ErbB2/ErbB3 signaling events

No Pathway Network information available for ErbB2/ErbB3 signaling events

Pathways in the ErbB2/ErbB3 signaling events SuperPath

#	Name	Source	Genes
1	ErbB2/ErbB3 signaling events	PubChem	AKT1 BAD CHRNA1 CHRNE DOCK7 ERBB2 ERBB3 FOS GRB2 JAK2 JUN MAP2K1 MAPK3 MAPK8 MTOR NF2 NFATC4 NRG1 NRG2 PIK3CA PIK3CB PIK3R1 PPP3CB PRKACA PTPN11 RAF1 RNF41 SHC1 SOS1 SRC STAT3 USP8 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DOCK7	Dedicator Of Cytokinesis 7	Protein Coding	1
2	NRG1	Neuregulin 1	Protein Coding	1
3	NRG2	Neuregulin 2	Protein Coding	1
4	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
5	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
6	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	1
7	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
8	RNF41	Ring Finger Protein 41	Protein Coding	1
9	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1
10	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
11	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
13	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
14	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
15	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
16	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
17	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
18	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
19	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
20	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
21	JAK2	Janus Kinase 2	Protein Coding	1
22	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
23	CHRNA1	Cholinergic Receptor Nicotinic Alpha 1 Subunit	Protein Coding	1
24	CHRNE	Cholinergic Receptor Nicotinic Epsilon Subunit	Protein Coding	1
25	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
26	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
27	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
28	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
29	SHC1	SHC Adaptor Protein 1	Protein Coding	1
30	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
31	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
32	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1

Disorders associated with ErbB2/ErbB3 signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	7.47
2	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.66
3	Rasopathy	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.43
4	Noonan syndrome 3	Enrichment	PTPN11, RAF1, SOS1	6.38
5	Colorectal cancer	Enrichment	AKT1, ERBB2, PIK3CA, PIK3R1, SRC	5.77
6	Lung non-small cell carcinoma	Enrichment	ERBB2, MAP2K1, PIK3CA	5.71
7	Meningioma	Enrichment	AKT1, NF2, PIK3CA	5.59
8	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.79
9	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.79
10	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, SHC1	4.56
11	Myasthenic syndrome, congenital, 1b, fast-channel	Enrichment	CHRNA1, CHRNE	4.49
12	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.49
13	Bladder cancer	Enrichment	ERBB2, ERBB3, PIK3CA	4.38
14	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	4.27
15	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.09
16	Myelofibrosis	Enrichment	JAK2, SRC	3.95
17	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	CHRNA1, CHRNE	3.95
18	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.95
19	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.95
20	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.72
21	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.72
22	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.62
23	Postsynaptic congenital myasthenic syndromes	Enrichment	CHRNA1, CHRNE	3.46
24	Congenital myasthenic syndrome	Enrichment	CHRNA1, CHRNE	3.32
25	Hydrops fetalis, nonimmune	Enrichment	CHRNA1, PTPN11	2.77
26	Ovarian cancer	Enrichment	AKT1, ERBB2, PIK3CA	2.77
27	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3	2.68
28	Erythroleukemia, familial	Enrichment	ERBB3	2.63
29	Macrodactyly	Enrichment	PIK3CA	2.63
30	Proteus syndrome	Enrichment	AKT1	2.63
31	Paget disease, extramammary	Enrichment	ERBB2	2.63
32	Metachondromatosis	Enrichment	PTPN11	2.63
33	Noonan syndrome 5	Enrichment	RAF1	2.63
34	Noonan syndrome 4	Enrichment	SOS1	2.63
35	Melorheostosis, isolated	Enrichment	MAP2K1	2.63
36	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.63
37	Schwannomatosis, vestibular	Enrichment	NF2	2.63
38	Leopard syndrome 1	Enrichment	PTPN11	2.63
39	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.63
40	Cowden syndrome 5	Enrichment	PIK3CA	2.63
41	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.63
42	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.63
43	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.63
44	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.63
45	Short syndrome	Enrichment	PIK3R1	2.63
46	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.63
47	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.63
48	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.63
49	Melorheostosis	Enrichment	MAP2K1	2.63
50	Leopard syndrome 2	Enrichment	RAF1	2.63
51	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.63
52	Cowden syndrome 6	Enrichment	AKT1	2.63
53	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.63
54	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.63
55	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.63
56	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.63
57	Thrombocytopenia 6	Enrichment	SRC	2.63
58	Trigonitis	Enrichment	RAF1	2.63
59	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.63
60	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	2.63
61	Hypospadias	Enrichment	PIK3CA	2.63
62	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.63
63	Rare venous malformation	Enrichment	PIK3CA	2.63
64	Diaphragmatic eventration	Enrichment	PIK3CA	2.63
65	Acoustic neuroma	Enrichment	NF2	2.63
66	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.63
67	Rare combined vascular malformation	Enrichment	PIK3CA	2.63
68	Cavernous lymphangioma	Enrichment	PIK3CA	2.63
69	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.63
70	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.63
71	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.63
72	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.63
73	Macrodactyly of toe	Enrichment	PIK3CA	2.63
74	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.63
75	Malignant astrocytoma	Enrichment	PTPN11	2.63
76	Non-immune hydrops fetalis	Enrichment	CHRNA1, PTPN11	2.62
77	Lung cancer	Enrichment	ERBB2, PIK3CA	2.59
78	Gastric cancer	Enrichment	ERBB2, PIK3CA	2.34
79	Fibromatosis, gingival, 1	Enrichment	SOS1	2.33
80	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	2.33
81	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.33
82	Pulmonic stenosis	Enrichment	SOS1	2.33
83	Schwannomatosis 1	Enrichment	NF2	2.33
84	Keratosis, seborrheic	Enrichment	PIK3CA	2.33
85	Noonan syndrome 8	Enrichment	PIK3CA	2.33
86	Thrombocythemia 3	Enrichment	JAK2	2.33
87	Werner syndrome	Enrichment	PTPN11	2.33
88	Cebalid syndrome	Enrichment	MTOR	2.33
89	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.33
90	Hypobetalipoproteinemia, familial, 2	Enrichment	DOCK7	2.33
91	Fibrolamellar carcinoma	Enrichment	PRKACA	2.33
92	Developmental and epileptic encephalopathy 23	Enrichment	DOCK7	2.33
93	Smith-kingsmore syndrome	Enrichment	MTOR	2.33
94	Polycythemia	Enrichment	JAK2	2.33
95	Hypereosinophilic syndrome	Enrichment	JAK2	2.33
96	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.32
97	Thrombocytopenia	Enrichment	PTPN11, SRC	2.25
98	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.15
99	Polycythemia vera	Enrichment	JAK2	2.15
100	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.15
101	Nuchal bleb, familial	Enrichment	SOS1	2.15
102	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.15
103	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.15
104	Hyper ige syndrome	Enrichment	STAT3	2.15
105	Immunodeficiency 14	Enrichment	PIK3R1	2.15
106	Cellular ependymoma	Enrichment	NF2	2.15
107	Tanycytic ependymoma	Enrichment	NF2	2.15
108	Papillary ependymoma	Enrichment	NF2	2.15
109	Tricuspid valve insufficiency	Enrichment	PTPN11	2.15
110	Spindle cell sarcoma	Enrichment	NF2	2.15
111	Clear cell ependymoma	Enrichment	NF2	2.15
112	Keratoacanthoma	Enrichment	PIK3CA	2.15
113	Erythrocytosis, familial, 1	Enrichment	JAK2	2.03
114	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.03
115	Budd-chiari syndrome	Enrichment	JAK2	2.03
116	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.03
117	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.03
118	Barrett esophagus	Enrichment	ERBB2	2.03
119	Congenital generalized lipodystrophy	Enrichment	FOS	2.03
120	Fetal akinesia deformation sequence 3	Enrichment	DOCK7	2.03
121	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.03
122	Cerebrovascular disease	Enrichment	PIK3CA	2.03
123	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.03
124	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.03
125	Full schwannomatosis	Enrichment	NF2	2.03
126	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.03
127	Benign ependymoma	Enrichment	NF2	2.03
128	Gingival fibromatosis	Enrichment	SOS1	2.03
129	Capillary malformations, congenital	Enrichment	PIK3CA	1.93
130	Myasthenic syndrome, congenital, 4a, slow-channel	Enrichment	CHRNE	1.93
131	Lymphoma	Enrichment	PTPN11	1.93
132	Myasthenic syndrome, congenital, 4b, fast-channel	Enrichment	CHRNE	1.93
133	Myeloproliferative neoplasm	Enrichment	JAK2	1.93
134	Histiocytoid hemangioma	Enrichment	FOS	1.93
135	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.85
136	Cowden syndrome 1	Enrichment	PIK3CA	1.85
137	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.85
138	Patent ductus arteriosus	Enrichment	PTPN11	1.85
139	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.85
140	Nevus, epidermal	Enrichment	PIK3CA	1.79
141	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.79
142	Essential thrombocythemia	Enrichment	JAK2	1.79
143	Gallbladder cancer	Enrichment	PIK3CA	1.79
144	Pilomyxoid astrocytoma	Enrichment	RAF1	1.79
145	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.73
146	Glioma susceptibility 1	Enrichment	ERBB2	1.73
147	Multiple pterygium syndrome, lethal type	Enrichment	CHRNA1	1.73
148	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.73
149	Ellis-van creveld syndrome	Enrichment	PRKACA	1.68
150	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.68
151	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.68
152	Primary hyperaldosteronism	Enrichment	USP8	1.68
153	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	CHRNE	1.63
154	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.63
155	Pectus excavatum	Enrichment	PTPN11	1.59
156	Meningioma, familial	Enrichment	NF2	1.59
157	Specific learning disability	Enrichment	PTPN11	1.59
158	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.57
159	Epicanthus	Enrichment	PTPN11	1.55
160	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.55
161	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.55
162	Congenital long qt syndrome	Enrichment	PTPN11	1.55
163	Aortic valve disease 1	Enrichment	SOS1	1.52
164	Acute promyelocytic leukemia	Enrichment	STAT3	1.52
165	Nk-cell enteropathy	Enrichment	PIK3CB	1.52
166	Osteoporosis	Enrichment	SRC	1.49
167	Lung cancer susceptibility 3	Enrichment	ERBB2	1.49
168	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.49
169	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.46
170	Lynch syndrome	Enrichment	PIK3CA	1.46
171	Rare genetic intellectual disability	Enrichment	MTOR	1.46
172	Inherited cancer-predisposing syndrome	Enrichment	NF2, PTPN11	1.41
173	Patent foramen ovale	Enrichment	PTPN11	1.38
174	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.36
175	Congenital myopathy	Enrichment	CHRNA1	1.36
176	Endometrial cancer	Enrichment	PIK3CA	1.31
177	Centronuclear myopathy	Enrichment	CHRNA1	1.31
178	Hepatocellular carcinoma	Enrichment	PIK3CA	1.30
179	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.26
180	Scoliosis	Enrichment	PTPN11	1.26
181	Strabismus	Enrichment	PTPN11	1.21
182	Prostate cancer	Enrichment	PIK3CA	1.18
183	Long qt syndrome 1	Enrichment	PTPN11	1.16
184	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.12
185	Left ventricular noncompaction	Enrichment	RAF1	1.10
186	Leukemia, acute myeloid	Enrichment	JAK2	1.04
187	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.01
188	Hypertelorism	Enrichment	PIK3CA	0.94
189	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.93
190	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.91
191	Primary ovarian insufficiency	Enrichment	JAK2	0.88
192	Autism	Enrichment	CHRNA1	0.80
193	Dilated cardiomyopathy	Enrichment	RAF1	0.76
194	Microcephaly	Enrichment	PTPN11	0.60

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ErbB2/ErbB3 signaling events

Pathway Network for ErbB2/ErbB3 signaling events

Member Pathways for ErbB2/ErbB3 signaling events

Pathways in the ErbB2/ErbB3 signaling events SuperPath

Associated Genes for ErbB2/ErbB3 signaling events

Associated Disorders for ErbB2/ErbB3 signaling events

Disorders associated with ErbB2/ErbB3 signaling events SuperPath

STRING Interaction Network for ErbB2/ErbB3 signaling events

Sources for ErbB2/ErbB3 signaling events