EPH-Ephrin signaling

Pathway network for the EPH-Ephrin signaling SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)
PubChem

Pathways in the EPH-Ephrin signaling SuperPath

#	Name	Source	Genes
1	EPH-Ephrin signaling	Reactome	ACTB ACTG1 ACTR2 ACTR3 ADAM10 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B ARHGEF28 ARHGEF7 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CFL1 CLTA CLTB CLTC CLTCL1 DNM1 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GIT1 GRIN1 GRIN2B HRAS ITSN1 KALRN LIMK1 LIMK2 LYN MMP2 MMP9 MYH10 MYH11 MYH14 MYH9 MYL12A MYL12B MYL6 MYL9 NCK2 NCSTN NGEF PAK1 PAK2 PAK3 PSEN1 PSEN2 PSENEN PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SDC2 SRC TIAM1 VAV2 VAV3 WASL YES1 (see all 91) (see less)
2	Cell adhesion Ephrins signaling	GeneGo (Thomson Reuters)	ADAM10 CDC42 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GRB10 GRB2 GRB7 HRAS ITSN1 KALRN MAP3K7 MAP4K4 MAPK8 NCK1 NCK2 NGEF PAK1 PIK3CG PTK2 PTPN13 PXN RAC1 RAF1 RAP1A RASA1 RGS3 RHOA RND1 SLA SRC TIAM1 VAV2 (see all 57) (see less)
3	EPH-ephrin mediated repulsion of cells	Reactome	ACTB ACTG1 ADAM10 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B CLTA CLTB CLTC CLTCL1 DNM1 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN LYN MMP2 MMP9 NCSTN PSEN1 PSEN2 PSENEN RAC1 SRC TIAM1 VAV2 VAV3 YES1 (see all 51) (see less)
4	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 ACTR2 ACTR3 ACTR3B ARHGAP35 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CAV1 CDC42 CFL1 CFL2 FN1 FYN ITGA5 ITGAV ITGB1 ITGB3 LIMK1 LIMK2 NISCH PAK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PTK2 RAC1 RHOA ROCK1 ROCK2 SRC TLN1 TLN2 VAV1 VCL WASL (see all 46) (see less)
5	EPHB-mediated forward signaling	Reactome	ACTB ACTG1 ACTR2 ACTR3 ARHGEF28 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CFL1 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GRIN1 GRIN2B HRAS ITSN1 KALRN LIMK1 LIMK2 LYN PAK1 PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SDC2 SRC TIAM1 WASL YES1 (see all 42) (see less)
6	EPHB forward signaling	PubChem	CDC42 CRK DNM1 EFNA5 EFNB1 EFNB2 EPHB1 EPHB2 EPHB3 EPHB4 GRB2 GRB7 HRAS ITSN1 KALRN MAP2K1 MAP4K4 MAPK3 NCK1 PAK1 PIK3CA PIK3R1 PTK2 PXN RAC1 RASA1 ROCK1 RRAS SH3GL2 SHC1 SRC SYNJ1 TF WASL (see all 34) (see less)
7	Ephrin signaling	Reactome	ARHGEF7 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GIT1 MYL12A NCK2 PAK1 PAK2 PAK3 RAC1 SRC (see all 18) (see less)
8	EphrinB-EPHB pathway	PubChem	EFNB1 EFNB2 EPHB1 EPHB2 EPHB3 EPHB4 (see all 6) (see less)

Gene overlap in member pathways for EPH-Ephrin signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EFNB1	Ephrin B1	Protein Coding	7
2	EFNB2	Ephrin B2	Protein Coding	7
3	EPHB1	EPH Receptor B1	Protein Coding	7
4	EPHB2	EPH Receptor B2	Protein Coding	7
5	EPHB3	EPH Receptor B3	Protein Coding	7
6	EPHB4	EPH Receptor B4	Protein Coding	7
7	RAC1	Rac Family Small GTPase 1	Protein Coding	7
8	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	7
9	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
10	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	6
11	EFNB3	Ephrin B3	Protein Coding	5
12	EPHB6	EPH Receptor B6	Protein Coding	5
13	PTK2	Protein Tyrosine Kinase 2	Protein Coding	5
14	CDC42	Cell Division Cycle 42	Protein Coding	5
15	EFNA5	Ephrin A5	Protein Coding	4
16	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
17	RHOA	Ras Homolog Family Member A	Protein Coding	4
18	RASA1	RAS P21 Protein Activator 1	Protein Coding	4
19	ACTB	Actin Beta	Protein Coding	4
20	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	4
21	ITSN1	Intersectin 1	Protein Coding	4
22	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	4
23	ACTG1	Actin Gamma 1	Protein Coding	4
24	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	4
25	KALRN	Kalirin RhoGEF Kinase	Protein Coding	4
26	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	3
27	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	3
28	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	3
29	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	3
30	ACTR3	Actin Related Protein 3	Protein Coding	3
31	ACTR2	Actin Related Protein 2	Protein Coding	3
32	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	3
33	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	3
34	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	3
35	CFL1	Cofilin 1	Protein Coding	3
36	DNM1	Dynamin 1	Protein Coding	3
37	EFNA1	Ephrin A1	Protein Coding	3
38	EFNA2	Ephrin A2	Protein Coding	3
39	EFNA3	Ephrin A3	Protein Coding	3
40	EFNA4	Ephrin A4	Protein Coding	3
41	EPHA2	EPH Receptor A2	Protein Coding	3
42	EPHA1	EPH Receptor A1	Protein Coding	3
43	EPHA3	EPH Receptor A3	Protein Coding	3
44	EPHA4	EPH Receptor A4	Protein Coding	3
45	EPHA5	EPH Receptor A5	Protein Coding	3
46	EPHA7	EPH Receptor A7	Protein Coding	3
47	EPHA8	EPH Receptor A8	Protein Coding	3
48	EPHA6	EPH Receptor A6	Protein Coding	3
49	LIMK1	LIM Domain Kinase 1	Protein Coding	3
50	LIMK2	LIM Domain Kinase 2	Protein Coding	3
51	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
52	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	3
53	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	3
54	NCK2	NCK Adaptor Protein 2	Protein Coding	3
55	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	3
56	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
57	MYL12A	Myosin Light Chain 12A	Protein Coding	2
58	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	2
59	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	2
60	CLTA	Clathrin Light Chain A	Protein Coding	2
61	CLTB	Clathrin Light Chain B	Protein Coding	2
62	CLTC	Clathrin Heavy Chain	Protein Coding	2
63	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	2
64	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	2
65	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	2
66	NCSTN	Nicastrin	Protein Coding	2
67	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	2
68	EPHA10	EPH Receptor A10	Protein Coding	2
69	GIT1	GIT ArfGAP 1	Protein Coding	2
70	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	2
71	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	2
72	MMP2	Matrix Metallopeptidase 2	Protein Coding	2
73	MMP9	Matrix Metallopeptidase 9	Protein Coding	2
74	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
75	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
76	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	2
77	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	2
78	PSEN1	Presenilin 1	Protein Coding	2
79	PSEN2	Presenilin 2	Protein Coding	2
80	SDC2	Syndecan 2	Protein Coding	2
81	ARHGEF28	Rho Guanine Nucleotide Exchange Factor 28	Protein Coding	2
82	CLTCL1	Clathrin Heavy Chain Like 1	Protein Coding	2
83	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	2
84	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
85	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
86	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	2
87	NCK1	NCK Adaptor Protein 1	Protein Coding	2
88	PXN	Paxillin	Protein Coding	2
89	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	2
90	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
91	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
92	MYL12B	Myosin Light Chain 12B	Protein Coding	1
93	MYL9	Myosin Light Chain 9	Protein Coding	1
94	MYH9	Myosin Heavy Chain 9	Protein Coding	1
95	MYH10	Myosin Heavy Chain 10	Protein Coding	1
96	MYH11	Myosin Heavy Chain 11	Protein Coding	1
97	MYL6	Myosin Light Chain 6	Protein Coding	1
98	MYH14	Myosin Heavy Chain 14	Protein Coding	1
99	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
100	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
101	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
102	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
103	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
104	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
105	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
106	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
107	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
108	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
109	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
110	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	1
111	SLA	Src Like Adaptor	Protein Coding	1
112	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
113	RND1	Rho Family GTPase 1	Protein Coding	1
114	ACTN4	Actinin Alpha 4	Protein Coding	1
115	ACTN1	Actinin Alpha 1	Protein Coding	1
116	ACTN2	Actinin Alpha 2	Protein Coding	1
117	ACTN3	Actinin Alpha 3	Protein Coding	1
118	CAV1	Caveolin 1	Protein Coding	1
119	CFL2	Cofilin 2	Protein Coding	1
120	FN1	Fibronectin 1	Protein Coding	1
121	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
122	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
123	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
124	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
125	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
126	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
127	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
128	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
129	TLN1	Talin 1	Protein Coding	1
130	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
131	VCL	Vinculin	Protein Coding	1
132	NISCH	Nischarin	Protein Coding	1
133	ACTR3B	Actin Related Protein 3B	Protein Coding	1
134	TLN2	Talin 2	Protein Coding	1
135	SYNJ1	Synaptojanin 1	Protein Coding	1
136	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
137	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
138	RRAS	RAS Related	Protein Coding	1
139	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	1
140	TF	Transferrin	Protein Coding	1
141	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
142	SHC1	SHC Adaptor Protein 1	Protein Coding	1

Disorders associated with EPH-Ephrin signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4, HRAS, MAP2K1, PIK3CA, RASA1	10.66
2	Arteriovenous malformation	Enrichment	EPHB4, HRAS, MAP2K1, PIK3CA, RASA1	10.57
3	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4, MAP2K1, PIK3CA, RASA1	8.93
4	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	5.63
5	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.03
6	Immune system disease	Enrichment	CDC42, PIK3CD	4.95
7	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.74
8	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, RRAS	4.61
9	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.47
10	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.47
11	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	4.38
12	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.22
13	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.17
14	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	4.04
15	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.90
16	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.78
17	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	3.54
18	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC, GRIN1, GRIN2B, ITSN1	3.46
19	Noonan syndrome 3	Enrichment	HRAS, RAF1	3.44
20	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.40
21	Lymphatic malformation 5	Enrichment	EPHB4	3.35
22	Craniofrontonasal syndrome	Enrichment	EFNB1	3.35
23	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	3.35
24	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	3.35
25	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	3.35
26	Vein of galen aneurysmal malformation	Enrichment	EPHB4	3.35
27	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.32
28	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1, ITGB3	3.30
29	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.30
30	Thrombocytopenia	Enrichment	ACTN1, ITGB3, SRC	3.25
31	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1	3.20
32	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1, RASA1	3.18
33	Hemangioma, capillary infantile	Enrichment	MYH9, RASA1	3.18
34	Lymphatic malformation 1	Enrichment	EPHB4	3.05
35	Intracranial hypertension, idiopathic	Enrichment	EPHB4	3.05
36	Hereditary lymphedema i	Enrichment	EPHB4	3.05
37	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, SRC	2.88
38	Lymphatic malformation 7	Enrichment	EPHB4	2.88
39	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	2.88
40	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.88
41	Knobloch syndrome 2	Enrichment	PAK2	2.88
42	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.88
43	Thrombocytopenia 6	Enrichment	SRC	2.88
44	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.88
45	Hydrops fetalis, nonimmune	Enrichment	EPHB4, HRAS	2.72
46	Rasopathy	Enrichment	HRAS, MAP2K1	2.72
47	Hemifacial hyperplasia	Enrichment	EFNB1	2.66
48	Bladder cancer	Enrichment	HRAS, PIK3CA	2.62
49	Prostate cancer	Enrichment	EPHB2, PIK3CA	2.62
50	Macrodactyly	Enrichment	PIK3CA	2.60
51	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.60
52	Melorheostosis, isolated	Enrichment	MAP2K1	2.60
53	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.60
54	Cowden syndrome 5	Enrichment	PIK3CA	2.60
55	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.60
56	Developmental and epileptic encephalopathy 53	Enrichment	SYNJ1	2.60
57	Atransferrinemia	Enrichment	TF	2.60
58	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.60
59	Short syndrome	Enrichment	PIK3R1	2.60
60	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.60
61	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.60
62	Melorheostosis	Enrichment	MAP2K1	2.60
63	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.60
64	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.60
65	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.60
66	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.60
67	Hypospadias	Enrichment	PIK3CA	2.60
68	Rare venous malformation	Enrichment	PIK3CA	2.60
69	Gorham's disease	Enrichment	RASA1	2.60
70	Diaphragmatic eventration	Enrichment	PIK3CA	2.60
71	Nocarh syndrome	Enrichment	CDC42	2.60
72	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.60
73	Rare combined vascular malformation	Enrichment	PIK3CA	2.60
74	Cavernous lymphangioma	Enrichment	PIK3CA	2.60
75	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.60
76	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.60
77	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.60
78	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.60
79	Macrodactyly of toe	Enrichment	PIK3CA	2.60
80	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.58
81	Non-immune hydrops fetalis	Enrichment	EPHB4, HRAS	2.57
82	Nonsyndromic hearing loss	Enrichment	ACTG1, EPHA10, MYH14	2.56
83	Baraitser-winter syndrome 1	Enrichment	ACTB	2.51
84	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.51
85	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.51
86	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.51
87	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.51
88	Becker nevus syndrome	Enrichment	ACTB	2.51
89	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.51
90	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.51
91	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.51
92	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.51
93	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.51
94	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.51
95	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.51
96	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.51
97	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.51
98	Baraitser-winter syndrome	Enrichment	ACTB	2.51
99	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.51
100	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.51
101	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.51
102	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.51
103	West syndrome	Enrichment	DNM1, GRIN1, GRIN2B	2.50
104	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	2.47
105	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.47
106	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.47
107	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.47
108	Congenital myopathy 8	Enrichment	ACTN2	2.47
109	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.47
110	Nemaline myopathy 7	Enrichment	CFL2	2.47
111	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.47
112	Actn3 deficiency	Enrichment	ACTN3	2.47
113	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.47
114	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.47
115	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.47
116	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.47
117	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.47
118	Capillary leak syndrome	Enrichment	TLN1	2.47
119	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.42
120	Acne inversa, familial, 1	Enrichment	NCSTN	2.42
121	Deafness, autosomal dominant 88	Enrichment	EPHA10	2.42
122	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.42
123	Alzheimer disease 18	Enrichment	ADAM10	2.42
124	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.42
125	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.42
126	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.42
127	Acne inversa, familial, 3	Enrichment	PSEN1	2.42
128	Congenital insensitivity to pain with severe intellectual disability	Enrichment	CLTCL1	2.42
129	Pash syndrome	Enrichment	NCSTN	2.42
130	Huntington's disease-like	Enrichment	PSEN2	2.42
131	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.38
132	Noonan syndrome 5	Enrichment	RAF1	2.38
133	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.38
134	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.38
135	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.38
136	Ventricular tachycardia, familial	Enrichment	GNAI2	2.38
137	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.38
138	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.38
139	Leopard syndrome 2	Enrichment	RAF1	2.38
140	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.38
141	Trigonitis	Enrichment	RAF1	2.38
142	Gnao1-related disorder	Enrichment	GNAO1	2.38
143	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.38
144	Costello syndrome	Enrichment	HRAS	2.30
145	Keratosis, seborrheic	Enrichment	PIK3CA	2.30
146	Noonan syndrome 8	Enrichment	PIK3CA	2.30
147	Parkinson disease 20, early-onset	Enrichment	SYNJ1	2.30
148	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.30
149	Wooly hair nevus	Enrichment	HRAS	2.30
150	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, MYH14, MYH9	2.29
151	Knobloch syndrome	Enrichment	PAK2	2.28
152	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.21
153	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.21
154	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	2.21
155	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.21
156	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	2.21
157	Immunodeficiency 133	Enrichment	ARPC5	2.21
158	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, DNM1, LIMK1	2.20
159	Microcephaly	Enrichment	ACTB, ACTG1, GRIN2B	2.19
160	Knobloch syndrome 1	Enrichment	PAK2	2.18
161	Deafness, autosomal dominant 17	Enrichment	MYH9	2.17
162	Deafness, autosomal dominant 4a	Enrichment	MYH14	2.17
163	Peripheral neuropathy, myopathy, hoarseness, and hearing loss	Enrichment	MYH14	2.17
164	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	2.17
165	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.17
166	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.17
167	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.17
168	Hypertelorism	Enrichment	EFNB1, PIK3CA	2.13
169	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.12
170	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.12
171	Anus, imperforate	Enrichment	MAP4K4	2.12
172	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.12
173	Large congenital melanocytic nevus	Enrichment	HRAS	2.12
174	Wieacker-wolff syndrome	Enrichment	RASA1	2.12
175	Spermatocytoma	Enrichment	HRAS	2.12
176	Atypical juvenile parkinsonism	Enrichment	SYNJ1	2.12
177	Keratoacanthoma	Enrichment	PIK3CA	2.12
178	Alzheimer disease 3	Enrichment	PSEN1	2.12
179	Pick disease of brain	Enrichment	PSEN1	2.12
180	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.12
181	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.12
182	Metaphyseal anadysplasia	Enrichment	MMP9	2.12
183	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.08
184	Hypopituitarism	Enrichment	GNAI2	2.08
185	Myelofibrosis	Enrichment	SRC	2.03
186	Complex neurodevelopmental disorder	Enrichment	GRIN2B, MYH10, PAK3, TIAM1	2.02
187	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.00
188	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.00
189	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	2.00
190	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.00
191	Cerebrovascular disease	Enrichment	PIK3CA	2.00
192	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.00
193	Epidermolytic nevus	Enrichment	HRAS	2.00
194	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.00
195	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.99
196	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.99
197	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.99
198	Intrinsic cardiomyopathy	Enrichment	ACTN2	1.99
199	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.99
200	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.95
201	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.95
202	Tetralogy of fallot	Enrichment	EPHB4	1.94
203	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.93
204	Astigmatism	Enrichment	GRIN2B	1.91
205	Aminoacylase 1 deficiency	Enrichment	ACTB	1.91
206	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.91
207	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.90
208	Hemimegalencephaly	Enrichment	PIK3CA	1.90
209	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.90
210	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11	1.87
211	Cataract 35	Enrichment	MYH9	1.87
212	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11	1.87
213	Pseudosarcomatous fibromatosis	Enrichment	MYH9	1.87
214	Visceral myopathy 2	Enrichment	MYH11	1.87
215	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.87
216	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.87
217	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2, VCL	1.86
218	Cowden syndrome 1	Enrichment	PIK3CA	1.83
219	Basal cell carcinoma 1	Enrichment	RASA1	1.83
220	Breast adenocarcinoma	Enrichment	PIK3CA	1.83
221	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.83
222	Dowling-degos disease 1	Enrichment	ADAM10	1.83
223	Dowling-degos disease	Enrichment	PSENEN	1.83
224	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.83
225	Breast cancer	Enrichment	PIK3CA, SHC1	1.82
226	Coloboma of choroid and retina	Enrichment	ACTG1	1.81
227	Sleep disorder	Enrichment	GRIN2B	1.81
228	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.78
229	Achromatopsia 4	Enrichment	GNAI3	1.78
230	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.78
231	Martsolf syndrome 1	Enrichment	ARHGAP35	1.77
232	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.77
233	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.77
234	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.76
235	Gallbladder cancer	Enrichment	PIK3CA	1.76
236	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.76
237	Follicular thyroid carcinoma	Enrichment	HRAS	1.76
238	Overgrowth syndrome	Enrichment	PIK3R1	1.76
239	Osteoporosis	Enrichment	SRC	1.73
240	Cataract 6, multiple types	Enrichment	EPHA2	1.73
241	Dementia	Enrichment	PSEN1	1.73
242	Aniridia	Enrichment	EPHA2	1.73
243	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.70
244	Lennox-gastaut syndrome	Enrichment	DNM1	1.70
245	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	1.70
246	Tricuspid valve insufficiency	Enrichment	MYH11	1.70
247	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.70
248	Limited scleroderma	Enrichment	CAV1	1.70
249	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.70
250	Typical nemaline myopathy	Enrichment	CFL2	1.70
251	Coronary heart disease 5	Enrichment	KALRN	1.65
252	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.65
253	Cowden syndrome	Enrichment	PIK3CA	1.65
254	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.65
255	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.63
256	Non-syndromic genetic deafness	Enrichment	ACTG1, MYH14	1.62
257	Semantic dementia	Enrichment	PSEN1	1.58
258	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.58
259	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYH11	1.58
260	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	MYH11	1.58
261	Mitral valve insufficiency	Enrichment	MYH11	1.58
262	Pilomyxoid astrocytoma	Enrichment	RAF1	1.54
263	Juvenile myelomonocytic leukemia	Enrichment	RRAS	1.53
264	Early-onset parkinson's disease	Enrichment	SYNJ1	1.53
265	Meningioma	Enrichment	PIK3CA	1.53
266	Early-onset posterior polar cataract	Enrichment	EPHA2	1.53
267	Dilated cardiomyopathy	Enrichment	ACTN2, VCL	1.52
268	Cat eye syndrome	Enrichment	ACTG1	1.52
269	Stereotypic movement disorder	Enrichment	DNM1	1.49
270	Visceral myopathy 1	Enrichment	MYH11	1.48
271	Deafness, autosomal recessive 63	Enrichment	MYH9	1.48
272	Congenital ptosis	Enrichment	MYH10	1.48
273	Choreatic disease	Enrichment	GNAO1	1.48
274	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.48
275	Progressive non-fluent aphasia	Enrichment	PSEN1	1.48
276	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.48
277	Peters-plus syndrome	Enrichment	ARHGAP35	1.48
278	Combined immunodeficiency	Enrichment	ARPC1B	1.47
279	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.47
280	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.47
281	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.44
282	Lynch syndrome	Enrichment	PIK3CA	1.43
283	Rhabdomyosarcoma	Enrichment	HRAS	1.40
284	Intestinal pseudo-obstruction	Enrichment	MYH11	1.40
285	Frontotemporal dementia 1	Enrichment	PSEN1	1.39
286	Neural tube defects	Enrichment	ITGB1	1.36
287	Nk-cell enteropathy	Enrichment	PIK3CB	1.36
288	Movement disease	Enrichment	GNAO1	1.34
289	Arteriovenous malformations of the brain	Enrichment	MAP4K4	1.33
290	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.33
291	Alzheimer's disease	Enrichment	PSEN1	1.32
292	Endometrial cancer	Enrichment	PIK3CA	1.29
293	Cataract	Enrichment	EPHA2	1.29
294	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	1.28
295	Hepatocellular carcinoma	Enrichment	PIK3CA	1.27
296	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.27
297	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11	1.23
298	Williams-beuren syndrome	Enrichment	LIMK1	1.22
299	Craniosynostosis	Enrichment	GRIN2B	1.22
300	Developmental and epileptic encephalopathy 1	Enrichment	SYNJ1	1.22
301	Rare genetic intellectual disability	Enrichment	GNAO1	1.21
302	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.21
303	Cataract 44	Enrichment	EPHA2	1.21
304	Lissencephaly	Enrichment	ACTG1	1.20
305	Early-onset nuclear cataract	Enrichment	EPHA2	1.18
306	Centronuclear myopathy	Enrichment	CFL2	1.16
307	Differentiated thyroid carcinoma	Enrichment	HRAS	1.15
308	Scoliosis	Enrichment	GRIN2B	1.14
309	Myocardial infarction	Enrichment	ITGB3	1.14
310	Lung cancer	Enrichment	PIK3CA	1.11
311	Skin disease	Enrichment	NCSTN	1.10
312	Microphthalmia/coloboma 12	Enrichment	MYH10	1.08
313	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11	1.05
314	Severe covid-19	Enrichment	ITGAV	1.03
315	Coloboma of macula	Enrichment	MYH10	1.02
316	Myopia	Enrichment	MYH11	1.02
317	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.02
318	Rare genetic deafness	Enrichment	ACTG1, MYH9	1.01
319	Cakut	Enrichment	ACTG1	1.00
320	Hypertension	Enrichment	MYH9	0.99
321	Gastric cancer	Enrichment	PIK3CA	0.99
322	Hereditary breast carcinoma	Enrichment	PIK3CA	0.98
323	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2	0.97
324	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4	0.96
325	Left ventricular noncompaction	Enrichment	ACTN2	0.95
326	Cerebral palsy	Enrichment	GRIN2B	0.94
327	Epilepsy	Enrichment	GRIN2B	0.93
328	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1	0.92
329	Centralopathic epilepsy	Enrichment	GRIN1	0.90
330	Nephrotic syndrome	Enrichment	FN1	0.87
331	Hypertrophic cardiomyopathy	Enrichment	ACTN2	0.87
332	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.85
333	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.78
334	Myeloma, multiple	Enrichment	PIK3R2	0.76
335	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.71
336	Ovarian cancer	Enrichment	PIK3CA	0.65
337	Autism spectrum disorder	Enrichment	MAP2K1	0.62
338	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYH11	0.59
339	Body mass index quantitative trait locus 11	Enrichment	MYH9	0.54
340	Congenital nervous system abnormality	Enrichment	PSEN1	0.48
341	Nervous system disease	Enrichment	PSEN1	0.48
342	Deafness, autosomal recessive	Enrichment	MYH9	0.46
343	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.46
344	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYH9	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EPH-Ephrin signaling

Pathway Network for EPH-Ephrin signaling

Pathway network for the EPH-Ephrin signaling SuperPath

Member Pathways for EPH-Ephrin signaling

Pathways in the EPH-Ephrin signaling SuperPath

Gene overlap in member pathways for EPH-Ephrin signaling SuperPath

Associated Genes for EPH-Ephrin signaling

Associated Disorders for EPH-Ephrin signaling

Disorders associated with EPH-Ephrin signaling SuperPath

STRING Interaction Network for EPH-Ephrin signaling

Sources for EPH-Ephrin signaling