E-cadherin signaling in keratinocytes

No Pathway Network information available for E-cadherin signaling in keratinocytes

Pathways in the E-cadherin signaling in keratinocytes SuperPath

#	Name	Source	Genes
1	E-cadherin signaling in keratinocytes	PubChem	AJUBA AKT1 CASR CDH1 CTNNA1 CTNND1 EGFR FMN1 FYN PIK3CA PIK3R1 PIP5K1A PLCG1 RAC1 RHOA SRC VASP ZYX (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FMN1	Formin 1	Protein Coding	1
2	ZYX	Zyxin	Protein Coding	1
3	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
5	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
6	CTNND1	Catenin Delta 1	Protein Coding	1
7	CTNNA1	Catenin Alpha 1	Protein Coding	1
8	CDH1	Cadherin 1	Protein Coding	1
9	AJUBA	Ajuba LIM Protein	Protein Coding	1
10	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
11	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
12	RHOA	Ras Homolog Family Member A	Protein Coding	1
13	RAC1	Rac Family Small GTPase 1	Protein Coding	1
14	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
15	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
16	CASR	Calcium Sensing Receptor	Protein Coding	1
17	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
18	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with E-cadherin signaling in keratinocytes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, CDH1, CTNNA1, PIK3CA, PIK3R1, SRC	8.99
2	Blepharocheilodontic syndrome 1	Enrichment	CDH1, CTNND1	5.78
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.30
4	Ovarian cancer	Enrichment	AKT1, CDH1, EGFR, PIK3CA	5.09
5	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	5.00
6	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	4.60
7	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.60
8	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.60
9	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	4.60
10	Cleft lip with or without cleft palate	Enrichment	CDH1, CTNND1	4.60
11	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, PIK3CA	4.60
12	Cowden syndrome	Enrichment	AKT1, PIK3CA	4.23
13	Lung non-small cell carcinoma	Enrichment	EGFR, PIK3CA	4.04
14	Meningioma	Enrichment	AKT1, PIK3CA	3.96
15	Lip and oral cavity carcinoma	Enrichment	EGFR, PIK3CA	3.96
16	Breast cancer	Enrichment	AKT1, CDH1, PIK3CA	3.90
17	Endometrial cancer	Enrichment	CDH1, PIK3CA	3.46
18	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CTNNA1, EGFR	3.18
19	Bladder cancer	Enrichment	EGFR, PIK3CA	3.18
20	Prostate cancer	Enrichment	CDH1, PIK3CA	3.18
21	Lung cancer	Enrichment	EGFR, PIK3CA	3.09
22	Macrodactyly	Enrichment	PIK3CA	2.88
23	Proteus syndrome	Enrichment	AKT1	2.88
24	Hypocalcemia, autosomal dominant 1	Enrichment	CASR	2.88
25	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.88
26	Hypocalciuric hypercalcemia, familial, type i	Enrichment	CASR	2.88
27	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.88
28	Cowden syndrome 5	Enrichment	PIK3CA	2.88
29	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.88
30	Short syndrome	Enrichment	PIK3R1	2.88
31	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.88
32	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.88
33	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.88
34	Epilepsy, idiopathic generalized 8	Enrichment	CASR	2.88
35	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.88
36	Cowden syndrome 6	Enrichment	AKT1	2.88
37	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.88
38	Thrombocytopenia 6	Enrichment	SRC	2.88
39	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.88
40	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.88
41	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.88
42	Hypospadias	Enrichment	PIK3CA	2.88
43	Hypercalcemia	Enrichment	CASR	2.88
44	Breast lobular carcinoma	Enrichment	CDH1	2.88
45	Familial hypocalciuric hypercalcemia	Enrichment	CASR	2.88
46	Rare venous malformation	Enrichment	PIK3CA	2.88
47	Diaphragmatic eventration	Enrichment	PIK3CA	2.88
48	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.88
49	Rare combined vascular malformation	Enrichment	PIK3CA	2.88
50	Cavernous lymphangioma	Enrichment	PIK3CA	2.88
51	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.88
52	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.88
53	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.88
54	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.88
55	Macrodactyly of toe	Enrichment	PIK3CA	2.88
56	Gastric cancer	Enrichment	CDH1, PIK3CA	2.84
57	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, FMN1	2.63
58	Hyperparathyroidism, neonatal severe	Enrichment	CASR	2.58
59	Keratosis, seborrheic	Enrichment	PIK3CA	2.58
60	Noonan syndrome 8	Enrichment	PIK3CA	2.58
61	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.58
62	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.58
63	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.58
64	Autosomal dominant hypocalcemia	Enrichment	CASR	2.58
65	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.58
66	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.40
67	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.40
68	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.40
69	Breast-ovarian cancer, familial 4	Enrichment	FMN1	2.40
70	Familial isolated hypoparathyroidism	Enrichment	CASR	2.40
71	Immunodeficiency 14	Enrichment	PIK3R1	2.40
72	Parathyroid adenoma	Enrichment	CASR	2.40
73	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.40
74	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.40
75	Keratoacanthoma	Enrichment	PIK3CA	2.40
76	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	2.28
77	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.28
78	Cerebrovascular disease	Enrichment	PIK3CA	2.28
79	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.28
80	Primary hyperparathyroidism	Enrichment	CASR	2.28
81	Capillary malformations, congenital	Enrichment	PIK3CA	2.18
82	Hemimegalencephaly	Enrichment	PIK3CA	2.18
83	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.10
84	Nevus, epidermal	Enrichment	PIK3CA	2.03
85	Myelofibrosis	Enrichment	SRC	2.03
86	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.03
87	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.03
88	Gallbladder cancer	Enrichment	PIK3CA	2.03
89	Overgrowth syndrome	Enrichment	PIK3R1	2.03
90	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.93
91	Arteriovenous malformation	Enrichment	PIK3CA	1.93
92	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.93
93	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.88
94	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.88
95	Osteoporosis	Enrichment	SRC	1.73
96	Lung cancer susceptibility 3	Enrichment	EGFR	1.73
97	Cleft lip/palate	Enrichment	CDH1	1.73
98	Lynch syndrome	Enrichment	PIK3CA	1.70
99	Gliosarcoma	Enrichment	EGFR	1.68
100	Pancreatitis, hereditary	Enrichment	CASR	1.65
101	Giant cell glioblastoma	Enrichment	EGFR	1.65
102	Arteriovenous malformations of the brain	Enrichment	EGFR	1.60
103	Craniosynostosis	Enrichment	CTNNA1	1.58
104	Hepatocellular carcinoma	Enrichment	PIK3CA	1.54
105	Hypertrophic cardiomyopathy	Enrichment	CASR	1.26
106	Thrombocytopenia	Enrichment	SRC	1.21
107	Hypertelorism	Enrichment	PIK3CA	1.17
108	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.49
109	Fundus dystrophy	Enrichment	CTNNA1	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

E-cadherin signaling in keratinocytes

Pathway Network for E-cadherin signaling in keratinocytes

Member Pathways for E-cadherin signaling in keratinocytes

Pathways in the E-cadherin signaling in keratinocytes SuperPath

Associated Genes for E-cadherin signaling in keratinocytes

Associated Disorders for E-cadherin signaling in keratinocytes

Disorders associated with E-cadherin signaling in keratinocytes SuperPath

STRING Interaction Network for E-cadherin signaling in keratinocytes

Sources for E-cadherin signaling in keratinocytes