Drug ADME

Pathway network for the Drug ADME SuperPath

Sources:

Reactome
PharmGKB
WikiPathways

Pathways in the Drug ADME SuperPath

#	Name	Source	Genes
1	Drug ADME	Reactome	ABCB1 ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCG2 ACSM2A ACSM2B ACSM4 ACSM5 ACY1 ADA ADH1A ADK AKR1C1 ALB BCHE BSG CES1 CES2 CNDP2 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 GGT1 GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GLYATL3 GMPS GSTA1 GSTA2 GSTM1 GSTP1 GSTT1 GUK1 HPRT1 HSD11B1 HSD11B2 IMPDH1 IMPDH2 ITPA MAPDA NAT1 NAT2 NME1 NME2 NT5C2 NUDT15 PCK1 PNP PON1 PON3 RAC1 SERPINA6 SLC16A1 SLC22A1 SLC22A2 SLC22A3 SLC22A7 SLC22A8 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLCO1A2 SLCO1B1 SLCO1B3 SLCO2B1 SULT1A1 SULT1A3 SULT1A4 SULT1C4 SULT1E1 SULT2A1 TPMT UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT3A1 UGT3A2 VAV1 VAV2 VAV3 XDH (see all 109) (see less)
2	Aspirin ADME	Reactome	ABCC2 ABCC3 ACSM2A ACSM2B ACSM4 ACSM5 ALB BCHE BSG CES1 CES2 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 GLYAT GLYATL1 GLYATL2 GLYATL3 SLC16A1 SLC22A7 SLCO2B1 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT3A1 UGT3A2 (see all 44) (see less)
3	Codeine and Morphine Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC2 ABCC3 CYP2C8 CYP2D6 CYP3A4 SLC22A1 UGT1A1 UGT1A10 UGT1A3 UGT1A8 UGT1A9 UGT2B15 UGT2B17 UGT2B4 UGT2B7 (see all 16) (see less)
4	Irinotecan Pathway, Pharmacodynamics	PharmGKB	ABCB1 ABCC2 ABCG2 BCHE CES1 CES2 TOP1 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A8 UGT1A9 (see all 14) (see less)
5	Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCC2 CES1 CES2 CYP2C8 CYP3A4 CYP3A5 IMPDH1 IMPDH2 UGT1A10 UGT1A7 UGT1A8 UGT1A9 UGT2B7 (see all 13) (see less)
6	Reactome/PharmGKB collaboration: Ribavirin Pathway, Pharmacokinetics	PharmGKB	ADA ADK GUK1 ITPA NME1 NME2 NT5C2 PNP SLC28A2 SLC28A3 SLC29A1 SLC29A3 (see all 12) (see less)
7	Atorvastatin Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC2 ABCG2 CYP2C8 CYP3A4 CYP3A5 PON1 PON3 SLCO1B1 UGT1A1 UGT1A3 UGT2B7 (see all 12) (see less)
8	Codeine and morphine metabolism	WikiPathways	ABCB1 ABCC2 ABCC3 CYP2D6 CYP3A4 SLCO1B1 UGT1A1 UGT1A10 UGT1A8 UGT1A9 UGT2B7 (see all 11) (see less)
9	Ribavirin ADME	Reactome	ADA ADK ITPA NME1 NME2 NT5C2 PNP SLC28A2 SLC28A3 SLC29A1 SLC29A3 (see all 11) (see less)
10	Carvedilol Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC2 CYP1A2 CYP2C9 CYP2D6 CYP2E1 CYP3A4 SLCO1A2 UGT1A1 UGT2B4 UGT2B7 (see all 11) (see less)
11	Apatinib Pathway, Pharmacokinetics	PharmGKB	CYP2C9 CYP2D6 CYP3A4 CYP3A5 UGT1A1 UGT1A3 UGT1A4 UGT1A8 UGT1A9 UGT2B4 UGT2B7 (see all 11) (see less)
12	Reactome/PharmGKB collaboration: Prednisone and Prednisolone Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC2 ABCC3 AKR1C1 ALB CYP3A4 HSD11B1 SERPINA6 UGT1A3 UGT2B17 UGT2B7 (see all 11) (see less)
13	Prednisone ADME	Reactome	ABCB1 AKR1C1 ALB CYP3A4 HSD11B1 HSD11B2 SERPINA6 UGT1A3 UGT2B17 UGT2B7 (see all 10) (see less)
14	Pitavastatin Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC3 ABCG2 CYP2D6 CYP3A4 SLCO1B1 SLCO1B3 UGT1A1 UGT1A3 UGT2B7 (see all 10) (see less)
15	Atorvastatin ADME	Reactome	ABCB1 ABCC2 CYP3A4 PON1 PON3 SLCO1B1 SLCO1B3 SLCO2B1 UGT1A3 (see all 9) (see less)
16	Abacavir ADME	Reactome	ABCB1 ABCG2 ADH1A MAPDA NT5C2 PCK1 SLC22A1 SLC22A2 SLC22A3 (see all 9) (see less)
17	Dolutegravir Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCG2 CYP3A4 SLC22A2 UGT1A1 UGT1A3 UGT1A9 (see all 7) (see less)
18	Hydrocodone Pathway, Pharmacokinetics	PharmGKB	CYP2C9 CYP2D6 CYP3A4 SULT1A3 UGT1A3 UGT2B7 (see all 6) (see less)
19	Ciprofloxacin ADME	Reactome	ABCG2 ALB SLC22A1 SLC22A8 SLCO1A2
20	Abacavir transmembrane transport	Reactome	ABCB1 ABCG2 SLC22A1 SLC22A2 SLC22A3
21	Abacavir metabolism	Reactome	ADH1A MAPDA NT5C2 PCK1
22	Dexamethasone Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CYP3A4 HSD11B1 HSD11B2

Gene overlap in member pathways for Drug ADME SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	15
2	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	13
3	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	12
4	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	12
5	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	10
6	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	10
7	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	8
8	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	8
9	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	8
10	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	7
11	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	6
12	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	5
13	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	5
14	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	5
15	ALB	Albumin	Protein Coding	5
16	NT5C2	5''-Nucleotidase, Cytosolic II	Protein Coding	5
17	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	5
18	SLC22A1	Solute Carrier Family 22 Member 1	Protein Coding	5
19	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	5
20	UGT2B17	UDP Glucuronosyltransferase Family 2 Member B17	Protein Coding	5
21	CES1	Carboxylesterase 1	Protein Coding	4
22	HSD11B1	Hydroxysteroid 11-Beta Dehydrogenase 1	Protein Coding	4
23	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	4
24	SLC22A2	Solute Carrier Family 22 Member 2	Protein Coding	4
25	CES2	Carboxylesterase 2	Protein Coding	4
26	ADA	Adenosine Deaminase	Protein Coding	3
27	SLCO2B1	Solute Carrier Organic Anion Transporter Family Member 2B1	Protein Coding	3
28	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	3
29	ADK	Adenosine Kinase	Protein Coding	3
30	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	3
31	MAPDA	N6-Methyl-AMP Deaminase	Protein Coding	3
32	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	3
33	SLC29A1	Solute Carrier Family 29 Member 1 (Augustine Blood Group)	Protein Coding	3
34	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	3
35	HSD11B2	Hydroxysteroid 11-Beta Dehydrogenase 2	Protein Coding	3
36	ITPA	Inosine Triphosphatase	Protein Coding	3
37	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	3
38	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	3
39	PNP	Purine Nucleoside Phosphorylase	Protein Coding	3
40	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	3
41	PON1	Paraoxonase 1	Protein Coding	3
42	PON3	Paraoxonase 3	Protein Coding	3
43	UGT1A7	UDP Glucuronosyltransferase Family 1 Member A7	Protein Coding	3
44	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	3
45	SLC29A3	Solute Carrier Family 29 Member 3	Protein Coding	3
46	BCHE	Butyrylcholinesterase	Protein Coding	3
47	SLC28A3	Solute Carrier Family 28 Member 3	Protein Coding	3
48	SLCO1A2	Solute Carrier Organic Anion Transporter Family Member 1A2	Protein Coding	3
49	SLC22A3	Solute Carrier Family 22 Member 3	Protein Coding	3
50	UGT2B15	UDP Glucuronosyltransferase Family 2 Member B15	Protein Coding	3
51	SERPINA6	Serpin Family A Member 6	Protein Coding	3
52	SLC28A2	Solute Carrier Family 28 Member 2	Protein Coding	3
53	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	3
54	GLYAT	Glycine-N-Acyltransferase	Protein Coding	2
55	UGT2B11	UDP Glucuronosyltransferase Family 2 Member B11	Protein Coding	2
56	SLC22A7	Solute Carrier Family 22 Member 7	Protein Coding	2
57	UGT2A1	UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus	Protein Coding	2
58	ACSM2A	Acyl-CoA Synthetase Medium Chain Family Member 2A	Protein Coding	2
59	UGT3A1	UDP Glycosyltransferase Family 3 Member A1	Protein Coding	2
60	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	2
61	UGT3A2	UDP Glycosyltransferase Family 3 Member A2	Protein Coding	2
62	GLYATL2	Glycine-N-Acyltransferase Like 2	Protein Coding	2
63	GUK1	Guanylate Kinase 1	Protein Coding	2
64	ACSM4	Acyl-CoA Synthetase Medium Chain Family Member 4	Protein Coding	2
65	ACSM2B	Acyl-CoA Synthetase Medium Chain Family Member 2B	Protein Coding	2
66	IMPDH1	Inosine Monophosphate Dehydrogenase 1	Protein Coding	2
67	IMPDH2	Inosine Monophosphate Dehydrogenase 2	Protein Coding	2
68	GLYATL3	Glycine-N-Acyltransferase Like 3	Protein Coding	2
69	UGT2B28	UDP Glucuronosyltransferase Family 2 Member B28	Protein Coding	2
70	UGT1A5	UDP Glucuronosyltransferase Family 1 Member A5	Protein Coding	2
71	ACSM5	Acyl-CoA Synthetase Medium Chain Family Member 5	Protein Coding	2
72	UGT2A2	UDP Glucuronosyltransferase Family 2 Member A2	Protein Coding	2
73	SLC16A1	Solute Carrier Family 16 Member 1	Protein Coding	2
74	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	2
75	BSG	Basigin (Ok Blood Group)	Protein Coding	2
76	UGT2B10	UDP Glucuronosyltransferase Family 2 Member B10	Protein Coding	2
77	UGT2A3	UDP Glucuronosyltransferase Family 2 Member A3	Protein Coding	2
78	GLYATL1	Glycine-N-Acyltransferase Like 1	Protein Coding	2
79	SLC22A8	Solute Carrier Family 22 Member 8	Protein Coding	2
80	NAT2	N-Acetyltransferase 2	Protein Coding	1
81	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	1
82	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
83	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
84	GGT6	Gamma-Glutamyltransferase 6	Protein Coding	1
85	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	1
86	GGT7	Gamma-Glutamyltransferase 7	Protein Coding	1
87	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	1
88	SULT1C4	Sulfotransferase Family 1C Member 4	Protein Coding	1
89	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	1
90	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	1
91	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	1
92	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
93	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	1
94	SLC29A2	Solute Carrier Family 29 Member 2	Protein Coding	1
95	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	1
96	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
97	SULT1A4	Sulfotransferase Family 1A Member 4	Protein Coding	1
98	NUDT15	Nudix Hydrolase 15	Protein Coding	1
99	CNDP2	Carnosine Dipeptidase 2	Protein Coding	1
100	RAC1	Rac Family Small GTPase 1	Protein Coding	1
101	SULT1E1	Sulfotransferase Family 1E Member 1	Protein Coding	1
102	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
103	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	1
104	TPMT	Thiopurine S-Methyltransferase	Protein Coding	1
105	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
106	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
107	XDH	Xanthine Dehydrogenase	Protein Coding	1
108	GMPS	Guanine Monophosphate Synthase	Protein Coding	1
109	NAT1	N-Acetyltransferase 1	Protein Coding	1
110	ACY1	Aminoacylase 1	Protein Coding	1
111	TOP1	DNA Topoisomerase I	Protein Coding	1
112	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1

Disorders associated with Drug ADME SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gilbert syndrome	Enrichment	SLCO1B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
2	Bilirubin metabolic disorder	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
3	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
4	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
5	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
6	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
7	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1, SLCO1B3	5.93
8	Apparent mineralocorticoid excess	Enrichment	HSD11B2	3.66
9	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.66
10	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	3.53
11	Severe combined immunodeficiency	Enrichment	ADA, PNP	3.51
12	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.43
13	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	3.43
14	Blood group, junior system	Enrichment	ABCG2	3.43
15	Congenital analbuminemia	Enrichment	ALB	3.43
16	Analbuminemia	Enrichment	ALB	3.43
17	Colchicine resistance	Enrichment	ABCB1	3.43
18	Encephalopathy, acute transient	Enrichment	ABCB1	3.43
19	Inflammatory bowel disease 13	Enrichment	ABCB1	3.43
20	Cortisone reductase deficiency 2	Enrichment	HSD11B1	3.35
21	Cortisone reductase deficiency	Enrichment	HSD11B1	3.35
22	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.35
23	Spastic paraplegia 45, autosomal recessive	Enrichment	NT5C2	3.23
24	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PON1, PON3	3.20
25	Corticosteroid-binding globulin deficiency	Enrichment	SERPINA6	3.13
26	Bone mineral density quantitative trait locus 12	Enrichment	UGT2B17	3.13
27	Hypermethioninemia due to adenosine kinase deficiency	Enrichment	ADK	3.09
28	Hemolytic disease of the fetus	Enrichment	SLC29A1	3.09
29	Purine nucleoside phosphorylase deficiency	Enrichment	PNP	3.09
30	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1	3.05
31	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.05
32	Retinitis pigmentosa 10	Enrichment	IMPDH1	3.02
33	Impdh2 enzyme activity, variation in	Enrichment	IMPDH2	3.02
34	Drug metabolism, altered, ces1-related	Enrichment	CES1	3.02
35	Leber congenital amaurosis 11	Enrichment	IMPDH1	3.02
36	Butyrylcholinesterase deficiency	Enrichment	BCHE	2.99
37	Coumarin resistance	Enrichment	CYP2C9	2.88
38	Microvascular complications of diabetes 5	Enrichment	PON1	2.88
39	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	2.83
40	Histiocytosis-lymphadenopathy plus syndrome	Enrichment	SLC29A3	2.79
41	Inosine triphosphatase deficiency	Enrichment	ITPA	2.79
42	Developmental and epileptic encephalopathy 35	Enrichment	ITPA	2.79
43	Mitochondrial dna depletion syndrome 21	Enrichment	GUK1	2.75
44	Dubin-johnson syndrome	Enrichment	ABCC2	2.70
45	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	2.61
46	Dysosteosclerosis	Enrichment	SLC29A3	2.61
47	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	IMPDH2	2.54
48	Adenosine deaminase deficiency	Enrichment	ADA	2.49
49	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.49
50	Erythrocyte lactate transporter defect	Enrichment	SLC16A1	2.49
51	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.40
52	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	2.39
53	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.39
54	Developmental dysplasia of the hip 1	Enrichment	AKR1C1	2.35
55	Monocarboxylate transporter 1 deficiency	Enrichment	SLC16A1	2.19
56	Hyperinsulinemic hypoglycemia, familial, 7	Enrichment	SLC16A1	2.19
57	Ketoacidosis due to monocarboxylate transporter-1 deficiency	Enrichment	SLC16A1	2.19
58	Tooth agenesis, selective, 1	Enrichment	ITPA	2.14
59	Acetylation, slow	Enrichment	NAT2	2.09
60	Thiopurines, poor metabolism of, 1	Enrichment	TPMT	2.09
61	Glutathionuria	Enrichment	GGT1	2.09
62	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.09
63	Thiopurines, poor metabolism of, 2	Enrichment	NUDT15	2.09
64	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.09
65	Omenn syndrome	Enrichment	ADA	2.09
66	Hypertension, essential	Enrichment	CYP3A5	1.86
67	Xanthinuria, type i	Enrichment	XDH	1.80
68	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.80
69	Kala-azar 2	Enrichment	GSTP1	1.80
70	Tooth agenesis	Enrichment	ITPA	1.75
71	Developmental and epileptic encephalopathy 1	Enrichment	ITPA	1.70
72	Lesch-nyhan syndrome	Enrichment	HPRT1	1.62
73	Hyperuricemia, hprt-related	Enrichment	HPRT1	1.62
74	Xanthinuria, type ii	Enrichment	XDH	1.62
75	Developmental and epileptic encephalopathy	Enrichment	ITPA	1.54
76	Aminoacylase 1 deficiency	Enrichment	ACY1	1.50
77	Dystonia	Enrichment	IMPDH2	1.48
78	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.15
79	Leber plus disease	Enrichment	IMPDH1	1.06
80	Retinitis pigmentosa	Enrichment	IMPDH1	0.73
81	Hereditary retinal dystrophy	Enrichment	IMPDH1	0.61
82	Fundus dystrophy	Enrichment	IMPDH1	0.61
83	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Drug ADME

Pathway Network for Drug ADME

Pathway network for the Drug ADME SuperPath

Member Pathways for Drug ADME

Pathways in the Drug ADME SuperPath

Gene overlap in member pathways for Drug ADME SuperPath

Associated Genes for Drug ADME

Associated Disorders for Drug ADME

Disorders associated with Drug ADME SuperPath

STRING Interaction Network for Drug ADME

Sources for Drug ADME