EGR2 and SOX10-mediated initiation of Schwann cell myelination

No Pathway Network information available for EGR2 and SOX10-mediated initiation of Schwann cell myelination

Pathways in the EGR2 and SOX10-mediated initiation of Schwann cell myelination SuperPath

#	Name	Source	Genes
1	EGR2 and SOX10-mediated initiation of Schwann cell myelination	Reactome	ADGRG6 ADGRV1 CYP51A1 DAG1 DRP2 EGR2 HDAC2 HMGCR LAMA2 LAMB1 LAMC1 MAG MBP MPZ NAB1 NAB2 PMP22 POU3F1 POU3F2 PRX SCD5 SMARCA4 SOX10 SREBF2 TEAD1 UTRN WWTR1 YAP1 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
2	CYP51A1	Cytochrome P450 Family 51 Subfamily A Member 1	Protein Coding	1
3	DAG1	Dystroglycan 1	Protein Coding	1
4	DRP2	Dystrophin Related Protein 2	Protein Coding	1
5	EGR2	Early Growth Response 2	Protein Coding	1
6	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
7	HDAC2	Histone Deacetylase 2	Protein Coding	1
8	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
9	LAMA2	Laminin Subunit Alpha 2	Protein Coding	1
10	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
11	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
12	MAG	Myelin Associated Glycoprotein	Protein Coding	1
13	MBP	Myelin Basic Protein	Protein Coding	1
14	MPZ	Myelin Protein Zero	Protein Coding	1
15	NAB1	NGFI-A Binding Protein 1	Protein Coding	1
16	NAB2	NGFI-A Binding Protein 2	Protein Coding	1
17	PMP22	Peripheral Myelin Protein 22	Protein Coding	1
18	POU3F1	POU Class 3 Homeobox 1	Protein Coding	1
19	POU3F2	POU Class 3 Homeobox 2	Protein Coding	1
20	ADGRG6	Adhesion G Protein-Coupled Receptor G6	Protein Coding	1
21	PRX	Periaxin	Protein Coding	1
22	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
23	SOX10	SRY-Box Transcription Factor 10	Protein Coding	1
24	SREBF2	Sterol Regulatory Element Binding Transcription Factor 2	Protein Coding	1
25	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	1
26	UTRN	Utrophin	Protein Coding	1
27	SCD5	Stearoyl-CoA Desaturase 5	Protein Coding	1
28	ADGRV1	Adhesion G Protein-Coupled Receptor V1	Protein Coding	1

Disorders associated with EGR2 and SOX10-mediated initiation of Schwann cell myelination SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2, MPZ, PMP22, PRX	10.05
2	Charcot-marie-tooth disease type 1	Enrichment	EGR2, MPZ, PMP22	8.10
3	Charcot-marie-tooth disease	Enrichment	LAMA2, MPZ, PMP22, PRX	5.86
4	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2, MPZ	5.39
5	Roussy-levy hereditary areflexic dystasia	Enrichment	MPZ, PMP22	5.39
6	Charcot-marie-tooth disease type 4	Enrichment	EGR2, MPZ, PRX	5.20
7	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	4.61
8	Peripheral nervous system disease	Enrichment	MPZ, PMP22, PRX	4.43
9	Neuropathy	Enrichment	MPZ, PMP22, PRX	4.43
10	Creatine phosphokinase, elevated serum	Enrichment	DAG1, LAMA2	3.31
11	Isolated elevated serum creatine phosphokinase levels	Enrichment	DAG1, LAMA2	3.31
12	Charcot-marie-tooth disease and deafness	Enrichment	PMP22	2.69
13	Guillain-barre syndrome, familial	Enrichment	PMP22	2.69
14	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.69
15	Charcot-marie-tooth disease, axonal, type 2j	Enrichment	MPZ	2.69
16	Neuropathy, hereditary, with liability to pressure palsies	Enrichment	PMP22	2.69
17	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.69
18	Muscular dystrophy-dystroglycanopathy , type a, 9	Enrichment	DAG1	2.69
19	Lissencephaly 5	Enrichment	LAMB1	2.69
20	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.69
21	Febrile seizures, familial, 4	Enrichment	ADGRV1	2.69
22	Charcot-marie-tooth disease, dominant intermediate d	Enrichment	MPZ	2.69
23	Charcot-marie-tooth disease, axonal, type 2i	Enrichment	MPZ	2.69
24	Deafness, autosomal dominant 79	Enrichment	SCD5	2.69
25	Muscular dystrophy-dystroglycanopathy , type c, 9	Enrichment	DAG1	2.69
26	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.69
27	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.69
28	Lethal congenital contracture syndrome 9	Enrichment	ADGRG6	2.69
29	Spastic paraplegia 75, autosomal recessive	Enrichment	MAG	2.69
30	Congenital cataract-severe neonatal hepatopathy-global developmental delay syndrome	Enrichment	CYP51A1	2.69
31	Autosomal dominant intermediate charcot-marie-tooth disease with neuropathic pain	Enrichment	MPZ	2.69
32	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.69
33	Charcot-marie-tooth disease type 2i	Enrichment	MPZ	2.69
34	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.69
35	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.69
36	Charcot-marie-tooth disease type 2j	Enrichment	MPZ	2.69
37	Muscle-eye-brain disease with bilateral multicystic leucodystrophy	Enrichment	DAG1	2.69
38	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	2.69
39	Charcot-marie-tooth disease, demyelinating, type 1a	Enrichment	PMP22	2.38
40	Charcot-marie-tooth disease, demyelinating, type 1b	Enrichment	MPZ	2.38
41	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	2.38
42	Hemangiopericytoma, malignant	Enrichment	NAB2	2.38
43	Waardenburg syndrome, type 4c	Enrichment	SOX10	2.38
44	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	2.38
45	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	MPZ	2.38
46	Usher syndrome, type iic	Enrichment	ADGRV1	2.38
47	Charcot-marie-tooth disease, demyelinating, type 4f	Enrichment	PRX	2.38
48	Lissencephaly 1	Enrichment	LAMB1	2.38
49	Neuropathy, congenital hypomyelinating, 2	Enrichment	MPZ	2.38
50	Charcot-marie-tooth disease type 1b	Enrichment	MPZ	2.38
51	Spinocerebellar ataxia 46	Enrichment	PRX	2.38
52	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	2.38
53	Charcot-marie-tooth disease type 1a	Enrichment	PMP22	2.38
54	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	SOX10	2.38
55	Otosclerosis 12	Enrichment	SMARCA4	2.38
56	Coffin-siris syndrome 4	Enrichment	SMARCA4	2.38
57	Charcot-marie-tooth disease type 4f	Enrichment	PRX	2.38
58	Waardenburg syndrome, type 2a	Enrichment	SOX10	2.21
59	Gaucher disease, type ii	Enrichment	PRX	2.21
60	Muscular dystrophy, duchenne type	Enrichment	UTRN	2.21
61	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	2.21
62	Gaucher's disease	Enrichment	PRX	2.21
63	Lama2-related muscular dystrophy	Enrichment	LAMA2	2.21
64	Pseudomyogenic hemangioendothelioma	Enrichment	WWTR1	2.08
65	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	MPZ	1.99
66	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	SOX10	1.99
67	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	1.99
68	Genetic motor neuron disease	Enrichment	MPZ	1.99
69	Sensory peripheral neuropathy	Enrichment	MPZ	1.99
70	Rare genetic deafness	Enrichment	ADGRV1, SOX10	1.94
71	Waardenburg syndrome, type 4a	Enrichment	SOX10	1.91
72	Waardenburg syndrome	Enrichment	SOX10	1.91
73	Waardenburg syndrome, type 1	Enrichment	SOX10	1.84
74	Usher syndrome, type iia	Enrichment	ADGRV1	1.84
75	Waardenburg syndrome, type 2e	Enrichment	SOX10	1.84
76	Motor neuron disease	Enrichment	MPZ	1.84
77	Congenital muscular dystrophy	Enrichment	LAMA2	1.79
78	Neuroblastoma	Enrichment	SMARCA4	1.79
79	Ventricular septal defect	Enrichment	SMARCA4	1.73
80	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.73
81	Epilepsy, idiopathic generalized	Enrichment	ADGRV1	1.65
82	Usher syndrome type 2	Enrichment	ADGRV1	1.65
83	Atrial heart septal defect	Enrichment	SMARCA4	1.65
84	Interatrial communication	Enrichment	SMARCA4	1.65
85	Microphthalmia/coloboma 12	Enrichment	YAP1	1.58
86	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.58
87	Multiple sclerosis	Enrichment	LAMB1	1.54
88	Walker-warburg syndrome	Enrichment	DAG1	1.54
89	Generalized epilepsy with febrile seizures plus	Enrichment	ADGRV1	1.54
90	Coloboma of macula	Enrichment	YAP1	1.52
91	Coffin-siris syndrome 1	Enrichment	SMARCA4	1.52
92	Usher syndrome, type i	Enrichment	ADGRV1	1.52
93	Familial hypercholesterolemia	Enrichment	SMARCA4	1.52
94	Cleft palate, isolated	Enrichment	SMARCA4	1.46
95	Kallmann syndrome	Enrichment	SOX10	1.33
96	Ear malformation	Enrichment	ADGRV1	1.31
97	Hirschsprung disease 1	Enrichment	SOX10	1.23
98	Usher syndrome	Enrichment	ADGRV1	1.18
99	Cerebral palsy	Enrichment	SMARCA4	1.11
100	Distal arthrogryposis	Enrichment	ADGRG6	1.08
101	Myeloma, multiple	Enrichment	YAP1	0.96
102	Deafness, autosomal recessive	Enrichment	ADGRV1	0.91
103	Autosomal recessive nonsyndromic deafness	Enrichment	ADGRV1	0.91
104	Dilated cardiomyopathy	Enrichment	LAMA2	0.82
105	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADGRV1	0.77
106	Inherited cancer-predisposing syndrome	Enrichment	SMARCA4	0.62
107	Retinitis pigmentosa	Enrichment	ADGRV1	0.45
108	Hereditary retinal dystrophy	Enrichment	ADGRV1	0.34
109	Fundus dystrophy	Enrichment	ADGRV1	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EGR2 and SOX10-mediated initiation of Schwann cell myelination

Pathway Network for EGR2 and SOX10-mediated initiation of Schwann cell myelination

Member Pathways for EGR2 and SOX10-mediated initiation of Schwann cell myelination

Pathways in the EGR2 and SOX10-mediated initiation of Schwann cell myelination SuperPath

Associated Genes for EGR2 and SOX10-mediated initiation of Schwann cell myelination

Associated Disorders for EGR2 and SOX10-mediated initiation of Schwann cell myelination

Disorders associated with EGR2 and SOX10-mediated initiation of Schwann cell myelination SuperPath

STRING Interaction Network for EGR2 and SOX10-mediated initiation of Schwann cell myelination

Sources for EGR2 and SOX10-mediated initiation of Schwann cell myelination