Endothelin pathways

No Pathway Network information available for Endothelin pathways

Pathways in the Endothelin pathways SuperPath

#	Name	Source	Genes
1	Endothelin pathways	WikiPathways	ADCY10 ADRA1A ADRB1 ATP2A2 CAD CALCA CALCRL CALM1 CNN1 ECE1 EDN1 EDNRA EDNRB GNA15 GNAI1 GNAS GNB5 GNG13 GUCY1B2 LOC105372522 MAP2K1 MAPK1 MT-CO2 MYL1 MYLK NOS3 NPY NPY1R PRKCA PTGIR RAF1 RAMP1 RIIAD1 (see all 33) (see less)
2	EGF/EGFR signaling pathway	WikiPathways	MT-CO2 NOS3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
2	MT-CO2	Mitochondrially Encoded Cytochrome C Oxidase II	Protein Coding	2
3	CALM1	Calmodulin 1	Protein Coding	1
4	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	1
5	CAD	Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase	Protein Coding	1
6	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
7	PTGIR	Prostaglandin I2 Receptor	Protein Coding	1
8	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
9	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
10	ADCY10	Adenylate Cyclase 10	Protein Coding	1
11	PRKCA	Protein Kinase C Alpha	Protein Coding	1
12	NPY1R	Neuropeptide Y Receptor Y1	Protein Coding	1
13	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
14	NPY	Neuropeptide Y	Protein Coding	1
15	MYLK	Myosin Light Chain Kinase	Protein Coding	1
16	MYL1	Myosin Light Chain 1	Protein Coding	1
17	GNAS	GNAS Complex Locus	Protein Coding	1
18	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
19	EDNRB	Endothelin Receptor Type B	Protein Coding	1
20	EDNRA	Endothelin Receptor Type A	Protein Coding	1
21	EDN1	Endothelin 1	Protein Coding	1
22	ECE1	Endothelin Converting Enzyme 1	Protein Coding	1
23	ADRB1	Adrenoceptor Beta 1	Protein Coding	1
24	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	1
25	GNB5	G Protein Subunit Beta 5	Protein Coding	1
26	RAMP1	Receptor Activity Modifying Protein 1	Protein Coding	1
27	CALCRL	Calcitonin Receptor Like Receptor	Protein Coding	1
28	CNN1	Calponin 1	Protein Coding	1
29	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
30	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
31	GUCY1B2	Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)	Pseudogene	1
32	RIIAD1	Regulatory Subunit Of Type II PKA R-Subunit Domain Containing 1	Protein Coding	1
33	GNA15	G Protein Subunit Alpha 15	Protein Coding	1

Disorders associated with Endothelin pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, RAF1	3.23
2	Alzheimer disease 2	Enrichment	NOS3	3.13
3	Pre-eclampsia	Enrichment	NOS3	3.13
4	Hypertension, essential	Enrichment	ECE1, NOS3	3.12
5	Mitochondrial myopathy, infantile, transient	Enrichment	MT-CO2	2.88
6	Noonan syndrome 1	Enrichment	MAP2K1, RAF1	2.85
7	Stroke, ischemic	Enrichment	NOS3	2.83
8	Familial colorectal cancer	Enrichment	MT-CO2	2.83
9	Mitochondrial myopathy with reversible cytochrome c oxidase deficiency	Enrichment	MT-CO2	2.83
10	Rasopathy	Enrichment	MAP2K1, RAF1	2.75
11	Cox deficiency, benign infantile mitochondrial myopathy	Enrichment	MT-CO2	2.69
12	Hirschsprung disease 1	Enrichment	ECE1, EDNRB	2.65
13	Noonan syndrome 5	Enrichment	RAF1	2.61
14	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.61
15	Resting heart rate, variation in	Enrichment	ADRB1	2.61
16	Melorheostosis, isolated	Enrichment	MAP2K1	2.61
17	Osseous heteroplasia, progressive	Enrichment	GNAS	2.61
18	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.61
19	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.61
20	Mandibulofacial dysostosis with alopecia	Enrichment	EDNRA	2.61
21	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.61
22	Auriculocondylar syndrome 3	Enrichment	EDN1	2.61
23	Noonan syndrome 13	Enrichment	MAPK1	2.61
24	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.61
25	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.61
26	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.61
27	Question mark ears, isolated	Enrichment	EDN1	2.61
28	Melorheostosis	Enrichment	MAP2K1	2.61
29	Hirschsprung disease, cardiac defects, and autonomic dysfunction	Enrichment	ECE1	2.61
30	Leopard syndrome 2	Enrichment	RAF1	2.61
31	Disorders of gnas inactivation	Enrichment	GNAS	2.61
32	Short sleep, familial natural, 2	Enrichment	ADRB1	2.61
33	Congenital myopathy 14	Enrichment	MYL1	2.61
34	Trigonitis	Enrichment	RAF1	2.61
35	Rhabdomyolysis 2	Enrichment	ATP2A2	2.61
36	Idiopathic hypercalciuria	Enrichment	ADCY10	2.61
37	Monostotic fibrous dysplasia	Enrichment	GNAS	2.61
38	Mazabraud syndrome	Enrichment	GNAS	2.61
39	Alzheimer disease, familial, 1	Enrichment	NOS3	2.60
40	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	MT-CO2	2.49
41	Tetralogy of fallot	Enrichment	MT-CO2	2.42
42	Mitochondrial complex v deficiency, mitochondrial type 1	Enrichment	MT-CO2	2.42
43	Neuropathy, ataxia, and retinitis pigmentosa	Enrichment	MT-CO2	2.42
44	Striatonigral degeneration, infantile, mitochondrial	Enrichment	MT-CO2	2.42
45	Camptodactyly of fingers	Enrichment	MT-CO2	2.42
46	Acrokeratosis verruciformis	Enrichment	ATP2A2	2.31
47	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.31
48	Hypercalciuria, absorptive, 2	Enrichment	ADCY10	2.31
49	Aganglionosis, total intestinal	Enrichment	EDNRB	2.31
50	Abcd syndrome	Enrichment	EDNRB	2.31
51	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.31
52	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.31
53	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.31
54	Developmental and epileptic encephalopathy 50	Enrichment	CAD	2.31
55	Long qt syndrome 14	Enrichment	CALM1	2.31
56	Pseudohypoparathyroidism	Enrichment	GNAS	2.31
57	Lymphatic malformation 8	Enrichment	CALCRL	2.31
58	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.31
59	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.31
60	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-CO2	2.26
61	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-CO2	2.25
62	Darier-white disease	Enrichment	ATP2A2	2.14
63	Mccune-albright syndrome	Enrichment	GNAS	2.14
64	Hirschsprung disease 2	Enrichment	EDNRB	2.14
65	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.14
66	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	2.14
67	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.14
68	Hypertelorism	Enrichment	MT-CO2	2.12
69	Primary ovarian insufficiency	Enrichment	NOS3	2.06
70	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.01
71	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	2.01
72	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.01
73	Auriculocondylar syndrome 1	Enrichment	EDN1	2.01
74	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.01
75	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.01
76	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.01
77	Leigh syndrome, nuclear	Enrichment	MT-CO2	1.99
78	Leigh disease	Enrichment	MT-CO2	1.95
79	Visceral myopathy 1	Enrichment	MYLK	1.92
80	Mitochondrial disease	Enrichment	MT-CO2	1.89
81	Leber plus disease	Enrichment	MT-CO2	1.86
82	Waardenburg syndrome, type 4a	Enrichment	EDNRB	1.84
83	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.84
84	Waardenburg syndrome	Enrichment	EDNRB	1.84
85	Waardenburg syndrome, type 2e	Enrichment	EDNRB	1.77
86	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.77
87	Noonan syndrome 3	Enrichment	RAF1	1.77
88	Brachydactyly	Enrichment	GNAS	1.77
89	Pilomyxoid astrocytoma	Enrichment	RAF1	1.77
90	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.71
91	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.71
92	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.71
93	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.71
94	Arteriovenous malformation	Enrichment	MAP2K1	1.66
95	Primary hyperaldosteronism	Enrichment	GNAS	1.66
96	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.66
97	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.62
98	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.58
99	Specific learning disability	Enrichment	MAPK1	1.58
100	Retinitis pigmentosa	Enrichment	MT-CO2	1.51
101	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.47
102	Heart, malformation of	Enrichment	MAPK1	1.37
103	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.28
104	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.25
105	Developmental and epileptic encephalopathy 1	Enrichment	CAD	1.23
106	Long qt syndrome 1	Enrichment	CALM1	1.15
107	Long qt syndrome	Enrichment	CALM1	1.14
108	Non-immune hydrops fetalis	Enrichment	CALCRL	1.14
109	Cystic fibrosis	Enrichment	EDNRA	1.12
110	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.11
111	Left ventricular noncompaction	Enrichment	RAF1	1.09
112	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.99
113	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.94
114	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.92
115	Deafness, autosomal recessive	Enrichment	EDNRB	0.85
116	Autosomal recessive nonsyndromic deafness	Enrichment	EDNRB	0.84
117	Rare genetic deafness	Enrichment	EDNRB	0.76
118	Dilated cardiomyopathy	Enrichment	RAF1	0.75
119	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EDNRB	0.71
120	Congenital nervous system abnormality	Enrichment	GNB5	0.64
121	Nervous system disease	Enrichment	GNB5	0.64
122	Autism spectrum disorder	Enrichment	MAP2K1	0.63
123	Microcephaly	Enrichment	MAPK1	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Endothelin pathways

Pathway Network for Endothelin pathways

Member Pathways for Endothelin pathways

Pathways in the Endothelin pathways SuperPath

Associated Genes for Endothelin pathways

Associated Disorders for Endothelin pathways

Disorders associated with Endothelin pathways SuperPath

STRING Interaction Network for Endothelin pathways

Sources for Endothelin pathways