DYRK1A involvement regarding cell proliferation in brain development

No Pathway Network information available for DYRK1A involvement regarding cell proliferation in brain development

Pathways in the DYRK1A involvement regarding cell proliferation in brain development SuperPath

#	Name	Source	Genes
1	DYRK1A involvement regarding cell proliferation in brain development	WikiPathways	AKT1S1 AMPH APH1A APP BACE1 CASP3 CASP9 CCND1 CDK4 CDK6 CDKN1B CREB1 CRY2 CSNK1A1 DCAF7 DEPTOR DLL1 DNER DNM1 DYRK1A E2F4 E2F5 EIF2B5 FGF2 FOXO1 GLI1 GMNN GSK3B H3-3A HES1 HES5 HIP1 LATS2 LIN37 LIN52 LIN54 LIN9 MAPT MLST8 MTOR NCSTN NEUROG2 NFATC1 NOTCH1 PSEN1 PSENEN RAD54L2 RBBP4 RBL1 RBL2 REST RPTOR SIRT1 SMARCB1 SPRY2 TFAP4 TFDP1 TFDP2 TFDP3 TP53 TSC1 TSC2 (see all 62) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EIF2B5	Eukaryotic Translation Initiation Factor 2B Subunit Epsilon	Protein Coding	1
2	AKT1S1	AKT1 Substrate 1	Protein Coding	1
3	CASP9	Caspase 9	Protein Coding	1
4	CASP3	Caspase 3	Protein Coding	1
5	TSC2	TSC Complex Subunit 2	Protein Coding	1
6	TSC1	TSC Complex Subunit 1	Protein Coding	1
7	TP53	Tumor Protein P53	Protein Coding	1
8	TFDP2	Transcription Factor Dp-2	Protein Coding	1
9	TFDP1	Transcription Factor Dp-1	Protein Coding	1
10	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	1
11	REST	RE1 Silencing Transcription Factor	Protein Coding	1
12	CCND1	Cyclin D1	Protein Coding	1
13	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
14	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
15	PSEN1	Presenilin 1	Protein Coding	1
16	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
17	GMNN	Geminin DNA Replication Inhibitor	Protein Coding	1
18	NOTCH1	Notch Receptor 1	Protein Coding	1
19	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
20	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	1
21	APP	Amyloid Beta Precursor Protein	Protein Coding	1
22	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
23	HIP1	Huntingtin Interacting Protein 1	Protein Coding	1
24	H3-3A	H3.3 Histone A	Protein Coding	1
25	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
26	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
27	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
28	LATS2	Large Tumor Suppressor Kinase 2	Protein Coding	1
29	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
30	BACE1	Beta-Secretase 1	Protein Coding	1
31	SIRT1	Sirtuin 1	Protein Coding	1
32	NCSTN	Nicastrin	Protein Coding	1
33	FOXO1	Forkhead Box O1	Protein Coding	1
34	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
35	E2F5	E2F Transcription Factor 5	Protein Coding	1
36	E2F4	E2F Transcription Factor 4	Protein Coding	1
37	DYRK1A	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A	Protein Coding	1
38	DNM1	Dynamin 1	Protein Coding	1
39	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
40	CRY2	Cryptochrome Circadian Regulator 2	Protein Coding	1
41	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
42	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
43	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
44	DCAF7	DDB1 And CUL4 Associated Factor 7	Protein Coding	1
45	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
46	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
47	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1
48	LIN52	Lin-52 DREAM MuvB Core Complex Component	Protein Coding	1
49	LIN54	Lin-54 DREAM MuvB Core Complex Component	Protein Coding	1
50	TFAP4	Transcription Factor AP-4	Protein Coding	1
51	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
52	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
53	NEUROG2	Neurogenin 2	Protein Coding	1
54	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	1
55	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
56	LIN37	Lin-37 DREAM MuvB Core Complex Component	Protein Coding	1
57	TFDP3	Transcription Factor Dp Family Member 3	Protein Coding	1
58	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
59	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
60	LIN9	Lin-9 DREAM MuvB Core Complex Component	Protein Coding	1
61	AMPH	Amphiphysin	Protein Coding	1
62	RAD54L2	RAD54 Like 2	Protein Coding	1

Disorders associated with DYRK1A involvement regarding cell proliferation in brain development SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	6.44
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	6.44
3	Adult hepatocellular carcinoma	Enrichment	TP53, TSC1, TSC2	5.13
4	Pick disease of brain	Enrichment	MAPT, PSEN1	4.69
5	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.69
6	Alzheimer's disease	Enrichment	APP, MAPT, PSEN1	4.60
7	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, SMARCB1, TP53, TSC1, TSC2	4.53
8	Alzheimer disease, familial, 1	Enrichment	APP, MAPT, PSEN1	4.23
9	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.21
10	Hamartoma	Enrichment	TSC1, TSC2	4.21
11	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1, TP53	4.21
12	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.91
13	Rhabdomyosarcoma 2	Enrichment	FOXO1, TP53	3.69
14	Dementia	Enrichment	MAPT, PSEN1	3.69
15	Semantic dementia	Enrichment	MAPT, PSEN1	3.37
16	Early-onset autosomal dominant alzheimer disease	Enrichment	APP, PSEN1	3.37
17	Glioma susceptibility 1	Enrichment	H3-3A, TP53	3.25
18	Progressive non-fluent aphasia	Enrichment	MAPT, PSEN1	3.14
19	Behavioral variant of frontotemporal dementia	Enrichment	MAPT, PSEN1	3.14
20	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	3.04
21	Frontotemporal dementia 1	Enrichment	MAPT, PSEN1	2.96
22	Ovarian cancer	Enrichment	CDKN1B, SMARCB1, TP53, TSC2	2.94
23	Diffuse large b-cell lymphoma	Enrichment	FOXO1, TP53	2.48
24	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.34
25	Acne inversa, familial, 1	Enrichment	NCSTN	2.34
26	Polydactyly, preaxial i	Enrichment	GLI1	2.34
27	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.34
28	Iga nephropathy 3	Enrichment	SPRY2	2.34
29	Intellectual developmental disorder, autosomal dominant 7	Enrichment	DYRK1A	2.34
30	Wilms tumor 6	Enrichment	REST	2.34
31	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.34
32	Polydactyly, postaxial, type a8	Enrichment	GLI1	2.34
33	Bone marrow failure syndrome 5	Enrichment	TP53	2.34
34	Papilloma of choroid plexus	Enrichment	TP53	2.34
35	Parkinson-dementia syndrome	Enrichment	MAPT	2.34
36	Basal cell carcinoma 7	Enrichment	TP53	2.34
37	Anaplastic thyroid carcinoma	Enrichment	TP53	2.34
38	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.34
39	Progressive supranuclear palsy	Enrichment	MAPT	2.34
40	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.34
41	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	2.34
42	Neuroendocrine tumor	Enrichment	CDKN1B	2.34
43	Deafness, autosomal dominant 27	Enrichment	REST	2.34
44	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.34
45	Neurilemmoma	Enrichment	SMARCB1	2.34
46	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.34
47	Acne inversa, familial, 3	Enrichment	PSEN1	2.34
48	Ductal carcinoma in situ	Enrichment	TP53	2.34
49	Coffin-siris syndrome 3	Enrichment	SMARCB1	2.34
50	Fibromatosis, gingival, 5	Enrichment	REST	2.34
51	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.34
52	Meier-gorlin syndrome 6	Enrichment	GMNN	2.34
53	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.34
54	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.34
55	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.34
56	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.34
57	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.34
58	Choroid plexus cancer	Enrichment	TP53	2.34
59	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.34
60	Pash syndrome	Enrichment	NCSTN	2.34
61	Bladder cancer	Enrichment	TP53, TSC1	2.11
62	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.04
63	Fibromatosis, gingival, 1	Enrichment	REST	2.04
64	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.04
65	Alzheimer disease 3	Enrichment	PSEN1	2.04
66	Cervical cancer	Enrichment	TP53	2.04
67	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.04
68	Schwannomatosis 1	Enrichment	SMARCB1	2.04
69	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.04
70	Lymphoma, hodgkin, classic	Enrichment	TP53	2.04
71	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.04
72	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.04
73	Cebalid syndrome	Enrichment	MTOR	2.04
74	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCB1	2.04
75	Congenital fibrosarcoma	Enrichment	TP53	2.04
76	Li-fraumeni syndrome 1	Enrichment	TP53	2.04
77	Sarcoma	Enrichment	TP53	2.04
78	Cervix carcinoma	Enrichment	TP53	2.04
79	Hodgkin's lymphoma	Enrichment	TP53	2.04
80	Smith-kingsmore syndrome	Enrichment	MTOR	2.04
81	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A	2.04
82	Postaxial polydactyly type b	Enrichment	GLI1	2.04
83	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.04
84	Malignant peritoneal mesothelioma	Enrichment	LATS2	2.04
85	Autism spectrum disorder	Enrichment	DYRK1A, SMARCB1, TSC2	1.87
86	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.86
87	Osteogenic sarcoma	Enrichment	TP53	1.86
88	Alzheimer disease 4	Enrichment	PSEN1	1.86
89	Nasopharyngeal carcinoma	Enrichment	TP53	1.86
90	Tuberous sclerosis 2	Enrichment	TSC2	1.86
91	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.86
92	Dedifferentiated liposarcoma	Enrichment	CDK4	1.86
93	Anaplastic astrocytoma	Enrichment	TP53	1.86
94	Xanthinuria, type ii	Enrichment	TSC2	1.86
95	Squamous cell carcinoma	Enrichment	TP53	1.86
96	Adenocarcinoma	Enrichment	TP53	1.86
97	Bone osteosarcoma	Enrichment	TP53	1.86
98	Schwannomatosis	Enrichment	SMARCB1	1.86
99	Melanoma of soft tissue	Enrichment	CREB1	1.86
100	Well-differentiated liposarcoma	Enrichment	CDK4	1.86
101	Keratoacanthoma	Enrichment	NOTCH1	1.86
102	Gastric cancer	Enrichment	CDK4, TP53	1.78
103	West syndrome	Enrichment	DNM1, TSC2	1.76
104	Small cell cancer of the lung	Enrichment	TP53	1.74
105	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.74
106	Mantle cell lymphoma	Enrichment	CCND1	1.74
107	Enophthalmos	Enrichment	DYRK1A	1.74
108	Dowling-degos disease	Enrichment	PSENEN	1.74
109	Lung sarcomatoid carcinoma	Enrichment	TP53	1.74
110	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.74
111	Primary hyperparathyroidism	Enrichment	CDKN1B	1.74
112	Full schwannomatosis	Enrichment	SMARCB1	1.74
113	Gingival fibromatosis	Enrichment	REST	1.74
114	Von hippel-lindau syndrome	Enrichment	CCND1	1.64
115	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.64
116	Lymphoma	Enrichment	TP53	1.64
117	Acute megakaryocytic leukemia	Enrichment	TP53	1.64
118	Hemimegalencephaly	Enrichment	MTOR	1.64
119	Hereditary breast ovarian cancer syndrome	Enrichment	EIF2B5, TP53	1.58
120	Myeloma, multiple	Enrichment	CCND1, TP53	1.57
121	Li-fraumeni syndrome	Enrichment	TP53	1.57
122	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.57
123	Keratoconus	Enrichment	TSC1	1.57
124	Adrenocortical carcinoma	Enrichment	TP53	1.57
125	Breast adenocarcinoma	Enrichment	TP53	1.57
126	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT, PSEN1	1.54
127	Esophageal cancer	Enrichment	TP53	1.50
128	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.50
129	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.50
130	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.50
131	Leukoencephalopathy with vanishing white matter 1	Enrichment	EIF2B5	1.50
132	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.50
133	Adams-oliver syndrome	Enrichment	NOTCH1	1.50
134	Alzheimer's disease 1	Enrichment	APP	1.50
135	Polycystic kidney disease 1	Enrichment	TSC2	1.50
136	Essential thrombocythemia	Enrichment	TP53	1.50
137	Gallbladder cancer	Enrichment	TP53	1.50
138	Overgrowth syndrome	Enrichment	MTOR	1.50
139	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.50
140	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.44
141	Lennox-gastaut syndrome	Enrichment	DNM1	1.44
142	Leukoencephalopathy with vanishing white matter 5	Enrichment	EIF2B5	1.44
143	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.44
144	Ellis-van creveld syndrome	Enrichment	GLI1	1.39
145	Leukoencephalopathy with vanishing white matter	Enrichment	EIF2B5	1.39
146	Primary hyperaldosteronism	Enrichment	TP53	1.39
147	Meier-gorlin syndrome 1	Enrichment	GMNN	1.35
148	Familial colorectal cancer	Enrichment	TP53	1.35
149	Meningioma, familial	Enrichment	SMARCB1	1.31
150	Myelodysplastic syndrome	Enrichment	TP53	1.31
151	Meningioma	Enrichment	SMARCB1	1.27
152	Lip and oral cavity carcinoma	Enrichment	TP53	1.27
153	Aortic valve disease 1	Enrichment	NOTCH1	1.24
154	Stereotypic movement disorder	Enrichment	DNM1	1.24
155	Nk-cell enteropathy	Enrichment	SMARCB1	1.24
156	Colorectal cancer	Enrichment	CCND1, TP53	1.22
157	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.21
158	Lung cancer susceptibility 3	Enrichment	TP53	1.21
159	Coffin-siris syndrome 1	Enrichment	SMARCB1	1.18
160	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.18
161	Polydactyly, postaxial, type a1	Enrichment	GLI1	1.18
162	Wilms tumor 1	Enrichment	REST	1.18
163	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.18
164	Kidney disease	Enrichment	TSC1	1.18
165	Rare genetic intellectual disability	Enrichment	MTOR	1.18
166	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.18
167	Male infertility with spermatogenesis disorder	Enrichment	DYRK1A	1.18
168	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.18
169	Rhabdomyosarcoma	Enrichment	TP53	1.15
170	Gliosarcoma	Enrichment	TP53	1.15
171	Microform holoprosencephaly	Enrichment	DLL1	1.15
172	Lobar holoprosencephaly	Enrichment	DLL1	1.15
173	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.13
174	Giant cell glioblastoma	Enrichment	TP53	1.13
175	Alobar holoprosencephaly	Enrichment	DLL1	1.13
176	Semilobar holoprosencephaly	Enrichment	DLL1	1.10
177	Congenital nervous system abnormality	Enrichment	PSEN1, TSC2	1.07
178	Nervous system disease	Enrichment	PSEN1, TSC2	1.07
179	Hepatoblastoma	Enrichment	TP53	1.04
180	Hepatocellular carcinoma	Enrichment	TP53	1.02
181	Microphthalmia	Enrichment	DYRK1A	1.02
182	Skin disease	Enrichment	NCSTN	1.02
183	Diamond-blackfan anemia 1	Enrichment	TP53	1.00
184	Parkinson disease, late-onset	Enrichment	MAPT	0.98
185	Pancreatic cancer	Enrichment	TP53	0.97
186	Tetralogy of fallot	Enrichment	NOTCH1	0.95
187	Prostate cancer	Enrichment	TP53	0.90
188	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.86
189	Connective tissue disease	Enrichment	NOTCH1	0.86
190	Diamond-blackfan anemia	Enrichment	TP53	0.82
191	Leukemia, acute myeloid	Enrichment	TP53	0.78
192	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	0.74
193	Hereditary breast carcinoma	Enrichment	TP53	0.74
194	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.69
195	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.67
196	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1	0.67
197	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.64
198	Breast cancer	Enrichment	TP53	0.54
199	Microcephaly	Enrichment	DYRK1A	0.36
200	Complex neurodevelopmental disorder	Enrichment	DYRK1A	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DYRK1A involvement regarding cell proliferation in brain development

Pathway Network for DYRK1A involvement regarding cell proliferation in brain development

Member Pathways for DYRK1A involvement regarding cell proliferation in brain development

Pathways in the DYRK1A involvement regarding cell proliferation in brain development SuperPath

Associated Genes for DYRK1A involvement regarding cell proliferation in brain development

Associated Disorders for DYRK1A involvement regarding cell proliferation in brain development

Disorders associated with DYRK1A involvement regarding cell proliferation in brain development SuperPath

STRING Interaction Network for DYRK1A involvement regarding cell proliferation in brain development

Sources for DYRK1A involvement regarding cell proliferation in brain development