Drug resistance of PDGFR mutants
Pathways in the Drug resistance of PDGFR mutants SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Drug resistance of PDGFR mutants | Reactome | |
| 2 | PDGFR mutants bind TKIs | Reactome | |
| 3 | Regorafenib-resistant PDGFR mutants | Reactome | |
| 4 | Imatinib-resistant PDGFR mutants | Reactome | |
| 5 | Sorafenib-resistant PDGFR mutants | Reactome | |
| 6 | Sunitinib-resistant PDGFR mutants | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | PDGFRA | Platelet Derived Growth Factor Receptor Alpha | Protein Coding | 6 |
Disorders associated with Drug resistance of PDGFR mutants SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Hypereosinophilic syndrome, idiopathic | Enrichment | PDGFRA | 4.13 |
| 2 | Gist-plus syndrome | Enrichment | PDGFRA | 4.13 |
| 3 | Myeloid and lymphoid neoplasms associated with pdgfra rearrangement | Enrichment | PDGFRA | 4.13 |
| 4 | Chronic eosinophilic leukemia | Enrichment | PDGFRA | 3.83 |
| 5 | B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality | Enrichment | PDGFRA | 3.83 |
| 6 | Primary hypereosinophilic syndrome | Enrichment | PDGFRA | 3.43 |
| 7 | Gastrointestinal stromal tumor | Enrichment | PDGFRA | 3.29 |
| 8 | Cleft lip/palate | Enrichment | PDGFRA | 2.99 |
| 9 | Ovarian cancer | Enrichment | PDGFRA | 2.13 |
| 10 | Inherited cancer-predisposing syndrome | Enrichment | PDGFRA | 2.01 |
