Ephrin B reverse signaling

No Pathway Network information available for Ephrin B reverse signaling

Pathways in the Ephrin B reverse signaling SuperPath

#	Name	Source	Genes
1	Ephrin B reverse signaling	PubChem	DNM1 EFNB1 EFNB2 EPHB1 EPHB4 ITGA2B ITGB3 LCK MAP2K4 MAP3K7 MAPK8 NCK2 PIK3CA PIK3R1 PTPN13 RAC1 RGS3 TIAM1 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	1
2	EFNB2	Ephrin B2	Protein Coding	1
3	EPHB1	EPH Receptor B1	Protein Coding	1
4	EPHB4	EPH Receptor B4	Protein Coding	1
5	EFNB1	Ephrin B1	Protein Coding	1
6	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
7	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
8	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
9	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
10	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
11	DNM1	Dynamin 1	Protein Coding	1
12	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
13	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
14	NCK2	NCK Adaptor Protein 2	Protein Coding	1
15	RAC1	Rac Family Small GTPase 1	Protein Coding	1
16	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
17	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
18	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Ephrin B reverse signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	5.30
2	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.30
3	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	4.60
4	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	4.46
5	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4, PIK3CA	4.46
6	Arteriovenous malformation	Enrichment	EPHB4, PIK3CA	4.23
7	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4, PIK3CA	4.13
8	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	4.13
9	Lymphatic malformation 5	Enrichment	EPHB4	2.88
10	Macrodactyly	Enrichment	PIK3CA	2.88
11	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.88
12	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.88
13	Cowden syndrome 5	Enrichment	PIK3CA	2.88
14	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.88
15	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.88
16	Short syndrome	Enrichment	PIK3R1	2.88
17	Craniofrontonasal syndrome	Enrichment	EFNB1	2.88
18	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.88
19	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.88
20	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.88
21	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.88
22	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.88
23	Immunodeficiency 22	Enrichment	LCK	2.88
24	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.88
25	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.88
26	Hypospadias	Enrichment	PIK3CA	2.88
27	Rare venous malformation	Enrichment	PIK3CA	2.88
28	Diaphragmatic eventration	Enrichment	PIK3CA	2.88
29	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.88
30	Rare combined vascular malformation	Enrichment	PIK3CA	2.88
31	Cavernous lymphangioma	Enrichment	PIK3CA	2.88
32	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.88
33	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.88
34	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.88
35	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.88
36	Macrodactyly of toe	Enrichment	PIK3CA	2.88
37	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	2.88
38	Vein of galen aneurysmal malformation	Enrichment	EPHB4	2.88
39	Thrombocytopenia	Enrichment	ITGA2B, ITGB3	2.74
40	Hypertelorism	Enrichment	EFNB1, PIK3CA	2.67
41	Lymphatic malformation 1	Enrichment	EPHB4	2.58
42	Intracranial hypertension, idiopathic	Enrichment	EPHB4	2.58
43	Keratosis, seborrheic	Enrichment	PIK3CA	2.58
44	Noonan syndrome 8	Enrichment	PIK3CA	2.58
45	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.58
46	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.58
47	Hereditary lymphedema i	Enrichment	EPHB4	2.58
48	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.40
49	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.40
50	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.40
51	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.40
52	Lymphatic malformation 7	Enrichment	EPHB4	2.40
53	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.40
54	Immunodeficiency 14	Enrichment	PIK3R1	2.40
55	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	2.40
56	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.40
57	Keratoacanthoma	Enrichment	PIK3CA	2.40
58	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.28
59	Cerebrovascular disease	Enrichment	PIK3CA	2.28
60	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.28
61	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.24
62	Hemifacial hyperplasia	Enrichment	EFNB1	2.18
63	Capillary malformations, congenital	Enrichment	PIK3CA	2.18
64	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	2.18
65	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.18
66	Hemimegalencephaly	Enrichment	PIK3CA	2.18
67	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.10
68	Cowden syndrome 1	Enrichment	PIK3CA	2.10
69	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.10
70	Breast adenocarcinoma	Enrichment	PIK3CA	2.10
71	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.10
72	Nevus, epidermal	Enrichment	PIK3CA	2.03
73	Gallbladder cancer	Enrichment	PIK3CA	2.03
74	Overgrowth syndrome	Enrichment	PIK3R1	2.03
75	Lennox-gastaut syndrome	Enrichment	DNM1	1.98
76	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.93
77	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.93
78	Cowden syndrome	Enrichment	PIK3CA	1.93
79	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.88
80	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.84
81	Meningioma	Enrichment	PIK3CA	1.80
82	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.80
83	Stereotypic movement disorder	Enrichment	DNM1	1.77
84	Lynch syndrome	Enrichment	PIK3CA	1.70
85	Endometrial cancer	Enrichment	PIK3CA	1.56
86	Hepatocellular carcinoma	Enrichment	PIK3CA	1.54
87	Myocardial infarction	Enrichment	ITGB3	1.54
88	Tetralogy of fallot	Enrichment	EPHB4	1.47
89	Hydrops fetalis, nonimmune	Enrichment	EPHB4	1.47
90	Bladder cancer	Enrichment	PIK3CA	1.42
91	Prostate cancer	Enrichment	PIK3CA	1.42
92	Non-immune hydrops fetalis	Enrichment	EPHB4	1.39
93	Lung cancer	Enrichment	PIK3CA	1.38
94	Severe combined immunodeficiency	Enrichment	LCK	1.37
95	Gastric cancer	Enrichment	PIK3CA	1.26
96	West syndrome	Enrichment	DNM1	1.25
97	Hereditary breast carcinoma	Enrichment	PIK3CA	1.25
98	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	1.14
99	Breast cancer	Enrichment	PIK3CA	1.02
100	Ovarian cancer	Enrichment	PIK3CA	0.90
101	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ephrin B reverse signaling

Pathway Network for Ephrin B reverse signaling

Member Pathways for Ephrin B reverse signaling

Pathways in the Ephrin B reverse signaling SuperPath

Associated Genes for Ephrin B reverse signaling

Associated Disorders for Ephrin B reverse signaling

Disorders associated with Ephrin B reverse signaling SuperPath

STRING Interaction Network for Ephrin B reverse signaling

Sources for Ephrin B reverse signaling