EphB-EphrinB Signaling

Pathway network for the EphB-EphrinB Signaling SuperPath

Sources:

QIAGEN
GeneGo (Thomson Reuters)

Pathways in the EphB-EphrinB Signaling SuperPath

#	Name	Source	Genes
1	EphB-EphrinB Signaling	QIAGEN	ABI1 AXIN1 CBL CDC42 CTNNB1 CXCL12 CXCR4 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HNRNPK HRAS ITSN1 ITSN2 KALRN MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 NCK2 PAK1 PTK2 PTK2B PXN RAC1 RAC2 RAC3 RGS3 VAV1 VAV2 VAV3 (see all 75) (see less)
2	Cytoskeleton remodeling Reverse signaling by ephrin B	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR2 ACTR3 ACTR3B ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 AXIN1 AXIN2 CTNNB1 CXCL12 CXCR4 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GSK3B HRAS ILK LIMS1 LIMS2 MAPT NCK2 PAK1 PTK2 PTPN13 PXN RAF1 RGS3 SOS1 SOS2 SRC TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 WASL WIPF1 WIPF2 (see all 85) (see less)
3	Ephrin-Eph Signaling	QIAGEN	ABI1 AFDN AXIN1 CBL CDC42 CTNNB1 CXCL12 CXCR4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GNA11 GNA12 GNA13 GNA14 GNA15 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITGB1 ITGB3 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 NCK1 NCK2 NGEF PIK3CG PTK2 PTK2B RAC1 RAC2 RAC3 RASA1 RGS3 RHOA ROCK1 ROCK2 RRAS (see all 81) (see less)

Gene overlap in member pathways for EphB-EphrinB Signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AXIN1	Axin 1	Protein Coding	3
2	CTNNB1	Catenin Beta 1	Protein Coding	3
3	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	3
4	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	3
5	EFNB1	Ephrin B1	Protein Coding	3
6	EFNB2	Ephrin B2	Protein Coding	3
7	EFNB3	Ephrin B3	Protein Coding	3
8	EPHB1	EPH Receptor B1	Protein Coding	3
9	EPHB2	EPH Receptor B2	Protein Coding	3
10	EPHB3	EPH Receptor B3	Protein Coding	3
11	EPHB4	EPH Receptor B4	Protein Coding	3
12	EPHB6	EPH Receptor B6	Protein Coding	3
13	GNB1	G Protein Subunit Beta 1	Protein Coding	3
14	GNB2	G Protein Subunit Beta 2	Protein Coding	3
15	GNB3	G Protein Subunit Beta 3	Protein Coding	3
16	GNB4	G Protein Subunit Beta 4	Protein Coding	3
17	GNB5	G Protein Subunit Beta 5	Protein Coding	3
18	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
19	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
20	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
21	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
22	GNG2	G Protein Subunit Gamma 2	Protein Coding	3
23	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
24	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
25	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
26	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
27	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
28	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
29	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
30	NCK2	NCK Adaptor Protein 2	Protein Coding	3
31	PTK2	Protein Tyrosine Kinase 2	Protein Coding	3
32	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	3
33	CBL	Cbl Proto-Oncogene	Protein Coding	2
34	CDC42	Cell Division Cycle 42	Protein Coding	2
35	GNA11	G Protein Subunit Alpha 11	Protein Coding	2
36	GNA12	G Protein Subunit Alpha 12	Protein Coding	2
37	GNA13	G Protein Subunit Alpha 13	Protein Coding	2
38	GNA14	G Protein Subunit Alpha 14	Protein Coding	2
39	GNA15	G Protein Subunit Alpha 15	Protein Coding	2
40	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
41	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
42	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
43	GNAO1	G Protein Subunit Alpha O1	Protein Coding	2
44	GNAS	GNAS Complex Locus	Protein Coding	2
45	GNAZ	G Protein Subunit Alpha Z	Protein Coding	2
46	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
47	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
48	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
49	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
50	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
51	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
52	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
53	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
54	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	2
55	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	2
56	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
57	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
58	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
59	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
60	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
61	PXN	Paxillin	Protein Coding	2
62	RAC1	Rac Family Small GTPase 1	Protein Coding	2
63	RAC2	Rac Family Small GTPase 2	Protein Coding	2
64	RAC3	Rac Family Small GTPase 3	Protein Coding	2
65	ABI1	Abl Interactor 1	Protein Coding	2
66	GNAL	G Protein Subunit Alpha L	Protein Coding	1
67	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	1
68	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	1
69	KALRN	Kalirin RhoGEF Kinase	Protein Coding	1
70	HNRNPK	Heterogeneous Nuclear Ribonucleoprotein K	Protein Coding	1
71	ITSN1	Intersectin 1	Protein Coding	1
72	ITSN2	Intersectin 2	Protein Coding	1
73	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
74	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
75	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
76	ACTB	Actin Beta	Protein Coding	1
77	ACTG1	Actin Gamma 1	Protein Coding	1
78	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
79	ILK	Integrin Linked Kinase	Protein Coding	1
80	LIMS1	LIM Zinc Finger Domain Containing 1	Protein Coding	1
81	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
82	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
83	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
84	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
85	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
86	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
87	TUBA4A	Tubulin Alpha 4a	Protein Coding	1
88	TUBA3C	Tubulin Alpha 3c	Protein Coding	1
89	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	1
90	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	1
91	TUBA1A	Tubulin Alpha 1a	Protein Coding	1
92	AXIN2	Axin 2	Protein Coding	1
93	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
94	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	1
95	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	1
96	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	1
97	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	1
98	ACTR3	Actin Related Protein 3	Protein Coding	1
99	ACTR2	Actin Related Protein 2	Protein Coding	1
100	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	1
101	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
102	TUBB3	Tubulin Beta 3 Class III	Protein Coding	1
103	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	1
104	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	1
105	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	1
106	TUBA8	Tubulin Alpha 8	Protein Coding	1
107	LIMS2	LIM Zinc Finger Domain Containing 2	Protein Coding	1
108	TUBB7P	Tubulin Beta 7 Pseudogene	Pseudogene	1
109	ACTR3B	Actin Related Protein 3B	Protein Coding	1
110	TUBAL3	Tubulin Alpha Like 3	Protein Coding	1
111	TUBA4B	Tubulin Alpha 4b	Protein Coding	1
112	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	1
113	TUBB6	Tubulin Beta 6 Class V	Protein Coding	1
114	TUBA1C	Tubulin Alpha 1c	Protein Coding	1
115	TUBA3E	Tubulin Alpha 3e	Protein Coding	1
116	TUBA3D	Tubulin Alpha 3d	Protein Coding	1
117	WIPF2	WAS/WASL Interacting Protein Family Member 2	Protein Coding	1
118	TUBB	Tubulin Beta Class I	Protein Coding	1
119	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	1
120	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	1
121	RHOA	Ras Homolog Family Member A	Protein Coding	1
122	EFNA1	Ephrin A1	Protein Coding	1
123	EFNA2	Ephrin A2	Protein Coding	1
124	EFNA3	Ephrin A3	Protein Coding	1
125	EFNA4	Ephrin A4	Protein Coding	1
126	EFNA5	Ephrin A5	Protein Coding	1
127	EPHA1	EPH Receptor A1	Protein Coding	1
128	EPHA2	EPH Receptor A2	Protein Coding	1
129	EPHA3	EPH Receptor A3	Protein Coding	1
130	EPHA4	EPH Receptor A4	Protein Coding	1
131	EPHA5	EPH Receptor A5	Protein Coding	1
132	EPHA7	EPH Receptor A7	Protein Coding	1
133	EPHA8	EPH Receptor A8	Protein Coding	1
134	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
135	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
136	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
137	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
138	NCK1	NCK Adaptor Protein 1	Protein Coding	1
139	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
140	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
141	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
142	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
143	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
144	RRAS	RAS Related	Protein Coding	1

Disorders associated with EphB-EphrinB Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	ACTG1, TUBA1A, TUBA3E, TUBB, TUBB2B, TUBB3	8.59
2	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	6.62
3	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	6.02
4	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	5.33
5	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.09
6	Noonan syndrome 1	Enrichment	HRAS, RAF1, SOS1, SOS2	4.94
7	Rasopathy	Enrichment	HRAS, RAF1, SOS1, SOS2	4.71
8	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.41
9	Anastomosing haemangioma	Enrichment	GNA11, GNA14	4.04
10	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, RAF1, SOS1	3.99
11	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1, GNAO1, GNB1, TUBB4A	3.92
12	Achromatopsia 4	Enrichment	GNAI3, GNAT2	3.75
13	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42	3.75
14	Capillary malformations, congenital	Enrichment	GNA11, RASA1	3.46
15	Congenital nervous system abnormality	Enrichment	CTNNB1, GNAO1, GNB5, TUBA1A, TUBB4A	3.28
16	Nervous system disease	Enrichment	CTNNB1, GNAO1, GNB5, TUBA1A, TUBB4A	3.28
17	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4, RASA1	3.14
18	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.10
19	Arteriovenous malformation	Enrichment	EPHB4, HRAS	2.98
20	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	2.98
21	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	2.97
22	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4, HRAS	2.88
23	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	2.87
24	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	2.77
25	Cerebral palsy	Enrichment	GNB1, TUBA1A, TUBB4A	2.73
26	Juvenile myelomonocytic leukemia	Enrichment	CBL, RRAS	2.65
27	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.46
28	Lymphatic malformation 5	Enrichment	EPHB4	2.26
29	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.26
30	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.26
31	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.26
32	Osseous heteroplasia, progressive	Enrichment	GNAS	2.26
33	Caudal duplication anomaly	Enrichment	AXIN1	2.26
34	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.26
35	Whim syndrome 1	Enrichment	CXCR4	2.26
36	Ventricular tachycardia, familial	Enrichment	GNAI2	2.26
37	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.26
38	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.26
39	Noonan syndrome 13	Enrichment	MAPK1	2.26
40	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.26
41	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.26
42	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.26
43	Craniofrontonasal syndrome	Enrichment	EFNB1	2.26
44	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.26
45	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.26
46	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.26
47	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	2.26
48	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.26
49	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	2.26
50	Dystonia 25	Enrichment	GNAL	2.26
51	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	2.26
52	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.26
53	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.26
54	Disorders of gnas inactivation	Enrichment	GNAS	2.26
55	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	2.26
56	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.26
57	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.26
58	Sick sinus syndrome 4	Enrichment	GNB2	2.26
59	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.26
60	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.26
61	Adenoid ameloblastoma	Enrichment	CTNNB1	2.26
62	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.26
63	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.26
64	Nocarh syndrome	Enrichment	CDC42	2.26
65	Monostotic fibrous dysplasia	Enrichment	GNAS	2.26
66	Gnao1-related disorder	Enrichment	GNAO1	2.26
67	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.26
68	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.26
69	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.26
70	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.26
71	Mazabraud syndrome	Enrichment	GNAS	2.26
72	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.26
73	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	2.26
74	Microcystic stromal tumor	Enrichment	CTNNB1	2.26
75	Vein of galen aneurysmal malformation	Enrichment	EPHB4	2.26
76	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.22
77	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.22
78	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.22
79	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.22
80	Gorham's disease	Enrichment	RASA1	2.22
81	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	2.20
82	Baraitser-winter syndrome 1	Enrichment	ACTB	2.20
83	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.20
84	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	2.20
85	Noonan syndrome 5	Enrichment	RAF1	2.20
86	Noonan syndrome 4	Enrichment	SOS1	2.20
87	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.20
88	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	2.20
89	Noonan syndrome 9	Enrichment	SOS2	2.20
90	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.20
91	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	2.20
92	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.20
93	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.20
94	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.20
95	Parkinson-dementia syndrome	Enrichment	MAPT	2.20
96	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.20
97	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.20
98	Progressive supranuclear palsy	Enrichment	MAPT	2.20
99	Becker nevus syndrome	Enrichment	ACTB	2.20
100	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.20
101	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.20
102	Leopard syndrome 2	Enrichment	RAF1	2.20
103	Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue	Enrichment	LIMS2	2.20
104	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.20
105	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.20
106	Thrombocytopenia 6	Enrichment	SRC	2.20
107	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.20
108	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.20
109	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.20
110	Trigonitis	Enrichment	RAF1	2.20
111	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.20
112	Baraitser-winter syndrome	Enrichment	ACTB	2.20
113	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.20
114	Congenital myopathy 26	Enrichment	TUBA4A	2.20
115	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.20
116	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.20
117	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.20
118	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.20
119	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.20
120	Autosomal recessive limb-girdle muscular dystrophy type 2w	Enrichment	LIMS2	2.20
121	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.20
122	Hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	2.19
123	Congenital stationary night blindness	Enrichment	GNAT1, GNB3	2.15
124	Hydrops fetalis, nonimmune	Enrichment	EPHB4, HRAS	2.05
125	Lymphatic malformation 1	Enrichment	EPHB4	1.96
126	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.96
127	Scoliosis, isolated 1	Enrichment	MAPK7	1.96
128	Costello syndrome	Enrichment	HRAS	1.96
129	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.96
130	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.96
131	Intracranial hypertension, idiopathic	Enrichment	EPHB4	1.96
132	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.96
133	Ovarian germ cell cancer	Enrichment	CBL	1.96
134	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	1.96
135	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.96
136	Angioma, tufted	Enrichment	GNA14	1.96
137	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.96
138	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.96
139	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.96
140	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.96
141	Pseudohypoparathyroidism	Enrichment	GNAS	1.96
142	Immune system disease	Enrichment	CDC42	1.96
143	Hypopituitarism	Enrichment	GNAI2	1.96
144	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.96
145	Hereditary lymphedema i	Enrichment	EPHB4	1.96
146	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.96
147	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.96
148	Malignant germ cell tumor of ovary	Enrichment	CBL	1.96
149	Teratoma	Enrichment	CTNNB1	1.96
150	Cerebral visual impairment	Enrichment	GNB1	1.96
151	Phakomatosis cesioflammea	Enrichment	GNA11	1.96
152	Wooly hair nevus	Enrichment	HRAS	1.96
153	Bladder cancer	Enrichment	CTNNB1, HRAS	1.95
154	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	1.90
155	Fibromatosis, gingival, 1	Enrichment	SOS1	1.90
156	Wiskott-aldrich syndrome	Enrichment	WIPF1	1.90
157	Pulmonic stenosis	Enrichment	SOS1	1.90
158	Pick disease of brain	Enrichment	MAPT	1.90
159	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.90
160	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.90
161	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	1.90
162	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	1.90
163	Keratoconus 9	Enrichment	TUBA3D	1.90
164	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	1.90
165	Lissencephaly 3	Enrichment	TUBA1A	1.90
166	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.90
167	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	1.90
168	Torsion dystonia 4	Enrichment	TUBB4A	1.90
169	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	1.90
170	Immunodeficiency 133	Enrichment	ARPC5	1.90
171	Continuous spikes and waves during sleep	Enrichment	TUBA1A	1.90
172	Non-immune hydrops fetalis	Enrichment	EPHB4, HRAS	1.90
173	Dystonia	Enrichment	GNAL, GNB1	1.80
174	Desmoid disease, hereditary	Enrichment	CTNNB1	1.78
175	Mccune-albright syndrome	Enrichment	GNAS	1.78
176	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.78
177	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.78
178	Anus, imperforate	Enrichment	CTNNB1	1.78
179	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.78
180	Large congenital melanocytic nevus	Enrichment	HRAS	1.78
181	Desmoid tumor	Enrichment	CTNNB1	1.78
182	Lymphatic malformation 7	Enrichment	EPHB4	1.78
183	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	1.78
184	Spermatocytoma	Enrichment	HRAS	1.78
185	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.78
186	Colorectal cancer	Enrichment	AXIN2, CTNNB1, SRC	1.76
187	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.75
188	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.75
189	Wieacker-wolff syndrome	Enrichment	RASA1	1.75
190	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.75
191	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.73
192	Nuchal bleb, familial	Enrichment	SOS1	1.73
193	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.73
194	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	1.73
195	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.73
196	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.66
197	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	1.66
198	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.66
199	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.66
200	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.66
201	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.66
202	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.66
203	Pilomatrixoma	Enrichment	CTNNB1	1.66
204	Au-kline syndrome	Enrichment	HNRNPK	1.66
205	Alazami syndrome	Enrichment	CTNNB1	1.66
206	Craniopharyngioma	Enrichment	CTNNB1	1.66
207	Epidermolytic nevus	Enrichment	HRAS	1.66
208	Familial sick sinus syndrome	Enrichment	GNB2	1.66
209	Aminoacylase 1 deficiency	Enrichment	ACTB	1.60
210	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.60
211	Gingival fibromatosis	Enrichment	SOS1	1.60
212	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.60
213	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.60
214	Hemifacial hyperplasia	Enrichment	EFNB1	1.56
215	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.56
216	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.56
217	Myeloproliferative neoplasm	Enrichment	CBL	1.56
218	Aggressive systemic mastocytosis	Enrichment	CBL	1.56
219	Cataract 6, multiple types	Enrichment	EPHA2	1.53
220	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.53
221	Aniridia	Enrichment	EPHA2	1.53
222	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.51
223	Dementia	Enrichment	MAPT	1.51
224	Coloboma of choroid and retina	Enrichment	ACTG1	1.51
225	West syndrome	Enrichment	GNAO1, TUBA1A	1.51
226	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, ITSN1	1.51
227	Melanoma, uveal	Enrichment	GNA11	1.49
228	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.49
229	Adrenocortical carcinoma	Enrichment	CTNNB1	1.49
230	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.45
231	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.45
232	Hemihyperplasia, isolated	Enrichment	RHOA	1.45
233	Hemangioma, capillary infantile	Enrichment	RASA1	1.45
234	Basal cell carcinoma 1	Enrichment	RASA1	1.45
235	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.45
236	Thrombocytopenia	Enrichment	SRC, TUBB1	1.44
237	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.43
238	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.43
239	Nevus, epidermal	Enrichment	HRAS	1.42
240	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.42
241	Brachydactyly	Enrichment	GNAS	1.42
242	Gallbladder cancer	Enrichment	CTNNB1	1.42
243	Follicular thyroid carcinoma	Enrichment	HRAS	1.42
244	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.39
245	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.39
246	Myelofibrosis	Enrichment	SRC	1.37
247	Semantic dementia	Enrichment	MAPT	1.37
248	Pilomyxoid astrocytoma	Enrichment	RAF1	1.37
249	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.36
250	Lennox-gastaut syndrome	Enrichment	MAPK10	1.36
251	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.36
252	Hypothyroidism	Enrichment	GNB1	1.36
253	Choreatic disease	Enrichment	GNAO1	1.36
254	Early-onset posterior polar cataract	Enrichment	EPHA2	1.33
255	Coronary heart disease 5	Enrichment	KALRN	1.31
256	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.31
257	Primary hyperaldosteronism	Enrichment	GNAS	1.31
258	Cryptorchidism	Enrichment	TUBA1A	1.31
259	Achromatopsia	Enrichment	GNAT2	1.27
260	Tooth agenesis, selective, 1	Enrichment	AXIN2	1.26
261	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.26
262	Progressive non-fluent aphasia	Enrichment	MAPT	1.26
263	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.26
264	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.23
265	Myelodysplastic syndrome	Enrichment	GNB1	1.23
266	Lung non-small cell carcinoma	Enrichment	HRAS	1.23
267	Movement disease	Enrichment	GNAO1	1.23
268	Specific learning disability	Enrichment	MAPK1	1.23
269	Cat eye syndrome	Enrichment	ACTG1	1.22
270	Lip and oral cavity carcinoma	Enrichment	HRAS	1.19
271	Frontotemporal dementia 1	Enrichment	MAPT	1.18
272	Combined immunodeficiency	Enrichment	ARPC1B	1.18
273	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.18
274	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.18
275	Congenital hypothyroidism	Enrichment	TUBB1	1.14
276	Medulloblastoma	Enrichment	CTNNB1	1.13
277	Cone-rod dystrophy 6	Enrichment	GNAT2	1.13
278	Neural tube defects	Enrichment	ITGB1	1.13
279	Aortic valve disease 1	Enrichment	SOS1	1.11
280	Alzheimer's disease	Enrichment	MAPT	1.11
281	Rare genetic intellectual disability	Enrichment	GNAO1	1.10
282	Cataract	Enrichment	EPHA2	1.09
283	Osteoporosis	Enrichment	SRC	1.07
284	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.07
285	Hypertension, essential	Enrichment	GNB3	1.05
286	Cleft palate, isolated	Enrichment	GNB1	1.05
287	Polycystic liver disease	Enrichment	CTNNB1	1.05
288	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.05
289	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.05
290	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.05
291	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.05
292	Heart, malformation of	Enrichment	MAPK1	1.02
293	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.02
294	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.02
295	Hydrocephalus, congenital, 1	Enrichment	TUBB	1.02
296	Isolated congenital microcephaly	Enrichment	TUBA3E	1.02
297	Cataract 44	Enrichment	EPHA2	1.01
298	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.00
299	Alzheimer disease, familial, 1	Enrichment	MAPT	0.99
300	Dandy-walker syndrome	Enrichment	TUBA1A	0.99
301	Early-onset nuclear cataract	Enrichment	EPHA2	0.99
302	Hepatoblastoma	Enrichment	CTNNB1	0.96
303	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.94
304	Myocardial infarction	Enrichment	ITGB3	0.91
305	Cone dystrophy	Enrichment	GNAT2	0.90
306	Tooth agenesis	Enrichment	AXIN2	0.89
307	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.89
308	Ovarian cancer	Enrichment	AXIN2, CTNNB1	0.88
309	Tetralogy of fallot	Enrichment	EPHB4	0.87
310	Strabismus	Enrichment	GNB1	0.86
311	Parkinson disease, late-onset	Enrichment	MAPT	0.85
312	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.85
313	Prostate cancer	Enrichment	EPHB2	0.83
314	Differentiated thyroid carcinoma	Enrichment	HRAS	0.83
315	Complex neurodevelopmental disorder	Enrichment	GNB2, RAC3	0.82
316	Auditory neuropathy	Enrichment	TUBB4A	0.82
317	Hirschsprung disease 1	Enrichment	AXIN2	0.78
318	Eye disease	Enrichment	GNAT2	0.75
319	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.74
320	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.73
321	Cakut	Enrichment	ACTG1	0.72
322	Left ventricular noncompaction	Enrichment	RAF1	0.70
323	Non-syndromic genetic deafness	Enrichment	ACTG1	0.69
324	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.68
325	Nonsyndromic hearing loss	Enrichment	ACTG1	0.63
326	Optic atrophy plus syndrome	Enrichment	TUBB6	0.62
327	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.62
328	Hypertelorism	Enrichment	EFNB1	0.60
329	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.55
330	Spastic ataxia	Enrichment	TUBB3	0.55
331	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.55
332	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	0.51
333	Breast cancer	Enrichment	GNG3	0.47
334	Rare genetic deafness	Enrichment	ACTG1	0.41
335	Dilated cardiomyopathy	Enrichment	RAF1	0.40
336	Leber plus disease	Enrichment	TUBB4B	0.35
337	Autism spectrum disorder	Enrichment	GNB1	0.34
338	Hereditary retinal dystrophy	Enrichment	GNAT1, GNAT2	0.32
339	Fundus dystrophy	Enrichment	GNAT1, GNAT2	0.32
340	Inherited cancer-predisposing syndrome	Enrichment	AXIN2	0.25
341	Retinitis pigmentosa	Enrichment	GNAT1	0.16

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

EphB-EphrinB Signaling

Pathway Network for EphB-EphrinB Signaling

Pathway network for the EphB-EphrinB Signaling SuperPath

Member Pathways for EphB-EphrinB Signaling

Pathways in the EphB-EphrinB Signaling SuperPath

Gene overlap in member pathways for EphB-EphrinB Signaling SuperPath

Associated Genes for EphB-EphrinB Signaling

Associated Disorders for EphB-EphrinB Signaling

Disorders associated with EphB-EphrinB Signaling SuperPath

STRING Interaction Network for EphB-EphrinB Signaling

Sources for EphB-EphrinB Signaling