EPHA-mediated growth cone collapse

Pathway network for the EPHA-mediated growth cone collapse SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)
QIAGEN
PubChem

Pathways in the EPHA-mediated growth cone collapse SuperPath

#	Name	Source	Genes
1	EPHA-mediated growth cone collapse	Reactome	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 FYN LYN MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 NGEF RHOA ROCK1 ROCK2 SRC YES1 (see all 29) (see less)
2	G-protein signaling RhoA regulation pathway	GeneGo (Thomson Reuters)	ARHGAP1 ARHGAP26 ARHGAP32 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF12 ARHGEF2 ARHGEF3 BMX DIAPH1 ECT2 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EZR FNTA FYN GNA11 GNA12 GNA13 GNAQ IGF1 IGF1R KIFAP3 MCF2L MYO9B NGEF PGGT1B PKN1 PLD1 PTK2 RAC1 RAP1GDS1 RHOA RHPN1 ROCK1 ROCK2 (see all 49) (see less)
3	EphrinA-EphR Signaling	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ADAM10 CDC42 CFL1 CFL2 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 FYN LIMK1 LIMK2 NGEF PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PIK3CG PTK2 PTK2B RAC1 RASA1 RHOA ROCK1 ROCK2 (see all 39) (see less)
4	EphrinA-EPHA pathway	PubChem	EFNA5 EPHA2 EPHA3 EPHA8
5	Ephrin A reverse signaling	PubChem	EFNA5 EPHA5 FYN

Gene overlap in member pathways for EPHA-mediated growth cone collapse SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EFNA5	Ephrin A5	Protein Coding	5
2	EPHA2	EPH Receptor A2	Protein Coding	4
3	EPHA3	EPH Receptor A3	Protein Coding	4
4	EPHA5	EPH Receptor A5	Protein Coding	4
5	EPHA8	EPH Receptor A8	Protein Coding	4
6	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
7	EFNA1	Ephrin A1	Protein Coding	3
8	EFNA2	Ephrin A2	Protein Coding	3
9	EFNA3	Ephrin A3	Protein Coding	3
10	EFNA4	Ephrin A4	Protein Coding	3
11	EPHA1	EPH Receptor A1	Protein Coding	3
12	EPHA4	EPH Receptor A4	Protein Coding	3
13	EPHA7	EPH Receptor A7	Protein Coding	3
14	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	3
15	RHOA	Ras Homolog Family Member A	Protein Coding	3
16	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	3
17	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	3
18	EPHA6	EPH Receptor A6	Protein Coding	2
19	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
20	RAC1	Rac Family Small GTPase 1	Protein Coding	2
21	MYL12B	Myosin Light Chain 12B	Protein Coding	1
22	MYL9	Myosin Light Chain 9	Protein Coding	1
23	EPHA10	EPH Receptor A10	Protein Coding	1
24	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
25	MYH9	Myosin Heavy Chain 9	Protein Coding	1
26	MYH10	Myosin Heavy Chain 10	Protein Coding	1
27	MYH11	Myosin Heavy Chain 11	Protein Coding	1
28	MYL6	Myosin Light Chain 6	Protein Coding	1
29	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
30	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
31	MYH14	Myosin Heavy Chain 14	Protein Coding	1
32	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
33	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
34	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
35	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
36	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	1
37	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
38	ECT2	Epithelial Cell Transforming 2	Protein Coding	1
39	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
40	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
41	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
42	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
43	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
44	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
45	MYO9B	Myosin IXB	Protein Coding	1
46	PGGT1B	Protein Geranylgeranyltransferase Type I Subunit Beta	Protein Coding	1
47	PLD1	Phospholipase D1	Protein Coding	1
48	PKN1	Protein Kinase N1	Protein Coding	1
49	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
50	EZR	Ezrin	Protein Coding	1
51	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
52	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
53	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	1
54	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
55	KIFAP3	Kinesin Associated Protein 3	Protein Coding	1
56	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	1
57	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
58	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
59	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
60	RHPN1	Rhophilin Rho GTPase Binding Protein 1	Protein Coding	1
61	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
62	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
63	ACTB	Actin Beta	Protein Coding	1
64	ACTG1	Actin Gamma 1	Protein Coding	1
65	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
66	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
67	CDC42	Cell Division Cycle 42	Protein Coding	1
68	CFL1	Cofilin 1	Protein Coding	1
69	CFL2	Cofilin 2	Protein Coding	1
70	LIMK1	LIM Domain Kinase 1	Protein Coding	1
71	LIMK2	LIM Domain Kinase 2	Protein Coding	1
72	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
73	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
74	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
75	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
76	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
77	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
78	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
79	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
80	RASA1	RAS P21 Protein Activator 1	Protein Coding	1

Disorders associated with EPHA-mediated growth cone collapse SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.09
2	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.89
3	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	4.42
4	Typical nemaline myopathy	Enrichment	ACTA1, CFL2	3.92
5	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.90
6	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	3.90
7	Melanoma, uveal	Enrichment	GNA11, GNAQ	3.72
8	Cataract 6, multiple types	Enrichment	EPHA2	2.83
9	Aniridia	Enrichment	EPHA2	2.83
10	Centronuclear myopathy	Enrichment	ACTA1, CFL2	2.79
11	Deafness, autosomal dominant 17	Enrichment	MYH9	2.67
12	Deafness, autosomal dominant 88	Enrichment	EPHA10	2.67
13	Deafness, autosomal dominant 4a	Enrichment	MYH14	2.67
14	Peripheral neuropathy, myopathy, hoarseness, and hearing loss	Enrichment	MYH14	2.67
15	Thrombocytopenia 6	Enrichment	SRC	2.67
16	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.67
17	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.67
18	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.67
19	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	2.67
20	Early-onset posterior polar cataract	Enrichment	EPHA2	2.63
21	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.54
22	Baraitser-winter syndrome 1	Enrichment	ACTB	2.54
23	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.54
24	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.54
25	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.54
26	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.54
27	Knobloch syndrome 2	Enrichment	PAK2	2.54
28	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.54
29	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.54
30	Nemaline myopathy 7	Enrichment	CFL2	2.54
31	Alzheimer disease 18	Enrichment	ADAM10	2.54
32	Becker nevus syndrome	Enrichment	ACTB	2.54
33	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.54
34	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.54
35	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.54
36	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.54
37	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.54
38	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.54
39	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.54
40	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.54
41	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.54
42	Baraitser-winter syndrome	Enrichment	ACTB	2.54
43	Gorham's disease	Enrichment	RASA1	2.54
44	Zebra body myopathy	Enrichment	ACTA1	2.54
45	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.54
46	Nocarh syndrome	Enrichment	CDC42	2.54
47	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.54
48	Actin-accumulation myopathy	Enrichment	ACTA1	2.54
49	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.54
50	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.54
51	Actg2 visceral myopathy	Enrichment	ACTG2	2.54
52	Nonsyndromic hearing loss	Enrichment	EPHA10, MYH14	2.44
53	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.44
54	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.44
55	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.44
56	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.44
57	Sturge-weber syndrome	Enrichment	GNAQ	2.44
58	Immunodeficiency 62	Enrichment	ARHGEF1	2.44
59	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.44
60	Celiac disease 4	Enrichment	MYO9B	2.44
61	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.44
62	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.44
63	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.44
64	Alfadhel syndrome	Enrichment	RAP1GDS1	2.44
65	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.44
66	Cataract	Enrichment	EPHA2	2.38
67	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11	2.37
68	Cataract 35	Enrichment	MYH9	2.37
69	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11	2.37
70	Pseudosarcomatous fibromatosis	Enrichment	MYH9	2.37
71	Visceral myopathy 2	Enrichment	MYH11	2.37
72	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	2.37
73	Thrombocytopenia	Enrichment	MYH9, SRC	2.33
74	Cataract 44	Enrichment	EPHA2	2.30
75	Microcephaly	Enrichment	ACTB, ACTG1, PAK3	2.28
76	Early-onset nuclear cataract	Enrichment	EPHA2	2.28
77	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYH14, MYH9	2.26
78	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.24
79	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.24
80	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.24
81	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.24
82	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.24
83	Moyamoya disease 5	Enrichment	ACTA2	2.24
84	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.24
85	Immune system disease	Enrichment	CDC42	2.24
86	Intestinal obstruction	Enrichment	ACTG2	2.24
87	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	2.19
88	Tricuspid valve insufficiency	Enrichment	MYH11	2.19
89	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.14
90	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.14
91	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.14
92	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYH11	2.07
93	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	MYH11	2.07
94	Mitral valve insufficiency	Enrichment	MYH11	2.07
95	Wieacker-wolff syndrome	Enrichment	RASA1	2.07
96	Visceral myopathy 1	Enrichment	MYH11	1.97
97	Deafness, autosomal recessive 63	Enrichment	MYH9	1.97
98	Congenital ptosis	Enrichment	MYH10	1.97
99	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.97
100	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.97
101	Dowling-degos disease 1	Enrichment	ADAM10	1.94
102	Nemaline myopathy 2	Enrichment	ACTA1	1.94
103	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.94
104	Aminoacylase 1 deficiency	Enrichment	ACTB	1.94
105	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.94
106	Knobloch syndrome	Enrichment	PAK2	1.94
107	Intermediate nemaline myopathy	Enrichment	ACTA1	1.94
108	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.94
109	Hemihyperplasia, isolated	Enrichment	RHOA	1.89
110	Hemangioma, capillary infantile	Enrichment	MYH9	1.89
111	Intestinal pseudo-obstruction	Enrichment	MYH11	1.89
112	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.84
113	Knobloch syndrome 1	Enrichment	PAK2	1.84
114	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.84
115	Coloboma of choroid and retina	Enrichment	ACTG1	1.84
116	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.84
117	Myelofibrosis	Enrichment	SRC	1.83
118	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.77
119	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.77
120	Moyamoya disease 1	Enrichment	ACTA2	1.77
121	Basal cell carcinoma 1	Enrichment	RASA1	1.77
122	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11	1.72
123	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.70
124	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.70
125	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.70
126	Pendred syndrome	Enrichment	DIAPH1	1.67
127	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.64
128	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.59
129	Arteriovenous malformation	Enrichment	RASA1	1.59
130	Microphthalmia/coloboma 12	Enrichment	MYH10	1.56
131	Cat eye syndrome	Enrichment	ACTG1	1.55
132	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.55
133	Nemaline myopathy	Enrichment	ACTA1	1.55
134	Osteoporosis	Enrichment	SRC	1.53
135	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11	1.53
136	Coloboma of macula	Enrichment	MYH10	1.50
137	Myopia	Enrichment	MYH11	1.50
138	Hypertension	Enrichment	MYH9	1.47
139	Lung cancer susceptibility 3	Enrichment	ACTA2	1.40
140	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.37
141	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26	1.37
142	Nk-cell enteropathy	Enrichment	IGF1R	1.34
143	Neuromuscular disease	Enrichment	ACTA1	1.30
144	Congenital myopathy	Enrichment	ACTA1	1.27
145	Williams-beuren syndrome	Enrichment	LIMK1	1.25
146	Lissencephaly	Enrichment	ACTG1	1.23
147	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.14
148	Non-syndromic genetic deafness	Enrichment	MYH14	1.13
149	Non-immune hydrops fetalis	Enrichment	ACTA1	1.07
150	Lung cancer	Enrichment	ACTA2	1.05
151	Connective tissue disease	Enrichment	ACTA2	1.05
152	Auditory neuropathy	Enrichment	DIAPH1	1.05
153	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYH11	1.05
154	Cakut	Enrichment	ACTG1	1.03
155	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.99
156	Body mass index quantitative trait locus 11	Enrichment	MYH9	0.99
157	Hypertelorism	Enrichment	MYH10	0.98
158	Myopathy	Enrichment	ACTA1	0.96
159	Distal arthrogryposis	Enrichment	ACTA1	0.94
160	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	0.94
161	Deafness, autosomal recessive	Enrichment	MYH9	0.90
162	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.89
163	Epilepsy	Enrichment	DIAPH1	0.87
164	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.83
165	Rare genetic deafness	Enrichment	MYH9	0.81
166	Colorectal cancer	Enrichment	SRC	0.77
167	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYH9	0.76
168	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.72
169	Dilated cardiomyopathy	Enrichment	ACTA1	0.69
170	Complex neurodevelopmental disorder	Enrichment	MYH10	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EPHA-mediated growth cone collapse

Pathway Network for EPHA-mediated growth cone collapse

Pathway network for the EPHA-mediated growth cone collapse SuperPath

Member Pathways for EPHA-mediated growth cone collapse

Pathways in the EPHA-mediated growth cone collapse SuperPath

Gene overlap in member pathways for EPHA-mediated growth cone collapse SuperPath

Associated Genes for EPHA-mediated growth cone collapse

Associated Disorders for EPHA-mediated growth cone collapse

Disorders associated with EPHA-mediated growth cone collapse SuperPath

STRING Interaction Network for EPHA-mediated growth cone collapse

Sources for EPHA-mediated growth cone collapse