Effects of PIP2 hydrolysis

No Pathway Network information available for Effects of PIP2 hydrolysis

Pathways in the Effects of PIP2 hydrolysis SuperPath

#	Name	Source	Genes
1	Effects of PIP2 hydrolysis	Reactome	ABHD12 ABHD6 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ ITPR1 ITPR2 ITPR3 MGLL PRKCD PRKCE PRKCH RASGRP1 RASGRP2 TRPC3 TRPC6 TRPC7 (see all 26) (see less)
2	Arachidonate production from DAG	Reactome	ABHD12 ABHD6 DAGLA DAGLB MGLL

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MGLL	Monoglyceride Lipase	Protein Coding	2
2	DAGLB	Diacylglycerol Lipase Beta	Protein Coding	2
3	ABHD12	Abhydrolase Domain Containing 12, Lysophospholipase	Protein Coding	2
4	ABHD6	Abhydrolase Domain Containing 6, Acylglycerol Lipase	Protein Coding	2
5	DAGLA	Diacylglycerol Lipase Alpha	Protein Coding	2
6	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
7	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
8	DGKK	Diacylglycerol Kinase Kappa	Protein Coding	1
9	DGKA	Diacylglycerol Kinase Alpha	Protein Coding	1
10	DGKB	Diacylglycerol Kinase Beta	Protein Coding	1
11	DGKG	Diacylglycerol Kinase Gamma	Protein Coding	1
12	DGKH	Diacylglycerol Kinase Eta	Protein Coding	1
13	DGKQ	Diacylglycerol Kinase Theta	Protein Coding	1
14	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
15	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
16	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
17	PRKCD	Protein Kinase C Delta	Protein Coding	1
18	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
19	PRKCH	Protein Kinase C Eta	Protein Coding	1
20	TRPC7	Transient Receptor Potential Cation Channel Subfamily C Member 7	Protein Coding	1
21	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	1
22	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	1
23	DGKZ	Diacylglycerol Kinase Zeta	Protein Coding	1
24	DGKE	Diacylglycerol Kinase Epsilon	Protein Coding	1
25	DGKD	Diacylglycerol Kinase Delta	Protein Coding	1
26	DGKI	Diacylglycerol Kinase Iota	Protein Coding	1

Disorders associated with Effects of PIP2 hydrolysis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neuroocular syndrome 2, paroxysmal type	Enrichment	DAGLA	3.43
2	Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract	Enrichment	ABHD12	3.13
3	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.72
4	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	2.72
5	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.72
6	Spinocerebellar ataxia 41	Enrichment	TRPC3	2.72
7	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.72
8	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.72
9	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.72
10	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.72
11	Immunodeficiency 64	Enrichment	RASGRP1	2.72
12	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.72
13	Nephrotic syndrome	Enrichment	DGKE, TRPC6	2.52
14	Autosomal dominant cerebellar ataxia	Enrichment	DAGLA	2.48
15	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.42
16	Nephrotic syndrome, type 7	Enrichment	DGKE	2.42
17	Hemolytic-uremic syndrome	Enrichment	DGKE	2.42
18	Gillespie syndrome	Enrichment	ITPR1	2.24
19	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.12
20	Cone dystrophy	Enrichment	ABHD12	2.05
21	Hemolytic uremic syndrome, atypical 1	Enrichment	DGKE	2.02
22	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.94
23	Stroke, ischemic	Enrichment	PRKCH	1.72
24	Congenital long qt syndrome	Enrichment	ITPR3	1.64
25	Multiple sclerosis	Enrichment	ITPR1	1.58
26	Anterior segment dysgenesis	Enrichment	ITPR1	1.55
27	Atypical hemolytic-uremic syndrome	Enrichment	DGKE	1.55
28	Focal segmental glomerulosclerosis	Enrichment	TRPC6	1.42
29	Severe covid-19	Enrichment	DGKE	1.27
30	Long qt syndrome 1	Enrichment	ITPR3	1.25
31	Genetic steroid-resistant nephrotic syndrome	Enrichment	TRPC6	1.20
32	Spastic ataxia	Enrichment	ITPR1	1.01
33	Hereditary retinal dystrophy	Enrichment	ABHD12	0.99
34	Fundus dystrophy	Enrichment	ABHD12	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Effects of PIP2 hydrolysis

Pathway Network for Effects of PIP2 hydrolysis

Member Pathways for Effects of PIP2 hydrolysis

Pathways in the Effects of PIP2 hydrolysis SuperPath

Associated Genes for Effects of PIP2 hydrolysis

Associated Disorders for Effects of PIP2 hydrolysis

Disorders associated with Effects of PIP2 hydrolysis SuperPath

STRING Interaction Network for Effects of PIP2 hydrolysis

Sources for Effects of PIP2 hydrolysis