Endothelins

No Pathway Network information available for Endothelins

Pathways in the Endothelins SuperPath

#	Name	Source	Genes
1	Endothelins	PubChem	AKT1 BCAR1 CDC42 COL1A2 COL3A1 CRK CYSLTR1 CYSLTR2 EDN1 EDN2 EDN3 EDNRA EDNRB FOS GNA12 HRAS JAK2 JUN MAP2K1 MAPK14 MAPK3 MAPK8 MMP1 PLA2G4A PTK2B RAC1 RAF1 RHOA SLC9A1 SLC9A3 SRC TRPC6 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EDN2	Endothelin 2	Protein Coding	1
2	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	1
3	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
4	EDNRB	Endothelin Receptor Type B	Protein Coding	1
5	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
6	EDN3	Endothelin 3	Protein Coding	1
7	CYSLTR2	Cysteinyl Leukotriene Receptor 2	Protein Coding	1
8	EDNRA	Endothelin Receptor Type A	Protein Coding	1
9	EDN1	Endothelin 1	Protein Coding	1
10	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
11	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
12	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
13	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
14	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
15	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
16	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
17	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
18	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
19	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
20	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
21	CDC42	Cell Division Cycle 42	Protein Coding	1
22	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
23	RHOA	Ras Homolog Family Member A	Protein Coding	1
24	RAC1	Rac Family Small GTPase 1	Protein Coding	1
25	JAK2	Janus Kinase 2	Protein Coding	1
26	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
27	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	1
28	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
29	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
30	CYSLTR1	Cysteinyl Leukotriene Receptor 1	Protein Coding	1
31	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
32	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1

Disorders associated with Endothelins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, RAF1	5.27
2	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, RAF1	4.69
3	Rasopathy	Enrichment	HRAS, MAP2K1, RAF1	4.52
4	Waardenburg syndrome, type 4a	Enrichment	EDN3, EDNRB	4.09
5	Myelofibrosis	Enrichment	JAK2, SRC	3.95
6	Noonan syndrome 3	Enrichment	HRAS, RAF1	3.95
7	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.82
8	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.72
9	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.62
10	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1	3.53
11	Osteoporosis	Enrichment	COL1A2, SRC	3.32
12	Ehlers-danlos syndrome	Enrichment	COL1A2, COL3A1	3.05
13	Hirschsprung disease 1	Enrichment	EDN3, EDNRB	2.68
14	Proteus syndrome	Enrichment	AKT1	2.63
15	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.63
16	Noonan syndrome 5	Enrichment	RAF1	2.63
17	Melorheostosis, isolated	Enrichment	MAP2K1	2.63
18	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.63
19	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	2.63
20	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.63
21	Mandibulofacial dysostosis with alopecia	Enrichment	EDNRA	2.63
22	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.63
23	Hirschsprung disease 4	Enrichment	EDN3	2.63
24	Waardenburg syndrome, type 4b	Enrichment	EDN3	2.63
25	Acrogeria, gottron type	Enrichment	COL3A1	2.63
26	Auriculocondylar syndrome 3	Enrichment	EDN1	2.63
27	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.63
28	Question mark ears, isolated	Enrichment	EDN1	2.63
29	Melorheostosis	Enrichment	MAP2K1	2.63
30	Leopard syndrome 2	Enrichment	RAF1	2.63
31	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.63
32	Cowden syndrome 6	Enrichment	AKT1	2.63
33	Thrombocytopenia 6	Enrichment	SRC	2.63
34	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.63
35	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.63
36	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.63
37	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.63
38	Trigonitis	Enrichment	RAF1	2.63
39	Nocarh syndrome	Enrichment	CDC42	2.63
40	Abdominal aortic aneurysm	Enrichment	COL3A1	2.63
41	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.63
42	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.63
43	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.63
44	Cystic fibrosis	Enrichment	EDNRA, SLC9A3	2.59
45	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.33
46	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.33
47	Aganglionosis, total intestinal	Enrichment	EDNRB	2.33
48	Costello syndrome	Enrichment	HRAS	2.33
49	Bruck syndrome 1	Enrichment	COL1A2	2.33
50	Abcd syndrome	Enrichment	EDNRB	2.33
51	Thrombocythemia 3	Enrichment	JAK2	2.33
52	Diarrhea 8, secretory sodium, congenital	Enrichment	SLC9A3	2.33
53	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.33
54	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A2	2.33
55	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.33
56	Aortic dissection	Enrichment	COL3A1	2.33
57	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.33
58	Immune system disease	Enrichment	CDC42	2.33
59	Polycythemia	Enrichment	JAK2	2.33
60	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A2	2.33
61	Hypereosinophilic syndrome	Enrichment	JAK2	2.33
62	Dentinogenesis imperfecta	Enrichment	COL1A2	2.33
63	Wooly hair nevus	Enrichment	HRAS	2.33
64	Polycythemia vera	Enrichment	JAK2	2.15
65	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SLC9A3	2.15
66	Hirschsprung disease 2	Enrichment	EDNRB	2.15
67	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.15
68	Large congenital melanocytic nevus	Enrichment	HRAS	2.15
69	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.15
70	Spermatocytoma	Enrichment	HRAS	2.15
71	High bone mass osteogenesis imperfecta	Enrichment	COL1A2	2.15
72	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A2	2.03
73	Erythrocytosis, familial, 1	Enrichment	JAK2	2.03
74	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.03
75	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.03
76	Budd-chiari syndrome	Enrichment	JAK2	2.03
77	Auriculocondylar syndrome 1	Enrichment	EDN1	2.03
78	Congenital generalized lipodystrophy	Enrichment	FOS	2.03
79	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.03
80	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.03
81	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.03
82	Epidermolytic nevus	Enrichment	HRAS	2.03
83	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A2	2.03
84	Myeloproliferative neoplasm	Enrichment	JAK2	1.93
85	Histiocytoid hemangioma	Enrichment	FOS	1.93
86	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.93
87	Breast cancer	Enrichment	AKT1, JUN	1.87
88	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A2	1.85
89	Melanoma, uveal	Enrichment	CYSLTR2	1.85
90	Osteogenesis imperfecta, type i	Enrichment	COL1A2	1.85
91	Hemihyperplasia, isolated	Enrichment	RHOA	1.85
92	Breast adenocarcinoma	Enrichment	AKT1	1.85
93	Classic ehlers-danlos syndrome	Enrichment	COL1A2	1.85
94	Waardenburg syndrome	Enrichment	EDNRB	1.85
95	Nevus, epidermal	Enrichment	HRAS	1.79
96	Osteogenesis imperfecta, type ii	Enrichment	COL1A2	1.79
97	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.79
98	Waardenburg syndrome, type 2e	Enrichment	EDNRB	1.79
99	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.79
100	Essential thrombocythemia	Enrichment	JAK2	1.79
101	Pilomyxoid astrocytoma	Enrichment	RAF1	1.79
102	Follicular thyroid carcinoma	Enrichment	HRAS	1.79
103	Colorectal cancer	Enrichment	AKT1, SRC	1.75
104	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.73
105	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.68
106	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.68
107	Congenital central hypoventilation syndrome	Enrichment	EDN3	1.68
108	Cowden syndrome	Enrichment	AKT1	1.68
109	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.68
110	Primary bone dysplasia	Enrichment	COL1A2	1.63
111	Osteochondrodysplasia	Enrichment	COL1A2	1.59
112	Meningioma	Enrichment	AKT1	1.55
113	Lip and oral cavity carcinoma	Enrichment	HRAS	1.55
114	Osteogenesis imperfecta, type iv	Enrichment	COL1A2	1.52
115	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.49
116	Osteogenesis imperfecta, type iii	Enrichment	COL1A2	1.46
117	Rhabdomyosarcoma	Enrichment	HRAS	1.43
118	Focal segmental glomerulosclerosis	Enrichment	TRPC6	1.34
119	Brittle bone disorder	Enrichment	COL1A2	1.28
120	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.26
121	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.22
122	Bladder cancer	Enrichment	HRAS	1.18
123	Differentiated thyroid carcinoma	Enrichment	HRAS	1.18
124	Non-immune hydrops fetalis	Enrichment	HRAS	1.15
125	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.12
126	Genetic steroid-resistant nephrotic syndrome	Enrichment	TRPC6	1.11
127	Left ventricular noncompaction	Enrichment	RAF1	1.10
128	Leukemia, acute myeloid	Enrichment	JAK2	1.04
129	Nephrotic syndrome	Enrichment	TRPC6	1.01
130	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL3A1	1.01
131	Hereditary breast carcinoma	Enrichment	AKT1	1.01
132	Sensorineural hearing loss	Enrichment	EDN3	0.97
133	Thrombocytopenia	Enrichment	SRC	0.97
134	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.93
135	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.91
136	Primary ovarian insufficiency	Enrichment	JAK2	0.88
137	Deafness, autosomal recessive	Enrichment	EDNRB	0.86
138	Autosomal recessive nonsyndromic deafness	Enrichment	EDNRB	0.85
139	Rare genetic deafness	Enrichment	EDNRB	0.77
140	Dilated cardiomyopathy	Enrichment	RAF1	0.76
141	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EDNRB	0.72
142	Ovarian cancer	Enrichment	AKT1	0.67
143	Autism spectrum disorder	Enrichment	MAP2K1	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Endothelins

Pathway Network for Endothelins

Member Pathways for Endothelins

Pathways in the Endothelins SuperPath

Associated Genes for Endothelins

Associated Disorders for Endothelins

Disorders associated with Endothelins SuperPath

STRING Interaction Network for Endothelins

Sources for Endothelins