E2F mediated regulation of DNA replication

Pathway network for the E2F mediated regulation of DNA replication SuperPath

Sources:

Reactome

Pathways in the E2F mediated regulation of DNA replication SuperPath

#	Name	Source	Genes
1	E2F mediated regulation of DNA replication	Reactome	CCNB1 CDK1 E2F1 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 RB1 TFDP1 TFDP2 (see all 22) (see less)
2	Inhibition of replication initiation of damaged DNA by RB1/E2F1	Reactome	E2F1 POLA1 POLA2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 RB1 TFDP1 TFDP2 (see all 13) (see less)
3	E2F-enabled inhibition of pre-replication complex formation	Reactome	CCNB1 CDK1 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 (see all 9) (see less)

Gene overlap in member pathways for E2F mediated regulation of DNA replication SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	E2F1	E2F Transcription Factor 1	Protein Coding	2
2	ORC6	Origin Recognition Complex Subunit 6	Protein Coding	2
3	ORC3	Origin Recognition Complex Subunit 3	Protein Coding	2
4	POLA2	DNA Polymerase Alpha 2, Accessory Subunit	Protein Coding	2
5	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	2
6	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	2
7	ORC2	Origin Recognition Complex Subunit 2	Protein Coding	2
8	ORC4	Origin Recognition Complex Subunit 4	Protein Coding	2
9	ORC5	Origin Recognition Complex Subunit 5	Protein Coding	2
10	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	2
11	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
12	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
13	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
14	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
15	PRIM1	DNA Primase Subunit 1	Protein Coding	2
16	PRIM2	DNA Primase Subunit 2	Protein Coding	2
17	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
18	TFDP1	Transcription Factor Dp-1	Protein Coding	2
19	TFDP2	Transcription Factor Dp-2	Protein Coding	2
20	MCM8	Minichromosome Maintenance 8 Homologous Recombination Repair Factor	Protein Coding	2
21	CCNB1	Cyclin B1	Protein Coding	2
22	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2

Disorders associated with E2F mediated regulation of DNA replication SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meier-gorlin syndrome 1	Enrichment	ORC1, ORC4, ORC6	7.62
2	Meier-gorlin syndrome 3	Enrichment	ORC6	3.18
3	Meier-gorlin syndrome 2	Enrichment	ORC4	3.18
4	Premature ovarian failure 10	Enrichment	MCM8	3.18
5	Van esch-o'driscoll syndrome	Enrichment	POLA1	3.02
6	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	3.02
7	Houge-janssens syndrome 2	Enrichment	PPP2R1A	3.02
8	Trilateral retinoblastoma	Enrichment	RB1	3.02
9	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	3.02
10	Lung oat cell carcinoma	Enrichment	RB1	3.02
11	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.72
12	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	2.72
13	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.72
14	Familial retinoblastoma	Enrichment	RB1	2.72
15	Retinoblastoma	Enrichment	RB1	2.54
16	Partington syndrome	Enrichment	POLA1	2.54
17	Osteogenic sarcoma	Enrichment	RB1	2.54
18	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.54
19	Hypotrichosis 8	Enrichment	RB1	2.54
20	Squamous cell carcinoma	Enrichment	RB1	2.54
21	Bone osteosarcoma	Enrichment	RB1	2.54
22	2q23.1 microduplication syndrome	Enrichment	ORC4	2.48
23	Small cell cancer of the lung	Enrichment	RB1	2.42
24	Lynch syndrome 4	Enrichment	RB1	2.42
25	Lip and oral cavity carcinoma	Enrichment	RB1	1.94
26	Azoospermia	Enrichment	MCM8	1.88
27	Lung cancer susceptibility 3	Enrichment	RB1	1.87
28	Seckel syndrome	Enrichment	PRIM1	1.87
29	Bladder cancer	Enrichment	RB1	1.56
30	Lung cancer	Enrichment	PPP2R1B	1.52
31	Ovarian cancer	Enrichment	RB1	1.03
32	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.95
33	Inherited cancer-predisposing syndrome	Enrichment	RB1	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

E2F mediated regulation of DNA replication

Pathway Network for E2F mediated regulation of DNA replication

Pathway network for the E2F mediated regulation of DNA replication SuperPath

Member Pathways for E2F mediated regulation of DNA replication

Pathways in the E2F mediated regulation of DNA replication SuperPath

Gene overlap in member pathways for E2F mediated regulation of DNA replication SuperPath

Associated Genes for E2F mediated regulation of DNA replication

Associated Disorders for E2F mediated regulation of DNA replication

Disorders associated with E2F mediated regulation of DNA replication SuperPath

STRING Interaction Network for E2F mediated regulation of DNA replication

Sources for E2F mediated regulation of DNA replication