Epigenetic regulation by WDR5-containing histone modifying complexes

Pathway network for the Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

Sources:

Reactome

Pathways in the Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

#	Name	Source	Genes
1	Epigenetic regulation by WDR5-containing histone modifying complexes	Reactome	ABL1 ACSL1 ACSS3 ADIPOQ AGPAT2 AJUBA AKAP8L ANGPTL4 ASH2L BOD1 BOD1L1 CCNC CD36 CDK5 CDK8 CEBPA CIDEC CREBBP CXXC1 DGAT2 DPY30 DR1 ELOVL5 EP300 FABP4 GPAM GPS2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HCFC1 HCFC2 HDAC3 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT8 KDM6A KMT2A KMT2B KMT2C KMT2D LIPE LPIN1 LPL MBIP MCRS1 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED23 MED24 MED27 MED30 MED31 MED4 MED6 MED7 MEN1 MGLL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 PAGR1 PAXIP1 PDK4 PEX11A PHF20 PHF20L1 PHLDA1 PLIN1 PLIN2 PLIN4 PNPLA2 PPARG PPARGC1A PPARGC1B PSIP1 RB1 RBBP5 RXRA SCD SCD5 SETD1A SETD1B SGF29 SIRT1 TADA2A TADA3 TASP1 TBL1X TBL1XR1 THRSP WDR5 WDR82 YEATS2 ZZZ3 (see all 165) (see less)
2	Epigenetic regulation of gene expression	Reactome	ABL1 ACSL1 ACSS3 ACTB ACTL6A ADIPOQ AEBP2 AGPAT2 AJUBA AKAP8L ANGPTL4 ARID1A ARID1B ARID4B ASH2L ATF7IP BAZ1B BAZ2A BCL7A BCL7B BCL7C BOD1 BOD1L1 C19orf84 CBX3 CBX5 CCNC CCNH CD36 CDK5 CDK7 CDK8 CEBPA CHD3 CHD4 CIDEC CREBBP CXXC1 DDX21 DEK DGAT2 DNMT1 DNMT3A DNMT3B DNMT3L DPF1 DPF2 DPF3 DPY30 DR1 EED EHMT1 EHMT2 ELOVL5 EP300 ERCC2 ERCC3 ERCC6 EZH2 FABP4 GATAD2A GATAD2B GPAM GPS2 GSK3B GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HCFC1 HCFC2 HDAC1 HDAC2 HDAC3 JARID2 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT8 KDM6A KMT2A KMT2B KMT2C KMT2D LIPE LPIN1 LPL MBD2 MBD3 MBIP MCRS1 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED23 MED24 MED27 MED30 MED31 MED4 MED6 MED7 MEN1 MGLL MNAT1 MORC2 MPHOSPH8 MTA1 MTA2 MTA3 MTF2 MTREX MYBBP1A MYO1C NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 PAGR1 PAXIP1 PDK4 PEX11A PHF1 PHF19 PHF20 PHF20L1 PHLDA1 PIWIL4 PLIN1 PLIN2 PLIN4 PNPLA2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L PPARG PPARGC1A PPARGC1B PPHLN1 PSIP1 RB1 RBBP4 RBBP5 RBBP7 RBM7 RNA45SN5 RRP8 RXRA SAP130 SAP18 SAP30 SAP30BP SAP30L SCD SCD5 SETD1A SETD1B SETDB1 SF3B1 SGF29 SIN3A SIN3B SIRT1 SMARCA2 SMARCA4 SMARCA5 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SPOCD1 SS18 SS18L1 SUDS3 SUMO2 SUV39H1 SUZ12 TADA2A TADA3 TAF1A TAF1B TAF1C TAF1D TASOR TASP1 TBL1X TBL1XR1 TBP TDG TET1 TET2 TET3 THRSP TRIM28 TTF1 UBE2I UBTF UHRF1 WDR5 WDR82 YEATS2 ZCCHC8 ZNF136 ZNF141 ZNF224 ZNF257 ZNF264 ZNF273 ZNF28 ZNF30 ZNF317 ZNF320 ZNF324 ZNF331 ZNF33A ZNF354A ZNF382 ZNF418 ZNF425 ZNF454 ZNF519 ZNF534 ZNF547 ZNF610 ZNF649 ZNF669 ZNF680 ZNF708 ZNF765 ZNF778 ZNF816 ZNF93 ZZZ3 (see all 317) (see less)
3	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Reactome	ABL1 ACSL1 ACSS3 ADIPOQ AGPAT2 AJUBA ANGPTL4 ASH2L CCNC CD36 CDK5 CDK8 CEBPA CIDEC CREBBP DGAT2 DPY30 ELOVL5 EP300 FABP4 GPAM GPS2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC3 KDM6A KMT2C KMT2D LIPE LPIN1 LPL MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED23 MED24 MED27 MED30 MED31 MED4 MED6 MED7 MGLL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 PAGR1 PAXIP1 PDK4 PEX11A PHLDA1 PLIN1 PLIN2 PLIN4 PNPLA2 PPARG PPARGC1A PPARGC1B RB1 RBBP5 RXRA SCD SCD5 SIRT1 TBL1X TBL1XR1 THRSP WDR5 (see all 134) (see less)
4	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	Reactome	ABL1 ACSL1 ACSS3 ADIPOQ AGPAT2 AJUBA ANGPTL4 ASH2L CCNC CD36 CDK5 CDK8 CEBPA CIDEC CREBBP DGAT2 DPY30 ELOVL5 EP300 FABP4 GPAM GPS2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC3 KDM6A KMT2C KMT2D LIPE LPIN1 LPL MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED23 MED24 MED27 MED30 MED31 MED4 MED6 MED7 MGLL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 PAGR1 PAXIP1 PDK4 PEX11A PHLDA1 PLIN1 PLIN2 PLIN4 PNPLA2 PPARG PPARGC1A PPARGC1B RB1 RBBP5 RXRA SCD SCD5 SIRT1 TBL1X TBL1XR1 THRSP WDR5 (see all 134) (see less)
5	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	Reactome	ABL1 ACSL1 ACSS3 ADIPOQ AGPAT2 AJUBA ANGPTL4 ASH2L CCNC CD36 CDK5 CDK8 CEBPA CIDEC CREBBP DGAT2 DPY30 ELOVL5 EP300 FABP4 GPAM GPS2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC3 KDM6A KMT2C KMT2D LIPE LPIN1 LPL MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED23 MED24 MED27 MED30 MED31 MED4 MED6 MED7 MGLL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 PAGR1 PAXIP1 PDK4 PEX11A PHLDA1 PLIN1 PLIN2 PLIN4 PNPLA2 PPARG PPARGC1A PPARGC1B RB1 RBBP5 RXRA SCD SCD5 SIRT1 TBL1X TBL1XR1 THRSP WDR5 (see all 134) (see less)

Gene overlap in member pathways for Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MED6	Mediator Complex Subunit 6	Protein Coding	5
2	MED16	Mediator Complex Subunit 16	Protein Coding	5
3	CDK5	Cyclin Dependent Kinase 5	Protein Coding	5
4	CDK8	Cyclin Dependent Kinase 8	Protein Coding	5
5	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	5
6	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	5
7	AGPAT2	1-Acylglycerol-3-Phosphate O-Acyltransferase 2	Protein Coding	5
8	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	5
9	WDR5	WD Repeat Domain 5	Protein Coding	5
10	MGLL	Monoglyceride Lipase	Protein Coding	5
11	H4C16	H4 Histone 16	Protein Coding	5
12	PLIN2	Perilipin 2	Protein Coding	5
13	H3C14	H3 Clustered Histone 14	Protein Coding	5
14	H2BC26	H2B Clustered Histone 26	Protein Coding	5
15	PPARGC1B	PPARG Coactivator 1 Beta	Protein Coding	5
16	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	5
17	EP300	EP300 Lysine Acetyltransferase	Protein Coding	5
18	FABP4	Fatty Acid Binding Protein 4	Protein Coding	5
19	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	5
20	PHLDA1	Pleckstrin Homology Like Domain Family A Member 1	Protein Coding	5
21	PAXIP1	PAX Interacting Protein 1	Protein Coding	5
22	NCOA6	Nuclear Receptor Coactivator 6	Protein Coding	5
23	LPIN1	Lipin 1	Protein Coding	5
24	SIRT1	Sirtuin 1	Protein Coding	5
25	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	5
26	H2BC1	H2B Clustered Histone 1	Protein Coding	5
27	GPS2	G Protein Pathway Suppressor 2	Protein Coding	5
28	MED4	Mediator Complex Subunit 4	Protein Coding	5
29	H2AC8	H2A Clustered Histone 8	Protein Coding	5
30	H2AC7	H2A Clustered Histone 7	Protein Coding	5
31	H2AX	H2A.X Variant Histone	Protein Coding	5
32	H2BC5	H2B Clustered Histone 5	Protein Coding	5
33	H2BC3	H2B Clustered Histone 3	Protein Coding	5
34	H3-3A	H3.3 Histone A	Protein Coding	5
35	H3-3B	H3.3 Histone B	Protein Coding	5
36	H3C15	H3 Clustered Histone 15	Protein Coding	5
37	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	5
38	LPL	Lipoprotein Lipase	Protein Coding	5
39	H2AB1	H2A.B Variant Histone 1	Protein Coding	5
40	MED31	Mediator Complex Subunit 31	Protein Coding	5
41	ANGPTL4	Angiopoietin Like 4	Protein Coding	5
42	PDK4	Pyruvate Dehydrogenase Kinase 4	Protein Coding	5
43	PLIN1	Perilipin 1	Protein Coding	5
44	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	5
45	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	5
46	MED1	Mediator Complex Subunit 1	Protein Coding	5
47	H4C15	H4 Clustered Histone 15	Protein Coding	5
48	H2AJ	H2A.J Histone	Protein Coding	5
49	PNPLA2	Patatin Like Domain 2, Triacylglycerol Lipase	Protein Coding	5
50	GPAM	Glycerol-3-Phosphate Acyltransferase, Mitochondrial	Protein Coding	5
51	KMT2C	Lysine Methyltransferase 2C	Protein Coding	5
52	RB1	RB Transcriptional Corepressor 1	Protein Coding	5
53	RBBP5	RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	5
54	ELOVL5	ELOVL Fatty Acid Elongase 5	Protein Coding	5
55	RXRA	Retinoid X Receptor Alpha	Protein Coding	5
56	SCD	Stearoyl-CoA Desaturase	Protein Coding	5
57	CIDEC	Cell Death Inducing DFFA Like Effector C	Protein Coding	5
58	H3C13	H3 Clustered Histone 13	Protein Coding	5
59	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	5
60	THRSP	Thyroid Hormone Responsive	Protein Coding	5
61	H2AC19	H2A Clustered Histone 19	Protein Coding	5
62	PLIN4	Perilipin 4	Protein Coding	5
63	KDM6A	Lysine Demethylase 6A	Protein Coding	5
64	PAGR1	PAXIP1 Associated Glutamate Rich Protein 1	Protein Coding	5
65	ACSS3	Acyl-CoA Synthetase Short Chain Family Member 3	Protein Coding	5
66	TBL1XR1	TBL1X/Y Related 1	Protein Coding	5
67	SCD5	Stearoyl-CoA Desaturase 5	Protein Coding	5
68	NCOA4	Nuclear Receptor Coactivator 4	Protein Coding	5
69	KMT2D	Lysine Methyltransferase 2D	Protein Coding	5
70	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	5
71	H4C9	H4 Clustered Histone 9	Protein Coding	5
72	H2AC14	H2A Clustered Histone 14	Protein Coding	5
73	H2AC6	H2A Clustered Histone 6	Protein Coding	5
74	H2AC4	H2A Clustered Histone 4	Protein Coding	5
75	H2AC18	H2A Clustered Histone 18	Protein Coding	5
76	H2AC20	H2A Clustered Histone 20	Protein Coding	5
77	H2BC8	H2B Clustered Histone 8	Protein Coding	5
78	H2BC13	H2B Clustered Histone 13	Protein Coding	5
79	H2BC15	H2B Clustered Histone 15	Protein Coding	5
80	H2BC14	H2B Clustered Histone 14	Protein Coding	5
81	H2BC7	H2B Clustered Histone 7	Protein Coding	5
82	H2BC6	H2B Clustered Histone 6	Protein Coding	5
83	H2BC9	H2B Clustered Histone 9	Protein Coding	5
84	H2BC10	H2B Clustered Histone 10	Protein Coding	5
85	H2BC4	H2B Clustered Histone 4	Protein Coding	5
86	H2BC17	H2B Clustered Histone 17	Protein Coding	5
87	H2BC21	H2B Clustered Histone 21	Protein Coding	5
88	H3C1	H3 Clustered Histone 1	Protein Coding	5
89	H3C4	H3 Clustered Histone 4	Protein Coding	5
90	H3C3	H3 Clustered Histone 3	Protein Coding	5
91	H3C6	H3 Clustered Histone 6	Protein Coding	5
92	H3C11	H3 Clustered Histone 11	Protein Coding	5
93	H3C8	H3 Clustered Histone 8	Protein Coding	5
94	H3C12	H3 Clustered Histone 12	Protein Coding	5
95	H3C10	H3 Clustered Histone 10	Protein Coding	5
96	H3C2	H3 Clustered Histone 2	Protein Coding	5
97	H4C1	H4 Clustered Histone 1	Protein Coding	5
98	H4C4	H4 Clustered Histone 4	Protein Coding	5
99	H4C6	H4 Clustered Histone 6	Protein Coding	5
100	H4C12	H4 Clustered Histone 12	Protein Coding	5
101	H4C11	H4 Clustered Histone 11	Protein Coding	5
102	H4C3	H4 Clustered Histone 3	Protein Coding	5
103	H4C8	H4 Clustered Histone 8	Protein Coding	5
104	H4C2	H4 Clustered Histone 2	Protein Coding	5
105	H4C5	H4 Clustered Histone 5	Protein Coding	5
106	H4C13	H4 Clustered Histone 13	Protein Coding	5
107	H4C14	H4 Clustered Histone 14	Protein Coding	5
108	MED10	Mediator Complex Subunit 10	Protein Coding	5
109	DGAT2	Diacylglycerol O-Acyltransferase 2	Protein Coding	5
110	DPY30	Dpy-30 Histone Methyltransferase Complex Regulatory Subunit	Protein Coding	5
111	AJUBA	Ajuba LIM Protein	Protein Coding	5
112	H2BC12	H2B Clustered Histone 12	Protein Coding	5
113	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	5
114	PEX11A	Peroxisomal Biogenesis Factor 11 Alpha	Protein Coding	5
115	HDAC3	Histone Deacetylase 3	Protein Coding	5
116	CCNC	Cyclin C	Protein Coding	5
117	H3C7	H3 Clustered Histone 7	Protein Coding	5
118	H2BC11	H2B Clustered Histone 11	Protein Coding	5
119	MED30	Mediator Complex Subunit 30	Protein Coding	5
120	ASH2L	ASH2 Like, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	5
121	MED14	Mediator Complex Subunit 14	Protein Coding	5
122	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	5
123	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	5
124	MED23	Mediator Complex Subunit 23	Protein Coding	5
125	MED17	Mediator Complex Subunit 17	Protein Coding	5
126	MED27	Mediator Complex Subunit 27	Protein Coding	5
127	MED7	Mediator Complex Subunit 7	Protein Coding	5
128	MED20	Mediator Complex Subunit 20	Protein Coding	5
129	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	5
130	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	5
131	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	5
132	MED24	Mediator Complex Subunit 24	Protein Coding	5
133	MED12	Mediator Complex Subunit 12	Protein Coding	5
134	MED13	Mediator Complex Subunit 13	Protein Coding	5
135	MCRS1	Microspherule Protein 1	Protein Coding	2
136	TADA3	Transcriptional Adaptor 3	Protein Coding	2
137	PSIP1	PC4 And SRSF1 Interacting Protein 1	Protein Coding	2
138	SGF29	SAGA Complex Associated Factor 29	Protein Coding	2
139	DR1	Down-Regulator Of Transcription 1	Protein Coding	2
140	SETD1B	SET Domain Containing 1B, Histone Lysine Methyltransferase	Protein Coding	2
141	BOD1L1	Biorientation Of Chromosomes In Cell Division 1 Like 1	Protein Coding	2
142	ZZZ3	Zinc Finger ZZ-Type Containing 3	Protein Coding	2
143	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	2
144	AKAP8L	A-Kinase Anchoring Protein 8 Like	Protein Coding	2
145	KANSL1	KAT8 Regulatory NSL Complex Subunit 1	Protein Coding	2
146	HCFC2	Host Cell Factor C2	Protein Coding	2
147	HCFC1	Host Cell Factor C1	Protein Coding	2
148	CXXC1	CXXC Finger Protein 1	Protein Coding	2
149	MEN1	Menin 1	Protein Coding	2
150	KMT2A	Lysine Methyltransferase 2A	Protein Coding	2
151	PHF20L1	PHD Finger Protein 20 Like 1	Protein Coding	2
152	PHF20	PHD Finger Protein 20	Protein Coding	2
153	MBIP	MAP3K12 Binding Inhibitory Protein 1	Protein Coding	2
154	KANSL2	KAT8 Regulatory NSL Complex Subunit 2	Protein Coding	2
155	TASP1	Taspase 1	Protein Coding	2
156	KANSL3	KAT8 Regulatory NSL Complex Subunit 3	Protein Coding	2
157	YEATS2	YEATS Domain Containing 2	Protein Coding	2
158	KAT14	Lysine Acetyltransferase 14	Protein Coding	2
159	TADA2A	Transcriptional Adaptor 2A	Protein Coding	2
160	WDR82	WD Repeat Domain 82	Protein Coding	2
161	KAT8	Lysine Acetyltransferase 8	Protein Coding	2
162	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	2
163	BOD1	Biorientation Of Chromosomes In Cell Division 1	Protein Coding	2
164	SETD1A	SET Domain Containing 1A, Histone Lysine Methyltransferase	Protein Coding	2
165	KMT2B	Lysine Methyltransferase 2B	Protein Coding	2
166	RNA45SN5	RNA, 45S Pre-Ribosomal N5	RNA Gene	1
167	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
168	RBM7	RNA Binding Motif Protein 7	Protein Coding	1
169	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
170	SAP18	Sin3A Associated Protein 18	Protein Coding	1
171	MYBBP1A	MYB Binding Protein 1a	Protein Coding	1
172	ZNF273	Zinc Finger Protein 273	Protein Coding	1
173	POLR1G	RNA Polymerase I Subunit G	Protein Coding	1
174	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	1
175	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	1
176	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	1
177	BAZ2A	Bromodomain Adjacent To Zinc Finger Domain 2A	Protein Coding	1
178	CBX3	Chromobox 3	Protein Coding	1
179	ZNF257	Zinc Finger Protein 257	Protein Coding	1
180	AEBP2	AE Binding Protein 2	Protein Coding	1
181	ZNF816	Zinc Finger Protein 816	Protein Coding	1
182	PIWIL4	Piwi Like RNA-Mediated Gene Silencing 4	Protein Coding	1
183	C19orf84	Chromosome 19 Open Reading Frame 84	Protein Coding	1
184	ZNF534	Zinc Finger Protein 534	Protein Coding	1
185	ZNF418	Zinc Finger Protein 418	Protein Coding	1
186	ZNF425	Zinc Finger Protein 425	Protein Coding	1
187	ZNF519	Zinc Finger Protein 519	Protein Coding	1
188	ZNF610	Zinc Finger Protein 610	Protein Coding	1
189	ZNF320	Zinc Finger Protein 320	Protein Coding	1
190	DNMT1	DNA Methyltransferase 1	Protein Coding	1
191	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	1
192	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	1
193	ZNF778	Zinc Finger Protein 778	Protein Coding	1
194	TET3	Tet Methylcytosine Dioxygenase 3	Protein Coding	1
195	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	1
196	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	1
197	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	1
198	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
199	POLR1F	RNA Polymerase I Subunit F	Protein Coding	1
200	MTF2	Metal Response Element Binding Transcription Factor 2	Protein Coding	1
201	MORC2	MORC Family CW-Type Zinc Finger 2	Protein Coding	1
202	TASOR	Transcription Activation Suppressor	Protein Coding	1
203	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	1
204	RRP8	Ribosomal RNA Processing 8	Protein Coding	1
205	SF3B1	Splicing Factor 3b Subunit 1	Protein Coding	1
206	CBX5	Chromobox 5	Protein Coding	1
207	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
208	MTREX	Mtr4 Exosome RNA Helicase	Protein Coding	1
209	ZNF324	Zinc Finger Protein 324	Protein Coding	1
210	POLR1A	RNA Polymerase I Subunit A	Protein Coding	1
211	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
212	SS18L1	SS18L1 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	1
213	PHF19	PHD Finger Protein 19	Protein Coding	1
214	ZNF547	Zinc Finger Protein 547	Protein Coding	1
215	ZNF454	Zinc Finger Protein 454	Protein Coding	1
216	SAP30BP	SAP30 Binding Protein	Protein Coding	1
217	UHRF1	Ubiquitin Like With PHD And Ring Finger Domains 1	Protein Coding	1
218	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
219	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	1
220	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	1
221	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	1
222	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	1
223	DNMT3L	DNA Methyltransferase 3 Like	Protein Coding	1
224	HDAC1	Histone Deacetylase 1	Protein Coding	1
225	HDAC2	Histone Deacetylase 2	Protein Coding	1
226	POLR1H	RNA Polymerase I Subunit H	Protein Coding	1
227	ZNF680	Zinc Finger Protein 680	Protein Coding	1
228	JARID2	Jumonji And AT-Rich Interaction Domain Containing 2	Protein Coding	1
229	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	1
230	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	1
231	MYO1C	Myosin IC	Protein Coding	1
232	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	1
233	PPHLN1	Periphilin 1	Protein Coding	1
234	ARID4B	AT-Rich Interaction Domain 4B	Protein Coding	1
235	PHF1	PHD Finger Protein 1	Protein Coding	1
236	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	1
237	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	1
238	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	1
239	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	1
240	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	1
241	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	1
242	MPHOSPH8	M-Phase Phosphoprotein 8	Protein Coding	1
243	TET2	Tet Methylcytosine Dioxygenase 2	Protein Coding	1
244	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	1
245	ZNF331	Zinc Finger Protein 331	Protein Coding	1
246	ZCCHC8	Zinc Finger CCHC-Type Containing 8	Protein Coding	1
247	ATF7IP	Activating Transcription Factor 7 Interacting Protein	Protein Coding	1
248	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	1
249	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	1
250	MTA3	Metastasis Associated 1 Family Member 3	Protein Coding	1
251	ZNF317	Zinc Finger Protein 317	Protein Coding	1
252	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
253	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
254	DPF2	Double PHD Fingers 2	Protein Coding	1
255	ACTB	Actin Beta	Protein Coding	1
256	BCL7A	BAF Chromatin Remodeling Complex Subunit BCL7A	Protein Coding	1
257	POLR1E	RNA Polymerase I Subunit E	Protein Coding	1
258	SUDS3	SIN3A Corepressor Complex Component SDS3	Protein Coding	1
259	ZNF649	Zinc Finger Protein 649	Protein Coding	1
260	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	1
261	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
262	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	1
263	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	1
264	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	1
265	SMARCD1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D1	Protein Coding	1
266	SMARCD2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D2	Protein Coding	1
267	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	1
268	SMARCE1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit E1	Protein Coding	1
269	SUMO2	Small Ubiquitin Like Modifier 2	Protein Coding	1
270	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	1
271	SUV39H1	SUV39H1 Histone Lysine Methyltransferase	Protein Coding	1
272	TBP	TATA-Box Binding Protein	Protein Coding	1
273	ZNF354A	Zinc Finger Protein 354A	Protein Coding	1
274	TDG	Thymine DNA Glycosylase	Protein Coding	1
275	TTF1	Transcription Termination Factor 1	Protein Coding	1
276	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
277	UBTF	Upstream Binding Transcription Factor	Protein Coding	1
278	ZNF708	Zinc Finger Protein 708	Protein Coding	1
279	ZNF28	Zinc Finger Protein 28	Protein Coding	1
280	ZNF33A	Zinc Finger Protein 33A	Protein Coding	1
281	ZNF136	Zinc Finger Protein 136	Protein Coding	1
282	ZNF141	Zinc Finger Protein 141	Protein Coding	1
283	ZNF224	Zinc Finger Protein 224	Protein Coding	1
284	TAF1D	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit D	Protein Coding	1
285	DEK	DEK Proto-Oncogene	Protein Coding	1
286	SAP130	Sin3A Associated Protein 130	Protein Coding	1
287	SAP30L	SAP30 Like	Protein Coding	1
288	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	1
289	ZNF669	Zinc Finger Protein 669	Protein Coding	1
290	TET1	Tet Methylcytosine Dioxygenase 1	Protein Coding	1
291	DPF3	Double PHD Fingers 3	Protein Coding	1
292	DPF1	Double PHD Fingers 1	Protein Coding	1
293	ZNF93	Zinc Finger Protein 93	Protein Coding	1
294	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	1
295	POLR1B	RNA Polymerase I Subunit B	Protein Coding	1
296	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	1
297	ZNF382	Zinc Finger Protein 382	Protein Coding	1
298	ACTL6A	Actin Like 6A	Protein Coding	1
299	EED	Embryonic Ectoderm Development	Protein Coding	1
300	SAP30	Sin3A Associated Protein 30	Protein Coding	1
301	MBD2	Methyl-CpG Binding Domain Protein 2	Protein Coding	1
302	ZNF30	Zinc Finger Protein 30	Protein Coding	1
303	TAF1C	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C	Protein Coding	1
304	TAF1B	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B	Protein Coding	1
305	TAF1A	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A	Protein Coding	1
306	CCNH	Cyclin H	Protein Coding	1
307	BAZ1B	Bromodomain Adjacent To Zinc Finger Domain 1B	Protein Coding	1
308	SPOCD1	SPOC Domain Containing 1	Protein Coding	1
309	MTA1	Metastasis Associated 1	Protein Coding	1
310	ZNF765	Zinc Finger Protein 765	Protein Coding	1
311	DDX21	DExD-Box Helicase 21	Protein Coding	1
312	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	1
313	BCL7C	BAF Chromatin Remodeling Complex Subunit BCL7C	Protein Coding	1
314	BCL7B	BAF Chromatin Remodeling Complex Subunit BCL7B	Protein Coding	1
315	ZNF264	Zinc Finger Protein 264	Protein Coding	1
316	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	1
317	SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1	Protein Coding	1

Disorders associated with Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coffin-siris syndrome 1	Enrichment	ARID1A, ARID1B, DPF2, SMARCA4, SMARCB1, SMARCC2, SMARCD1, SMARCE1	9.31
2	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.03
3	Myeloma, multiple	Enrichment	CREBBP, DNMT3A, H3C1, KMT2C, KMT2D, NCOR2, RXRA, TET2, TET3	5.27
4	Rare genetic intellectual disability	Enrichment	ARID1B, CREBBP, DNMT3A, EP300, KMT2A	4.78
5	Complex neurodevelopmental disorder	Enrichment	CDK8, H4C3, H4C5, H4C9, KAT8, KMT2B, MED13, MED27, SETD1A	4.70
6	Kabuki syndrome 1	Enrichment	KDM6A, KMT2A, KMT2D	4.46
7	Charge syndrome	Enrichment	EP300, KDM6A, KMT2D	4.12
8	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.01
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.01
10	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.01
11	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.54
12	Corpus callosum, agenesis of	Enrichment	ARID1B, CREBBP, ERCC2, MED12	3.49
13	Isolated corpus callosum agenesis	Enrichment	ARID1B, CREBBP, ERCC2, MED12	3.49
14	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ARID1B, CREBBP, ERCC2, MED12	3.49
15	Treacher collins syndrome 1	Enrichment	POLR1B, POLR1C, POLR1D	3.38
16	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	3.26
17	Kleefstra syndrome	Enrichment	EHMT1, KMT2C	3.26
18	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	3.26
19	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1, KMT2C	3.26
20	Congenital generalized lipodystrophy	Enrichment	AGPAT2, PPARG	3.24
21	Trichothiodystrophy	Enrichment	ERCC2, ERCC3, GTF2H5	3.02
22	Autism spectrum disorder	Enrichment	ARID1B, DNMT3A, EED, EHMT1, KDM6A, KMT2A, KMT2C, SETD1A, SMARCB1	2.99
23	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.85
24	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.85
25	Weaver syndrome	Enrichment	EZH2, SUZ12	2.79
26	Myelodysplastic syndrome with ring sideroblasts	Enrichment	SF3B1, TET2	2.79
27	Leukemia, acute myeloid	Enrichment	CEBPA, DNMT3A, KMT2A, SF3B1, TET2	2.64
28	Microcephaly	Enrichment	ABL1, ACTB, ARID1A, ARID1B, EP300, KMT2A, KMT2D, MED12, SMARCA5	2.62
29	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	2.58
30	Nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	2.50
31	Blepharophimosis	Enrichment	ARID1B, SMARCA2	2.50
32	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1, SF3B1	2.50
33	Smarca2-related nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	2.50
34	Bladder cancer	Enrichment	ARID1A, ERCC2, KDM6A, RB1	2.36
35	Inherited acute myeloid leukemia	Enrichment	CEBPA, ZCCHC8	2.28
36	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3	2.28
37	Lip and oral cavity carcinoma	Enrichment	ABL1, RB1	2.22
38	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC2, ERCC6	2.11
39	Wiedemann-steiner syndrome	Enrichment	ARID1B, KMT2A	2.11
40	Kleefstra syndrome 1	Enrichment	EHMT1, KMT2C	2.11
41	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B, UHRF1	2.11
42	Hypertrichosis	Enrichment	ARID1B, CREBBP	2.11
43	Heart disease	Enrichment	ABL1, CREBBP	2.09
44	Diffuse large b-cell lymphoma	Enrichment	CREBBP, DNMT3A, TBL1XR1	2.03
45	Kabuki syndrome 2	Enrichment	KDM6A	2.01
46	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.01
47	Branchial cleft anomalies	Enrichment	KMT2D	2.01
48	Coronary heart disease 7	Enrichment	CD36	2.01
49	Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy	Enrichment	MED23	2.01
50	Lipodystrophy, familial partial, type 5	Enrichment	CIDEC	2.01
51	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.01
52	Neurodevelopmental disorder with spasticity, cataracts, and cerebellar hypoplasia	Enrichment	MED27	2.01
53	Myopathy with rimmed ubiquitin-positive autophagic vacuolation, autosomal dominant	Enrichment	PLIN4	2.01
54	Lipodystrophy, congenital generalized, type 1	Enrichment	AGPAT2	2.01
55	Spinocerebellar ataxia 38	Enrichment	ELOVL5	2.01
56	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.01
57	Plasma triglyceride level quantitative trait locus	Enrichment	ANGPTL4	2.01
58	Deafness, autosomal dominant 79	Enrichment	SCD5	2.01
59	Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome	Enrichment	KMT2D	2.01
60	Kleefstra syndrome 2	Enrichment	KMT2C	2.01
61	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.01
62	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.01
63	Guillouet-gordon syndrome	Enrichment	MED16	2.01
64	Trilateral retinoblastoma	Enrichment	RB1	2.01
65	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.01
66	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.01
67	Autosomal dominant charcot-marie-tooth disease type 2 due to dgat2 mutation	Enrichment	DGAT2	2.01
68	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.01
69	Menke-hennekam syndrome	Enrichment	CREBBP	2.01
70	Primary triglyceride deposit cardiomyovasculopathy	Enrichment	PNPLA2	2.01
71	Lung oat cell carcinoma	Enrichment	RB1	2.01
72	Leukemia, chronic myeloid	Enrichment	ABL1, SF3B1	1.98
73	Hydrocephalus, congenital, 1	Enrichment	CDK8, MED12	1.97
74	Li-ghorbani-weisz-hubshman syndrome	Enrichment	KAT8	1.91
75	Neurodevelopmental disorder with speech impairment and dysmorphic facies	Enrichment	SETD1A	1.91
76	Adrenal cortical adenoma	Enrichment	MEN1	1.91
77	Epilepsy, early-onset, 2, with or without developmental delay	Enrichment	SETD1A	1.91
78	Epilepsy, familial adult myoclonic, 4	Enrichment	YEATS2	1.91
79	Intellectual developmental disorder with seizures and language delay	Enrichment	SETD1B	1.91
80	Intellectual developmental disorder, autosomal dominant 68	Enrichment	KMT2B	1.91
81	Suleiman-el-hattab syndrome	Enrichment	TASP1	1.91
82	Generalized isolated dystonia	Enrichment	KMT2B	1.91
83	Kmt2b-related disorders	Enrichment	KMT2B	1.91
84	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	1.91
85	Adrenal adenoma	Enrichment	MEN1	1.91
86	Inherited cancer-predisposing syndrome	Enrichment	CEBPA, ERCC3, EZH2, MEN1, RB1, SMARCA4, SMARCB1, SMARCE1	1.91
87	Hyperlipoproteinemia, type i	Enrichment	LPL	1.71
88	Argininemia	Enrichment	MED23	1.71
89	Thumb deformity	Enrichment	CREBBP	1.71
90	Ebstein anomaly	Enrichment	CDK8	1.71
91	Carotid intimal medial thickness 1	Enrichment	PPARG	1.71
92	Hardikar syndrome	Enrichment	MED12	1.71
93	Opitz-kaveggia syndrome	Enrichment	MED12	1.71
94	Neutral lipid storage disease with myopathy	Enrichment	PNPLA2	1.71
95	Complement component c1s deficiency	Enrichment	KMT2D	1.71
96	Lipase deficiency, combined	Enrichment	LPL	1.71
97	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.71
98	Choanal atresia, posterior	Enrichment	KMT2D	1.71
99	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.71
100	Ohdo syndrome, x-linked	Enrichment	MED12	1.71
101	Menke-hennekam syndrome 2	Enrichment	EP300	1.71
102	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.71
103	Familial lipoprotein lipase deficiency	Enrichment	LPL	1.71
104	Cholestasis-pigmentary retinopathy-cleft palate syndrome	Enrichment	MED12	1.71
105	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	1.71
106	Med12-related disorders	Enrichment	MED12	1.71
107	Familial partial lipodystrophy	Enrichment	PPARG	1.71
108	Blepharophimosis - intellectual disability syndrome, mkb type	Enrichment	MED12	1.71
109	Familial retinoblastoma	Enrichment	RB1	1.71
110	Torticollis	Enrichment	ACTL6A	1.63
111	Baraitser-winter syndrome 1	Enrichment	ACTB	1.63
112	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	1.63
113	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	1.63
114	Coffin-siris syndrome 5	Enrichment	SMARCE1	1.63
115	Gand syndrome	Enrichment	GATAD2B	1.63
116	Polydactyly, postaxial, type a6	Enrichment	ZNF141	1.63
117	Coffin-siris syndrome 11	Enrichment	SMARCD1	1.63
118	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	1.63
119	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	1.63
120	Treacher collins syndrome 4	Enrichment	POLR1B	1.63
121	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.63
122	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	1.63
123	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	1.63
124	Imagawa-matsumoto syndrome	Enrichment	SUZ12	1.63
125	Developmental delay with variable intellectual disability and dysmorphic facies	Enrichment	JARID2	1.63
126	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	1.63
127	Xeroderma pigmentosum group b	Enrichment	ERCC3	1.63
128	Becker nevus syndrome	Enrichment	ACTB	1.63
129	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.63
130	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	1.63
131	Treacher collins syndrome 2	Enrichment	POLR1D	1.63
132	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	1.63
133	Developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy	Enrichment	MORC2	1.63
134	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	1.63
135	Neurilemmoma	Enrichment	SMARCB1	1.63
136	Coffin-siris syndrome 3	Enrichment	SMARCB1	1.63
137	Tet3-related beck-fahrner syndrome	Enrichment	TET3	1.63
138	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	1.63
139	Arid1b-related disorder	Enrichment	ARID1B	1.63
140	Ovarian small cell carcinoma	Enrichment	SMARCA4	1.63
141	Cohen-gibson syndrome	Enrichment	EED	1.63
142	Charcot-marie-tooth disease, axonal, type 2z	Enrichment	MORC2	1.63
143	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	1.63
144	Coffin-siris syndrome 7	Enrichment	DPF2	1.63
145	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.63
146	Beck-fahrner syndrome	Enrichment	TET3	1.63
147	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	1.63
148	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 5	Enrichment	ZCCHC8	1.63
149	Baraitser-winter syndrome	Enrichment	ACTB	1.63
150	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	1.63
151	Facial cleft	Enrichment	SMARCE1	1.63
152	Wilms tumor 7	Enrichment	TRIM28	1.63
153	Autosomal recessive severe congenital neutropenia	Enrichment	SMARCD2	1.63
154	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.63
155	Xeroderma pigmentosum group d	Enrichment	ERCC2	1.63
156	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.63
157	Myelodysplastic neoplasm with increased blasts type 2	Enrichment	TET2	1.63
158	Myelodysplastic neoplasm with increased blasts type 1	Enrichment	TET2	1.63
159	Myelodysplastic neoplasm with low blasts	Enrichment	TET2	1.63
160	Hyperparathyroidism 1	Enrichment	MEN1	1.62
161	Mitochondrial complex iv deficiency, nuclear type 19	Enrichment	KAT14	1.62
162	Medullary thyroid carcinoma	Enrichment	MEN1	1.62
163	Insulinoma	Enrichment	MEN1	1.62
164	Dystonia 28, childhood-onset	Enrichment	KMT2B	1.62
165	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	1.62
166	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	1.62
167	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	1.62
168	Null pituitary adenoma	Enrichment	MEN1	1.62
169	Silent pituitary adenoma	Enrichment	MEN1	1.62
170	Gigantism	Enrichment	MEN1	1.62
171	Xeroderma pigmentosum, variant type	Enrichment	ERCC2, ERCC3	1.58
172	Meningioma, familial	Enrichment	SMARCB1, SMARCE1	1.58
173	Myelodysplastic syndrome	Enrichment	SF3B1, TET2	1.58
174	Atrial heart septal defect	Enrichment	ACTL6A, SMARCA4	1.58
175	Interatrial communication	Enrichment	ACTL6A, SMARCA4	1.58
176	Specific learning disability	Enrichment	DNMT3A, KMT2B	1.58
177	Retinoblastoma	Enrichment	RB1	1.53
178	Intellectual developmental disorder, x-linked, syndromic, lujan-fryns type	Enrichment	MED12	1.53
179	Pierpont syndrome	Enrichment	TBL1XR1	1.53
180	Myoglobinuria, acute recurrent, autosomal recessive	Enrichment	LPIN1	1.53
181	Osteogenic sarcoma	Enrichment	RB1	1.53
182	Adiponectin deficiency	Enrichment	ADIPOQ	1.53
183	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	1.53
184	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.53
185	Microcephaly, postnatal progressive, with seizures and brain atrophy	Enrichment	MED17	1.53
186	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	1.53
187	Anus, imperforate	Enrichment	MED12	1.53
188	Intellectual developmental disorder, autosomal dominant 61	Enrichment	MED13	1.53
189	Hypotrichosis 8	Enrichment	RB1	1.53
190	Tethered spinal cord syndrome	Enrichment	CREBBP	1.53
191	Squamous cell carcinoma	Enrichment	RB1	1.53
192	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.53
193	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.53
194	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.53
195	Bone osteosarcoma	Enrichment	RB1	1.53
196	Meningioma	Enrichment	SMARCB1, SMARCE1	1.51
197	Differentiated thyroid carcinoma	Enrichment	NCOA4, PPARG	1.48
198	Dystonia 12	Enrichment	KMT2B	1.44
199	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	HCFC1	1.44
200	Pituitary adenoma 1, multiple types	Enrichment	MEN1	1.44
201	Koolen-de vries syndrome	Enrichment	KANSL1	1.44
202	Cellular ependymoma	Enrichment	MEN1	1.44
203	Tanycytic ependymoma	Enrichment	MEN1	1.44
204	Papillary ependymoma	Enrichment	MEN1	1.44
205	Parathyroid adenoma	Enrichment	MEN1	1.44
206	Growth hormone secreting pituitary adenoma	Enrichment	MEN1	1.44
207	Aip familial isolated pituitary adenomas	Enrichment	MEN1	1.44
208	Familial isolated hyperparathyroidism	Enrichment	MEN1	1.44
209	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	1.44
210	Clear cell ependymoma	Enrichment	MEN1	1.44
211	Isolated growth hormone deficiency, type ii	Enrichment	MED13	1.41
212	Small cell cancer of the lung	Enrichment	RB1	1.41
213	Microtia-anotia	Enrichment	KMT2D	1.41
214	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.41
215	Leptin deficiency or dysfunction	Enrichment	PPARG	1.41
216	Lynch syndrome 4	Enrichment	RB1	1.41
217	Intellectual developmental disorder, autosomal dominant 26	Enrichment	KMT2D	1.41
218	Blood platelet disease	Enrichment	CD36	1.41
219	Hereditary recurrent myoglobinuria	Enrichment	LPIN1	1.41
220	Coronary artery anomaly	Enrichment	LPL	1.41
221	Cerebral malaria	Enrichment	CD36	1.41
222	Pituitary stalk interruption syndrome	Enrichment	DNMT1, SMARCA2	1.39
223	Alopecia, androgenetic, 1	Enrichment	SMARCD1	1.34
224	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	1.34
225	Trichomegaly	Enrichment	ARID1B	1.34
226	Specific granule deficiency 1	Enrichment	SMARCD2	1.34
227	Treacher collins syndrome 3	Enrichment	POLR1C	1.34
228	Spinocerebellar ataxia 17	Enrichment	TBP	1.34
229	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.34
230	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.34
231	Schwannomatosis 1	Enrichment	SMARCB1	1.34
232	Chromosome 6q24-q25 deletion syndrome	Enrichment	ARID1B	1.34
233	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	1.34
234	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	1.34
235	Immunodeficiency 75 with lymphoproliferation	Enrichment	TET2	1.34
236	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	ARID1B	1.34
237	Specific granule deficiency 2	Enrichment	SMARCD2	1.34
238	Snijders blok-campeau syndrome	Enrichment	CHD3	1.34
239	Coffin-siris syndrome 8	Enrichment	SMARCC2	1.34
240	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	1.34
241	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	1.34
242	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	1.34
243	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.34
244	Otosclerosis 12	Enrichment	SMARCA4	1.34
245	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.34
246	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	1.34
247	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	1.34
248	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	1.34
249	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	1.34
250	Cockayne syndrome type 3	Enrichment	ERCC6	1.34
251	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	DEK	1.34
252	Specific granule deficiency	Enrichment	SMARCD2	1.34
253	Polydactyly, postaxial, type a1	Enrichment	EP300, ZNF141	1.33
254	Prolactinoma	Enrichment	MEN1	1.32
255	Primary hyperparathyroidism	Enrichment	MEN1	1.32
256	Benign ependymoma	Enrichment	MEN1	1.32
257	Hyperlipidemia, familial combined, 3	Enrichment	LPL	1.31
258	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.31
259	Amblyopia	Enrichment	KMT2D	1.31
260	Lymphoma	Enrichment	KMT2D	1.31
261	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.31
262	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	ARID1A, ARID1B	1.28
263	Gliosarcoma	Enrichment	DNMT3A, PPARG	1.28
264	Autism	Enrichment	CREBBP, KMT2B, KMT2D	1.24
265	Giant cell glioblastoma	Enrichment	DNMT3A, PPARG	1.23
266	Acute megakaryocytic leukemia	Enrichment	KMT2A	1.23
267	Moyamoya angiopathy	Enrichment	ABL1	1.17
268	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.17
269	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.16
270	Night blindness, congenital stationary, type 1b	Enrichment	ZNF454	1.16
271	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	1.16
272	De sanctis-cacchione syndrome	Enrichment	ERCC6	1.16
273	Sarcoma, synovial	Enrichment	SS18	1.16
274	Burn-mckeown syndrome	Enrichment	POLR1A	1.16
275	Uv-sensitive syndrome 1	Enrichment	ERCC6	1.16
276	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	1.16
277	Nail disorder, nonsyndromic congenital, 9	Enrichment	ARID1B	1.16
278	Coffin-siris syndrome 2	Enrichment	ARID1A	1.16
279	Umbilical hernia	Enrichment	ACTL6A	1.16
280	Wieacker-wolff syndrome	Enrichment	CCNH	1.16
281	Uv-sensitive syndrome	Enrichment	ERCC6	1.16
282	Premature ovarian failure 11	Enrichment	ERCC6	1.16
283	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1	1.16
284	Periventricular leukomalacia	Enrichment	ARID1A	1.16
285	Neurodegeneration, childhood-onset, with brain atrophy	Enrichment	UBTF	1.16
286	Schwannomatosis	Enrichment	SMARCB1	1.16
287	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1, MED12	1.15
288	Familial adult myoclonic epilepsy	Enrichment	YEATS2	1.15
289	Multiple endocrine neoplasia, type i	Enrichment	MEN1	1.09
290	Gastrointestinal stromal tumor	Enrichment	MEN1	1.09
291	Macular degeneration, age-related, 5	Enrichment	ERCC6	1.04
292	Aminoacylase 1 deficiency	Enrichment	ACTB	1.04
293	Craniopharyngioma	Enrichment	ERCC2	1.04
294	Full schwannomatosis	Enrichment	SMARCB1	1.04
295	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	TET2	1.04
296	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.04
297	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	1.03
298	Cornelia de lange syndrome 1	Enrichment	KMT2A	0.98
299	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	SETD1A	0.98
300	Cornelia de lange syndrome	Enrichment	KMT2A	0.98
301	Capillary malformations, congenital	Enrichment	CCNH	0.95
302	Cockayne syndrome a	Enrichment	ERCC6	0.95
303	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	0.95
304	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C	0.95
305	Night blindness, congenital stationary, type 1c	Enrichment	ZNF454	0.95
306	Myeloproliferative neoplasm	Enrichment	DNMT3A	0.95
307	Glioblastoma	Enrichment	DNMT3A	0.95
308	Aggressive systemic mastocytosis	Enrichment	TET2	0.95
309	Rare syndromic intellectual disability	Enrichment	UBTF	0.95
310	Endometrial stromal sarcoma	Enrichment	SUZ12	0.95
311	Diaphragmatic hernia, congenital	Enrichment	CDK8	0.92
312	Acute promyelocytic leukemia	Enrichment	TBL1XR1	0.92
313	Diabetes mellitus	Enrichment	MEN1	0.90
314	Lung cancer susceptibility 3	Enrichment	RB1	0.89
315	Cockayne syndrome b	Enrichment	ERCC6	0.88
316	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	0.88
317	Melanoma, uveal	Enrichment	SF3B1	0.88
318	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	0.88
319	Facioscapulohumeral muscular dystrophy 1	Enrichment	DNMT3B	0.88
320	Waardenburg syndrome, type 4a	Enrichment	POLR2F	0.88
321	Wilms tumor 5	Enrichment	TRIM28	0.88
322	Hemangioma, capillary infantile	Enrichment	CCNH	0.88
323	Basal cell carcinoma 1	Enrichment	CCNH	0.88
324	Inguinal hernia	Enrichment	ACTL6A	0.88
325	Waardenburg syndrome	Enrichment	POLR2F	0.88
326	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	0.88
327	Male infertility with spermatogenesis disorder	Enrichment	KMT2D	0.86
328	Waardenburg syndrome, type 1	Enrichment	POLR2F	0.82
329	Myelofibrosis	Enrichment	TET2	0.82
330	Waardenburg syndrome, type 2e	Enrichment	POLR2F	0.82
331	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	0.82
332	Third-degree atrioventricular block	Enrichment	TET2	0.82
333	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	0.82
334	Essential thrombocythemia	Enrichment	TET2	0.82
335	Cockayne syndrome	Enrichment	ERCC6	0.82
336	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	0.82
337	Congenital hydrocephalus	Enrichment	SMARCC1	0.82
338	Dandy-walker syndrome	Enrichment	KMT2D	0.81
339	Cardiomyopathy, dilated, 1e	Enrichment	MED12	0.81
340	Syndromic intellectual disability	Enrichment	MED16	0.81
341	Heart, malformation of	Enrichment	CDK8	0.79
342	Lung cancer	Enrichment	ERCC6, KMT2D	0.77
343	Gastroesophageal reflux	Enrichment	ACTL6A	0.76
344	Ewing sarcoma	Enrichment	SMARCA5	0.76
345	Neuroblastoma	Enrichment	SMARCA4	0.76
346	Hypertension	Enrichment	MEN1	0.75
347	Cardiomyopathy, dilated, 1a	Enrichment	LPL	0.73
348	Inflammatory bowel disease 1	Enrichment	ERCC2	0.72
349	Arteriovenous malformation	Enrichment	CCNH	0.72
350	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	TET2	0.72
351	Ventricular septal defect	Enrichment	SMARCA4	0.72
352	Hypotrichosis simplex	Enrichment	ERCC2	0.72
353	Malaria	Enrichment	CD36	0.69
354	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	0.69
355	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	0.68
356	Polymicrogyria	Enrichment	EHMT1	0.68
357	Melanoma	Enrichment	DNMT3A	0.68
358	Ovarian cancer	Enrichment	ERCC2, ERCC3, RB1, SMARCB1	0.68
359	Scoliosis	Enrichment	CREBBP	0.67
360	Colorectal cancer	Enrichment	EP300, PPARG	0.67
361	Strabismus	Enrichment	KMT2D	0.63
362	Septooptic dysplasia	Enrichment	ARID1A	0.61
363	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	0.58
364	Stereotypic movement disorder	Enrichment	JARID2	0.58
365	Nk-cell enteropathy	Enrichment	SMARCB1	0.58
366	Congenital nervous system abnormality	Enrichment	CREBBP, KMT2D	0.55
367	Nervous system disease	Enrichment	CREBBP, KMT2D	0.55
368	Wilms tumor 1	Enrichment	TRIM28	0.52
369	Familial hypercholesterolemia	Enrichment	SMARCA4	0.52
370	Body mass index quantitative trait locus 11	Enrichment	DNMT3A, PPARG	0.49
371	Autosomal dominant non-syndromic intellectual disability	Enrichment	JARID2, SETD1B	0.49
372	Cleft palate, isolated	Enrichment	SMARCA4	0.48
373	Type 2 diabetes mellitus	Enrichment	PPARG	0.47
374	Dystonia	Enrichment	KMT2B	0.46
375	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MED12	0.45
376	Parkinson's disease	Enrichment	TBP	0.44
377	Dyskeratosis congenita	Enrichment	ZCCHC8	0.44
378	Williams-beuren syndrome	Enrichment	BAZ1B	0.42
379	Leukodystrophy	Enrichment	ERCC2	0.42
380	Epilepsy	Enrichment	SETD1B	0.41
381	Hepatoblastoma	Enrichment	ERCC2	0.41
382	Schizophrenia	Enrichment	EHMT1, SETD1A	0.40
383	Congenital stationary night blindness	Enrichment	ZNF454	0.38
384	Kallmann syndrome	Enrichment	POLR2F	0.38
385	Parkinson disease, late-onset	Enrichment	TBP	0.36
386	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.36
387	Autosomal recessive non-syndromic intellectual disability	Enrichment	MED23	0.36
388	Hydrops fetalis, nonimmune	Enrichment	ARID1A	0.34
389	Hereditary breast ovarian cancer syndrome	Enrichment	MEN1	0.31
390	Hirschsprung disease 1	Enrichment	POLR2F	0.30
391	Non-immune hydrops fetalis	Enrichment	ARID1A	0.28
392	Cerebral palsy	Enrichment	SMARCA4	0.22
393	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYO1C	0.15
394	Spastic ataxia	Enrichment	DNMT1	0.15
395	Familial isolated dilated cardiomyopathy	Enrichment	TAF1A	0.15
396	Rare genetic deafness	Enrichment	POLR2F	0.07
397	Leber plus disease	Enrichment	ZNF454	0.05
398	Hereditary retinal dystrophy	Enrichment	ZNF454	0.00
399	Fundus dystrophy	Enrichment	ZNF454	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Epigenetic regulation by WDR5-containing histone modifying complexes

Pathway Network for Epigenetic regulation by WDR5-containing histone modifying complexes

Pathway network for the Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

Member Pathways for Epigenetic regulation by WDR5-containing histone modifying complexes

Pathways in the Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

Gene overlap in member pathways for Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

Associated Genes for Epigenetic regulation by WDR5-containing histone modifying complexes

Associated Disorders for Epigenetic regulation by WDR5-containing histone modifying complexes

Disorders associated with Epigenetic regulation by WDR5-containing histone modifying complexes SuperPath

STRING Interaction Network for Epigenetic regulation by WDR5-containing histone modifying complexes

Sources for Epigenetic regulation by WDR5-containing histone modifying complexes