Epithelial to mesenchymal transition in colorectal cancer

No Pathway Network information available for Epithelial to mesenchymal transition in colorectal cancer

Pathways in the Epithelial to mesenchymal transition in colorectal cancer SuperPath

#	Name	Source	Genes
1	Epithelial to mesenchymal transition in colorectal cancer	WikiPathways	AKT1 AKT2 AKT3 CDH1 CDH2 CDKL2 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN24 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CRB3 CTDSP1 CTNNB1 DLK1 DLL1 DLL3 DLL4 DSP EED EIF5A2 EZH2 FMNL2 FN1 FOXC2 FOXM1 FOXQ1 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GDF15 GRB2 GSK3B HIF1A HRAS ID1 ID2 ITGA5 JAG1 JAG2 JUP KRAS LATS2 LRP5 LRP6 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MEF2D MIR9-2 MMP15 MMP2 MMP9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NR2C2 NRP2 NUBPL OCLN PAK1 PALS1 PDCD6 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKD1 PKP1 PKP2 PROX1 RAF1 RBBP4 RBPJ SHC1 SMAD2 SMAD3 SMAD4 SNAI1 SNAI2 SOS1 SOS2 SPARC STRAP SUZ12 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TJP1 TMPRSS4 TP53 TRAF6 TUSC3 TWIST1 TWIST2 VTN WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B ZEB1 ZEB2 (see all 161) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDH1	Cadherin 1	Protein Coding	1
2	ZEB2	Zinc Finger E-Box Binding Homeobox 2	Protein Coding	1
3	GDF15	Growth Differentiation Factor 15	Protein Coding	1
4	FOXQ1	Forkhead Box Q1	Protein Coding	1
5	CLDN9	Claudin 9	Protein Coding	1
6	CLDN1	Claudin 1	Protein Coding	1
7	CLDN2	Claudin 2	Protein Coding	1
8	CLDN8	Claudin 8	Protein Coding	1
9	CLDN10	Claudin 10	Protein Coding	1
10	CDKL2	Cyclin Dependent Kinase Like 2	Protein Coding	1
11	WNT3A	Wnt Family Member 3A	Protein Coding	1
12	NRP2	Neuropilin 2	Protein Coding	1
13	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
14	EED	Embryonic Ectoderm Development	Protein Coding	1
15	FZD8	Frizzled Class Receptor 8	Protein Coding	1
16	FZD6	Frizzled Class Receptor 6	Protein Coding	1
17	FZD4	Frizzled Class Receptor 4	Protein Coding	1
18	WNT5B	Wnt Family Member 5B	Protein Coding	1
19	WNT10A	Wnt Family Member 10A	Protein Coding	1
20	NUBPL	NUBP Iron-Sulfur Cluster Assembly Factor, Mitochondrial	Protein Coding	1
21	TUSC3	Tumor Suppressor Candidate 3	Protein Coding	1
22	WNT2B	Wnt Family Member 2B	Protein Coding	1
23	WNT11	Wnt Family Member 11	Protein Coding	1
24	WNT10B	Wnt Family Member 10B	Protein Coding	1
25	WNT8A	Wnt Family Member 8A	Protein Coding	1
26	WNT7A	Wnt Family Member 7A	Protein Coding	1
27	WNT5A	Wnt Family Member 5A	Protein Coding	1
28	WNT3	Wnt Family Member 3	Protein Coding	1
29	WNT2	Wnt Family Member 2	Protein Coding	1
30	WNT1	Wnt Family Member 1	Protein Coding	1
31	VTN	Vitronectin	Protein Coding	1
32	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
33	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
34	NR2C2	Nuclear Receptor Subfamily 2 Group C Member 2	Protein Coding	1
35	TP53	Tumor Protein P53	Protein Coding	1
36	CLDN5	Claudin 5	Protein Coding	1
37	TJP1	Tight Junction Protein 1	Protein Coding	1
38	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
39	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
40	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
41	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
42	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
43	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	1
44	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	1
45	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
46	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
47	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
48	SNAI2	Snail Family Transcriptional Repressor 2	Protein Coding	1
49	SHC1	SHC Adaptor Protein 1	Protein Coding	1
50	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
51	TMPRSS4	Transmembrane Serine Protease 4	Protein Coding	1
52	PROX1	Prospero Homeobox 1	Protein Coding	1
53	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
54	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
55	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
56	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
57	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
58	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
59	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
60	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
61	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
62	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
63	WNT4	Wnt Family Member 4	Protein Coding	1
64	PKP2	Plakophilin 2	Protein Coding	1
65	PKP1	Plakophilin 1	Protein Coding	1
66	PKD1	Polycystin 1, Transient Receptor Potential Channel Interacting	Protein Coding	1
67	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
68	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
69	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
70	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
71	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
72	CLDN18	Claudin 18	Protein Coding	1
73	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
74	CLDN11	Claudin 11	Protein Coding	1
75	NOTCH4	Notch Receptor 4	Protein Coding	1
76	NOTCH3	Notch Receptor 3	Protein Coding	1
77	NOTCH2	Notch Receptor 2	Protein Coding	1
78	NOTCH1	Notch Receptor 1	Protein Coding	1
79	MMP15	Matrix Metallopeptidase 15	Protein Coding	1
80	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
81	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
82	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
83	SMAD4	SMAD Family Member 4	Protein Coding	1
84	SMAD3	SMAD Family Member 3	Protein Coding	1
85	SMAD2	SMAD Family Member 2	Protein Coding	1
86	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
87	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
88	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
89	JUP	Junction Plakoglobin	Protein Coding	1
90	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
91	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
92	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
93	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
94	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
95	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
96	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
97	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
98	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
99	LATS2	Large Tumor Suppressor Kinase 2	Protein Coding	1
100	FZD2	Frizzled Class Receptor 2	Protein Coding	1
101	CLDN15	Claudin 15	Protein Coding	1
102	CLDN14	Claudin 14	Protein Coding	1
103	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
104	FN1	Fibronectin 1	Protein Coding	1
105	FOXM1	Forkhead Box M1	Protein Coding	1
106	FOXC2	Forkhead Box C2	Protein Coding	1
107	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
108	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
109	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
110	DSP	Desmoplakin	Protein Coding	1
111	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
112	CTNNB1	Catenin Beta 1	Protein Coding	1
113	CLDN19	Claudin 19	Protein Coding	1
114	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
115	CLDN7	Claudin 7	Protein Coding	1
116	CLDN3	Claudin 3	Protein Coding	1
117	CLDN4	Claudin 4	Protein Coding	1
118	COL4A6	Collagen Type IV Alpha 6 Chain	Protein Coding	1
119	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	1
120	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	1
121	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
122	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
123	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
124	TWIST2	Twist Family BHLH Transcription Factor 2	Protein Coding	1
125	FMNL2	Formin Like 2	Protein Coding	1
126	STRAP	Serine/Threonine Kinase Receptor Associated Protein	Protein Coding	1
127	CLDN16	Claudin 16	Protein Coding	1
128	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
129	OCLN	Occludin	Protein Coding	1
130	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
131	CDH2	Cadherin 2	Protein Coding	1
132	CRB3	Crumbs Cell Polarity Complex Component 3	Protein Coding	1
133	CLDN6	Claudin 6	Protein Coding	1
134	CLDN12	Claudin 12	Protein Coding	1
135	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
136	CLDN23	Claudin 23	Protein Coding	1
137	FZD10	Frizzled Class Receptor 10	Protein Coding	1
138	FZD9	Frizzled Class Receptor 9	Protein Coding	1
139	FZD7	Frizzled Class Receptor 7	Protein Coding	1
140	FZD1	Frizzled Class Receptor 1	Protein Coding	1
141	FZD3	Frizzled Class Receptor 3	Protein Coding	1
142	FZD5	Frizzled Class Receptor 5	Protein Coding	1
143	WNT9B	Wnt Family Member 9B	Protein Coding	1
144	WNT9A	Wnt Family Member 9A	Protein Coding	1
145	WNT8B	Wnt Family Member 8B	Protein Coding	1
146	WNT7B	Wnt Family Member 7B	Protein Coding	1
147	WNT6	Wnt Family Member 6	Protein Coding	1
148	PALS1	Protein Associated With LIN7 1, MAGUK P55 Family Member	Protein Coding	1
149	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
150	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
151	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
152	CTDSP1	CTD Small Phosphatase 1	Protein Coding	1
153	EIF5A2	Eukaryotic Translation Initiation Factor 5A2	Protein Coding	1
154	CLDN22	Claudin 22	Protein Coding	1
155	WNT16	Wnt Family Member 16	Protein Coding	1
156	CLDN20	Claudin 20	Protein Coding	1
157	MIR9-2	MicroRNA 9-2	RNA Gene	1
158	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
159	CLDN17	Claudin 17	Protein Coding	1
160	PDCD6	Programmed Cell Death 6	Protein Coding	1
161	CLDN24	Claudin 24	Protein Coding	1

Disorders associated with Epithelial to mesenchymal transition in colorectal cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	9.64
2	Gallbladder cancer	Enrichment	CTNNB1, KRAS, PIK3CA, SMAD4, TP53	8.34
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.21
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, RAF1, SOS1	7.93
5	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	7.80
6	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1, SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	7.39
7	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA, TP53	6.55
8	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2, DSP, JUP, PKP2, TGFB3	6.39
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	6.19
10	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	5.78
11	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2, PIK3CA	5.78
12	Digenic alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	5.78
13	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, PIK3CA	5.23
14	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.19
15	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.19
16	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.19
17	Colorectal cancer	Enrichment	AKT1, CDH1, CTNNB1, FZD3, PIK3CA, PIK3R1, SMAD4, TP53	5.06
18	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSP, JUP, PKP2, TGFB3	5.06
19	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSP, JUP, PKP2, TGFB3	5.06
20	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3, COL4A4, COL4A5	4.79
21	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	4.79
22	Autosomal dominant alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	4.79
23	Alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	4.79
24	Bladder cancer	Enrichment	CTNNB1, HRAS, KRAS, PIK3CA, TP53	4.68
25	Kidney disease	Enrichment	COL4A3, COL4A4, COL4A5, PKD1	4.63
26	Nevus, epidermal	Enrichment	HRAS, KRAS, PIK3CA	4.26
27	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.26
28	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	4.26
29	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1, ZEB2	4.06
30	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	4.06
31	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	3.88
32	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA, TP53	3.88
33	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.85
34	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1, CLDN16	3.85
35	Hypomagnesemia 5, renal, with or without ocular involvement	Enrichment	CLDN16, CLDN19	3.85
36	Renal hypomagnesemia 5 with ocular involvement	Enrichment	CLDN16, CLDN19	3.85
37	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	3.85
38	X-linked diffuse leiomyomatosis-alport syndrome	Enrichment	COL4A5, COL4A6	3.85
39	Gastric cancer	Enrichment	CDH1, KRAS, PIK3CA, SMAD4, TP53	3.83
40	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, KRAS, PIK3CA, TP53	3.78
41	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	3.73
42	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	3.73
43	Breast cancer	Enrichment	AKT1, CDH1, KRAS, PIK3CA, SHC1, TP53	3.58
44	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA, TP53	3.48
45	Hematuria, benign familial, 1	Enrichment	COL4A3, COL4A4	3.38
46	Weaver syndrome	Enrichment	EZH2, SUZ12	3.38
47	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	3.38
48	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.38
49	Epidermolysis bullosa, lethal acantholytic	Enrichment	DSP, JUP	3.38
50	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.38
51	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.38
52	Aortic valve disease 1	Enrichment	DSP, NOTCH1, SOS1	3.37
53	Chronic kidney disease	Enrichment	COL4A4, COL4A5, WNT9B	3.37
54	Non-immune hydrops fetalis	Enrichment	FOXC2, FZD6, HRAS, KRAS	3.33
55	Lynch syndrome	Enrichment	KRAS, PIK3CA, TGFBR2	3.17
56	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSP, JUP, PKP2	3.09
57	Hypertension	Enrichment	COL4A4, COL4A5, PKD1	3.09
58	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	3.08
59	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS	3.08
60	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, KRAS	3.08
61	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3, COL4A4	3.08
62	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2, WNT5A	3.08
63	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.08
64	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	3.08
65	Retinopathy of prematurity	Enrichment	FZD4, LRP5	3.08
66	Cerebrovascular disease	Enrichment	NOTCH3, PIK3CA	3.08
67	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.08
68	Autosomal dominant robinow syndrome	Enrichment	FZD2, WNT5A	3.08
69	Autosomal recessive alport syndrome	Enrichment	COL4A3, COL4A4	3.08
70	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	3.01
71	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	3.01
72	Ovarian cancer	Enrichment	AKT1, CDH1, CTNNB1, KRAS, PIK3CA, TP53	2.89
73	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	PKP2, TGFB3	2.86
74	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2, WNT5A	2.86
75	Arrhythmogenic right ventricular dysplasia 1	Enrichment	PKP2, TGFB3	2.86
76	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	2.86
77	Familial porencephaly	Enrichment	COL4A1, COL4A2	2.86
78	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	2.86
79	Nephrotic syndrome	Enrichment	COL4A3, COL4A4, COL4A5, FN1	2.78
80	Hepatoblastoma	Enrichment	CTNNB1, JAG1, TP53	2.73
81	Renal dysplasia, cystic	Enrichment	PKD1, WNT9B	2.69
82	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	2.69
83	Autosomal recessive robinow syndrome	Enrichment	FZD2, WNT5A	2.69
84	Adrenocortical carcinoma	Enrichment	CTNNB1, TP53	2.69
85	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	2.69
86	Inherited arrhythmogenic cardiomyopathy	Enrichment	DSP, PKP2	2.69
87	Multicystic kidney dysplasia	Enrichment	FZD3, PKD1	2.69
88	Multicystic dysplastic kidney	Enrichment	FZD3, PKD1	2.69
89	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA, TP53	2.67
90	Tooth agenesis	Enrichment	LRP6, WNT10A, WNT10B	2.67
91	Esophageal cancer	Enrichment	TGFBR2, TP53	2.55
92	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.55
93	Megacolon	Enrichment	AKT3, ZEB2	2.55
94	Pancreatic cancer	Enrichment	KRAS, SMAD4, TP53	2.51
95	Hydrops fetalis, nonimmune	Enrichment	FOXC2, FZD6, HRAS	2.46
96	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSP, PKP2	2.32
97	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.32
98	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSP, PKP2	2.32
99	Prostate cancer	Enrichment	CDH1, PIK3CA, TP53	2.32
100	Nephrocalcinosis	Enrichment	CLDN16, CLDN19	2.23
101	Nephrolithiasis	Enrichment	CLDN16, CLDN19	2.23
102	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.23
103	Connective tissue disease	Enrichment	NOTCH1, SMAD3, TGFBR2	2.20
104	Left ventricular noncompaction	Enrichment	DSP, PKP2, RAF1	2.09
105	Meningioma	Enrichment	AKT1, PIK3CA	2.07
106	Osteogenesis imperfecta, type iv	Enrichment	SPARC, WNT1	2.00
107	Cerebral palsy	Enrichment	COL4A1, COL4A2, PALS1	1.96
108	Osteoporosis	Enrichment	LRP5, WNT1	1.94
109	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1, SMAD3	1.94
110	Lung cancer susceptibility 3	Enrichment	KRAS, TP53	1.94
111	Macrodactyly	Enrichment	PIK3CA	1.93
112	Proteus syndrome	Enrichment	AKT1	1.93
113	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	1.93
114	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	1.93
115	Barber-say syndrome	Enrichment	TWIST2	1.93
116	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	1.93
117	Hypomagnesemia 3, renal	Enrichment	CLDN16	1.93
118	Pseudo-torch syndrome 1	Enrichment	OCLN	1.93
119	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.93
120	Oculoectodermal syndrome	Enrichment	KRAS	1.93
121	Alport syndrome 1, x-linked	Enrichment	COL4A5	1.93
122	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	1.93
123	Exudative vitreoretinopathy 4	Enrichment	LRP5	1.93
124	Ectodermal dysplasia/skin fragility syndrome	Enrichment	PKP1	1.93
125	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	1.93
126	Noonan syndrome 5	Enrichment	RAF1	1.93
127	Noonan syndrome 4	Enrichment	SOS1	1.93
128	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	1.93
129	Intellectual developmental disorder, autosomal recessive 7	Enrichment	TUSC3	1.93
130	Melorheostosis, isolated	Enrichment	MAP2K1	1.93
131	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.93
132	Omodysplasia 2	Enrichment	FZD2	1.93
133	Focal facial dermal dysplasia 2, brauer-setleis type	Enrichment	TWIST2	1.93
134	Hajdu-cheney syndrome	Enrichment	NOTCH2	1.93
135	Alagille syndrome 2	Enrichment	NOTCH2	1.93
136	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.93
137	Lateral meningocele syndrome	Enrichment	NOTCH3	1.93
138	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.93
139	Cowden syndrome 5	Enrichment	PIK3CA	1.93
140	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.93
141	Split-hand/foot malformation 6	Enrichment	WNT10B	1.93
142	Focal facial dermal dysplasia 3, setleis type	Enrichment	TWIST2	1.93
143	Tooth agenesis, selective, 7	Enrichment	LRP6	1.93
144	Noonan syndrome 9	Enrichment	SOS2	1.93
145	Tooth agenesis, selective, 8	Enrichment	WNT10B	1.93
146	Ablepharon-macrostomia syndrome	Enrichment	TWIST2	1.93
147	Exudative vitreoretinopathy 8	Enrichment	LRP6	1.93
148	Naxos disease	Enrichment	JUP	1.93
149	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.93
150	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	1.93
151	Noonan syndrome 13	Enrichment	MAPK1	1.93
152	Helix syndrome	Enrichment	CLDN10	1.93
153	Adams-oliver syndrome 6	Enrichment	DLL4	1.93
154	Deafness, x-linked 6	Enrichment	COL4A6	1.93
155	Hyperemesis gravidarum	Enrichment	GDF15	1.93
156	Short syndrome	Enrichment	PIK3R1	1.93
157	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.93
158	Bone marrow failure syndrome 5	Enrichment	TP53	1.93
159	Deafness, autosomal recessive 116	Enrichment	CLDN9	1.93
160	Azoospermia, obstructive, with nephrolithiasis	Enrichment	CLDN2	1.93
161	Diarrhea 9	Enrichment	WNT2B	1.93
162	Papilloma of choroid plexus	Enrichment	TP53	1.93
163	Basal cell carcinoma 7	Enrichment	TP53	1.93
164	Porencephaly	Enrichment	COL4A1	1.93
165	Imagawa-matsumoto syndrome	Enrichment	SUZ12	1.93
166	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	1.93
167	Anaplastic thyroid carcinoma	Enrichment	TP53	1.93
168	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	1.93
169	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	1.93
170	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	1.93
171	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.93
172	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.93
173	Camurati-engelmann disease 2	Enrichment	TGFB2	1.93
174	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.93
175	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.93
176	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	1.93
177	Santos syndrome	Enrichment	WNT7A	1.93
178	Melorheostosis	Enrichment	MAP2K1	1.93
179	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.93
180	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	1.93
181	Leopard syndrome 2	Enrichment	RAF1	1.93
182	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.93
183	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.93
184	Cowden syndrome 6	Enrichment	AKT1	1.93
185	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	1.93
186	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	1.93
187	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.93
188	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.93
189	Microphthalmia/coloboma 11	Enrichment	FZD5	1.93
190	Ductal carcinoma in situ	Enrichment	TP53	1.93
191	Loeys-dietz syndrome 5	Enrichment	TGFB3	1.93
192	Cohen-gibson syndrome	Enrichment	EED	1.93
193	Leukodystrophy, hypomyelinating, 22	Enrichment	CLDN11	1.93
194	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	1.93
195	Mitochondrial complex i deficiency, nuclear type 21	Enrichment	NUBPL	1.93
196	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	1.93
197	Primary hypomagnesemia	Enrichment	CLDN16	1.93
198	Trigonitis	Enrichment	RAF1	1.93
199	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.93
200	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.93
201	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.93
202	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.93
203	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	1.93
204	Adenoid ameloblastoma	Enrichment	CTNNB1	1.93
205	Heritable thoracic aortic disease	Enrichment	SMAD4	1.93
206	Col4a1-related disorders	Enrichment	COL4A1	1.93
207	Autosomal recessive cerebral atrophy	Enrichment	TMPRSS4	1.93
208	Skin fragility-woolly hair-palmoplantar keratoderma syndrome	Enrichment	DSP	1.93
209	Hypospadias	Enrichment	PIK3CA	1.93
210	Lrp5-related primary osteoporosis	Enrichment	LRP5	1.93
211	Capillary hemangioma	Enrichment	AKT3	1.93
212	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.93
213	Transient cerebral ischemia	Enrichment	NOTCH3	1.93
214	Breast lobular carcinoma	Enrichment	CDH1	1.93
215	Congenital pulmonary airway malformation	Enrichment	KRAS	1.93
216	Choroid plexus cancer	Enrichment	TP53	1.93
217	Rare venous malformation	Enrichment	PIK3CA	1.93
218	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	1.93
219	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	1.93
220	Diaphragmatic eventration	Enrichment	PIK3CA	1.93
221	Renovascular hypertension	Enrichment	PKD1	1.93
222	X-linked alport syndrome	Enrichment	COL4A5	1.93
223	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.93
224	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.93
225	Rare combined vascular malformation	Enrichment	PIK3CA	1.93
226	Cavernous lymphangioma	Enrichment	PIK3CA	1.93
227	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.93
228	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	1.93
229	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.93
230	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.93
231	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.93
232	Macrodactyly of toe	Enrichment	PIK3CA	1.93
233	Microcystic stromal tumor	Enrichment	CTNNB1	1.93
234	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.93
235	Corpus callosum, agenesis of	Enrichment	CDH2, COL4A1	1.88
236	Isolated corpus callosum agenesis	Enrichment	CDH2, COL4A1	1.88
237	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2, COL4A1	1.88
238	Rhabdomyosarcoma	Enrichment	HRAS, TP53	1.82
239	Heart, malformation of	Enrichment	JAG1, MAPK1	1.72
240	Polycystic kidney disease	Enrichment	COL4A4, PKD1	1.72
241	Inherited cancer-predisposing syndrome	Enrichment	CDH1, EZH2, PKD1, SMAD4, TP53	1.69
242	Arteriovenous malformations of the brain	Enrichment	CDH2, KRAS	1.68
243	Focal segmental glomerulosclerosis	Enrichment	COL4A4, COL4A5	1.64
244	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.63
245	Fibromatosis, gingival, 1	Enrichment	SOS1	1.63
246	Myhre syndrome	Enrichment	SMAD4	1.63
247	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.63
248	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.63
249	Camurati-engelmann disease 1	Enrichment	TGFB1	1.63
250	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.63
251	Costello syndrome	Enrichment	HRAS	1.63
252	Van buchem disease	Enrichment	LRP5	1.63
253	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.63
254	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.63
255	Robinow-sorauf syndrome	Enrichment	TWIST1	1.63
256	Mowat-wilson syndrome	Enrichment	ZEB2	1.63
257	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.63
258	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.63
259	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.63
260	Arrhythmogenic right ventricular dysplasia, familial, 8	Enrichment	DSP	1.63
261	Cervical cancer	Enrichment	TP53	1.63
262	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.63
263	Pulmonic stenosis	Enrichment	SOS1	1.63
264	Tetraamelia syndrome 1	Enrichment	WNT3	1.63
265	Piebald trait	Enrichment	SNAI2	1.63
266	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.63
267	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.63
268	Lymphedema-distichiasis syndrome	Enrichment	FOXC2	1.63
269	Keratosis, seborrheic	Enrichment	PIK3CA	1.63
270	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.63
271	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.63
272	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	1.63
273	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.63
274	Adams-oliver syndrome 5	Enrichment	NOTCH1	1.63
275	Specific language impairment 5	Enrichment	COL4A4	1.63
276	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.63
277	Noonan syndrome 8	Enrichment	PIK3CA	1.63
278	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.63
279	Lymphoma, hodgkin, classic	Enrichment	TP53	1.63
280	Keratosis palmoplantaris striata ii	Enrichment	DSP	1.63
281	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.63
282	Adams-oliver syndrome 3	Enrichment	RBPJ	1.63
283	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	1.63
284	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	Enrichment	DSP	1.63
285	Sweeney-cox syndrome	Enrichment	TWIST1	1.63
286	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	1.63
287	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.63
288	Infantile myofibromatosis	Enrichment	NOTCH3	1.63
289	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.63
290	Senior-loken syndrome 7	Enrichment	AKT3	1.63
291	Progressive familial heart block	Enrichment	DSP	1.63
292	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.63
293	Central precocious puberty	Enrichment	DLK1	1.63
294	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	1.63
295	Osteogenesis imperfecta, type xvii	Enrichment	SPARC	1.63
296	Depressive disorder	Enrichment	NOTCH3	1.63
297	Camurati-engelmann disease	Enrichment	TGFB1	1.63
298	Congenital fibrosarcoma	Enrichment	TP53	1.63
299	Glomerulonephritis	Enrichment	COL4A4	1.63
300	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.63
301	Li-fraumeni syndrome 1	Enrichment	TP53	1.63
302	Cardiomyopathy, dilated, with woolly hair and keratoderma	Enrichment	DSP	1.63
303	Sarcoma	Enrichment	TP53	1.63
304	Deafness, autosomal recessive 29	Enrichment	CLDN14	1.63
305	Intellectual developmental disorder, autosomal recessive 24	Enrichment	TUSC3	1.63
306	Cervix carcinoma	Enrichment	TP53	1.63
307	Immune system disease	Enrichment	PIK3CD	1.63
308	Hodgkin's lymphoma	Enrichment	TP53	1.63
309	Bardet-biedl syndrome 16	Enrichment	AKT3	1.63
310	Polycystic kidney disease 3	Enrichment	PKD1	1.63
311	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.63
312	Metaphyseal anadysplasia	Enrichment	MMP9	1.63
313	Crohn's disease	Enrichment	FMNL2	1.63
314	Teratoma	Enrichment	CTNNB1	1.63
315	Osteosclerosis	Enrichment	LRP5	1.63
316	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	1.63
317	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.63
318	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.63
319	Tafro syndrome	Enrichment	MAP2K2	1.63
320	Malignant peritoneal mesothelioma	Enrichment	LATS2	1.63
321	Wooly hair nevus	Enrichment	HRAS	1.63
322	Endometrial cancer	Enrichment	CDH1, PIK3CA	1.60
323	Myeloma, multiple	Enrichment	KRAS, PIK3R2, TP53	1.54
324	Brittle bone disorder	Enrichment	LRP5, WNT1	1.52
325	Desmoid disease, hereditary	Enrichment	CTNNB1	1.45
326	Craniosynostosis 1	Enrichment	TWIST1	1.45
327	Retinal arteries, tortuosity of	Enrichment	COL4A1	1.45
328	Alagille syndrome 1	Enrichment	JAG1	1.45
329	Juvenile polyposis syndrome	Enrichment	SMAD4	1.45
330	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.45
331	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.45
332	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.45
333	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	PKD1	1.45
334	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.45
335	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	1.45
336	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.45
337	Nuchal bleb, familial	Enrichment	SOS1	1.45
338	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.45
339	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.45
340	Osteogenic sarcoma	Enrichment	TP53	1.45
341	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	1.45
342	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	1.45
343	Nasopharyngeal carcinoma	Enrichment	TP53	1.45
344	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.45
345	Tuberous sclerosis 2	Enrichment	PKD1	1.45
346	Brain small vessel disease 2	Enrichment	COL4A2	1.45
347	Thrombocytopenia 5	Enrichment	CLDN16	1.45
348	Anus, imperforate	Enrichment	CTNNB1	1.45
349	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	1.45
350	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSP	1.45
351	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.45
352	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	1.45
353	Woolly hair-skin fragility syndrome	Enrichment	DSP	1.45
354	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	1.45
355	Large congenital melanocytic nevus	Enrichment	HRAS	1.45
356	Desmoid tumor	Enrichment	CTNNB1	1.45
357	Keratosis palmoplantaris striata	Enrichment	DSP	1.45
358	Precocious puberty, central, 2	Enrichment	DLK1	1.45
359	Nail disease	Enrichment	FZD6	1.45
360	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	1.45
361	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.45
362	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	1.45
363	Anaplastic astrocytoma	Enrichment	TP53	1.45
364	Squamous cell carcinoma	Enrichment	TP53	1.45
365	Adenocarcinoma	Enrichment	TP53	1.45
366	Intraocular pressure quantitative trait locus	Enrichment	ZEB1	1.45
367	Migraine without aura	Enrichment	NOTCH3	1.45
368	Hematuria, benign familial, 2	Enrichment	COL4A3	1.45
369	End stage renal disease	Enrichment	PKD1	1.45
370	Bone osteosarcoma	Enrichment	TP53	1.45
371	Spermatocytoma	Enrichment	HRAS	1.45
372	Arachnoid cyst	Enrichment	PALS1	1.45
373	Tetraamelia syndrome	Enrichment	WNT3	1.45
374	Enchondromatosis	Enrichment	HIF1A	1.45
375	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	1.42
376	Auditory neuropathy	Enrichment	CDH2, NOTCH3	1.42
377	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS	1.34
378	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.33
379	Small cell cancer of the lung	Enrichment	TP53	1.33
380	Schizencephaly	Enrichment	COL4A1	1.33
381	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.33
382	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.33
383	Kagami-ogata syndrome	Enrichment	DLK1	1.33
384	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.33
385	Saethre-chotzen syndrome	Enrichment	TWIST1	1.33
386	Pilomatrixoma	Enrichment	CTNNB1	1.33
387	Temple syndrome	Enrichment	DLK1	1.33
388	Alazami syndrome	Enrichment	CTNNB1	1.33
389	Orofacial cleft	Enrichment	LRP6	1.33
390	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.33
391	Ectodermal dysplasia	Enrichment	WNT10A	1.33
392	Tuberous sclerosis	Enrichment	PKD1	1.33
393	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.33
394	Craniopharyngioma	Enrichment	CTNNB1	1.33
395	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.33
396	Pilocytic astrocytoma	Enrichment	KRAS	1.33
397	Corneal dystrophy	Enrichment	ZEB1	1.33
398	Epidermolytic nevus	Enrichment	HRAS	1.33
399	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.33
400	Eyelid coloboma	Enrichment	FZD5	1.33
401	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	1.33
402	Genetic central precocious puberty in male	Enrichment	DLK1	1.33
403	Vitreoretinopathy	Enrichment	LRP5	1.33
404	Orofacial clefting syndrome	Enrichment	LRP6	1.33
405	Middle aortic syndrome	Enrichment	JAG1	1.33
406	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	COL4A6	1.33
407	Gingival fibromatosis	Enrichment	SOS1	1.33
408	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.33
409	Lens coloboma	Enrichment	FZD5	1.33
410	Long qt syndrome 1	Enrichment	DSP, PKP2	1.31
411	Lung cancer	Enrichment	KRAS, PIK3CA	1.26
412	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.24
413	Capillary malformations, congenital	Enrichment	PIK3CA	1.24
414	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.24
415	Polycystic liver disease 1 with or without kidney cysts	Enrichment	PKD1	1.24
416	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.24
417	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	PKD1	1.24
418	Norrie disease	Enrichment	FZD4	1.24
419	Rhabdomyosarcoma 2	Enrichment	TP53	1.24
420	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.24
421	Fuchs' endothelial dystrophy	Enrichment	ZEB1	1.24
422	Lymphoma	Enrichment	TP53	1.24
423	Cardiac arrest	Enrichment	DSP	1.24
424	Polycystic liver disease 1	Enrichment	PKD1	1.24
425	Hemangioma	Enrichment	PKD1	1.24
426	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.24
427	Aplasia cutis congenita	Enrichment	DLL4	1.24
428	Vascular dementia	Enrichment	NOTCH3	1.24
429	Acute megakaryocytic leukemia	Enrichment	TP53	1.24
430	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.24
431	Coloboma of choroid and retina	Enrichment	FZD5	1.24
432	Endometrial stromal sarcoma	Enrichment	SUZ12	1.24
433	Mitochondrial oxidative phosphorylation disorder	Enrichment	NUBPL	1.24
434	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.24
435	Atrial septal defect 1	Enrichment	TGFB2	1.16
436	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.16
437	Li-fraumeni syndrome	Enrichment	TP53	1.16
438	Coloboma of optic nerve	Enrichment	FZD5	1.16
439	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	1.16
440	Cowden syndrome 1	Enrichment	PIK3CA	1.16
441	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.16
442	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.16
443	Anxiety	Enrichment	PALS1	1.16
444	Anterior segment dysgenesis 5	Enrichment	COL4A1	1.16
445	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.16
446	Renal hypoplasia	Enrichment	WNT9B	1.16
447	Keratoconus	Enrichment	COL4A1	1.16
448	Diarrhea	Enrichment	WNT2B	1.16
449	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.16
450	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.16
451	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3	1.16
452	Cleft lip with or without cleft palate	Enrichment	CDH1	1.16
453	Dilated cardiomyopathy	Enrichment	DSP, JUP, RAF1	1.16
454	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	PKD1	1.10
455	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.10
456	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.10
457	Coats disease	Enrichment	FZD4	1.10
458	Waardenburg syndrome, type 2e	Enrichment	SNAI2	1.10
459	Leukemia, chronic myeloid	Enrichment	KRAS	1.10
460	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.10
461	Polycystic kidney disease 1	Enrichment	PKD1	1.10
462	Essential thrombocythemia	Enrichment	TP53	1.10
463	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.10
464	Follicular thyroid carcinoma	Enrichment	HRAS	1.10
465	Overgrowth syndrome	Enrichment	PIK3R1	1.10
466	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.10
467	Leukemia, acute myeloid	Enrichment	KRAS, TP53	1.09
468	Type 2 diabetes mellitus	Enrichment	AKT2, RBPJ	1.05
469	Glioma susceptibility 1	Enrichment	TP53	1.04
470	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	1.04
471	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.04
472	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	PKD1	1.04
473	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.04
474	Perrault syndrome	Enrichment	CLDN14	1.04
475	Myocarditis	Enrichment	DSP	1.04
476	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.04
477	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.04
478	Inflammatory bowel disease 1	Enrichment	FMNL2	0.99
479	Cystic kidney disease	Enrichment	PKD1	0.99
480	Primary hyperaldosteronism	Enrichment	TP53	0.99
481	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	0.99
482	Renal agenesis, bilateral	Enrichment	WNT9B	0.99
483	Cat eye syndrome	Enrichment	FZD5	0.95
484	Leukemia, chronic lymphocytic	Enrichment	TP53	0.95
485	Peters-plus syndrome	Enrichment	COL4A1	0.95
486	Stroke, ischemic	Enrichment	NOTCH3	0.95
487	Polymicrogyria	Enrichment	AKT3	0.95
488	Familial colorectal cancer	Enrichment	TP53	0.95
489	Migraine with or without aura 1	Enrichment	NOTCH3	0.91
490	Pectus excavatum	Enrichment	TGFBR1	0.91
491	Myelodysplastic syndrome	Enrichment	TP53	0.91
492	Specific learning disability	Enrichment	MAPK1	0.91
493	Familial isolated dilated cardiomyopathy	Enrichment	DSP, RAF1	0.88
494	Congenital nervous system abnormality	Enrichment	CTNNB1, TUSC3, ZEB2	0.88
495	Nervous system disease	Enrichment	CTNNB1, TUSC3, ZEB2	0.88
496	Cardiac conduction defect	Enrichment	DSP	0.87
497	Juvenile myelomonocytic leukemia	Enrichment	KRAS	0.87
498	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, TP53	0.86
499	Microphthalmia/coloboma 12	Enrichment	FZD5	0.84
500	Nk-cell enteropathy	Enrichment	PIK3CB	0.84
501	Medulloblastoma	Enrichment	CTNNB1	0.81
502	Walker-warburg syndrome	Enrichment	COL4A1	0.81
503	Cleft lip/palate	Enrichment	CDH1	0.81
504	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.81
505	Isolated macular dystrophy	Enrichment	COL4A5	0.81
506	Coloboma of macula	Enrichment	FZD5	0.79
507	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.79
508	Hydrocephalus	Enrichment	FZD3	0.79
509	Myopia	Enrichment	COL4A4	0.79
510	Anterior segment dysgenesis	Enrichment	COL4A1	0.79
511	Atypical hemolytic-uremic syndrome	Enrichment	COL4A5	0.79
512	Autosomal dominant polycystic kidney disease	Enrichment	PKD1	0.79
513	Septopreoptic holoprosencephaly	Enrichment	DLL1	0.79
514	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	0.79
515	Creatine phosphokinase, elevated serum	Enrichment	PKD1	0.76
516	Wolff-parkinson-white syndrome	Enrichment	JUP	0.76
517	Isolated elevated serum creatine phosphokinase levels	Enrichment	PKD1	0.76
518	Gliosarcoma	Enrichment	TP53	0.76
519	Isolated congenital microcephaly	Enrichment	OCLN	0.76
520	Microform holoprosencephaly	Enrichment	DLL1	0.76
521	Lobar holoprosencephaly	Enrichment	DLL1	0.76
522	Microcephaly	Enrichment	COL4A1, CTNNB1, MAPK1	0.75
523	Interstitial lung disease 2	Enrichment	DSP	0.74
524	Cardiomyopathy, dilated, 1e	Enrichment	PKP2	0.74
525	Giant cell glioblastoma	Enrichment	TP53	0.74
526	Alobar holoprosencephaly	Enrichment	DLL1	0.74
527	Semilobar holoprosencephaly	Enrichment	DLL1	0.71
528	Diffuse large b-cell lymphoma	Enrichment	TP53	0.69
529	Macs syndrome	Enrichment	WNT7B	0.67
530	Cardiomyopathy, dilated, 1a	Enrichment	DSP	0.65
531	Cardiomyopathy, dilated, 1g	Enrichment	DSP	0.64
532	Microphthalmia	Enrichment	WNT7B	0.64
533	Diamond-blackfan anemia 1	Enrichment	TP53	0.62
534	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.60
535	Brugada syndrome	Enrichment	PKP2	0.57
536	Long qt syndrome	Enrichment	DSP	0.51
537	Cystic fibrosis	Enrichment	TGFB1	0.50
538	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.49
539	Male infertility	Enrichment	CLDN2	0.48
540	Cakut	Enrichment	COL4A1	0.48
541	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3	0.48
542	Diamond-blackfan anemia	Enrichment	TP53	0.46
543	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NUBPL	0.44
544	Autism spectrum disorder	Enrichment	EED, MAP2K1	0.43
545	Distal arthrogryposis	Enrichment	FZD3	0.40
546	Hypertrophic cardiomyopathy	Enrichment	PKP2	0.40
547	Sensorineural hearing loss	Enrichment	CLDN14	0.36
548	Thrombocytopenia	Enrichment	SMAD4	0.36
549	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.35
550	Hypertelorism	Enrichment	PIK3CA	0.33
551	Autosomal recessive non-syndromic intellectual disability	Enrichment	TUSC3	0.30
552	Primary ovarian insufficiency	Enrichment	NOTCH2	0.30
553	Deafness, autosomal recessive	Enrichment	CLDN14	0.28
554	Autosomal recessive nonsyndromic deafness	Enrichment	CLDN14	0.27
555	Rare genetic deafness	Enrichment	COL4A5	0.21
556	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CLDN14	0.18
557	Hereditary retinal dystrophy	Enrichment	FZD4, JAG1, LRP5	0.17
558	Fundus dystrophy	Enrichment	FZD4, JAG1, LRP5	0.17
559	Complex neurodevelopmental disorder	Enrichment	PALS1	0.11

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Epithelial to mesenchymal transition in colorectal cancer

Pathway Network for Epithelial to mesenchymal transition in colorectal cancer

Member Pathways for Epithelial to mesenchymal transition in colorectal cancer

Pathways in the Epithelial to mesenchymal transition in colorectal cancer SuperPath

Associated Genes for Epithelial to mesenchymal transition in colorectal cancer

Associated Disorders for Epithelial to mesenchymal transition in colorectal cancer

Disorders associated with Epithelial to mesenchymal transition in colorectal cancer SuperPath

STRING Interaction Network for Epithelial to mesenchymal transition in colorectal cancer

Sources for Epithelial to mesenchymal transition in colorectal cancer