EPHA2 forward signaling

No Pathway Network information available for EPHA2 forward signaling

Pathways in the EPHA2 forward signaling SuperPath

#	Name	Source	Genes
1	EPHA2 forward signaling	PubChem	ACP1 ARHGAP35 BCAR1 CBL EFNA1 EPHA2 GRB2 INPPL1 PAK1 PIK3CA PIK3R1 PTK2 RAC1 RHOA SHC1 SRC TIAM1 VAV2 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EPHA2	EPH Receptor A2	Protein Coding	1
2	EFNA1	Ephrin A1	Protein Coding	1
3	ACP1	Acid Phosphatase 1	Protein Coding	1
4	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	1
5	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
6	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
7	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
8	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
9	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
10	RHOA	Ras Homolog Family Member A	Protein Coding	1
11	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
12	RAC1	Rac Family Small GTPase 1	Protein Coding	1
13	CBL	Cbl Proto-Oncogene	Protein Coding	1
14	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
15	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
16	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
17	SHC1	SHC Adaptor Protein 1	Protein Coding	1
18	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with EPHA2 forward signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.30
2	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.60
3	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, SRC	3.71
4	Macrodactyly	Enrichment	PIK3CA	2.88
5	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.88
6	Cowden syndrome 5	Enrichment	PIK3CA	2.88
7	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.88
8	Short syndrome	Enrichment	PIK3R1	2.88
9	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.88
10	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.88
11	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.88
12	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.88
13	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.88
14	Thrombocytopenia 6	Enrichment	SRC	2.88
15	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.88
16	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.88
17	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.88
18	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.88
19	Hypospadias	Enrichment	PIK3CA	2.88
20	Rare venous malformation	Enrichment	PIK3CA	2.88
21	Diaphragmatic eventration	Enrichment	PIK3CA	2.88
22	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.88
23	Rare combined vascular malformation	Enrichment	PIK3CA	2.88
24	Cavernous lymphangioma	Enrichment	PIK3CA	2.88
25	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.88
26	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.88
27	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.88
28	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.88
29	Macrodactyly of toe	Enrichment	PIK3CA	2.88
30	Ovarian germ cell cancer	Enrichment	CBL	2.58
31	Schneckenbecken dysplasia	Enrichment	INPPL1	2.58
32	Keratosis, seborrheic	Enrichment	PIK3CA	2.58
33	Noonan syndrome 8	Enrichment	PIK3CA	2.58
34	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.58
35	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.58
36	Malignant germ cell tumor of ovary	Enrichment	CBL	2.58
37	Opsismodysplasia	Enrichment	INPPL1	2.40
38	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.40
39	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.40
40	Immunodeficiency 14	Enrichment	PIK3R1	2.40
41	Keratoacanthoma	Enrichment	PIK3CA	2.40
42	Breast cancer	Enrichment	PIK3CA, SHC1	2.36
43	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.28
44	Cerebrovascular disease	Enrichment	PIK3CA	2.28
45	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.28
46	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.28
47	Cataract 6, multiple types	Enrichment	EPHA2	2.18
48	Capillary malformations, congenital	Enrichment	PIK3CA	2.18
49	Martsolf syndrome 1	Enrichment	ARHGAP35	2.18
50	Myeloproliferative neoplasm	Enrichment	CBL	2.18
51	Hemimegalencephaly	Enrichment	PIK3CA	2.18
52	Aniridia	Enrichment	EPHA2	2.18
53	Aggressive systemic mastocytosis	Enrichment	CBL	2.18
54	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.10
55	Cowden syndrome 1	Enrichment	PIK3CA	2.10
56	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	2.10
57	Breast adenocarcinoma	Enrichment	PIK3CA	2.10
58	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.10
59	Nevus, epidermal	Enrichment	PIK3CA	2.03
60	Myelofibrosis	Enrichment	SRC	2.03
61	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.03
62	Gallbladder cancer	Enrichment	PIK3CA	2.03
63	Overgrowth syndrome	Enrichment	PIK3R1	2.03
64	Early-onset posterior polar cataract	Enrichment	EPHA2	1.98
65	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.93
66	Arteriovenous malformation	Enrichment	PIK3CA	1.93
67	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.93
68	Cowden syndrome	Enrichment	PIK3CA	1.93
69	Peters-plus syndrome	Enrichment	ARHGAP35	1.88
70	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.88
71	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.88
72	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.84
73	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.80
74	Meningioma	Enrichment	PIK3CA	1.80
75	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.80
76	Osteoporosis	Enrichment	SRC	1.73
77	Cataract	Enrichment	EPHA2	1.73
78	Lynch syndrome	Enrichment	PIK3CA	1.70
79	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.70
80	Rhabdomyosarcoma	Enrichment	CBL	1.68
81	Cataract 44	Enrichment	EPHA2	1.65
82	Early-onset nuclear cataract	Enrichment	EPHA2	1.63
83	Endometrial cancer	Enrichment	PIK3CA	1.56
84	Hepatocellular carcinoma	Enrichment	PIK3CA	1.54
85	Noonan syndrome 1	Enrichment	CBL	1.52
86	Rasopathy	Enrichment	CBL	1.47
87	Bladder cancer	Enrichment	PIK3CA	1.42
88	Prostate cancer	Enrichment	PIK3CA	1.42
89	Lung cancer	Enrichment	PIK3CA	1.38
90	Gastric cancer	Enrichment	PIK3CA	1.26
91	Hereditary breast carcinoma	Enrichment	PIK3CA	1.25
92	Thrombocytopenia	Enrichment	SRC	1.21
93	Hypertelorism	Enrichment	PIK3CA	1.17
94	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	1.15
95	Ovarian cancer	Enrichment	PIK3CA	0.90
96	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EPHA2 forward signaling

Pathway Network for EPHA2 forward signaling

Member Pathways for EPHA2 forward signaling

Pathways in the EPHA2 forward signaling SuperPath

Associated Genes for EPHA2 forward signaling

Associated Disorders for EPHA2 forward signaling

Disorders associated with EPHA2 forward signaling SuperPath

STRING Interaction Network for EPHA2 forward signaling

Sources for EPHA2 forward signaling