DREAM Repression and Dynorphin Expression

Pathway network for the DREAM Repression and Dynorphin Expression SuperPath

Sources:

QIAGEN
WikiPathways
Reactome

Pathways in the DREAM Repression and Dynorphin Expression SuperPath

#	Name	Source	Genes
1	DREAM Repression and Dynorphin Expression	QIAGEN	ATF4 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CREB1 CREB3 CREB3L4 CREM FOS JUN KCNIP3 MAPK1 MAPK3 OPRK1 PDYN POLR2A POLR2B POLR2C PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B (see all 48) (see less)
2	Calpain Protease Regulates Cellular Mechanics	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CAPN1 CAPN10 CAPN11 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN9 CAPNS1 CAST CCNA1 CCNA2 CCNB1 CCNB2 CCNB3 CCND1 CCND2 CCND3 CCNE1 CDK1 CDK2 CDK4 CDK6 CDKN1B EGF EGFR EZR GRB2 HRAS ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 KRAS MAPK1 MAPK12 MAPK3 MAPK6 MAPK7 MRAS NRAS PLPP3 PTK2 PTK2B PXN RB1 RRAS RRAS2 SRC TLN1 TLN2 VCL (see all 106) (see less)
3	Caspase Cascade	QIAGEN	APAF1 ARHGDIB BAD BID BIRC2 BIRC3 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CAPN1 CAPN10 CAPN11 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN9 CAPNS1 CASP1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CRADD CYCS DAXX DFFA DIABLO FADD FAS FASLG GRB10 GRB14 GRB2 GRB7 GZMB LMNA LMNB1 LMNB2 LTA MAP3K14 MAPK10 MAPK8 MAPK9 NCK2 NFKB1 PAK1 PARP1 PRF1 PRKDC RB1 RIPK2 SMPD1 SMPD2 SMPD3 TNF TNFRSF1A TNFRSF1B TRADD TRAF2 (see all 87) (see less)
4	BMP Pathway	QIAGEN	ACVR1 ACVR2B ACVRL1 ATF2 ATF4 BMP2 BMP3 BMP4 BMP7 BMPR1A BMPR1B BMPR2 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CAMK4 CREB1 CREB3 CREB3L4 CREBBP EP300 FOS FOXH1 GATA1 GATA2 GATA3 GATA4 GATA5 GATA6 JUN MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 NFKB1 NKX2-5 OAZ1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B SMAD1 SMAD4 SMAD5 SMAD9 STAT3 TAB1 TAB2 (see all 78) (see less)
5	Arrhythmogenic right ventricular cardiomyopathy	WikiPathways	ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 ATP2A2 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CDH2 CTNNA1 CTNNA2 CTNNA3 CTNNB1 DAG1 DES DMD DSC2 DSG2 DSP EMD GJA1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JUP LAMA2 LEF1 LMNA PKP2 RYR2 SGCA SGCB SGCD SGCG SLC8A1 TCF7 TCF7L1 TCF7L2 (see all 74) (see less)
6	nNOS Signaling in Skeletal Muscle	QIAGEN	CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 CAPN1 CAPN10 CAPN11 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN9 CAPNS1 CHRNA1 DAG1 DMD NOS1 RYR1 RYR2 RYR3 SNTA1 SNTB1 (see all 48) (see less)
7	TOB in Osteoblast Signaling	QIAGEN	ATF4 BMP2 BMPR1A BMPR1B BMPR2 CREB1 CREB3 CREB3L4 CREBBP EP300 SMAD1 SMAD4 SMAD5 SMAD9 TOB1 (see all 15) (see less)
8	Presynaptic depolarization and calcium channel opening	Reactome	CACNA1A CACNA1B CACNA1E CACNA2D1 CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4 (see all 12) (see less)

Gene overlap in member pathways for DREAM Repression and Dynorphin Expression SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	7
2	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	7
3	CACNA2D3	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3	Protein Coding	7
4	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	7
5	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	7
6	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	7
7	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	7
8	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	7
9	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	7
10	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	6
11	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	6
12	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	6
13	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	6
14	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	6
15	CACNA1F	Calcium Voltage-Gated Channel Subunit Alpha1 F	Protein Coding	6
16	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	6
17	CACNA2D4	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4	Protein Coding	6
18	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	6
19	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	6
20	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	6
21	CACNG6	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 6	Protein Coding	6
22	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	6
23	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	6
24	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	5
25	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	5
26	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	5
27	ATF4	Activating Transcription Factor 4	Protein Coding	3
28	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	3
29	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	3
30	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	3
31	CAPN1	Calpain 1	Protein Coding	3
32	CAPN10	Calpain 10	Protein Coding	3
33	CAPN11	Calpain 11	Protein Coding	3
34	CAPN2	Calpain 2	Protein Coding	3
35	CAPN3	Calpain 3	Protein Coding	3
36	CAPN5	Calpain 5	Protein Coding	3
37	CAPN6	Calpain 6	Protein Coding	3
38	CAPN7	Calpain 7	Protein Coding	3
39	CAPN9	Calpain 9	Protein Coding	3
40	CAPNS1	Calpain Small Subunit 1	Protein Coding	3
41	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
42	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
43	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
44	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
45	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
46	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
47	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
48	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	2
49	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	2
50	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	2
51	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	2
52	ACTB	Actin Beta	Protein Coding	2
53	ACTG1	Actin Gamma 1	Protein Coding	2
54	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
55	ITGA1	Integrin Subunit Alpha 1	Protein Coding	2
56	ITGA10	Integrin Subunit Alpha 10	Protein Coding	2
57	ITGA11	Integrin Subunit Alpha 11	Protein Coding	2
58	ITGA2	Integrin Subunit Alpha 2	Protein Coding	2
59	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	2
60	ITGA3	Integrin Subunit Alpha 3	Protein Coding	2
61	ITGA4	Integrin Subunit Alpha 4	Protein Coding	2
62	ITGA5	Integrin Subunit Alpha 5	Protein Coding	2
63	ITGA6	Integrin Subunit Alpha 6	Protein Coding	2
64	ITGA7	Integrin Subunit Alpha 7	Protein Coding	2
65	ITGA8	Integrin Subunit Alpha 8	Protein Coding	2
66	ITGA9	Integrin Subunit Alpha 9	Protein Coding	2
67	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
68	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
69	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
70	ITGB4	Integrin Subunit Beta 4	Protein Coding	2
71	ITGB5	Integrin Subunit Beta 5	Protein Coding	2
72	ITGB6	Integrin Subunit Beta 6	Protein Coding	2
73	ITGB7	Integrin Subunit Beta 7	Protein Coding	2
74	ITGB8	Integrin Subunit Beta 8	Protein Coding	2
75	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
76	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
77	LMNA	Lamin A/C	Protein Coding	2
78	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
79	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
80	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
81	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
82	BMP2	Bone Morphogenetic Protein 2	Protein Coding	2
83	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	2
84	BMPR1B	Bone Morphogenetic Protein Receptor Type 1B	Protein Coding	2
85	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	2
86	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
87	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
88	SMAD1	SMAD Family Member 1	Protein Coding	2
89	SMAD4	SMAD Family Member 4	Protein Coding	2
90	SMAD5	SMAD Family Member 5	Protein Coding	2
91	SMAD9	SMAD Family Member 9	Protein Coding	2
92	RYR2	Ryanodine Receptor 2	Protein Coding	2
93	DMD	Dystrophin	Protein Coding	2
94	DAG1	Dystroglycan 1	Protein Coding	2
95	CREM	CAMP Responsive Element Modulator	Protein Coding	1
96	KCNIP3	Potassium Voltage-Gated Channel Interacting Protein 3	Protein Coding	1
97	OPRK1	Opioid Receptor Kappa 1	Protein Coding	1
98	PDYN	Prodynorphin	Protein Coding	1
99	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
100	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
101	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
102	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
103	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
104	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
105	CAST	Calpastatin	Protein Coding	1
106	CCNA1	Cyclin A1	Protein Coding	1
107	CCNA2	Cyclin A2	Protein Coding	1
108	CCNB1	Cyclin B1	Protein Coding	1
109	CCNB2	Cyclin B2	Protein Coding	1
110	CCNB3	Cyclin B3	Protein Coding	1
111	CCND1	Cyclin D1	Protein Coding	1
112	CCND2	Cyclin D2	Protein Coding	1
113	CCND3	Cyclin D3	Protein Coding	1
114	CCNE1	Cyclin E1	Protein Coding	1
115	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
116	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
117	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
118	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
119	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
120	EGF	Epidermal Growth Factor	Protein Coding	1
121	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
122	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
123	ITGAD	Integrin Subunit Alpha D	Protein Coding	1
124	ITGAE	Integrin Subunit Alpha E	Protein Coding	1
125	ITGAL	Integrin Subunit Alpha L	Protein Coding	1
126	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
127	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
128	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
129	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
130	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
131	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
132	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
133	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
134	PLPP3	Phospholipid Phosphatase 3	Protein Coding	1
135	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
136	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
137	PXN	Paxillin	Protein Coding	1
138	RRAS	RAS Related	Protein Coding	1
139	RRAS2	RAS Related 2	Protein Coding	1
140	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
141	TLN1	Talin 1	Protein Coding	1
142	TLN2	Talin 2	Protein Coding	1
143	VCL	Vinculin	Protein Coding	1
144	EZR	Ezrin	Protein Coding	1
145	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
146	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
147	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
148	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
149	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
150	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
151	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
152	CASP1	Caspase 1	Protein Coding	1
153	CASP10	Caspase 10	Protein Coding	1
154	CASP2	Caspase 2	Protein Coding	1
155	CASP3	Caspase 3	Protein Coding	1
156	CASP6	Caspase 6	Protein Coding	1
157	CASP7	Caspase 7	Protein Coding	1
158	CASP8	Caspase 8	Protein Coding	1
159	CASP9	Caspase 9	Protein Coding	1
160	CRADD	CARD And Death Domain Containing Adaptor Protein	Protein Coding	1
161	CYCS	Cytochrome C, Somatic	Protein Coding	1
162	DAXX	Death Domain Associated Protein	Protein Coding	1
163	DFFA	DNA Fragmentation Factor Subunit Alpha	Protein Coding	1
164	FADD	Fas Associated Via Death Domain	Protein Coding	1
165	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
166	GRB14	Growth Factor Receptor Bound Protein 14	Protein Coding	1
167	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	1
168	GZMB	Granzyme B	Protein Coding	1
169	LMNB1	Lamin B1	Protein Coding	1
170	LMNB2	Lamin B2	Protein Coding	1
171	LTA	Lymphotoxin Alpha	Protein Coding	1
172	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
173	NCK2	NCK Adaptor Protein 2	Protein Coding	1
174	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
175	PRF1	Perforin 1	Protein Coding	1
176	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
177	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
178	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	1
179	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
180	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
181	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
182	TNF	Tumor Necrosis Factor	Protein Coding	1
183	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
184	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
185	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
186	FASLG	Fas Ligand	Protein Coding	1
187	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
188	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
189	ACVR1	Activin A Receptor Type 1	Protein Coding	1
190	ACVR2B	Activin A Receptor Type 2B	Protein Coding	1
191	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	1
192	ATF2	Activating Transcription Factor 2	Protein Coding	1
193	BMP3	Bone Morphogenetic Protein 3	Protein Coding	1
194	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
195	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
196	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
197	FOXH1	Forkhead Box H1	Protein Coding	1
198	GATA1	GATA Binding Protein 1	Protein Coding	1
199	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	1
200	GATA3	GATA Binding Protein 3	Protein Coding	1
201	GATA4	GATA Binding Protein 4	Protein Coding	1
202	GATA5	GATA Binding Protein 5	Protein Coding	1
203	GATA6	GATA Binding Protein 6	Protein Coding	1
204	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
205	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
206	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	1
207	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
208	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
209	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
210	NKX2-5	NK2 Homeobox 5	Protein Coding	1
211	OAZ1	Ornithine Decarboxylase Antizyme 1	Protein Coding	1
212	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
213	ACTN2	Actinin Alpha 2	Protein Coding	1
214	ACTN1	Actinin Alpha 1	Protein Coding	1
215	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
216	ACTN4	Actinin Alpha 4	Protein Coding	1
217	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
218	TCF7	Transcription Factor 7	Protein Coding	1
219	SLC8A1	Solute Carrier Family 8 Member A1	Protein Coding	1
220	SGCG	Sarcoglycan Gamma	Protein Coding	1
221	SGCD	Sarcoglycan Delta	Protein Coding	1
222	SGCB	Sarcoglycan Beta	Protein Coding	1
223	SGCA	Sarcoglycan Alpha	Protein Coding	1
224	PKP2	Plakophilin 2	Protein Coding	1
225	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
226	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
227	LAMA2	Laminin Subunit Alpha 2	Protein Coding	1
228	JUP	Junction Plakoglobin	Protein Coding	1
229	CTNNA3	Catenin Alpha 3	Protein Coding	1
230	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
231	EMD	Emerin	Protein Coding	1
232	DSP	Desmoplakin	Protein Coding	1
233	DSG2	Desmoglein 2	Protein Coding	1
234	DSC2	Desmocollin 2	Protein Coding	1
235	DES	Desmin	Protein Coding	1
236	CTNNB1	Catenin Beta 1	Protein Coding	1
237	CTNNA2	Catenin Alpha 2	Protein Coding	1
238	CTNNA1	Catenin Alpha 1	Protein Coding	1
239	CDH2	Cadherin 2	Protein Coding	1
240	ACTN3	Actinin Alpha 3	Protein Coding	1
241	CALM1	Calmodulin 1	Protein Coding	1
242	CALM2	Calmodulin 2	Protein Coding	1
243	CALM3	Calmodulin 3	Protein Coding	1
244	CHRNA1	Cholinergic Receptor Nicotinic Alpha 1 Subunit	Protein Coding	1
245	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
246	RYR1	Ryanodine Receptor 1	Protein Coding	1
247	RYR3	Ryanodine Receptor 3	Protein Coding	1
248	SNTA1	Syntrophin Alpha 1	Protein Coding	1
249	SNTB1	Syntrophin Beta 1	Protein Coding	1
250	TOB1	Transducer Of ERBB2, 1	Protein Coding	1

Disorders associated with DREAM Repression and Dynorphin Expression SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	CTNNA3, DSC2, DSG2, DSP, JUP, LMNA, PKP2, RYR2	10.85
2	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	CTNNA3, DSC2, DSG2, DSP, JUP, LMNA, PKP2, RYR2	10.85
3	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2, CTNNA3, DSC2, DSG2, DSP, JUP, LMNA, PKP2, RYR2	10.84
4	Dilated cardiomyopathy	Enrichment	ACTN2, DES, DMD, DSG2, DSP, EMD, JUP, LAMA2, LMNA, SGCB, SGCD	10.49
5	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2, CTNNA3, DES, DSC2, DSG2, DSP, JUP, LMNA, PKP2, RYR2	10.47
6	Long qt syndrome	Enrichment	CACNA1C, CACNA1S, CTNNA3, DSG2, DSP, LMNA, RYR2	9.59
7	Cardiac conduction defect	Enrichment	CACNA1C, DSG2, DSP, LMNA, RYR2	8.49
8	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3, RYR2	8.02
9	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2, DES, DMD, DSG2, DSP, LMNA, SGCD	7.87
10	Noonan syndrome 1	Enrichment	HRAS, KRAS, MRAS, NRAS, RRAS, RRAS2	7.75
11	Long qt syndrome 1	Enrichment	CACNA1C, CALM1, CALM2, CALM3, SNTA1	7.22
12	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSG2, DSP, LMNA, PKP2	7.00
13	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSC2, DSG2, DSP, PKP2	7.00
14	Brugada syndrome	Enrichment	CACNA1C, CACNA2D1, CACNB2, LMNA, PKP2	6.60
15	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	5.99
16	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS	5.95
17	Left ventricular noncompaction	Enrichment	ACTN2, DSP, LMNA, PKP2, RYR2	5.92
18	Rasopathy	Enrichment	HRAS, KRAS, MRAS, NRAS, RRAS2	5.82
19	Ventricular septal defect 1	Enrichment	BMP2, BMP7, GATA4	5.74
20	Congenital heart defects, multiple types, 4	Enrichment	BMP7, GATA4, GATA6	5.74
21	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.73
22	Neuromuscular disease	Enrichment	DES, EMD, LMNA, SGCD	5.63
23	Patent foramen ovale	Enrichment	GATA4, GATA6, NKX2-5, TAB2	5.54
24	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	SGCA, SGCB, SGCD, SGCG	5.53
25	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	5.51
26	Lung cancer susceptibility 3	Enrichment	ACTA2, EGFR, KRAS, RB1	5.48
27	Juvenile polyposis syndrome	Enrichment	BMPR1A, SMAD4	5.47
28	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2, SMAD9	5.47
29	Brachydactyly, type a2	Enrichment	BMP2, BMPR1B	5.16
30	Muscular dystrophy	Enrichment	DMD, LMNA, SGCA, SGCD	5.10
31	Familial atrial fibrillation	Enrichment	GATA4, GATA5, GATA6, NKX2-5	5.01
32	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A, SMAD4	4.94
33	Tetralogy of fallot	Enrichment	GATA4, GATA5, GATA6, NKX2-5	4.86
34	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B, CACNA2D1	4.85
35	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.80
36	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.77
37	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.77
38	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1, ITGA2B, ITGB3	4.74
39	Creatine phosphokinase, elevated serum	Enrichment	CAPN3, DAG1, DMD	4.65
40	Isolated elevated serum creatine phosphokinase levels	Enrichment	CAPN3, DAG1, DMD	4.65
41	Heritable pulmonary arterial hypertension	Enrichment	ACVRL1, BMPR2, SMAD9	4.53
42	Progressive familial heart block	Enrichment	DES, DSP	4.53
43	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.53
44	Fibrodysplasia ossificans progressiva	Enrichment	ACVR1, BMPR2	4.49
45	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	4.44
46	Congenital myopathy	Enrichment	CACNA1S, CHRNA1, RYR1	4.41
47	Aortic valve disease 1	Enrichment	GATA5, NKX2-5, TAB2	4.30
48	Centronuclear myopathy	Enrichment	CACNA1S, CHRNA1, RYR1	4.28
49	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.22
50	Heart disease	Enrichment	CREBBP, GATA4, NKX2-5	4.20
51	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, RB1	4.14
52	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C, RYR2	4.14
53	Malignant hyperthermia	Enrichment	CACNA1S, RYR1	4.14
54	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.06
55	Epidermolysis bullosa, lethal acantholytic	Enrichment	DSP, JUP	4.06
56	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.01
57	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, RB1	4.01
58	Cardiomyopathy, dilated, 1e	Enrichment	DES, LMNA, PKP2	4.00
59	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.93
60	Psoriatic arthritis	Enrichment	LTA, TNF	3.92
61	Heart conduction disease	Enrichment	CACNA1C, RYR2	3.91
62	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD, LMNA	3.76
63	Emery-dreifuss muscular dystrophy	Enrichment	EMD, LMNA	3.76
64	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.74
65	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1, RYR2	3.74
66	Cardiomyopathy, dilated, 1a	Enrichment	DSC2, DSP, LMNA	3.71
67	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	3.71
68	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	DSC2, PKP2	3.54
69	Cardiac arrest	Enrichment	CACNA2D1, DSP	3.54
70	Arrhythmogenic right ventricular dysplasia 1	Enrichment	DSC2, PKP2	3.54
71	Persistent truncus arteriosus	Enrichment	GATA6, NKX2-5	3.49
72	Multiple pterygium syndrome, lethal type	Enrichment	CHRNA1, RYR1	3.47
73	Congenital muscular dystrophy	Enrichment	CAPN3, RYR1	3.47
74	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1, RYR2	3.47
75	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.44
76	Myopathy	Enrichment	CAPN3, DMD, RYR1	3.43
77	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	CAPN3, LMNA	3.40
78	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	3.36
79	Inherited arrhythmogenic cardiomyopathy	Enrichment	DSP, PKP2	3.36
80	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.36
81	Hydrops fetalis	Enrichment	RYR1, RYR3	3.36
82	Developmental and epileptic encephalopathy	Enrichment	CACNA1E, CACNA2D2	3.35
83	Conotruncal heart malformations	Enrichment	GATA6, NKX2-5	3.32
84	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.22
85	Migraine with or without aura 1	Enrichment	CACNA1A, CAPN3	3.18
86	Hereditary hemorrhagic telangiectasia	Enrichment	ACVRL1, SMAD4	3.17
87	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2, DES, DMD	3.12
88	Myocarditis	Enrichment	DSP, LMNA	3.09
89	Epilepsy, idiopathic generalized 9	Enrichment	CACNB4	3.05
90	Brugada syndrome 4	Enrichment	CACNB2	3.05
91	Episodic ataxia, type 5	Enrichment	CACNB4	3.05
92	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	3.05
93	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	3.05
94	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	3.05
95	Sporadic hemiplegic migraine	Enrichment	CACNA1A	3.05
96	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	3.05
97	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	3.05
98	Lennox-gastaut syndrome	Enrichment	CACNA1A, MAPK10	3.05
99	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	2.99
100	Cone-rod dystrophy 6	Enrichment	CACNA1F, CACNA2D4	2.96
101	Lung cancer	Enrichment	CASP8, FAS, FASLG	2.96
102	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	2.96
103	Acromesomelic dysplasia 3	Enrichment	BMPR1B	2.96
104	Brachydactyly, type a1, d	Enrichment	BMPR1B	2.96
105	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.96
106	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.96
107	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.96
108	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.96
109	Heritable thoracic aortic disease	Enrichment	SMAD4	2.96
110	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.96
111	Primary pulmonary hypertension	Enrichment	BMPR2	2.96
112	Pulmonary hypertension	Enrichment	BMPR2	2.96
113	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	2.96
114	Menke-hennekam syndrome	Enrichment	CREBBP	2.96
115	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, PRF1	2.95
116	Ovarian cancer	Enrichment	CDKN1B, EGFR, KRAS, RB1, RRAS2	2.94
117	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.91
118	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.91
119	Noonan syndrome 3	Enrichment	HRAS, KRAS	2.91
120	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.91
121	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.84
122	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	2.78
123	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.75
124	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	2.75
125	Progressive bulbar palsy	Enrichment	CACNA1A	2.75
126	Non-immune hydrops fetalis	Enrichment	ACTA1, HRAS, KRAS	2.75
127	Beckwith-wiedemann syndrome	Enrichment	DMD, RYR1	2.74
128	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA, SGCB	2.73
129	Myhre syndrome	Enrichment	SMAD4	2.66
130	Thumb deformity	Enrichment	CREBBP	2.66
131	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	2.66
132	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.66
133	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.66
134	Menke-hennekam syndrome 2	Enrichment	EP300	2.66
135	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	2.66
136	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.66
137	Craniosynostosis 7	Enrichment	BMP2	2.66
138	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A	2.66
139	Pulmonary venoocclusive disease	Enrichment	BMPR2	2.66
140	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.66
141	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.66
142	Thrombocytopenia	Enrichment	ACTN1, ITGA2B, ITGB3	2.65
143	Pulmonary hypertension, primary, 1	Enrichment	ACVRL1, BMPR2	2.61
144	Acute promyelocytic leukemia	Enrichment	PRKAR1A, STAT3	2.61
145	Van der woude syndrome 1	Enrichment	CACNA1E	2.58
146	Hereditary episodic ataxia	Enrichment	CACNA1A	2.58
147	Congenital stationary night blindness	Enrichment	CACNA1F, CACNA2D4	2.53
148	Brachydactyly, type a1	Enrichment	BMPR1B	2.48
149	Brachydactyly, type c	Enrichment	BMPR1B	2.48
150	Acromesomelic dysplasia 2a	Enrichment	BMPR1B	2.48
151	Acromesomelic dysplasia 2c	Enrichment	BMPR1B	2.48
152	Acromesomelic dysplasia 2b	Enrichment	BMPR1B	2.48
153	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	2.48
154	Tethered spinal cord syndrome	Enrichment	CREBBP	2.48
155	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.48
156	Melanoma of soft tissue	Enrichment	CREB1	2.48
157	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	2.45
158	Spinocerebellar ataxia 6	Enrichment	CACNA1A	2.45
159	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	2.45
160	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	2.45
161	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	2.45
162	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	2.45
163	Episodic ataxia	Enrichment	CACNA1A	2.45
164	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	2.45
165	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.45
166	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	2.45
167	Carney complex, type 1	Enrichment	PRKAR1A	2.45
168	Noonan syndrome 13	Enrichment	MAPK1	2.45
169	Neurodevelopmental disorder with speech impairment and with or without seizures	Enrichment	CACNA1I	2.45
170	Congenital myopathy 18	Enrichment	CACNA1S	2.45
171	Cone-rod dystrophy, x-linked, 3	Enrichment	CACNA1F	2.45
172	Retinal cone dystrophy 4	Enrichment	CACNA2D4	2.45
173	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.45
174	Myxoma, intracardiac	Enrichment	PRKAR1A	2.45
175	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.45
176	Brugada syndrome 3	Enrichment	CACNA1C	2.45
177	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.45
178	Malignant hyperthermia 5	Enrichment	CACNA1S	2.45
179	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.45
180	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.45
181	Spinocerebellar ataxia 42	Enrichment	CACNA1G	2.45
182	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	2.45
183	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.45
184	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.45
185	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.45
186	Conn's syndrome	Enrichment	CACNA1H	2.45
187	Atypical timothy syndrome	Enrichment	CACNA1C	2.45
188	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.45
189	Timothy syndrome type 2	Enrichment	CACNA1C	2.45
190	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	2.45
191	Timothy syndrome type 1	Enrichment	CACNA1C	2.45
192	Cacna1c-related disorders	Enrichment	CACNA1C	2.45
193	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.45
194	Muscular dystrophy, becker type	Enrichment	DMD	2.45
195	Muscular dystrophy-dystroglycanopathy , type a, 9	Enrichment	DAG1	2.45
196	Vitreoretinopathy, neovascular inflammatory	Enrichment	CAPN5	2.45
197	Congenital myopathy 20	Enrichment	RYR3	2.45
198	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.45
199	Cardiomyopathy, dilated, 3b	Enrichment	DMD	2.45
200	Long qt syndrome 12	Enrichment	SNTA1	2.45
201	Long qt syndrome 16	Enrichment	CALM3	2.45
202	Muscular dystrophy-dystroglycanopathy , type c, 9	Enrichment	DAG1	2.45
203	Polycystic ovary syndrome	Enrichment	CAPN10	2.45
204	Congenital myopathy with myasthenic-like onset	Enrichment	RYR1	2.45
205	Long qt syndrome 15	Enrichment	CALM2	2.45
206	Symptomatic form of muscular dystrophy of duchenne and becker in female carriers	Enrichment	DMD	2.45
207	Progressive muscular atrophy	Enrichment	CAPN3	2.45
208	Duchenne and becker muscular dystrophy	Enrichment	DMD	2.45
209	Muscle-eye-brain disease with bilateral multicystic leucodystrophy	Enrichment	DAG1	2.45
210	Qualitative or quantitative defects of calpain	Enrichment	CAPN3	2.45
211	Calf-predominant weakness-gastrocnemius medialis atrophy-distal myopathy	Enrichment	RYR1	2.45
212	Qualitative or quantitative defects of dystrophin	Enrichment	DMD	2.45
213	Benign samaritan congenital myopathy	Enrichment	RYR1	2.45
214	Colorectal cancer	Enrichment	EP300, SMAD4	2.39
215	Episodic ataxia, type 2	Enrichment	CACNA1A	2.35
216	Congenital short qt syndrome	Enrichment	CACNA2D1	2.35
217	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD, LMNA	2.33
218	Diffuse large b-cell lymphoma	Enrichment	CREBBP, STAT3	2.28
219	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.26
220	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.26
221	Baraitser-winter syndrome 1	Enrichment	ACTB	2.26
222	Muscular dystrophy, limb-girdle, autosomal recessive 6	Enrichment	SGCD	2.26
223	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	2.26
224	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.26
225	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.26
226	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.26
227	Oculodentodigital dysplasia	Enrichment	GJA1	2.26
228	Scapuloperoneal syndrome, neurogenic, kaeser type	Enrichment	DES	2.26
229	Muscular dystrophy, limb-girdle, autosomal recessive 5	Enrichment	SGCG	2.26
230	Arrhythmogenic right ventricular dysplasia, familial, 13	Enrichment	CTNNA3	2.26
231	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.26
232	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.26
233	Naxos disease	Enrichment	JUP	2.26
234	Cortical dysplasia, complex, with other brain malformations 9	Enrichment	CTNNA2	2.26
235	Congenital myopathy 8	Enrichment	ACTN2	2.26
236	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.26
237	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.26
238	Cardiomyopathy, dilated, 1l	Enrichment	SGCD	2.26
239	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.26
240	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.26
241	Actn3 deficiency	Enrichment	ACTN3	2.26
242	Becker nevus syndrome	Enrichment	ACTB	2.26
243	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.26
244	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.26
245	Autosomal recessive limb-girdle muscular dystrophy type 2c	Enrichment	SGCG	2.26
246	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.26
247	Atypical werner syndrome	Enrichment	LMNA	2.26
248	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.26
249	Autosomal recessive limb-girdle muscular dystrophy type 2f	Enrichment	SGCD	2.26
250	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.26
251	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.26
252	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.26
253	Adenoid ameloblastoma	Enrichment	CTNNB1	2.26
254	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.26
255	Baraitser-winter syndrome	Enrichment	ACTB	2.26
256	Mandibuloacral dysplasia	Enrichment	LMNA	2.26
257	Atrioventricular block	Enrichment	LMNA	2.26
258	Skin fragility-woolly hair-palmoplantar keratoderma syndrome	Enrichment	DSP	2.26
259	Rhabdomyolysis 2	Enrichment	ATP2A2	2.26
260	Qualitative or quantitative defects of sarcoglycan	Enrichment	SGCA	2.26
261	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.26
262	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.26
263	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.26
264	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.26
265	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.26
266	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.26
267	Microcystic stromal tumor	Enrichment	CTNNB1	2.26
268	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.26
269	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	2.26
270	Laminopathy	Enrichment	LMNA	2.26
271	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.26
272	Atrial septal defect 7 with or without atrioventricular conduction defects	Enrichment	NKX2-5	2.24
273	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.24
274	Hypothyroidism, congenital, nongoitrous, 5	Enrichment	NKX2-5	2.24
275	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	2.24
276	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	2.24
277	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	2.24
278	Telangiectasia, hereditary hemorrhagic, type 2	Enrichment	ACVRL1	2.24
279	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.24
280	Atrioventricular septal defect 4	Enrichment	GATA4	2.24
281	Atrioventricular septal defect 5	Enrichment	GATA6	2.24
282	Congenital heart defects, multiple types, 5	Enrichment	GATA5	2.24
283	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	2.24
284	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	2.24
285	Microphthalmia, syndromic 6	Enrichment	BMP4	2.24
286	Orofacial cleft 11	Enrichment	BMP4	2.24
287	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.24
288	Atrial septal defect 2	Enrichment	GATA4	2.24
289	Ventricular septal defect 3	Enrichment	NKX2-5	2.24
290	Immunodeficiency 21	Enrichment	GATA2	2.24
291	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.24
292	Hypoplastic left heart syndrome 2	Enrichment	NKX2-5	2.24
293	Atrial septal defect 9	Enrichment	GATA6	2.24
294	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.24
295	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.24
296	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	2.24
297	Telangiectasis	Enrichment	ACVRL1	2.24
298	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	2.24
299	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	2.24
300	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.24
301	Aortic arch interruption	Enrichment	NKX2-5	2.24
302	Atrial heart septal defect 7	Enrichment	NKX2-5	2.24
303	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.24
304	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.24
305	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.24
306	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1, ITGA7	2.23
307	Cone-rod dystrophy 2	Enrichment	CACNA1F, CACNA2D4, ITGA4	2.22
308	Brugada syndrome 1	Enrichment	CACNA2D1	2.21
309	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.19
310	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.19
311	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.19
312	Caspase 8 deficiency	Enrichment	CASP8	2.19
313	Leprosy 4	Enrichment	LTA	2.19
314	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.19
315	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.19
316	Epilepsy, progressive myoclonic, 9	Enrichment	LMNB2	2.19
317	Thrombocytopenia 4	Enrichment	CYCS	2.19
318	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.19
319	Lipodystrophy, partial, acquired	Enrichment	LMNB2	2.19
320	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	Enrichment	CRADD	2.19
321	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.19
322	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.19
323	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.19
324	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.19
325	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.19
326	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.19
327	Microcephaly 27, primary, autosomal dominant	Enrichment	LMNB2	2.19
328	Trilateral retinoblastoma	Enrichment	RB1	2.19
329	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.19
330	Immunodeficiency 112	Enrichment	MAP3K14	2.19
331	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.19
332	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.19
333	Nik deficiency	Enrichment	MAP3K14	2.19
334	Lung oat cell carcinoma	Enrichment	RB1	2.19
335	Behcet syndrome	Enrichment	FAS, TNFRSF1A	2.19
336	Atrial septal defect 1	Enrichment	BMP2	2.18
337	Hypertrichosis	Enrichment	CREBBP	2.18
338	Eye disease	Enrichment	CACNA1F, CACNA2D4	2.17
339	Alternating hemiplegia of childhood	Enrichment	CACNA1A	2.15
340	Difference of sex development	Enrichment	CACNA1A	2.15
341	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.15
342	Timothy syndrome	Enrichment	CACNA1C	2.15
343	Night blindness, congenital stationary, type 2a	Enrichment	CACNA1F	2.15
344	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.15
345	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.15
346	Spinocerebellar ataxia 23	Enrichment	PDYN	2.15
347	Long qt syndrome 8	Enrichment	CACNA1C	2.15
348	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.15
349	Usher syndrome, type iv	Enrichment	PRKAR1A	2.15
350	Acrodysostosis	Enrichment	PRKAR1A	2.15
351	Fibrolamellar carcinoma	Enrichment	PRKACA	2.15
352	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.15
353	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.15
354	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.15
355	Malignant hyperthermia 1	Enrichment	RYR1	2.15
356	Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome	Enrichment	RYR2	2.15
357	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.15
358	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	2.15
359	Long qt syndrome 14	Enrichment	CALM1	2.15
360	Ventricular tachycardia, catecholaminergic polymorphic, 2	Enrichment	RYR2	2.15
361	King-denborough syndrome	Enrichment	RYR1	2.15
362	Exercise-induced malignant hyperthermia	Enrichment	RYR1	2.15
363	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C, LMNA	2.13
364	Gallbladder cancer	Enrichment	SMAD4	2.11
365	Oculoectodermal syndrome	Enrichment	KRAS	2.11
366	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.11
367	Hypomagnesemia 4, renal	Enrichment	EGF	2.11
368	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.11
369	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.11
370	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.11
371	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.11
372	Melanosis, neurocutaneous	Enrichment	NRAS	2.11
373	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.11
374	Noonan syndrome 6	Enrichment	NRAS	2.11
375	Noonan syndrome 11	Enrichment	MRAS	2.11
376	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.11
377	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.11
378	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.11
379	Neuroendocrine tumor	Enrichment	CDKN1B	2.11
380	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.11
381	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.11
382	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.11
383	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.11
384	Thrombocytopenia 6	Enrichment	SRC	2.11
385	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.11
386	Congenital pulmonary airway malformation	Enrichment	KRAS	2.11
387	Zebra body myopathy	Enrichment	ACTA1	2.11
388	Capillary leak syndrome	Enrichment	TLN1	2.11
389	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.11
390	Actin-accumulation myopathy	Enrichment	ACTA1	2.11
391	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.11
392	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.11
393	Neurocutaneous melanocytosis	Enrichment	NRAS	2.11
394	Actg2 visceral myopathy	Enrichment	ACTG2	2.11
395	Cerebral palsy	Enrichment	CACNA1A, CACNA1C	2.08
396	Hemochromatosis, type 1	Enrichment	BMP2	2.05
397	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A, SMAD4	2.04
398	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.02
399	Epilepsy, myoclonic juvenile	Enrichment	CACNB4	2.01
400	Tooth agenesis, selective, 1	Enrichment	BMPR2	2.00
401	Charge syndrome	Enrichment	EP300	2.00
402	Autoinflammatory disease	Enrichment	PRF1, TNFRSF1A	1.99
403	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.98
404	Type 1 diabetes mellitus 2	Enrichment	CAPN10	1.98
405	Muscular dystrophy, duchenne type	Enrichment	DMD	1.98
406	Lynch syndrome 5	Enrichment	RYR1	1.98
407	Muscular dystrophy, limb-girdle, autosomal dominant 4	Enrichment	CAPN3	1.98
408	Autosomal recessive limb-girdle muscular dystrophy type 2a	Enrichment	CAPN3	1.98
409	Bronchopulmonary dysplasia	Enrichment	RYR1	1.98
410	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.96
411	Acrokeratosis verruciformis	Enrichment	ATP2A2	1.96
412	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.96
413	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.96
414	Arrhythmogenic right ventricular dysplasia, familial, 8	Enrichment	DSP	1.96
415	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.96
416	Arrhythmogenic right ventricular dysplasia, familial, 11	Enrichment	DSC2	1.96
417	Muscular dystrophy, limb-girdle, autosomal recessive 4	Enrichment	SGCB	1.96
418	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.96
419	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.96
420	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.96
421	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.96
422	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.96
423	Hallermann-streiff syndrome	Enrichment	GJA1	1.96
424	Cardiomyopathy, dilated, 1i	Enrichment	DES	1.96
425	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	SGCA	1.96
426	Syndactyly, type iii	Enrichment	GJA1	1.96
427	Syndactyly, type v	Enrichment	GJA1	1.96
428	Keratosis palmoplantaris striata ii	Enrichment	DSP	1.96
429	Cardiomyopathy, dilated, 1bb	Enrichment	DSG2	1.96
430	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	1.96
431	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	Enrichment	DSP	1.96
432	Restrictive dermopathy 2	Enrichment	LMNA	1.96
433	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.96
434	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.96
435	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	SGCA	1.96
436	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.96
437	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.96
438	Craniometaphyseal dysplasia	Enrichment	GJA1	1.96
439	Split hand-foot malformation	Enrichment	LEF1	1.96
440	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.96
441	Cardiomyopathy, dilated, with woolly hair and keratoderma	Enrichment	DSP	1.96
442	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.96
443	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.96
444	Familial partial lipodystrophy	Enrichment	LMNA	1.96
445	Qualitative or quantitative defects of beta-sarcoglycan	Enrichment	SGCB	1.96
446	Teratoma	Enrichment	CTNNB1	1.96
447	Glycoproteinosis	Enrichment	SGCB	1.96
448	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.96
449	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.96
450	Myeloproliferative syndrome, transient	Enrichment	GATA1	1.94
451	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.94
452	Porphyria, congenital erythropoietic	Enrichment	GATA1	1.94
453	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.94
454	Heterotaxy, visceral, 4, autosomal	Enrichment	ACVR2B	1.94
455	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	1.94
456	Acute basophilic leukemia	Enrichment	GATA1	1.94
457	46,xy sex reversal 3	Enrichment	GATA4	1.94
458	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.94
459	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.94
460	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.94
461	Familial isolated congenital asplenia	Enrichment	NKX2-5	1.94
462	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.94
463	Deletion 5q35	Enrichment	NKX2-5	1.94
464	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.94
465	Common variable immunodeficiency 12	Enrichment	NFKB1	1.94
466	Familial colorectal cancer type x	Enrichment	BMPR1A	1.92
467	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	LMNB2	1.89
468	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.89
469	Deafness, autosomal dominant 64	Enrichment	DIABLO	1.89
470	Immunodeficiency 127	Enrichment	TNF	1.89
471	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.89
472	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.89
473	Familial retinoblastoma	Enrichment	RB1	1.89
474	Oculootodental syndrome	Enrichment	FADD	1.89
475	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNA1I, CACNG2	1.87
476	Aland island eye disease	Enrichment	CACNA1F	1.85
477	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.85
478	Carney complex variant	Enrichment	PRKAR1A	1.85
479	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.85
480	Congenital generalized lipodystrophy	Enrichment	FOS	1.85
481	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.85
482	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	RYR1	1.85
483	Myopathy, centronuclear, 2	Enrichment	RYR1	1.85
484	Sacral defect with anterior meningocele	Enrichment	RYR1	1.85
485	Amyotrophy, monomelic	Enrichment	RYR3	1.85
486	Myasthenic syndrome, congenital, 1b, fast-channel	Enrichment	CHRNA1	1.85
487	Intellectual developmental disorder, autosomal dominant 26	Enrichment	RYR1	1.85
488	Atrial fibrillation	Enrichment	SNTA1	1.85
489	Congenital myopathy 1a	Enrichment	RYR1	1.85
490	Idiopathic achalasia	Enrichment	NOS1	1.85
491	Paroxysmal familial ventricular fibrillation	Enrichment	RYR2	1.85
492	Spastic ataxia	Enrichment	CACNA1G, CACNB4	1.82
493	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.81
494	Scoliosis, isolated 1	Enrichment	MAPK7	1.81
495	Costello syndrome	Enrichment	HRAS	1.81
496	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.81
497	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.81
498	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.81
499	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.81
500	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.81
501	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	Enrichment	CAST	1.81
502	Moyamoya disease 5	Enrichment	ACTA2	1.81
503	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.81
504	Noonan syndrome 12	Enrichment	RRAS2	1.81
505	Intestinal obstruction	Enrichment	ACTG2	1.81
506	Wooly hair nevus	Enrichment	HRAS	1.81
507	Darier-white disease	Enrichment	ATP2A2	1.79
508	Desmoid disease, hereditary	Enrichment	CTNNB1	1.79
509	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.79
510	Myopathy, myofibrillar, 1	Enrichment	DES	1.79
511	Restrictive dermopathy 1	Enrichment	LMNA	1.79
512	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	1.79
513	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.79
514	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.79
515	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	1.79
516	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.79
517	Anus, imperforate	Enrichment	CTNNB1	1.79
518	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSP	1.79
519	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.79
520	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.79
521	Woolly hair-skin fragility syndrome	Enrichment	DSP	1.79
522	Desmoid tumor	Enrichment	CTNNB1	1.79
523	Keratosis palmoplantaris striata	Enrichment	DSP	1.79
524	Intrinsic cardiomyopathy	Enrichment	ACTN2	1.79
525	Restrictive dermopathy	Enrichment	LMNA	1.79
526	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.79
527	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.79
528	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.79
529	Lama2-related muscular dystrophy	Enrichment	LAMA2	1.79
530	Polydactyly, postaxial, type a1	Enrichment	EP300	1.78
531	Corpus callosum, agenesis of	Enrichment	CREBBP	1.78
532	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.78
533	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.78
534	Pelvic organ prolapse	Enrichment	TAB2	1.77
535	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	1.77
536	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.77
537	Hyper ige syndrome	Enrichment	STAT3	1.77
538	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.77
539	End stage renal disease	Enrichment	GATA3	1.77
540	Hydrops fetalis, nonimmune	Enrichment	ACTA1, HRAS	1.76
541	Amblyopia	Enrichment	CACNA1F	1.76
542	Histiocytoid hemangioma	Enrichment	FOS	1.76
543	Congenital myopathy 1b, autosomal recessive	Enrichment	RYR1	1.76
544	Retinoblastoma	Enrichment	RB1	1.72
545	Mycosis fungoides	Enrichment	TNFRSF1B	1.72
546	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.72
547	Niemann-pick disease, type a	Enrichment	SMPD1	1.72
548	Osteogenic sarcoma	Enrichment	RB1	1.72
549	Niemann-pick disease, type b	Enrichment	SMPD1	1.72
550	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.72
551	Hypotrichosis 8	Enrichment	RB1	1.72
552	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	1.72
553	Squamous cell carcinoma	Enrichment	RB1	1.72
554	Migraine without aura	Enrichment	TNF	1.72
555	Bone osteosarcoma	Enrichment	RB1	1.72
556	Vogt-koyanagi-harada disease	Enrichment	FAS	1.72
557	Saczary syndrome	Enrichment	TNFRSF1B	1.72
558	Charcot-marie-tooth disease	Enrichment	LAMA2, LMNA	1.68
559	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	1.68
560	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.68
561	Childhood absence epilepsy	Enrichment	CACNA1H	1.68
562	Myopathy, centronuclear, 1	Enrichment	RYR1	1.68
563	Muscular dystrophy, limb-girdle, autosomal recessive 1	Enrichment	CAPN3	1.68
564	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.66
565	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.66
566	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	1.66
567	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.66
568	Microtia-anotia	Enrichment	LMNA	1.66
569	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.66
570	Pilomatrixoma	Enrichment	CTNNB1	1.66
571	Retinitis pigmentosa 26	Enrichment	ITGA4	1.66
572	Aminoacylase 1 deficiency	Enrichment	ACTB	1.66
573	Alazami syndrome	Enrichment	CTNNB1	1.66
574	Craniopharyngioma	Enrichment	CTNNB1	1.66
575	Sick sinus syndrome	Enrichment	LMNA	1.66
576	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.66
577	Auditory neuropathy	Enrichment	CACNA1A	1.64
578	Down syndrome	Enrichment	GATA1	1.64
579	Hemophilia a	Enrichment	ACVRL1	1.64
580	Factor viii deficiency	Enrichment	ACVRL1	1.64
581	Hereditary progressive cardiac conduction defect	Enrichment	NKX2-5	1.64
582	Transposition of the great arteries	Enrichment	GATA4	1.64
583	Middle aortic syndrome	Enrichment	GATA6	1.64
584	Hypertrophic cardiomyopathy	Enrichment	ACTN2, PKP2	1.64
585	Langerhans cell histiocytosis	Enrichment	NRAS	1.63
586	Body mass index quantitative trait locus 12	Enrichment	CAST	1.63
587	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.63
588	Proprotein convertase 1/3 deficiency	Enrichment	CAST	1.63
589	Dedifferentiated liposarcoma	Enrichment	CDK4	1.63
590	Spermatocytoma	Enrichment	HRAS	1.63
591	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.63
592	Well-differentiated liposarcoma	Enrichment	CDK4	1.63
593	Strabismus	Enrichment	CACNA1A	1.63
594	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	CHRNA1	1.61
595	Small cell cancer of the lung	Enrichment	RB1	1.59
596	Lynch syndrome 4	Enrichment	RB1	1.59
597	Cerebral malaria	Enrichment	TNF	1.59
598	Scoliosis	Enrichment	CREBBP	1.58
599	Autism	Enrichment	CHRNA1, DMD	1.57
600	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.57
601	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.57
602	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.57
603	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	1.57
604	Epidermolysis bullosa	Enrichment	ITGA6	1.57
605	Aplasia cutis congenita	Enrichment	ITGB4	1.57
606	Cleft upper lip	Enrichment	GJA1	1.57
607	Coloboma of choroid and retina	Enrichment	ACTG1	1.57
608	Pancreatic cancer	Enrichment	SMAD4	1.56
609	Acute megakaryocytic leukemia	Enrichment	GATA1	1.55
610	Breast cancer	Enrichment	CACNA2D1, JUN	1.54
611	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1	1.53
612	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.51
613	Nemaline myopathy 2	Enrichment	ACTA1	1.51
614	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.51
615	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	1.51
616	Mantle cell lymphoma	Enrichment	CCND1	1.51
617	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.51
618	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.51
619	Pilocytic astrocytoma	Enrichment	KRAS	1.51
620	Pregnancy loss, recurrent 1	Enrichment	CCNB3	1.51
621	Epidermolytic nevus	Enrichment	HRAS	1.51
622	Primary hyperparathyroidism	Enrichment	CDKN1B	1.51
623	Intermediate nemaline myopathy	Enrichment	ACTA1	1.51
624	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.50
625	Primary hyperaldosteronism	Enrichment	CACNA1H	1.50
626	Limb-girdle muscular dystrophy	Enrichment	CAPN3	1.50
627	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.50
628	Niemann-pick disease, type c1	Enrichment	SMPD1	1.50
629	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.50
630	Niemann-pick disease	Enrichment	SMPD1	1.50
631	Vascular dementia	Enrichment	TNF	1.50
632	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.50
633	Idiopathic aplastic anemia	Enrichment	PRF1	1.50
634	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.49
635	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.49
636	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.49
637	Split-hand/foot malformation 1	Enrichment	LEF1	1.49
638	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.49
639	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ACVRL1	1.47
640	Anterior segment dysgenesis 5	Enrichment	BMP4	1.47
641	Double outlet right ventricle	Enrichment	NKX2-5	1.47
642	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, CTNNA2	1.44
643	Bethlem myopathy 1a	Enrichment	LMNA	1.43
644	Megacolon	Enrichment	SLC8A1	1.43
645	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.43
646	Myofibrillar myopathy	Enrichment	DES	1.43
647	Congenital hydrocephalus	Enrichment	SGCD	1.43
648	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.42
649	Specific learning disability	Enrichment	MAPK1	1.42
650	Pectus excavatum	Enrichment	DMD	1.42
651	Atrial heart septal defect	Enrichment	DMD	1.42
652	Interatrial communication	Enrichment	DMD	1.42
653	Visceral myopathy 1	Enrichment	ACTG2	1.41
654	Von hippel-lindau syndrome	Enrichment	CCND1	1.41
655	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.41
656	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.41
657	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.41
658	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	NKX2-5	1.40
659	Common variable immunodeficiency	Enrichment	NFKB1	1.40
660	Postsynaptic congenital myasthenic syndromes	Enrichment	CHRNA1	1.38
661	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.37
662	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.37
663	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.37
664	Hypoplastic left heart syndrome	Enrichment	GJA1	1.37
665	Gastric cancer	Enrichment	CDK4, KRAS	1.35
666	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	RYR1	1.35
667	Clubfoot	Enrichment	RYR1	1.35
668	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.35
669	Cowden syndrome 1	Enrichment	EGFR	1.34
670	Moyamoya disease 1	Enrichment	ACTA2	1.34
671	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.34
672	Breast adenocarcinoma	Enrichment	KRAS	1.34
673	Typical nemaline myopathy	Enrichment	ACTA1	1.34
674	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD4	1.32
675	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.32
676	Renal agenesis, bilateral	Enrichment	ITGA8	1.32
677	Walker-warburg syndrome	Enrichment	DAG1	1.31
678	Congenital myasthenic syndrome	Enrichment	CHRNA1	1.31
679	Myopia	Enrichment	CACNA1F	1.29
680	Cat eye syndrome	Enrichment	ACTG1	1.27
681	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.27
682	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.27
683	Myelofibrosis	Enrichment	SRC	1.27
684	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.27
685	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.27
686	Pilomyxoid astrocytoma	Enrichment	KRAS	1.27
687	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.27
688	Peters-plus syndrome	Enrichment	BMP4	1.25
689	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.25
690	Stickler syndrome	Enrichment	BMP4	1.25
691	Sudden infant death syndrome	Enrichment	CALM2	1.23
692	Myeloma, multiple	Enrichment	CREBBP	1.22
693	Myelodysplastic syndrome	Enrichment	GATA2	1.21
694	Heart, malformation of	Enrichment	MAPK1	1.21
695	Aplastic anemia	Enrichment	PRF1	1.21
696	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	1.19
697	Epicanthus	Enrichment	ACVR1	1.17
698	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.17
699	Arteriovenous malformation	Enrichment	HRAS	1.17
700	Asthma	Enrichment	TNF	1.17
701	Neural tube defects	Enrichment	ITGB1	1.16
702	Diaphragmatic hernia, congenital	Enrichment	GATA6	1.14
703	Protein-deficiency anemia	Enrichment	GATA1	1.14
704	Hereditary retinal dystrophy	Enrichment	CACNA1F, CACNA2D4, CTNNA1, ITGA4	1.13
705	Fundus dystrophy	Enrichment	CACNA1F, CACNA2D4, CTNNA1, ITGA4	1.13
706	Multiple sclerosis	Enrichment	ITGB4	1.13
707	Medulloblastoma	Enrichment	CTNNB1	1.13
708	Isolated macular dystrophy	Enrichment	ITGA4	1.13
709	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.12
710	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.12
711	Nemaline myopathy	Enrichment	ACTA1	1.12
712	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.11
713	Cleft lip/palate	Enrichment	BMP4	1.11
714	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.11
715	Alzheimer's disease	Enrichment	TNF	1.10
716	Cone dystrophy	Enrichment	CACNA2D4	1.09
717	Septopreoptic holoprosencephaly	Enrichment	FOXH1	1.08
718	Midline interhemispheric variant of holoprosencephaly	Enrichment	FOXH1	1.08
719	Wolff-parkinson-white syndrome	Enrichment	JUP	1.08
720	Microform holoprosencephaly	Enrichment	FOXH1	1.05
721	Lobar holoprosencephaly	Enrichment	FOXH1	1.05
722	Interstitial lung disease 2	Enrichment	DSP	1.05
723	Polycystic liver disease	Enrichment	CTNNB1	1.05
724	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.05
725	Congenital nervous system abnormality	Enrichment	CACNA1A	1.05
726	Nervous system disease	Enrichment	CACNA1A	1.05
727	Alobar holoprosencephaly	Enrichment	FOXH1	1.03
728	Semilobar holoprosencephaly	Enrichment	FOXH1	1.01
729	Craniosynostosis	Enrichment	CTNNA1	0.98
730	Osteoporosis	Enrichment	SRC	0.98
731	Lissencephaly	Enrichment	ACTG1	0.96
732	Hepatoblastoma	Enrichment	CTNNB1	0.96
733	Lynch syndrome	Enrichment	KRAS	0.95
734	Hepatocellular carcinoma	Enrichment	CTNNB1	0.95
735	Cardiomyopathy, dilated, 1g	Enrichment	DSP	0.95
736	Myocardial infarction	Enrichment	ITGB3	0.95
737	Skin disease	Enrichment	ITGB4	0.95
738	Fanconi anemia, complementation group a	Enrichment	DMD	0.93
739	Rhabdomyosarcoma	Enrichment	HRAS	0.93
740	Gliosarcoma	Enrichment	EGFR	0.93
741	Visceral heterotaxy	Enrichment	ACVR2B	0.92
742	Non-syndromic x-linked intellectual disability	Enrichment	DMD	0.92
743	Fetal akinesia deformation sequence 1	Enrichment	RYR1	0.91
744	Diamond-blackfan anemia 1	Enrichment	GATA1	0.91
745	Melanoma, cutaneous malignant 1	Enrichment	CDK4	0.90
746	Giant cell glioblastoma	Enrichment	EGFR	0.90
747	Malaria	Enrichment	TNF	0.86
748	Distal arthrogryposis	Enrichment	RYR1	0.86
749	Optic atrophy plus syndrome	Enrichment	CACNA1F	0.84
750	Complex neurodevelopmental disorder	Enrichment	CACNA1C, TCF7L2	0.83
751	Severe covid-19	Enrichment	ITGAV	0.83
752	Peripheral nervous system disease	Enrichment	LMNA	0.79
753	Neuropathy	Enrichment	LMNA	0.79
754	Cakut	Enrichment	ACTG1	0.77
755	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4	0.77
756	Retinitis pigmentosa	Enrichment	CACNA1F, CACNA2D4	0.76
757	Non-syndromic genetic deafness	Enrichment	ACTG1	0.75
758	Diamond-blackfan anemia	Enrichment	GATA1	0.73
759	Schizophrenia	Enrichment	DMD	0.72
760	Primary ovarian insufficiency	Enrichment	RYR3	0.72
761	Type 2 diabetes mellitus	Enrichment	TCF7L2	0.69
762	Nonsyndromic hearing loss	Enrichment	ACTG1	0.69
763	Nephrotic syndrome	Enrichment	ITGA3	0.68
764	Systemic lupus erythematosus	Enrichment	TNF	0.65
765	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.65
766	Connective tissue disease	Enrichment	ACTA2	0.65
767	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.63
768	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.61
769	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	0.56
770	Hereditary breast carcinoma	Enrichment	KRAS	0.53
771	Autosomal recessive non-syndromic intellectual disability	Enrichment	CRADD	0.51
772	Body mass index quantitative trait locus 11	Enrichment	CAST	0.49
773	Rare genetic deafness	Enrichment	ACTG1	0.45
774	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DREAM Repression and Dynorphin Expression

Pathway Network for DREAM Repression and Dynorphin Expression

Pathway network for the DREAM Repression and Dynorphin Expression SuperPath

Member Pathways for DREAM Repression and Dynorphin Expression

Pathways in the DREAM Repression and Dynorphin Expression SuperPath

Gene overlap in member pathways for DREAM Repression and Dynorphin Expression SuperPath

Associated Genes for DREAM Repression and Dynorphin Expression

Associated Disorders for DREAM Repression and Dynorphin Expression

Disorders associated with DREAM Repression and Dynorphin Expression SuperPath

STRING Interaction Network for DREAM Repression and Dynorphin Expression

Sources for DREAM Repression and Dynorphin Expression