EML4 and NUDC in mitotic spindle formation

Pathway network for the EML4 and NUDC in mitotic spindle formation SuperPath

Sources:

Reactome

Pathways in the EML4 and NUDC in mitotic spindle formation SuperPath

#	Name	Source	Genes
1	EML4 and NUDC in mitotic spindle formation	Reactome	AHCTF1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC20 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 EML4 ERCC6L INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NEK6 NEK7 NEK9 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PLK1 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B XPO1 ZW10 ZWILCH ZWINT (see all 119) (see less)
2	Mitotic Prometaphase	Reactome	ACTR1A AHCTF1 AKAP9 ALMS1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CCNB1 CCNB2 CCP110 CDC20 CDCA5 CDCA8 CDK1 CDK5RAP2 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CLASP2 CLIP1 CNTRL CPAP CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B DCTN1 DCTN2 DCTN3 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 EML4 ERCC6L FIRRM HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HDAC8 HSP90AA1 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 MZT1 MZT2A MZT2B NCAPD2 NCAPG NCAPH NDC80 NDE1 NDEL1 NEDD1 NEK2 NEK6 NEK7 NEK9 NINL NME7 NSL1 NUDC NUF2 NUMA1 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PDS5A PDS5B PLK1 PLK4 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKACA PRKAR2B RAD21 RANBP2 RANGAP1 RCC2 RPS27 SDCCAG8 SEC13 SEH1L SFI1 SGO1 SGO2 SKA1 SKA2 SMC1A SMC2 SMC3 SMC4 SPC24 SPC25 SPDL1 SSNA1 STAG1 STAG2 TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 WAPL XPO1 YWHAE YWHAG ZW10 ZWILCH ZWINT (see all 206) (see less)
3	RHO GTPases Activate Formins	Reactome	ACTB ACTG1 AHCTF1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC20 CDC42 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DAAM1 DIAPH1 DIAPH2 DIAPH3 DSN1 DVL1 DVL2 DVL3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L EVL FMNL1 FMNL2 FMNL3 INCENP ITGB1 ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 MRTFA NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PFN1 PFN2 PLK1 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAC1 RANBP2 RANGAP1 RCC2 RHOA RHOB RHOC RHOD RPS27 SCAI SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 SRC SRF SRGAP2 TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B XPO1 ZW10 ZWILCH ZWINT (see all 142) (see less)
4	Resolution of Sister Chromatid Cohesion	Reactome	AHCTF1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CCNB1 CCNB2 CDC20 CDCA5 CDCA8 CDK1 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L FIRRM HDAC8 INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PDS5A PDS5B PLK1 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAD21 RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SMC1A SMC3 SPC24 SPC25 SPDL1 STAG1 STAG2 TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B WAPL XPO1 ZW10 ZWILCH ZWINT (see all 129) (see less)
5	Mitotic Spindle Checkpoint	Reactome	AHCTF1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PLK1 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 TAOK1 UBE2C UBE2D1 UBE2E1 UBE2S XPO1 ZW10 ZWILCH ZWINT (see all 113) (see less)
6	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Reactome	AHCTF1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC20 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PLK1 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 TAOK1 XPO1 ZW10 ZWILCH ZWINT (see all 96) (see less)
7	Amplification of signal from the kinetochores	Reactome	AHCTF1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC20 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PLK1 PMF1 PMF1-BGLAP PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 TAOK1 XPO1 ZW10 ZWILCH ZWINT (see all 96) (see less)

Gene overlap in member pathways for EML4 and NUDC in mitotic spindle formation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CENPS-CORT	CENPS-CORT Readthrough	Protein Coding	7
2	PMF1-BGLAP	PMF1-BGLAP Readthrough	Protein Coding	7
3	NDC80	NDC80 Kinetochore Complex Component	Protein Coding	7
4	CENPA	Centromere Protein A	Protein Coding	7
5	CENPC	Centromere Protein C	Protein Coding	7
6	CENPE	Centromere Protein E	Protein Coding	7
7	CENPF	Centromere Protein F	Protein Coding	7
8	NUDC	Nuclear Distribution C, Dynein Complex Regulator	Protein Coding	7
9	KIF2C	Kinesin Family Member 2C	Protein Coding	7
10	ZWINT	ZW10 Interacting Kinetochore Protein	Protein Coding	7
11	PMF1	Polyamine Modulated Factor 1	Protein Coding	7
12	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	7
13	SPC24	SPC24 Component Of NDC80 Kinetochore Complex	Protein Coding	7
14	SGO2	Shugoshin 2	Protein Coding	7
15	SGO1	Shugoshin 1	Protein Coding	7
16	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	7
17	DYNC1I1	Dynein Cytoplasmic 1 Intermediate Chain 1	Protein Coding	7
18	DYNC1I2	Dynein Cytoplasmic 1 Intermediate Chain 2	Protein Coding	7
19	DYNC1LI2	Dynein Cytoplasmic 1 Light Intermediate Chain 2	Protein Coding	7
20	SKA1	Spindle And Kinetochore Associated Complex Subunit 1	Protein Coding	7
21	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	7
22	CLASP2	Cytoplasmic Linker Associated Protein 2	Protein Coding	7
23	NUP160	Nucleoporin 160	Protein Coding	7
24	CLASP1	Cytoplasmic Linker Associated Protein 1	Protein Coding	7
25	ITGB3BP	Integrin Subunit Beta 3 Binding Protein	Protein Coding	7
26	CENPI	Centromere Protein I	Protein Coding	7
27	AHCTF1	AT-Hook Containing Transcription Factor 1	Protein Coding	7
28	NSL1	NSL1 Component Of MIS12 Kinetochore Complex	Protein Coding	7
29	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	7
30	SKA2	Spindle And Kinetochore Associated Complex Subunit 2	Protein Coding	7
31	NUP43	Nucleoporin 43	Protein Coding	7
32	INCENP	Inner Centromere Protein	Protein Coding	7
33	CENPS	Centromere Protein S	Protein Coding	7
34	KIF2A	Kinesin Family Member 2A	Protein Coding	7
35	CENPP	Centromere Protein P	Protein Coding	7
36	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	7
37	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	7
38	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	7
39	DYNC1LI1	Dynein Cytoplasmic 1 Light Intermediate Chain 1	Protein Coding	7
40	PLK1	Polo Like Kinase 1	Protein Coding	7
41	NDE1	NudE Neurodevelopment Protein 1	Protein Coding	7
42	ERCC6L	ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase	Protein Coding	7
43	SPDL1	Spindle Apparatus Coiled-Coil Protein 1	Protein Coding	7
44	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	7
45	ZWILCH	Zwilch Kinetochore Protein	Protein Coding	7
46	CDCA8	Cell Division Cycle Associated 8	Protein Coding	7
47	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	7
48	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	7
49	CENPQ	Centromere Protein Q	Protein Coding	7
50	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	7
51	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	7
52	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	7
53	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	7
54	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	7
55	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	7
56	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	7
57	NUP133	Nucleoporin 133	Protein Coding	7
58	CENPN	Centromere Protein N	Protein Coding	7
59	RCC2	Regulator Of Chromosome Condensation 2	Protein Coding	7
60	KNL1	Kinetochore Scaffold 1	Protein Coding	7
61	NUP107	Nucleoporin 107	Protein Coding	7
62	SPC25	SPC25 Component Of NDC80 Kinetochore Complex	Protein Coding	7
63	TAOK1	TAO Kinase 1	Protein Coding	7
64	RANBP2	RAN Binding Protein 2	Protein Coding	7
65	RANGAP1	Ran GTPase Activating Protein 1	Protein Coding	7
66	RPS27	Ribosomal Protein S27	Protein Coding	7
67	CLIP1	CAP-Gly Domain Containing Linker Protein 1	Protein Coding	7
68	SEC13	SEC13 Homolog, Nuclear Pore And COPII Component	Protein Coding	7
69	CENPK	Centromere Protein K	Protein Coding	7
70	CENPH	Centromere Protein H	Protein Coding	7
71	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	7
72	BUB1B	BUB1 Mitotic Checkpoint Serine/Threonine Kinase B	Protein Coding	7
73	XPO1	Exportin 1	Protein Coding	7
74	MIS12	MIS12 Kinetochore Complex Component	Protein Coding	7
75	CENPM	Centromere Protein M	Protein Coding	7
76	NUP37	Nucleoporin 37	Protein Coding	7
77	CENPO	Centromere Protein O	Protein Coding	7
78	CENPU	Centromere Protein U	Protein Coding	7
79	NUP85	Nucleoporin 85	Protein Coding	7
80	DSN1	DSN1 Component Of MIS12 Kinetochore Complex	Protein Coding	7
81	CENPT	Centromere Protein T	Protein Coding	7
82	B9D2	B9 Domain Containing 2	Protein Coding	7
83	NDEL1	NudE Neurodevelopment Protein 1 Like 1	Protein Coding	7
84	SEH1L	SEH1 Like Nucleoporin	Protein Coding	7
85	KIF18A	Kinesin Family Member 18A	Protein Coding	7
86	NUF2	NUF2 Component Of NDC80 Kinetochore Complex	Protein Coding	7
87	MAD1L1	Mitotic Arrest Deficient 1 Like 1	Protein Coding	7
88	KIF2B	Kinesin Family Member 2B	Protein Coding	7
89	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	7
90	CENPL	Centromere Protein L	Protein Coding	7
91	ZW10	Zw10 Kinetochore Protein	Protein Coding	7
92	BUB3	BUB3 Mitotic Checkpoint Protein	Protein Coding	7
93	AURKB	Aurora Kinase B	Protein Coding	7
94	KNTC1	Kinetochore Associated 1	Protein Coding	7
95	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	7
96	CDC20	Cell Division Cycle 20	Protein Coding	7
97	TUBA1B	Tubulin Alpha 1b	Protein Coding	4
98	TUBB3	Tubulin Beta 3 Class III	Protein Coding	4
99	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	4
100	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	4
101	TUBA3E	Tubulin Alpha 3e	Protein Coding	4
102	TUBA3D	Tubulin Alpha 3d	Protein Coding	4
103	TUBB8B	Tubulin Beta 8B	Protein Coding	4
104	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	4
105	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	4
106	TUBA8	Tubulin Alpha 8	Protein Coding	4
107	TUBA4A	Tubulin Alpha 4a	Protein Coding	4
108	TUBA3C	Tubulin Alpha 3c	Protein Coding	4
109	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	4
110	TUBA1A	Tubulin Alpha 1a	Protein Coding	4
111	TUBAL3	Tubulin Alpha Like 3	Protein Coding	4
112	TUBA4B	Tubulin Alpha 4b	Protein Coding	4
113	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	4
114	TUBB6	Tubulin Beta 6 Class V	Protein Coding	4
115	TUBA1C	Tubulin Alpha 1c	Protein Coding	4
116	NEK6	NIMA Related Kinase 6	Protein Coding	2
117	NEK7	NIMA Related Kinase 7	Protein Coding	2
118	EML4	EMAP Like 4	Protein Coding	2
119	NEK9	NIMA Related Kinase 9	Protein Coding	2
120	STAG1	STAG1 Cohesin Complex Component	Protein Coding	2
121	STAG2	STAG2 Cohesin Complex Component	Protein Coding	2
122	CDCA5	Cell Division Cycle Associated 5	Protein Coding	2
123	PDS5B	PDS5 Cohesin Associated Factor B	Protein Coding	2
124	WAPL	WAPL Cohesin Release Factor	Protein Coding	2
125	PDS5A	PDS5 Cohesin Associated Factor A	Protein Coding	2
126	FIRRM	FIGNL1 Interacting Regulator Of Recombination And Mitosis	Protein Coding	2
127	HDAC8	Histone Deacetylase 8	Protein Coding	2
128	RAD21	RAD21 Cohesin Complex Component	Protein Coding	2
129	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	2
130	CCNB1	Cyclin B1	Protein Coding	2
131	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	2
132	CCNB2	Cyclin B2	Protein Coding	2
133	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
134	SMC4	Structural Maintenance Of Chromosomes 4	Protein Coding	1
135	ACTR1A	Actin Related Protein 1A	Protein Coding	1
136	AKAP9	A-Kinase Anchoring Protein 9	Protein Coding	1
137	TUBGCP3	Tubulin Gamma Complex Component 3	Protein Coding	1
138	DCTN2	Dynactin Subunit 2	Protein Coding	1
139	SMC2	Structural Maintenance Of Chromosomes 2	Protein Coding	1
140	CETN2	Centrin 2	Protein Coding	1
141	PLK4	Polo Like Kinase 4	Protein Coding	1
142	SDCCAG8	SHH Signaling And Ciliogenesis Regulator SDCCAG8	Protein Coding	1
143	TUBGCP2	Tubulin Gamma Complex Component 2	Protein Coding	1
144	CNTRL	Centriolin	Protein Coding	1
145	CEP43	Centrosomal Protein 43	Protein Coding	1
146	CEP250	Centrosomal Protein 250	Protein Coding	1
147	DCTN3	Dynactin Subunit 3	Protein Coding	1
148	TUBGCP5	Tubulin Gamma Complex Component 5	Protein Coding	1
149	HAUS1	HAUS Augmin Like Complex Subunit 1	Protein Coding	1
150	NEDD1	NEDD1 Gamma-Tubulin Ring Complex Targeting Factor	Protein Coding	1
151	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1
152	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
153	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
154	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
155	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
156	DCTN1	Dynactin Subunit 1	Protein Coding	1
157	TUBB	Tubulin Beta Class I	Protein Coding	1
158	CEP164	Centrosomal Protein 164	Protein Coding	1
159	NINL	Ninein Like	Protein Coding	1
160	CEP131	Centrosomal Protein 131	Protein Coding	1
161	CEP152	Centrosomal Protein 152	Protein Coding	1
162	HAUS5	HAUS Augmin Like Complex Subunit 5	Protein Coding	1
163	NCAPH	Non-SMC Condensin I Complex Subunit H	Protein Coding	1
164	TUBG2	Tubulin Gamma 2	Protein Coding	1
165	TUBGCP4	Tubulin Gamma Complex Component 4	Protein Coding	1
166	NME7	NME/NM23 Family Member 7	Protein Coding	1
167	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
168	MZT1	Mitotic Spindle Organizing Protein 1	Protein Coding	1
169	NEK2	NIMA Related Kinase 2	Protein Coding	1
170	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	1
171	ODF2	Outer Dense Fiber Of Sperm Tails 2	Protein Coding	1
172	PCM1	Pericentriolar Material 1	Protein Coding	1
173	PCNT	Pericentrin	Protein Coding	1
174	HAUS6	HAUS Augmin Like Complex Subunit 6	Protein Coding	1
175	HAUS4	HAUS Augmin Like Complex Subunit 4	Protein Coding	1
176	CEP192	Centrosomal Protein 192	Protein Coding	1
177	HAUS2	HAUS Augmin Like Complex Subunit 2	Protein Coding	1
178	HAUS7	HAUS Augmin Like Complex Subunit 7	Protein Coding	1
179	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
180	CEP72	Centrosomal Protein 72	Protein Coding	1
181	CDK5RAP2	CDK5 Regulatory Subunit Associated Protein 2	Protein Coding	1
182	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
183	CPAP	Centrosome Assembly And Centriole Elongation Protein	Protein Coding	1
184	NCAPG	Non-SMC Condensin I Complex Subunit G	Protein Coding	1
185	MZT2A	Mitotic Spindle Organizing Protein 2A	Protein Coding	1
186	TUBG1	Tubulin Gamma 1	Protein Coding	1
187	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
188	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
189	ALMS1	ALMS1 Centrosome And Basal Body Associated Protein	Protein Coding	1
190	HAUS3	HAUS Augmin Like Complex Subunit 3	Protein Coding	1
191	CEP76	Centrosomal Protein 76	Protein Coding	1
192	MZT2B	Mitotic Spindle Organizing Protein 2B	Protein Coding	1
193	CEP290	Centrosomal Protein 290	Protein Coding	1
194	CEP63	Centrosomal Protein 63	Protein Coding	1
195	CEP70	Centrosomal Protein 70	Protein Coding	1
196	CEP78	Centrosomal Protein 78	Protein Coding	1
197	OFD1	OFD1 Centriole And Centriolar Satellite Protein	Protein Coding	1
198	TUBGCP6	Tubulin Gamma Complex Component 6	Protein Coding	1
199	SSNA1	SS Nuclear Autoantigen 1	Protein Coding	1
200	HAUS8	HAUS Augmin Like Complex Subunit 8	Protein Coding	1
201	CEP41	Centrosomal Protein 41	Protein Coding	1
202	CEP135	Centrosomal Protein 135	Protein Coding	1
203	CEP57	Centrosomal Protein 57	Protein Coding	1
204	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	1
205	SFI1	SFI1 Centrin Binding Protein	Protein Coding	1
206	NCAPD2	Non-SMC Condensin I Complex Subunit D2	Protein Coding	1
207	FMNL2	Formin Like 2	Protein Coding	1
208	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
209	DIAPH2	Diaphanous Related Formin 2	Protein Coding	1
210	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
211	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
212	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
213	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	1
214	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	1
215	SCAI	Suppressor Of Cancer Cell Invasion	Protein Coding	1
216	RHOD	Ras Homolog Family Member D	Protein Coding	1
217	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
218	RHOA	Ras Homolog Family Member A	Protein Coding	1
219	RHOB	Ras Homolog Family Member B	Protein Coding	1
220	RHOC	Ras Homolog Family Member C	Protein Coding	1
221	EVL	Enah/Vasp-Like	Protein Coding	1
222	PFN1	Profilin 1	Protein Coding	1
223	PFN2	Profilin 2	Protein Coding	1
224	MRTFA	Myocardin Related Transcription Factor A	Protein Coding	1
225	RAC1	Rac Family Small GTPase 1	Protein Coding	1
226	ACTB	Actin Beta	Protein Coding	1
227	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
228	SRF	Serum Response Factor	Protein Coding	1
229	ACTG1	Actin Gamma 1	Protein Coding	1
230	FMNL1	Formin Like 1	Protein Coding	1
231	DIAPH3	Diaphanous Related Formin 3	Protein Coding	1
232	FMNL3	Formin Like 3	Protein Coding	1
233	CDC42	Cell Division Cycle 42	Protein Coding	1
234	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	1
235	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	1
236	ANAPC16	Anaphase Promoting Complex Subunit 16	Protein Coding	1
237	CDC26	Cell Division Cycle 26	Protein Coding	1
238	ANAPC15	Anaphase Promoting Complex Subunit 15	Protein Coding	1
239	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	1
240	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	1
241	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	1
242	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	1
243	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	1
244	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	1
245	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	1
246	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
247	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	1
248	CDC23	Cell Division Cycle 23	Protein Coding	1
249	CDC16	Cell Division Cycle 16	Protein Coding	1
250	CDC27	Cell Division Cycle 27	Protein Coding	1

Disorders associated with EML4 and NUDC in mitotic spindle formation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	CPAP, DYNC1H1, MZT2B, PAFAH1B1, TUBA1A, TUBA3E, TUBB, TUBB2B, TUBB3, TUBG1	11.22
2	Primary autosomal recessive microcephaly	Enrichment	CDK5RAP2, CENPE, CEP135, CEP152, CEP63, CPAP, KNL1, NUP37	7.72
3	Seckel syndrome	Enrichment	CENPE, CEP152, CPAP, NUP85, PCNT, PLK4	7.51
4	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1, BUB1B, BUB3, CEP57, MAD1L1	7.38
5	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	6.18
6	Cornelia de lange syndrome 1	Enrichment	HDAC8, RAD21, SMC1A, SMC3	6.02
7	Cornelia de lange syndrome	Enrichment	HDAC8, RAD21, SMC1A, SMC3	6.02
8	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	5.58
9	Genetic steroid-resistant nephrotic syndrome	Enrichment	NUP107, NUP133, NUP160, NUP37, NUP85	5.42
10	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	4.89
11	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	PLK4, TUBGCP4, TUBGCP6	4.86
12	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B, CEP57, MAD1L1	4.47
13	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.96
14	Keratoconus 9	Enrichment	MZT2A, TUBA3D	3.64
15	Lissencephaly 3	Enrichment	CPAP, TUBA1A	3.64
16	Microcephaly	Enrichment	CDK5RAP2, CPAP, DYNC1H1, HDAC8, NUF2, SMC1A, TUBB4A, YWHAG	3.24
17	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3	3.19
18	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3	3.19
19	Seckel syndrome 5	Enrichment	CEP152, CPAP	3.17
20	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1, YWHAE	3.17
21	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1, YWHAE	3.17
22	Senior-loken syndrome 1	Enrichment	CEP164, CEP290, SDCCAG8	3.05
23	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3	2.97
24	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3	2.97
25	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	2.88
26	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	2.81
27	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3	2.80
28	Isolated congenital microcephaly	Enrichment	CPAP, MZT2B, TUBA3E	2.78
29	Galloway-mowat syndrome	Enrichment	NUP107, NUP133	2.67
30	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1, TUBG1	2.65
31	Fanconi anemia, complementation group c	Enrichment	HDAC8, TAOK1	2.62
32	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	2.58
33	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	2.48
34	Cortical dysplasia, complex, with other brain malformations 3	Enrichment	KIF2A	2.15
35	Premature chromatid separation trait	Enrichment	BUB1B	2.15
36	Developmental delay with or without intellectual impairment or behavioral abnormalities	Enrichment	TAOK1	2.15
37	Nephrotic syndrome, type 19	Enrichment	NUP160	2.15
38	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	2.15
39	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.15
40	Galloway-mowat syndrome 8	Enrichment	NUP133	2.15
41	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.15
42	Microcephaly 4, primary, autosomal recessive	Enrichment	KNL1	2.15
43	Microcephaly 24, primary, autosomal recessive	Enrichment	NUP37	2.15
44	Microhydranencephaly	Enrichment	NDE1	2.15
45	Galloway-mowat syndrome 7	Enrichment	NUP107	2.15
46	Lissencephaly 4 with microcephaly	Enrichment	NDE1	2.15
47	Meckel syndrome, type 10	Enrichment	B9D2	2.15
48	Nephrotic syndrome, type 11	Enrichment	NUP107	2.15
49	Dync1h1-related disorders	Enrichment	DYNC1H1	2.15
50	Microcephaly 13, primary, autosomal recessive	Enrichment	CENPE	2.15
51	Ovarian dysgenesis 6	Enrichment	NUP107	2.15
52	Short stature and microcephaly with genital anomalies	Enrichment	CENPT	2.15
53	Nephrotic syndrome, type 18	Enrichment	NUP133	2.15
54	Neurodevelopmental disorder with microcephaly and structural brain anomalies	Enrichment	DYNC1I2	2.15
55	Hydranencephaly	Enrichment	NDE1	2.15
56	Microcephaly 30, primary, autosomal recessive	Enrichment	BUB1	2.15
57	Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	Enrichment	MAD1L1	2.15
58	Nde1-related microhydranencephaly	Enrichment	NDE1	2.15
59	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	2.15
60	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	2.15
61	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.15
62	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.08
63	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.08
64	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.06
65	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.06
66	Arthrogryposis, perthes disease, and upward gaze palsy	Enrichment	NEK9	2.06
67	Nevus comedonicus	Enrichment	NEK9	2.06
68	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.06
69	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.06
70	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.06
71	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.06
72	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.06
73	Lethal congenital contracture syndrome 10	Enrichment	NEK9	2.06
74	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.06
75	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.06
76	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.06
77	Congenital myopathy 26	Enrichment	TUBA4A	2.06
78	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.06
79	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.06
80	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.06
81	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.02
82	Holoprosencephaly 13, x-linked	Enrichment	STAG2	2.02
83	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.02
84	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	2.02
85	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.02
86	Mullegama-klein-martinez syndrome	Enrichment	STAG2	2.02
87	Intellectual developmental disorder, autosomal dominant 47	Enrichment	STAG1	2.02
88	Mungan syndrome	Enrichment	RAD21	2.02
89	Xq25 microduplication syndrome	Enrichment	STAG2	2.02
90	Polymicrogyria	Enrichment	DYNC1H1, OFD1	2.02
91	Isolated joubert syndrome	Enrichment	B9D2, CEP41, OFD1	1.98
92	Baraitser-winter syndrome 1	Enrichment	ACTB	1.98
93	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	1.98
94	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	1.98
95	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.98
96	Premature ovarian failure 2a	Enrichment	DIAPH2	1.98
97	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	1.98
98	Becker nevus syndrome	Enrichment	ACTB	1.98
99	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.98
100	Thrombocytopenia 6	Enrichment	SRC	1.98
101	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	1.98
102	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.98
103	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.98
104	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	1.98
105	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.98
106	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.98
107	Baraitser-winter syndrome	Enrichment	ACTB	1.98
108	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.98
109	Nocarh syndrome	Enrichment	CDC42	1.98
110	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.98
111	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.98
112	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	1.91
113	Aortic aneurysm, familial thoracic 4	Enrichment	NDE1	1.85
114	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	1.85
115	Microcephalic osteodysplastic primordial dwarfism, type i	Enrichment	CLASP1	1.85
116	Stromme syndrome	Enrichment	CENPF	1.85
117	Lowry-wood syndrome	Enrichment	CLASP1	1.85
118	Nephronophthisis-like nephropathy 1	Enrichment	RANGAP1	1.85
119	Macroglossia	Enrichment	TAOK1	1.85
120	Lissencephaly 1	Enrichment	PAFAH1B1	1.85
121	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Enrichment	DYNC1I2	1.85
122	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.85
123	Roifman syndrome	Enrichment	CLASP1	1.85
124	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	1.85
125	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	NDE1	1.85
126	Nephrotic syndrome, type 17	Enrichment	NUP85	1.85
127	Neurodevelopmental disorder with developmental delay and with or without motor or speech delay	Enrichment	TAOK1	1.85
128	Spinal muscular atrophy with lower extremity predominant	Enrichment	DYNC1H1	1.85
129	Body mass index quantitative trait locus 19	Enrichment	CENPO	1.85
130	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	1.85
131	Visceral myopathy 2	Enrichment	NDE1	1.85
132	Degenerative disc disease	Enrichment	CENPP	1.85
133	Methylmalonic aciduria and homocystinuria, cbll type	Enrichment	CENPT	1.85
134	Rnu4atac-opathy	Enrichment	CLASP1	1.85
135	Chronic atrial and intestinal dysrhythmia	Enrichment	SGO1	1.85
136	Diamond-blackfan anemia 17	Enrichment	RPS27	1.85
137	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.85
138	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.85
139	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	1.85
140	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	1.82
141	Perry syndrome	Enrichment	DCTN1	1.82
142	Retinitis pigmentosa 23	Enrichment	OFD1	1.82
143	Simpson-golabi-behmel syndrome, type 2	Enrichment	OFD1	1.82
144	Microcephaly 3, primary, autosomal recessive	Enrichment	CDK5RAP2	1.82
145	Microcephaly 9, primary, autosomal recessive	Enrichment	CEP152	1.82
146	Microcephaly and chorioretinopathy, autosomal recessive, 2	Enrichment	PLK4	1.82
147	Microcephaly 8, primary, autosomal recessive	Enrichment	CEP135	1.82
148	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	1.82
149	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	1.82
150	Cone-rod dystrophy and hearing loss 1	Enrichment	CEP78	1.82
151	Microcephalic osteodysplastic primordial dwarfism, type ii	Enrichment	PCNT	1.82
152	Long qt syndrome 11	Enrichment	AKAP9	1.82
153	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	1.82
154	Joubert syndrome 15	Enrichment	CEP41	1.82
155	Nephronophthisis 15	Enrichment	CEP164	1.82
156	Retinitis pigmentosa 67	Enrichment	NEK2	1.82
157	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.82
158	Seckel syndrome 6	Enrichment	CEP63	1.82
159	Microcephaly and chorioretinopathy 2	Enrichment	PLK4	1.82
160	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	1.82
161	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.82
162	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	1.82
163	Microcephaly 23, primary, autosomal recessive	Enrichment	NCAPH	1.82
164	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	1.82
165	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	1.82
166	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, CENPP, DIAPH3	1.77
167	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	1.76
168	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	1.76
169	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	1.76
170	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.76
171	Torsion dystonia 4	Enrichment	TUBB4A	1.76
172	Continuous spikes and waves during sleep	Enrichment	TUBA1A	1.76
173	Congenital nervous system abnormality	Enrichment	DYNC1H1, SMC1A, TUBA1A, TUBB4A	1.73
174	Nervous system disease	Enrichment	DYNC1H1, SMC1A, TUBA1A, TUBB4A	1.73
175	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.72
176	Syndactyly, type iii	Enrichment	HDAC8	1.72
177	Wilson-turner syndrome	Enrichment	HDAC8	1.72
178	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.68
179	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.68
180	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3	1.68
181	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.68
182	Immunodeficiency 66	Enrichment	MRTFA	1.68
183	Immune system disease	Enrichment	CDC42	1.68
184	Crohn's disease	Enrichment	FMNL2	1.68
185	Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)	Enrichment	MRTFA	1.68
186	Spondyloepiphyseal dysplasia congenita	Enrichment	CLASP1	1.68
187	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	CENPT	1.68
188	Band heterotopia	Enrichment	PAFAH1B1	1.68
189	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.68
190	Tricuspid valve insufficiency	Enrichment	NDE1	1.68
191	Corpus callosum, agenesis of	Enrichment	CDK5RAP2, TUBA1A	1.67
192	Isolated corpus callosum agenesis	Enrichment	CDK5RAP2, TUBA1A	1.67
193	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDK5RAP2, TUBA1A	1.67
194	Hydrocephalus, congenital, 1	Enrichment	OFD1, TUBB	1.62
195	Bardet-biedl syndrome	Enrichment	ALMS1, CEP290, SDCCAG8	1.59
196	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.58
197	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.58
198	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	1.58
199	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.58
200	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.55
201	Cystinuria	Enrichment	CENPF	1.55
202	Ciliary dyskinesia, primary, 29	Enrichment	CENPF	1.55
203	Ectodermal dysplasia	Enrichment	RANBP2	1.55
204	Mitral valve insufficiency	Enrichment	NDE1	1.55
205	Polycystic kidney disease	Enrichment	CEP290, HDAC8	1.52
206	Auditory neuropathy	Enrichment	DIAPH1, TUBB4A	1.52
207	Microcephaly and chorioretinopathy, autosomal recessive, 1	Enrichment	TUBGCP6	1.52
208	Spondyloepiphyseal dysplasia tarda, x-linked	Enrichment	OFD1	1.52
209	Orofaciodigital syndrome i	Enrichment	OFD1	1.52
210	Microcephaly 6, primary, autosomal recessive	Enrichment	CPAP	1.52
211	Seckel syndrome 4	Enrichment	CPAP	1.52
212	Mosaic variegated aneuploidy syndrome 2	Enrichment	CEP57	1.52
213	Cone-rod dystrophy and hearing loss 2	Enrichment	CEP250	1.52
214	Cortical dysplasia, complex, with other brain malformations 4	Enrichment	TUBG1	1.52
215	Joubert syndrome 10	Enrichment	OFD1	1.52
216	Microcephaly 21, primary, autosomal recessive	Enrichment	NCAPD2	1.52
217	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.52
218	Cortical dysplasia, complex, with other brain malformations 15	Enrichment	TUBGCP2	1.52
219	Microcephaly and chorioretinopathy 1	Enrichment	TUBGCP6	1.52
220	Senior-loken syndrome 7	Enrichment	SDCCAG8	1.52
221	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TUBGCP4	1.52
222	Spondyloepiphyseal dysplasia tarda	Enrichment	OFD1	1.52
223	Fibrolamellar carcinoma	Enrichment	PRKACA	1.52
224	Bardet-biedl syndrome 16	Enrichment	SDCCAG8	1.52
225	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	1.52
226	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	1.52
227	Microcephaly and chorioretinopathy 3	Enrichment	TUBGCP4	1.52
228	Hereditary retinal dystrophy	Enrichment	ALMS1, CEP164, CEP250, CEP290, CEP78, NEK2, OFD1, SDCCAG8, TUBGCP6	1.48
229	Fundus dystrophy	Enrichment	ALMS1, CEP164, CEP250, CEP290, CEP78, NEK2, OFD1, SDCCAG8, TUBGCP6	1.48
230	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	1.46
231	Lissencephaly 2	Enrichment	NDE1	1.46
232	Spinal muscular atrophy	Enrichment	DYNC1H1	1.46
233	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	1.46
234	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	1.43
235	Joubert syndrome 1	Enrichment	B9D2, CEP290, OFD1	1.40
236	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B, DYNC1H1, TAOK1	1.40
237	Deafness, autosomal recessive 63	Enrichment	ANAPC15	1.39
238	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.38
239	Aminoacylase 1 deficiency	Enrichment	ACTB	1.38
240	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.38
241	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.38
242	Inflammatory myofibroblastic tumor	Enrichment	RANBP2	1.38
243	Intestinal pseudo-obstruction	Enrichment	NDE1	1.38
244	Goldberg-shprintzen syndrome	Enrichment	NEK9	1.37
245	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.37
246	Prognathism, mandibular	Enrichment	CSNK2B	1.35
247	Alstrom syndrome	Enrichment	ALMS1	1.35
248	Simpson-golabi-behmel syndrome, type 1	Enrichment	OFD1	1.35
249	Senior-loken syndrome 6	Enrichment	CEP290	1.35
250	Joubert syndrome 5	Enrichment	CEP290	1.35
251	Meckel syndrome, type 6	Enrichment	CEP290	1.35
252	Myopathy, myofibrillar, 7	Enrichment	CEP63	1.35
253	End stage renal disease	Enrichment	ALMS1	1.35
254	Cog7-congenital disorder of glycosylation	Enrichment	CEP290	1.35
255	Occipital encephalocele	Enrichment	CEP290	1.35
256	Advanced sleep phase syndrome	Enrichment	CSNK1D	1.35
257	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	1.34
258	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	1.31
259	Body mass index quantitative trait locus 11	Enrichment	CENPO, NUDC	1.31
260	Coloboma of choroid and retina	Enrichment	ACTG1	1.29
261	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.29
262	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.29
263	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	1.26
264	Perrault syndrome	Enrichment	SGO2	1.26
265	Meckel syndrome, type 4	Enrichment	CEP290	1.23
266	Orofaciodigital syndrome iii	Enrichment	OFD1	1.23
267	Bardet-biedl syndrome 14	Enrichment	CEP290	1.23
268	Enophthalmos	Enrichment	CSNK2B	1.23
269	Syndactyly	Enrichment	CSNK2B	1.23
270	Orofaciodigital syndrome	Enrichment	OFD1	1.23
271	Hemihyperplasia, isolated	Enrichment	RHOA	1.21
272	Moyamoya disease 1	Enrichment	DIAPH1	1.21
273	Pendred syndrome	Enrichment	DIAPH1	1.21
274	Colorectal cancer	Enrichment	BUB1, BUB1B, SRC	1.20
275	Cryptorchidism	Enrichment	TUBA1A	1.17
276	Myelofibrosis	Enrichment	SRC	1.15
277	Meckel syndrome, type 1	Enrichment	B9D2, CEP290	1.15
278	Rett syndrome, congenital variant	Enrichment	SMC1A	1.13
279	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	CPAP	1.13
280	Coach syndrome 1	Enrichment	OFD1	1.13
281	Microcephaly 1, primary, autosomal recessive	Enrichment	CPAP	1.13
282	Leber congenital amaurosis 10	Enrichment	CEP290	1.13
283	Night blindness	Enrichment	CEP290	1.13
284	Joubert syndrome with ocular defect	Enrichment	CEP41	1.13
285	Genetic motor neuron disease	Enrichment	DCTN1	1.13
286	Endometrial stromal sarcoma	Enrichment	YWHAE	1.13
287	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.12
288	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1	1.09
289	46 xx gonadal dysgenesis	Enrichment	NUP107	1.09
290	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B, DYNC1H1, SMC3	1.07
291	Cone-rod dystrophy 2	Enrichment	ALMS1, CEP290, CEP78	1.07
292	Renal dysplasia, cystic	Enrichment	CEP290	1.06
293	Kidney clear cell sarcoma	Enrichment	YWHAE	1.06
294	Nk-cell enteropathy	Enrichment	AURKB	1.05
295	Nephronophthisis	Enrichment	CEP290, INCENP	1.05
296	Thrombocytopenia	Enrichment	SRC, TUBB1	1.05
297	Inflammatory bowel disease 1	Enrichment	FMNL2	1.04
298	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.04
299	Atrial heart septal defect	Enrichment	HDAC8	1.00
300	Interatrial communication	Enrichment	HDAC8	1.00
301	Cat eye syndrome	Enrichment	ACTG1	1.00
302	Congenital hypothyroidism	Enrichment	TUBB1	1.00
303	Myopia	Enrichment	NDE1	1.00
304	Arima syndrome	Enrichment	CEP290	0.99
305	Usher syndrome, type iiia	Enrichment	CEP78	0.99
306	Moyamoya angiopathy	Enrichment	CEP78	0.99
307	Spastic paraplegia 4, autosomal dominant	Enrichment	OFD1	0.94
308	Immunodeficiency 47	Enrichment	CEP290	0.94
309	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1	0.92
310	Neural tube defects	Enrichment	ITGB1	0.89
311	Charcot-marie-tooth disease	Enrichment	DCTN1, DYNC1H1	0.89
312	Ellis-van creveld syndrome	Enrichment	PRKACA	0.89
313	Osteoporosis	Enrichment	SRC	0.86
314	Dandy-walker syndrome	Enrichment	TUBA1A	0.86
315	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	0.85
316	Stickler syndrome	Enrichment	ALMS1	0.85
317	West syndrome	Enrichment	CSNK1E, TUBA1A	0.84
318	Tooth agenesis	Enrichment	RANBP2	0.84
319	Alobar holoprosencephaly	Enrichment	STAG2	0.82
320	Orofaciodigital syndrome vi	Enrichment	OFD1	0.81
321	Frontotemporal dementia 1	Enrichment	DCTN1	0.81
322	Specific learning disability	Enrichment	YWHAG	0.81
323	Leber plus disease	Enrichment	ALMS1, CEP290, TUBB4B	0.76
324	Acute promyelocytic leukemia	Enrichment	NUMA1	0.74
325	Hirschsprung disease 1	Enrichment	NUP98	0.73
326	Prostate cancer	Enrichment	MAD1L1	0.73
327	Severe covid-19	Enrichment	CENPF	0.73
328	Spastic ataxia	Enrichment	CEP290, TUBB3	0.72
329	Rare genetic deafness	Enrichment	ACTG1, DIAPH1	0.70
330	Lung cancer	Enrichment	PPP2R1B	0.69
331	Peripheral nervous system disease	Enrichment	DYNC1H1	0.69
332	Neuropathy	Enrichment	DYNC1H1	0.69
333	Kidney disease	Enrichment	CEP290	0.69
334	Diamond-blackfan anemia	Enrichment	RPS27	0.65
335	Myopathy	Enrichment	DYNC1H1	0.61
336	Leukodystrophy	Enrichment	ALMS1	0.58
337	Focal segmental glomerulosclerosis	Enrichment	SDCCAG8	0.58
338	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.56
339	Cakut	Enrichment	ACTG1	0.52
340	Non-syndromic genetic deafness	Enrichment	ACTG1	0.50
341	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	0.50
342	Optic atrophy plus syndrome	Enrichment	TUBB6	0.49
343	Brugada syndrome	Enrichment	AKAP9	0.48
344	Autosomal recessive non-syndromic intellectual disability	Enrichment	CLIP1	0.47
345	Primary ovarian insufficiency	Enrichment	SGO2	0.46
346	Epilepsy	Enrichment	DIAPH1	0.46
347	Nonsyndromic hearing loss	Enrichment	ACTG1	0.45
348	Differentiated thyroid carcinoma	Enrichment	PCM1	0.45
349	Long qt syndrome 1	Enrichment	AKAP9	0.43
350	Stargardt disease 1	Enrichment	ALMS1	0.43
351	Visceral heterotaxy 5	Enrichment	NME7	0.42
352	Long qt syndrome	Enrichment	AKAP9	0.42
353	Connective tissue disease	Enrichment	OFD1	0.41
354	Usher syndrome	Enrichment	CEP250	0.40
355	Retinitis pigmentosa	Enrichment	ALMS1, CEP290, NEK2, OFD1	0.40
356	Eye disease	Enrichment	ALMS1	0.38
357	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PFN1	0.34
358	Hereditary spastic paraplegia	Enrichment	CEP63	0.32
359	Ovarian cancer	Enrichment	BUB1B	0.29
360	Sensorineural hearing loss	Enrichment	CEP78	0.28
361	Complex neurodevelopmental disorder	Enrichment	CSNK2A1, PPP2CA	0.25
362	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	0.24
363	Primary ciliary dyskinesia	Enrichment	OFD1	0.16

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EML4 and NUDC in mitotic spindle formation

Pathway Network for EML4 and NUDC in mitotic spindle formation

Pathway network for the EML4 and NUDC in mitotic spindle formation SuperPath

Member Pathways for EML4 and NUDC in mitotic spindle formation

Pathways in the EML4 and NUDC in mitotic spindle formation SuperPath

Gene overlap in member pathways for EML4 and NUDC in mitotic spindle formation SuperPath

Associated Genes for EML4 and NUDC in mitotic spindle formation

Associated Disorders for EML4 and NUDC in mitotic spindle formation

Disorders associated with EML4 and NUDC in mitotic spindle formation SuperPath

STRING Interaction Network for EML4 and NUDC in mitotic spindle formation

Sources for EML4 and NUDC in mitotic spindle formation