichment	MLH1	2.88
28	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	2.88
29	Anaplastic thyroid carcinoma	Enrichment	TP53	2.88
30	Inflammatory bowel disease 13	Enrichment	ABCB1	2.88
31	Acatalasemia	Enrichment	CAT	2.88
32	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	2.88
33	Glutathione peroxidase deficiency	Enrichment	GPX1	2.88
34	Ductal carcinoma in situ	Enrichment	TP53	2.88
35	Blood group, junior system	Enrichment	ABCG2	2.88
36	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.88
37	Rectal benign neoplasm	Enrichment	MSH2	2.88
38	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.88
39	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.88
40	Ascending colon cancer	Enrichment	MSH2	2.88
41	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.88
42	Choroid plexus cancer	Enrichment	TP53	2.88
43	Ovarian cyst	Enrichment	MSH2	2.88
44	Xeroderma pigmentosum group d	Enrichment	ERCC2	2.88
45	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.88
46	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.79
47	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	2.79
48	Mitochondrial complex i deficiency, nuclear type 8	Enrichment	NDUFS3	2.79
49	Mitochondrial complex i deficiency, nuclear type 6	Enrichment	NDUFS2	2.79
50	Leber-like hereditary optic neuropathy, autosomal recessive 2	Enrichment	NDUFS2	2.79
51	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.58
52	Cervical cancer	Enrichment	TP53	2.58
53	Xanthinuria, type i	Enrichment	XDH	2.58
54	Lymphoma, hodgkin, classic	Enrichment	TP53	2.58
55	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.58
56	Congenital fibrosarcoma	Enrichment	TP53	2.58
57	Li-fraumeni syndrome 1	Enrichment	TP53	2.58
58	Sarcoma	Enrichment	TP53	2.58
59	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.58
60	Cervix carcinoma	Enrichment	TP53	2.58
61	Hodgkin's lymphoma	Enrichment	TP53	2.58
62	Common variable immunodeficiency 12	Enrichment	NFKB1	2.58
63	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.58
64	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	2.49
65	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	2.49
66	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.49
67	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.49
68	Dubin-johnson syndrome	Enrichment	ABCC2	2.40
69	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	2.40
70	Osteogenic sarcoma	Enrichment	TP53	2.40
71	Nasopharyngeal carcinoma	Enrichment	TP53	2.40
72	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.40
73	Anaplastic astrocytoma	Enrichment	TP53	2.40
74	Xanthinuria, type ii	Enrichment	XDH	2.40
75	Squamous cell carcinoma	Enrichment	TP53	2.40
76	Cellular ependymoma	Enrichment	MSH2	2.40
77	Tanycytic ependymoma	Enrichment	MSH2	2.40
78	Papillary ependymoma	Enrichment	MSH2	2.40
79	Adenocarcinoma	Enrichment	TP53	2.40
80	Bone osteosarcoma	Enrichment	TP53	2.40
81	Clear cell ependymoma	Enrichment	MSH2	2.40
82	Primary ovarian insufficiency	Enrichment	NOS3, POR	2.39
83	Mitochondrial complex iii deficiency, nuclear type 1	Enrichment	NDUFS7	2.31
84	Small cell cancer of the lung	Enrichment	TP53	2.28
85	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.28
86	Lynch syndrome 4	Enrichment	MSH2	2.28
87	Lung sarcomatoid carcinoma	Enrichment	TP53	2.28
88	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.28
89	Craniopharyngioma	Enrichment	ERCC2	2.28
90	Benign ependymoma	Enrichment	MSH2	2.28
91	Idiopathic achalasia	Enrichment	NOS1	2.19
92	Alzheimer disease 2	Enrichment	NOS3	2.18
93	Rhabdomyosarcoma 2	Enrichment	TP53	2.18
94	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	2.18
95	Pre-eclampsia	Enrichment	NOS3	2.18
96	Lymphoma	Enrichment	TP53	2.18
97	Glioblastoma	Enrichment	MSH2	2.18
98	Acute megakaryocytic leukemia	Enrichment	TP53	2.18
99	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2	2.18
100	Li-fraumeni syndrome	Enrichment	TP53	2.10
101	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC2	2.10
102	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.10
103	Adrenocortical carcinoma	Enrichment	TP53	2.10
104	Breast adenocarcinoma	Enrichment	TP53	2.10
105	Esophageal cancer	Enrichment	TP53	2.03
106	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.03
107	Essential thrombocythemia	Enrichment	TP53	2.03
108	Motor neuron disease	Enrichment	SOD1	2.03
109	Gallbladder cancer	Enrichment	TP53	2.03
110	Common variable immunodeficiency	Enrichment	NFKB1	2.03
111	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.03
112	Glioma susceptibility 1	Enrichment	TP53	1.98
113	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.98
114	Inflammatory bowel disease 1	Enrichment	ERCC2	1.93
115	Adult hepatocellular carcinoma	Enrichment	TP53	1.93
116	Primary hyperaldosteronism	Enrichment	TP53	1.93
117	Colonic benign neoplasm	Enrichment	MLH1	1.93
118	Hypotrichosis simplex	Enrichment	ERCC2	1.93
119	Trichothiodystrophy	Enrichment	ERCC2	1.93
120	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.88
121	Leukemia, chronic lymphocytic	Enrichment	TP53	1.88
122	Stroke, ischemic	Enrichment	NOS3	1.88
123	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.88
124	Xeroderma pigmentosum, variant type	Enrichment	ERCC2	1.84
125	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.84
126	Myelodysplastic syndrome	Enrichment	TP53	1.84
127	Uterine corpus cancer	Enrichment	MSH2	1.84
128	Lip and oral cavity carcinoma	Enrichment	TP53	1.80
129	Breast-ovarian cancer, familial 1	Enrichment	MSH2	1.77
130	Lung cancer susceptibility 3	Enrichment	TP53	1.73
131	Corpus callosum, agenesis of	Enrichment	ERCC2	1.70
132	Isolated corpus callosum agenesis	Enrichment	ERCC2	1.70
133	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	1.70
134	Alzheimer disease, familial, 1	Enrichment	NOS3	1.65
135	Hypertension, essential	Enrichment	NOS3	1.65
136	Lipoid congenital adrenal hyperplasia	Enrichment	POR	1.65
137	Diffuse large b-cell lymphoma	Enrichment	TP53	1.60
138	Leukodystrophy	Enrichment	ERCC2	1.58
139	Hepatocellular carcinoma	Enrichment	TP53	1.54
140	Diamond-blackfan anemia 1	Enrichment	TP53	1.52
141	Pancreatic cancer	Enrichment	TP53	1.49
142	Malaria	Enrichment	NOS2	1.44
143	Prostate cancer	Enrichment	TP53	1.42
144	Lung cancer	Enrichment	MLH1	1.38
145	Diamond-blackfan anemia	Enrichment	TP53	1.33
146	Leukemia, acute myeloid	Enrichment	TP53	1.29
147	Leber hereditary optic neuropathy, modifier of	Enrichment	NDUFS2	1.23
148	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.17
149	Myeloma, multiple	Enrichment	TP53	1.14
150	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	1.13
151	Leigh syndrome, nuclear	Enrichment	NDUFS7	0.97
152	Leigh disease	Enrichment	NDUFS7	0.93
153	Leber plus disease	Enrichment	NDUFS2	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Doxorubicin Pathway, Pharmacokinetics

Pathway Network for Doxorubicin Pathway, Pharmacokinetics

Member Pathways for Doxorubicin Pathway, Pharmacokinetics

Pathways in the Doxorubicin Pathway, Pharmacokinetics SuperPath

Associated Genes for Doxorubicin Pathway, Pharmacokinetics

Associated Disorders for Doxorubicin Pathway, Pharmacokinetics

Disorders associated with Doxorubicin Pathway, Pharmacokinetics SuperPath

STRING Interaction Network for Doxorubicin Pathway, Pharmacokinetics

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