EDA signaling in hair follicle development

No Pathway Network information available for EDA signaling in hair follicle development

Pathways in the EDA signaling in hair follicle development SuperPath

#	Name	Source	Genes
1	EDA signaling in hair follicle development	WikiPathways	BMP1 DKK1 DKK4 EDAR EDARADD GLI1 LTB PTCH1 RELB SHH SOSTDC1 (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BMP1	Bone Morphogenetic Protein 1	Protein Coding	1
2	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
3	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
4	PTCH1	Patched 1	Protein Coding	1
5	LTB	Lymphotoxin Beta	Protein Coding	1
6	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
7	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
8	EDARADD	EDAR Associated Via Death Domain	Protein Coding	1
9	EDAR	Ectodysplasin A Receptor	Protein Coding	1
10	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
11	SOSTDC1	Sclerostin Domain Containing 1	Protein Coding	1

Disorders associated with EDA signaling in hair follicle development SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	EDAR, EDARADD	5.75
2	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	5.45
3	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	EDAR, EDARADD	5.22
4	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	EDAR, EDARADD	5.22
5	Polydactyly, postaxial, type a1	Enrichment	GLI1, PTCH1	4.20
6	Septopreoptic holoprosencephaly	Enrichment	PTCH1, SHH	4.20
7	Midline interhemispheric variant of holoprosencephaly	Enrichment	PTCH1, SHH	4.20
8	Microform holoprosencephaly	Enrichment	PTCH1, SHH	4.15
9	Lobar holoprosencephaly	Enrichment	PTCH1, SHH	4.15
10	Alobar holoprosencephaly	Enrichment	PTCH1, SHH	4.09
11	Semilobar holoprosencephaly	Enrichment	PTCH1, SHH	4.04
12	Macs syndrome	Enrichment	PTCH1, SHH	3.95
13	Tooth agenesis	Enrichment	EDAR, EDARADD	3.86
14	Holoprosencephaly 3	Enrichment	SHH	3.09
15	Chiari malformation type i	Enrichment	DKK1	3.09
16	Schilbach-rott syndrome	Enrichment	PTCH1	3.09
17	Microphthalmia/coloboma 5	Enrichment	SHH	3.09
18	Polydactyly, preaxial i	Enrichment	GLI1	3.09
19	Polydactyly, postaxial, type a8	Enrichment	GLI1	3.09
20	Hair morphology 1	Enrichment	EDAR	3.09
21	Ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant	Enrichment	EDARADD	3.09
22	Immunodeficiency 53	Enrichment	RELB	3.09
23	Turner syndrome	Enrichment	PTCH1	3.09
24	Monosomy 9q22.3	Enrichment	PTCH1	3.09
25	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	3.09
26	Solitary median maxillary central incisor	Enrichment	SHH	2.79
27	Osteogenesis imperfecta, type xiii	Enrichment	BMP1	2.79
28	Postaxial polydactyly type b	Enrichment	GLI1	2.79
29	Isolated radial hemimelia	Enrichment	SHH	2.79
30	Syndactyly, type iv	Enrichment	SHH	2.61
31	Osteoporosis, juvenile	Enrichment	DKK1	2.61
32	Holoprosencephaly 7	Enrichment	PTCH1	2.61
33	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.61
34	High bone mass osteogenesis imperfecta	Enrichment	BMP1	2.61
35	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	EDAR	2.49
36	Schizencephaly	Enrichment	SHH	2.49
37	Ectodermal dysplasia	Enrichment	EDAR	2.49
38	Basal cell nevus syndrome 1	Enrichment	PTCH1	2.31
39	Basal cell carcinoma 1	Enrichment	PTCH1	2.31
40	Mitochondrial dna depletion syndrome 4a	Enrichment	EDAR	2.25
41	Congenital hydrocephalus	Enrichment	PTCH1	2.25
42	Overgrowth syndrome	Enrichment	PTCH1	2.25
43	Mitochondrial dna depletion syndrome 4b	Enrichment	EDAR	2.19
44	Ellis-van creveld syndrome	Enrichment	GLI1	2.14
45	Septooptic dysplasia	Enrichment	SHH	2.01
46	Medulloblastoma	Enrichment	PTCH1	1.95
47	Osteogenesis imperfecta, type iii	Enrichment	BMP1	1.92
48	Rhabdomyosarcoma	Enrichment	PTCH1	1.89
49	Microphthalmia	Enrichment	PTCH1	1.75
50	Brittle bone disorder	Enrichment	BMP1	1.73
51	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	1.36
52	Autism	Enrichment	SHH	1.25
53	Ovarian cancer	Enrichment	PTCH1	1.10
54	Inherited cancer-predisposing syndrome	Enrichment	PTCH1	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EDA signaling in hair follicle development

Pathway Network for EDA signaling in hair follicle development

Member Pathways for EDA signaling in hair follicle development

Pathways in the EDA signaling in hair follicle development SuperPath

Associated Genes for EDA signaling in hair follicle development

Associated Disorders for EDA signaling in hair follicle development

Disorders associated with EDA signaling in hair follicle development SuperPath

STRING Interaction Network for EDA signaling in hair follicle development

Sources for EDA signaling in hair follicle development