E-cadherin signaling in the nascent adherens junction

No Pathway Network information available for E-cadherin signaling in the nascent adherens junction

Pathways in the E-cadherin signaling in the nascent adherens junction SuperPath

#	Name	Source	Genes
1	E-cadherin signaling in the nascent adherens junction	PubChem	ABI1 AFDN AKT1 AP1M1 ARF6 CA2 CCND1 CDC42 CDH1 CRK CTNNA1 CTNNB1 CTNND1 CTTN CYFIP2 DLG1 ENAH IQGAP1 ITGAE ITGB7 JUP KLHL20 NCKAP1 NME1 PIK3CA PIK3R1 PIP5K1C RAC1 RAPGEF1 RHOA SRC TIAM1 TJP1 VAV2 WASF2 (see all 35) (see less)
2	AlphaE beta7 integrin cell surface interactions	PubChem	CDH1 ITGAE ITGB7

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ITGAE	Integrin Subunit Alpha E	Protein Coding	2
2	ITGB7	Integrin Subunit Beta 7	Protein Coding	2
3	CDH1	Cadherin 1	Protein Coding	2
4	AP1M1	Adaptor Related Protein Complex 1 Subunit Mu 1	Protein Coding	1
5	KLHL20	Kelch Like Family Member 20	Protein Coding	1
6	ENAH	ENAH Actin Regulator	Protein Coding	1
7	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
8	ABI1	Abl Interactor 1	Protein Coding	1
9	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	1
10	WASF2	WASP Family Member 2	Protein Coding	1
11	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	1
12	CTTN	Cortactin	Protein Coding	1
13	CCND1	Cyclin D1	Protein Coding	1
14	NCKAP1	NCK Associated Protein 1	Protein Coding	1
15	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
16	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
17	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
18	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
19	CTNND1	Catenin Delta 1	Protein Coding	1
20	CTNNB1	Catenin Beta 1	Protein Coding	1
21	CTNNA1	Catenin Alpha 1	Protein Coding	1
22	JUP	Junction Plakoglobin	Protein Coding	1
23	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
24	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
25	CDC42	Cell Division Cycle 42	Protein Coding	1
26	RHOA	Ras Homolog Family Member A	Protein Coding	1
27	RAC1	Rac Family Small GTPase 1	Protein Coding	1
28	ARF6	ARF GTPase 6	Protein Coding	1
29	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
30	TJP1	Tight Junction Protein 1	Protein Coding	1
31	CA2	Carbonic Anhydrase 2	Protein Coding	1
32	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
33	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
34	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
35	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with E-cadherin signaling in the nascent adherens junction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, CCND1, CDH1, CTNNA1, CTNNB1, PIK3CA, PIK3R1, SRC	10.27
2	Blepharocheilodontic syndrome 1	Enrichment	CDH1, CTNND1	5.19
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.71
4	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	4.41
5	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.02
6	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.02
7	Cleft lip with or without cleft palate	Enrichment	CDH1, CTNND1	4.02
8	Ovarian cancer	Enrichment	AKT1, CDH1, CTNNB1, PIK3CA	3.90
9	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA	3.87
10	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, PIK3CA	3.71
11	Breast lobular carcinoma	Enrichment	CDH1	3.66
12	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.64
13	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.64
14	Meningioma	Enrichment	AKT1, PIK3CA	3.38
15	Cleft lip/palate	Enrichment	CDH1, DLG1	3.24
16	Breast cancer	Enrichment	AKT1, CDH1, PIK3CA	3.03
17	Endometrial cancer	Enrichment	CDH1, PIK3CA	2.88
18	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.84
19	Bladder cancer	Enrichment	CTNNB1, PIK3CA	2.60
20	Prostate cancer	Enrichment	CDH1, PIK3CA	2.60
21	Macrodactyly	Enrichment	PIK3CA	2.59
22	Proteus syndrome	Enrichment	AKT1	2.59
23	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.59
24	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.59
25	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.59
26	Cowden syndrome 5	Enrichment	PIK3CA	2.59
27	Naxos disease	Enrichment	JUP	2.59
28	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.59
29	Short syndrome	Enrichment	PIK3R1	2.59
30	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.59
31	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.59
32	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.59
33	Cowden syndrome 6	Enrichment	AKT1	2.59
34	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.59
35	Thrombocytopenia 6	Enrichment	SRC	2.59
36	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.59
37	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.59
38	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.59
39	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.59
40	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.59
41	Adenoid ameloblastoma	Enrichment	CTNNB1	2.59
42	Hypospadias	Enrichment	PIK3CA	2.59
43	Rare venous malformation	Enrichment	PIK3CA	2.59
44	Diaphragmatic eventration	Enrichment	PIK3CA	2.59
45	Nocarh syndrome	Enrichment	CDC42	2.59
46	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.59
47	Rare combined vascular malformation	Enrichment	PIK3CA	2.59
48	Cavernous lymphangioma	Enrichment	PIK3CA	2.59
49	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.59
50	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.59
51	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.59
52	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.59
53	Macrodactyly of toe	Enrichment	PIK3CA	2.59
54	Microcystic stromal tumor	Enrichment	CTNNB1	2.59
55	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.29
56	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.29
57	Keratosis, seborrheic	Enrichment	PIK3CA	2.29
58	Noonan syndrome 8	Enrichment	PIK3CA	2.29
59	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1	2.29
60	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.29
61	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.29
62	Osteopetrosis, autosomal recessive 3	Enrichment	CA2	2.29
63	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.29
64	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.29
65	Immune system disease	Enrichment	CDC42	2.29
66	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.29
67	Teratoma	Enrichment	CTNNB1	2.29
68	Immunodeficiency 72	Enrichment	NCKAP1	2.29
69	Gastric cancer	Enrichment	CDH1, PIK3CA	2.26
70	Desmoid disease, hereditary	Enrichment	CTNNB1	2.11
71	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.11
72	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	2.11
73	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.11
74	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.11
75	Anus, imperforate	Enrichment	CTNNB1	2.11
76	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.11
77	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	2.11
78	Desmoid tumor	Enrichment	CTNNB1	2.11
79	Immunodeficiency 14	Enrichment	PIK3R1	2.11
80	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.11
81	Keratoacanthoma	Enrichment	PIK3CA	2.11
82	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.99
83	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.99
84	Pilomatrixoma	Enrichment	CTNNB1	1.99
85	Alazami syndrome	Enrichment	CTNNB1	1.99
86	Mantle cell lymphoma	Enrichment	CCND1	1.99
87	Cerebrovascular disease	Enrichment	PIK3CA	1.99
88	Craniopharyngioma	Enrichment	CTNNB1	1.99
89	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.99
90	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.99
91	Capillary malformations, congenital	Enrichment	PIK3CA	1.89
92	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.89
93	Von hippel-lindau syndrome	Enrichment	CCND1	1.89
94	Osteopetrosis	Enrichment	CA2	1.89
95	Hemimegalencephaly	Enrichment	PIK3CA	1.89
96	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.81
97	Cowden syndrome 1	Enrichment	PIK3CA	1.81
98	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.81
99	Adrenocortical carcinoma	Enrichment	CTNNB1	1.81
100	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.81
101	Nevus, epidermal	Enrichment	PIK3CA	1.75
102	Myelofibrosis	Enrichment	SRC	1.75
103	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.75
104	Overgrowth syndrome	Enrichment	PIK3R1	1.75
105	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.69
106	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.64
107	Arteriovenous malformation	Enrichment	PIK3CA	1.64
108	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.59
109	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.59
110	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.59
111	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.55
112	Inherited cancer-predisposing syndrome	Enrichment	CDH1	1.54
113	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.52
114	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.52
115	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.52
116	Osteoporosis	Enrichment	SRC	1.45
117	Medulloblastoma	Enrichment	CTNNB1	1.45
118	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.45
119	Lynch syndrome	Enrichment	PIK3CA	1.42
120	Wolff-parkinson-white syndrome	Enrichment	JUP	1.39
121	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.39
122	Polycystic liver disease	Enrichment	CTNNB1	1.37
123	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.37
124	Craniosynostosis	Enrichment	CTNNA1	1.30
125	Hepatoblastoma	Enrichment	CTNNB1	1.28
126	Lung cancer	Enrichment	PIK3CA	1.10
127	Thrombocytopenia	Enrichment	SRC	0.93
128	Hypertelorism	Enrichment	PIK3CA	0.90
129	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.88
130	Myeloma, multiple	Enrichment	CCND1	0.87
131	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2	0.87
132	Dilated cardiomyopathy	Enrichment	JUP	0.73
133	Congenital nervous system abnormality	Enrichment	CTNNB1	0.62
134	Nervous system disease	Enrichment	CTNNB1	0.62
135	Microcephaly	Enrichment	CTNNB1	0.56
136	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.56
137	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.27
138	Fundus dystrophy	Enrichment	CTNNA1	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

E-cadherin signaling in the nascent adherens junction

Pathway Network for E-cadherin signaling in the nascent adherens junction

Member Pathways for E-cadherin signaling in the nascent adherens junction

Pathways in the E-cadherin signaling in the nascent adherens junction SuperPath

Associated Genes for E-cadherin signaling in the nascent adherens junction

Associated Disorders for E-cadherin signaling in the nascent adherens junction

Disorders associated with E-cadherin signaling in the nascent adherens junction SuperPath

STRING Interaction Network for E-cadherin signaling in the nascent adherens junction

Sources for E-cadherin signaling in the nascent adherens junction