EPHA forward signaling

No Pathway Network information available for EPHA forward signaling

#	Name	Source	Genes
1	EPHA forward signaling	PubChem	ARHGEF15 CBL CDK5 CRK EFNA1 EFNA2 EFNA5 EPHA1 EPHA3 EPHA4 EPHA8 LCK NGEF PIK3CG PIK3R6 PLCG1 RHOA ROCK1 VAV2 (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EFNA2	Ephrin A2	Protein Coding	1
2	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	1
3	EPHA3	EPH Receptor A3	Protein Coding	1
4	EPHA8	EPH Receptor A8	Protein Coding	1
5	EFNA1	Ephrin A1	Protein Coding	1
6	EFNA5	Ephrin A5	Protein Coding	1
7	EPHA4	EPH Receptor A4	Protein Coding	1
8	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
9	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
10	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
11	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
12	EPHA1	EPH Receptor A1	Protein Coding	1
13	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
14	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
15	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
16	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
17	RHOA	Ras Homolog Family Member A	Protein Coding	1
18	CBL	Cbl Proto-Oncogene	Protein Coding	1
19	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.85
2	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.85
3	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.85
4	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.85
5	Immunodeficiency 22	Enrichment	LCK	2.85
6	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.85
7	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.85
8	Ovarian germ cell cancer	Enrichment	CBL	2.55
9	Malignant germ cell tumor of ovary	Enrichment	CBL	2.55
10	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.25
11	Myeloproliferative neoplasm	Enrichment	CBL	2.16
12	Aggressive systemic mastocytosis	Enrichment	CBL	2.16
13	Hemihyperplasia, isolated	Enrichment	RHOA	2.08
14	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.78
15	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.68
16	Rhabdomyosarcoma	Enrichment	CBL	1.65
17	Noonan syndrome 1	Enrichment	CBL	1.50
18	Rasopathy	Enrichment	CBL	1.45
19	Severe combined immunodeficiency	Enrichment	LCK	1.34
20	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	1.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for EPHA forward signaling