Early SARS-CoV-2 Infection Events

Pathway network for the Early SARS-CoV-2 Infection Events SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Early SARS-CoV-2 Infection Events SuperPath

#	Name	Source	Genes
1	Early SARS-CoV-2 Infection Events	Reactome	ACE2 AGRN BECN1 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CTSL DDX5 FURIN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HAVCR1 HSPG2 ISCU MAP1LC3B NRP1 PIK3C3 PIK3R4 RB1 RNF103-CHMP3 SDC1 SDC2 SDC3 SDC4 TMPRSS2 UVRAG VCP VHL ZCRB1 (see all 38) (see less)
2	SARS-CoV-2 Infection	WikiPathways	ACE2 BECN1 CANX CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CTSL DAD1 DDOST DDX5 EDEM2 FURIN FUT8 GALNT1 GANAB GSK3A GSK3B MAGT1 MAN1B1 MAN2A1 MAP1LC3B MGAT1 MGAT2 MGAT4A MGAT4B MGAT4C MGAT5 MOGS PARP10 PARP14 PARP16 PARP4 PARP6 PARP8 PARP9 PIK3C3 PIK3R4 PRKCSH RB1 RNF103-CHMP3 RPN1 RPN2 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 STT3A SUMO1 TMPRSS2 TUSC3 UBA52 UBB UBC UBE2I UVRAG VCP VHL ZCRB1 (see all 68) (see less)
3	SARS-CoV-1 Infection	WikiPathways	ACE2 BECN1 CANX CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CTSL DDX5 GALNT1 GANAB GSK3A GSK3B MAP1LC3B MGAT1 MOGS PARP10 PARP14 PARP16 PARP4 PARP6 PARP8 PARP9 PIK3C3 PIK3R4 PRKCSH RB1 RNF103-CHMP3 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 SUMO1 TMPRSS2 UBA52 UBB UBC UBE2I UVRAG VCP VHL ZCRB1 (see all 51) (see less)
4	Translation of Structural Proteins	Reactome	CANX GALNT1 GANAB GSK3A GSK3B MGAT1 MOGS PARP10 PARP14 PARP16 PARP4 PARP6 PARP8 PARP9 PRKCSH RPS27A ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 SUMO1 UBA52 UBB UBC UBE2I (see all 29) (see less)
5	Attachment and Entry	Reactome	ACE2 AGRN CTSL FURIN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HAVCR1 HSPG2 NRP1 SDC1 SDC2 SDC3 SDC4 TMPRSS2 VCP (see all 19) (see less)
6	Translation of Replicase and Assembly of the Replication Transcription Complex	Reactome	BECN1 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 ISCU MAP1LC3B PIK3C3 PIK3R4 RNF103-CHMP3 UVRAG (see all 15) (see less)
7	Translation of Replicase and Assembly of the Replication Transcription Complex	Reactome	BECN1 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 MAP1LC3B PIK3C3 PIK3R4 RNF103-CHMP3 UVRAG (see all 14) (see less)
8	Maturation of protein 3a	Reactome	GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 (see all 9) (see less)
9	Maturation of protein 3a	Reactome	GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 (see all 9) (see less)
10	Maturation of spike protein	Reactome	CANX GANAB MGAT1 MOGS PRKCSH
11	Attachment and Entry	Reactome	ACE2 CTSL TMPRSS2 VCP
12	Defective MOGS causes CDG-2b	Reactome	MOGS

Gene overlap in member pathways for Early SARS-CoV-2 Infection Events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RNF103-CHMP3	RNF103-CHMP3 Readthrough	Protein Coding	5
2	CHMP4B	Charged Multivesicular Body Protein 4B	Protein Coding	5
3	CTSL	Cathepsin L	Protein Coding	5
4	CHMP2B	Charged Multivesicular Body Protein 2B	Protein Coding	5
5	CHMP2A	Charged Multivesicular Body Protein 2A	Protein Coding	5
6	CHMP4A	Charged Multivesicular Body Protein 4A	Protein Coding	5
7	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	5
8	CHMP3	Charged Multivesicular Body Protein 3	Protein Coding	5
9	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	5
10	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	5
11	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	5
12	UVRAG	UV Radiation Resistance Associated	Protein Coding	5
13	VCP	Valosin Containing Protein	Protein Coding	5
14	CHMP6	Charged Multivesicular Body Protein 6	Protein Coding	5
15	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	5
16	BECN1	Beclin 1	Protein Coding	5
17	CHMP7	Charged Multivesicular Body Protein 7	Protein Coding	5
18	CHMP4C	Charged Multivesicular Body Protein 4C	Protein Coding	5
19	ST6GALNAC4	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4	Protein Coding	5
20	ST3GAL2	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2	Protein Coding	5
21	ST3GAL1	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1	Protein Coding	5
22	ST6GALNAC3	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3	Protein Coding	5
23	GALNT1	Polypeptide N-Acetylgalactosaminyltransferase 1	Protein Coding	5
24	ST6GALNAC2	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2	Protein Coding	5
25	ST3GAL4	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4	Protein Coding	5
26	ST6GAL1	ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1	Protein Coding	5
27	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	5
28	MOGS	Mannosyl-Oligosaccharide Glucosidase	Protein Coding	5
29	MGAT1	Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase	Protein Coding	4
30	PRKCSH	PRKCSH Beta Subunit Of Glucosidase II	Protein Coding	4
31	CANX	Calnexin	Protein Coding	4
32	GANAB	Glucosidase II Alpha Subunit	Protein Coding	4
33	DDX5	DEAD-Box Helicase 5	Protein Coding	3
34	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	3
35	RB1	RB Transcriptional Corepressor 1	Protein Coding	3
36	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	3
37	ZCRB1	Zinc Finger CCHC-Type And RNA Binding Motif Containing 1	Protein Coding	3
38	PARP4	Poly(ADP-Ribose) Polymerase Family Member 4	Protein Coding	3
39	PARP10	Poly(ADP-Ribose) Polymerase Family Member 10	Protein Coding	3
40	PARP6	Poly(ADP-Ribose) Polymerase Family Member 6	Protein Coding	3
41	PARP16	Poly(ADP-Ribose) Polymerase Family Member 16	Protein Coding	3
42	PARP8	Poly(ADP-Ribose) Polymerase Family Member 8	Protein Coding	3
43	PARP9	Poly(ADP-Ribose) Polymerase Family Member 9	Protein Coding	3
44	PARP14	Poly(ADP-Ribose) Polymerase Family Member 14	Protein Coding	3
45	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	3
46	UBC	Ubiquitin C	Protein Coding	3
47	UBB	Ubiquitin B	Protein Coding	3
48	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	3
49	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	3
50	RPS27A	Ribosomal Protein S27a	Protein Coding	3
51	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
52	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	3
53	GPC6	Glypican 6	Protein Coding	2
54	GPC2	Glypican 2	Protein Coding	2
55	GPC4	Glypican 4	Protein Coding	2
56	GPC5	Glypican 5	Protein Coding	2
57	ISCU	Iron-Sulfur Cluster Assembly Enzyme	Protein Coding	2
58	HAVCR1	Hepatitis A Virus Cellular Receptor 1	Protein Coding	2
59	GPC3	Glypican 3	Protein Coding	2
60	GPC1	Glypican 1	Protein Coding	2
61	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	2
62	AGRN	Agrin	Protein Coding	2
63	SDC1	Syndecan 1	Protein Coding	2
64	SDC2	Syndecan 2	Protein Coding	2
65	SDC4	Syndecan 4	Protein Coding	2
66	NRP1	Neuropilin 1	Protein Coding	2
67	SDC3	Syndecan 3	Protein Coding	2
68	MGAT4B	Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase B	Protein Coding	1
69	MGAT4A	Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A	Protein Coding	1
70	MGAT4C	MGAT4 Family Member C	Protein Coding	1
71	EDEM2	ER Degradation Enhancing Alpha-Mannosidase Like Protein 2	Protein Coding	1
72	MAN1B1	Mannosidase Alpha Class 1B Member 1	Protein Coding	1
73	FUT8	Fucosyltransferase 8	Protein Coding	1
74	MAN2A1	Mannosidase Alpha Class 2A Member 1	Protein Coding	1
75	MGAT2	Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
76	MGAT5	Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
77	RPN2	Ribophorin II	Protein Coding	1
78	DAD1	Defender Against Cell Death 1	Protein Coding	1
79	STT3A	STT3 Oligosaccharyltransferase Complex Catalytic Subunit A	Protein Coding	1
80	DDOST	Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit	Protein Coding	1
81	RPN1	Ribophorin I	Protein Coding	1
82	TUSC3	Tumor Suppressor Candidate 3	Protein Coding	1
83	MAGT1	Magnesium Transporter 1	Protein Coding	1

Disorders associated with Early SARS-CoV-2 Infection Events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Covid-19	Direct
2	Severe acute respiratory syndrome	Direct
3	Immunodeficiency 47	Direct
4	Progressive non-fluent aphasia	Enrichment	CHMP2B, VCP	3.31
5	Behavioral variant of frontotemporal dementia	Enrichment	CHMP2B, VCP	3.31
6	Polycystic liver disease	Enrichment	GANAB, PRKCSH	2.74
7	Autosomal dominant polycystic liver disease	Enrichment	GANAB, PRKCSH	2.74
8	Cataract 31, multiple types	Enrichment	CHMP4B	2.42
9	Intellectual developmental disorder, autosomal recessive 12	Enrichment	ST3GAL3	2.42
10	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.42
11	Orofacial cleft 10	Enrichment	SUMO1	2.42
12	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.42
13	Multisystem proteinopathy	Enrichment	VCP	2.42
14	Trilateral retinoblastoma	Enrichment	RB1	2.42
15	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.42
16	St3gal3-cdg	Enrichment	ST3GAL3	2.42
17	Retinal hemangioblastoma	Enrichment	VHL	2.42
18	Lung oat cell carcinoma	Enrichment	RB1	2.42
19	Congenital disorder of glycosylation, type iia	Enrichment	MGAT2	2.30
20	Intellectual developmental disorder, autosomal recessive 7	Enrichment	TUSC3	2.30
21	Congenital disorder of glycosylation, type iw, autosomal recessive	Enrichment	STT3A	2.30
22	Congenital disorder of glycosylation, type icc	Enrichment	MAGT1	2.30
23	Congenital disorder of glycosylation, type ir	Enrichment	DDOST	2.30
24	Congenital disorder of glycosylation iw	Enrichment	STT3A	2.30
25	Man1b1-congenital disorder of glycosylation	Enrichment	MAN1B1	2.30
26	Congenital disorder of glycosylation, type iib	Enrichment	MOGS	2.12
27	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.12
28	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.12
29	Developmental and epileptic encephalopathy 15	Enrichment	ST3GAL3	2.12
30	Polycystic kidney disease 3	Enrichment	GANAB	2.12
31	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.12
32	Familial retinoblastoma	Enrichment	RB1	2.12
33	Submucosal cleft palate	Enrichment	UBB	2.12
34	Cleft hard palate	Enrichment	UBB	2.12
35	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.12
36	Immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia	Enrichment	MAGT1	2.00
37	Rafiq syndrome	Enrichment	MAN1B1	2.00
38	Congenital disorder of glycosylation with defective fucosylation 1	Enrichment	FUT8	2.00
39	Intellectual developmental disorder, autosomal recessive 24	Enrichment	TUSC3	2.00
40	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	STT3A	2.00
41	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	RPN1	2.00
42	Retinoblastoma	Enrichment	RB1	1.95
43	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	1.95
44	Uvula, bifid	Enrichment	UBB	1.95
45	Osteogenic sarcoma	Enrichment	RB1	1.95
46	Cleft soft palate	Enrichment	UBB	1.95
47	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.95
48	Hypotrichosis 8	Enrichment	RB1	1.95
49	Primary polycythemia	Enrichment	VHL	1.95
50	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	1.95
51	Squamous cell carcinoma	Enrichment	RB1	1.95
52	Bone osteosarcoma	Enrichment	RB1	1.95
53	Small cell cancer of the lung	Enrichment	RB1	1.83
54	Erythrocytosis, familial, 2	Enrichment	VHL	1.83
55	Au-kline syndrome	Enrichment	VHL	1.83
56	Lynch syndrome 4	Enrichment	RB1	1.83
57	Cataract 6, multiple types	Enrichment	CHMP4B	1.73
58	Polycystic liver disease 1 with or without kidney cysts	Enrichment	PRKCSH	1.73
59	Dementia, lewy body	Enrichment	VCP	1.73
60	Fanconi anemia, complementation group d2	Enrichment	VHL	1.73
61	Von hippel-lindau syndrome	Enrichment	VHL	1.73
62	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	GANAB	1.73
63	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.73
64	Polycystic liver disease 1	Enrichment	PRKCSH	1.73
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHMP2B, VCP	1.70
66	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	VHL	1.65
67	Renal cell carcinoma, papillary, 1	Enrichment	VHL	1.58
68	Multiple enchondromatosis, maffucci type	Enrichment	VHL	1.58
69	Semantic dementia	Enrichment	CHMP2B	1.58
70	Early-onset posterior polar cataract	Enrichment	CHMP4B	1.53
71	Autosomal recessive non-syndromic intellectual disability	Enrichment	MAN1B1, TUSC3	1.47
72	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.43
73	Lip and oral cavity carcinoma	Enrichment	RB1	1.35
74	Alzheimer's disease	Enrichment	VCP	1.32
75	Pheochromocytoma	Enrichment	VHL	1.29
76	Lung cancer susceptibility 3	Enrichment	RB1	1.29
77	Renal cell carcinoma, nonpapillary	Enrichment	VHL	1.26
78	Autosomal dominant polycystic kidney disease	Enrichment	GANAB	1.26
79	Alzheimer disease, familial, 1	Enrichment	VCP	1.21
80	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.16
81	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.12
82	Tooth agenesis	Enrichment	SUMO1	1.10
83	Congenital disorder of glycosylation, type in	Enrichment	MAGT1	1.09
84	Inherited cancer-predisposing syndrome	Enrichment	RB1, VHL	1.06
85	Bladder cancer	Enrichment	RB1	0.98
86	Fanconi anemia, complementation group a	Enrichment	VHL	0.91
87	Developmental and epileptic encephalopathy	Enrichment	ST3GAL3	0.90
88	Ovarian cancer	Enrichment	RB1	0.50
89	Congenital nervous system abnormality	Enrichment	TUSC3	0.38
90	Nervous system disease	Enrichment	TUSC3	0.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Early SARS-CoV-2 Infection Events

Pathway Network for Early SARS-CoV-2 Infection Events

Pathway network for the Early SARS-CoV-2 Infection Events SuperPath

Member Pathways for Early SARS-CoV-2 Infection Events

Pathways in the Early SARS-CoV-2 Infection Events SuperPath

Gene overlap in member pathways for Early SARS-CoV-2 Infection Events SuperPath

Associated Genes for Early SARS-CoV-2 Infection Events

Associated Disorders for Early SARS-CoV-2 Infection Events

Disorders associated with Early SARS-CoV-2 Infection Events SuperPath

STRING Interaction Network for Early SARS-CoV-2 Infection Events

Sources for Early SARS-CoV-2 Infection Events