E2F transcription factor network

No Pathway Network information available for E2F transcription factor network

Pathways in the E2F transcription factor network SuperPath

#	Name	Source	Genes
1	E2F transcription factor network	PubChem	APAF1 ATM BRCA1 CASP7 CBX5 CCNA2 CCND3 CCNE1 CDC25A CDC6 CDK1 CDK2 CDKN1A CDKN1B CDKN2A CDKN2C CEBPA DHFR E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 E2F7 HBP1 HDAC1 HIC1 KAT2A KAT2B MAD2L1BP MCL1 MCM3 MYBL2 MYC ORC1 PLAU POLA1 PRMT5 PTGDR RANBP1 RB1 RBBP4 RBBP8 RBL1 RRM1 RRM2 RYBP SERPINE1 SIRT1 SMARCA2 SP1 SULT2A1 TFDP1 TFDP2 TFE3 TK1 TOPBP1 TP73 TRIM28 TRRAP TYMS UXT WASF1 XRCC1 YY1 (see all 66) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAD2L1BP	MAD2L1 Binding Protein	Protein Coding	1
2	E2F3	E2F Transcription Factor 3	Protein Coding	1
3	E2F5	E2F Transcription Factor 5	Protein Coding	1
4	E2F2	E2F Transcription Factor 2	Protein Coding	1
5	HBP1	HMG-Box Transcription Factor 1	Protein Coding	1
6	TFE3	Transcription Factor Binding To IGHM Enhancer 3	Protein Coding	1
7	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	1
8	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	1
9	WASF1	WASP Family Member 1	Protein Coding	1
10	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
11	UXT	Ubiquitously Expressed Prefoldin Like Chaperone	Protein Coding	1
12	TP73	Tumor Protein P73	Protein Coding	1
13	E2F7	E2F Transcription Factor 7	Protein Coding	1
14	RYBP	RING1 And YY1 Binding Protein	Protein Coding	1
15	E2F6	E2F Transcription Factor 6	Protein Coding	1
16	TFDP2	Transcription Factor Dp-2	Protein Coding	1
17	TFDP1	Transcription Factor Dp-1	Protein Coding	1
18	PRMT5	Protein Arginine Methyltransferase 5	Protein Coding	1
19	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
20	RANBP1	RAN Binding Protein 1	Protein Coding	1
21	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
22	HIC1	HIC ZBTB Transcriptional Repressor 1	Protein Coding	1
23	MCM3	Minichromosome Maintenance Complex Component 3	Protein Coding	1
24	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	1
25	CCNE1	Cyclin E1	Protein Coding	1
26	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	1
27	E2F4	E2F Transcription Factor 4	Protein Coding	1
28	MYBL2	MYB Proto-Oncogene Like 2	Protein Coding	1
29	CDC6	Cell Division Cycle 6	Protein Coding	1
30	CCNA2	Cyclin A2	Protein Coding	1
31	CDC25A	Cell Division Cycle 25A	Protein Coding	1
32	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
33	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
34	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	1
35	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	1
36	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	1
37	XRCC1	X-Ray Repair Cross Complementing 1	Protein Coding	1
38	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
39	CASP7	Caspase 7	Protein Coding	1
40	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
41	E2F1	E2F Transcription Factor 1	Protein Coding	1
42	DHFR	Dihydrofolate Reductase	Protein Coding	1
43	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	1
44	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
45	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
46	CBX5	Chromobox 5	Protein Coding	1
47	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
48	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
49	SERPINE1	Serpin Family E Member 1	Protein Coding	1
50	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
51	SP1	Sp1 Transcription Factor	Protein Coding	1
52	SIRT1	Sirtuin 1	Protein Coding	1
53	YY1	YY1 Transcription Factor	Protein Coding	1
54	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
55	CCND3	Cyclin D3	Protein Coding	1
56	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
57	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
58	HDAC1	Histone Deacetylase 1	Protein Coding	1
59	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
60	TYMS	Thymidylate Synthetase	Protein Coding	1
61	TK1	Thymidine Kinase 1	Protein Coding	1
62	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	1
63	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	1
64	PTGDR	Prostaglandin D2 Receptor	Protein Coding	1
65	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
66	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1

Disorders associated with E2F transcription factor network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, CDKN2A, RB1	6.60
2	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, CDKN1B, CDKN2A, CEBPA, DHFR, RB1	5.47
3	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2C	5.42
4	Pancreatic cancer	Enrichment	ATM, BRCA1, CDKN2A, RBBP8	5.22
5	Ovarian cancer	Enrichment	ATM, BRCA1, CDKN1B, CDKN2A, RB1	3.89
6	Endometrial cancer	Enrichment	ATM, BRCA1, DHFR	3.86
7	Small cell cancer of the lung	Enrichment	RB1, TP73	3.86
8	Meier-gorlin syndrome 1	Enrichment	CDC6, ORC1	2.99
9	Gastric cancer	Enrichment	ATM, BRCA1, CDKN2A	2.93
10	Uterine corpus cancer	Enrichment	ATM, BRCA1	2.90
11	Lip and oral cavity carcinoma	Enrichment	CDKN2A, RB1	2.83
12	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1	2.76
13	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.31
14	Van esch-o'driscoll syndrome	Enrichment	POLA1	2.31
15	Seckel syndrome 2	Enrichment	RBBP8	2.31
16	Asthma-related traits 1	Enrichment	PTGDR	2.31
17	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	2.31
18	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.31
19	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	2.31
20	Renal cell carcinoma, xp11-associated	Enrichment	TFE3	2.31
21	Intellectual developmental disorder, x-linked, syndromic, with pigmentary mosaicism and coarse facies	Enrichment	TFE3	2.31
22	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	2.31
23	Infant-type hemispheric glioma	Enrichment	BRCA1	2.31
24	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.31
25	Jawad syndrome	Enrichment	RBBP8	2.31
26	Neuroendocrine tumor	Enrichment	CDKN1B	2.31
27	Endometrial serous adenocarcinoma	Enrichment	ATM	2.31
28	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.31
29	Meier-gorlin syndrome 5	Enrichment	CDC6	2.31
30	Deafness, autosomal dominant 75	Enrichment	TRRAP	2.31
31	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	2.31
32	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	2.31
33	Spinocerebellar ataxia, autosomal recessive 26	Enrichment	XRCC1	2.31
34	Trilateral retinoblastoma	Enrichment	RB1	2.31
35	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.31
36	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.31
37	Wilms tumor 7	Enrichment	TRIM28	2.31
38	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.31
39	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.31
40	Primary peritoneal carcinoma	Enrichment	BRCA1	2.31
41	Lung oat cell carcinoma	Enrichment	RB1	2.31
42	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, MYC	2.26
43	Prostate cancer	Enrichment	ATM, BRCA1	2.06
44	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.01
45	Burkitt lymphoma	Enrichment	MYC	2.01
46	Quebec platelet disorder	Enrichment	PLAU	2.01
47	Alveolar soft part sarcoma	Enrichment	TFE3	2.01
48	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.01
49	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.01
50	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.01
51	Gabriele-de vries syndrome	Enrichment	YY1	2.01
52	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.01
53	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.01
54	Pancreatic cancer 4	Enrichment	BRCA1	2.01
55	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.01
56	High grade glioma	Enrichment	ATM	2.01
57	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.01
58	Insulinoma	Enrichment	YY1	2.01
59	T-cell prolymphocytic leukemia	Enrichment	ATM	2.01
60	Inflammatory breast carcinoma	Enrichment	BRCA1	2.01
61	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	2.01
62	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.01
63	Peritoneum cancer	Enrichment	BRCA1	2.01
64	Bilateral breast cancer	Enrichment	BRCA1	2.01
65	Familial retinoblastoma	Enrichment	RB1	2.01
66	Retinoblastoma	Enrichment	RB1	1.84
67	Ataxia-telangiectasia	Enrichment	ATM	1.84
68	Polycythemia vera	Enrichment	ATM	1.84
69	Partington syndrome	Enrichment	POLA1	1.84
70	Osteogenic sarcoma	Enrichment	RB1	1.84
71	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.84
72	Miller-dieker lissencephaly syndrome	Enrichment	HIC1	1.84
73	Familial adenomatous polyposis 4	Enrichment	DHFR	1.84
74	Hypotrichosis 8	Enrichment	RB1	1.84
75	Koolen-de vries syndrome	Enrichment	ATM	1.84
76	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.84
77	Squamous cell carcinoma	Enrichment	RB1	1.84
78	Adenocarcinoma	Enrichment	ATM	1.84
79	Bone osteosarcoma	Enrichment	RB1	1.84
80	Respiratory failure	Enrichment	TP73	1.84
81	Renal cell carcinoma	Enrichment	TFE3	1.84
82	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.71
83	Nicolaides-baraitser syndrome	Enrichment	SMARCA2	1.71
84	Cholangiocarcinoma	Enrichment	BRCA1	1.71
85	Lynch syndrome 4	Enrichment	RB1	1.71
86	Mantle cell lymphoma	Enrichment	ATM	1.71
87	Blepharophimosis	Enrichment	SMARCA2	1.71
88	Malignant epithelioid hemangioendothelioma	Enrichment	TFE3	1.71
89	Smarca2-related nicolaides-baraitser syndrome	Enrichment	SMARCA2	1.71
90	Primary hyperparathyroidism	Enrichment	CDKN1B	1.71
91	Oculomotor apraxia	Enrichment	ATM	1.71
92	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.71
93	Hereditary breast carcinoma	Enrichment	ATM, BRCA1	1.71
94	Alzheimer disease 2	Enrichment	PLAU	1.62
95	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.62
96	Ciliary dyskinesia, primary, 40	Enrichment	E2F6	1.62
97	Glioblastoma	Enrichment	ATM	1.62
98	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.62
99	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.62
100	Li-fraumeni syndrome	Enrichment	CDKN2A	1.54
101	Wilms tumor 5	Enrichment	TRIM28	1.54
102	Adrenocortical carcinoma	Enrichment	CDKN2A	1.54
103	Clear cell renal cell carcinoma	Enrichment	ATM	1.54
104	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.54
105	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1	1.53
106	Myeloma, multiple	Enrichment	ATM, CDKN2C	1.52
107	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.47
108	Renal cell carcinoma with mit translocations	Enrichment	TFE3	1.47
109	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.47
110	Colonic benign neoplasm	Enrichment	ATM	1.37
111	Lynch syndrome 1	Enrichment	ATM	1.32
112	Leukemia, chronic lymphocytic	Enrichment	ATM	1.32
113	Melanoma	Enrichment	CDKN2A	1.32
114	Breast cancer	Enrichment	ATM, BRCA1	1.29
115	Immune deficiency disease	Enrichment	ATM	1.28
116	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.28
117	Familial colorectal cancer type x	Enrichment	ATM	1.28
118	Lung cancer susceptibility 3	Enrichment	RB1	1.18
119	Periventricular nodular heterotopia	Enrichment	BRCA1	1.18
120	Seckel syndrome	Enrichment	RBBP8	1.18
121	Pituitary stalk interruption syndrome	Enrichment	SMARCA2	1.18
122	Colorectal cancer	Enrichment	ATM, BRCA1	1.17
123	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.15
124	Wilms tumor 1	Enrichment	TRIM28	1.15
125	Rhabdomyosarcoma	Enrichment	BRCA1	1.12
126	Gliosarcoma	Enrichment	ATM	1.12
127	Alzheimer disease, familial, 1	Enrichment	PLAU	1.10
128	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.10
129	Polycystic liver disease	Enrichment	CDC25A	1.10
130	Giant cell glioblastoma	Enrichment	ATM	1.10
131	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.10
132	Dyskeratosis congenita	Enrichment	TYMS	1.05
133	Lung cancer	Enrichment	BRCA1	0.84
134	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.80
135	Leukemia, acute myeloid	Enrichment	CEBPA	0.75
136	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TRRAP	0.65
137	Complex neurodevelopmental disorder	Enrichment	WASF1	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

E2F transcription factor network

Pathway Network for E2F transcription factor network

Member Pathways for E2F transcription factor network

Pathways in the E2F transcription factor network SuperPath

Associated Genes for E2F transcription factor network

Associated Disorders for E2F transcription factor network

Disorders associated with E2F transcription factor network SuperPath

STRING Interaction Network for E2F transcription factor network

Sources for E2F transcription factor network