ERK pathway in Huntington's disease

No Pathway Network information available for ERK pathway in Huntington's disease

Pathways in the ERK pathway in Huntington's disease SuperPath

#	Name	Source	Genes
1	ERK pathway in Huntington's disease	WikiPathways	BDNF CASP3 CASP7 CREB1 EGF EGFR ELK1 GRM1 HRAS HTT MAP2K7 MAPK1 NTRK2 RAF1 RPS6KA5 (see all 15) (see less)
2	TNF-related weak inducer of apoptosis (TWEAK) signaling pathway	WikiPathways	CASP3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CASP3	Caspase 3	Protein Coding	2
2	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
3	CASP7	Caspase 7	Protein Coding	1
4	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
5	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
6	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
7	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
8	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
10	HTT	Huntingtin	Protein Coding	1
11	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	1
12	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
13	EGF	Epidermal Growth Factor	Protein Coding	1
14	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
15	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with ERK pathway in Huntington's disease SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 3	Enrichment	HRAS, RAF1	4.62
2	Pilomyxoid astrocytoma	Enrichment	NTRK2, RAF1	4.62
3	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	4.50
4	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS	4.20
5	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	4.13
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, RAF1	3.93
7	Noonan syndrome 1	Enrichment	HRAS, RAF1	3.55
8	Rasopathy	Enrichment	HRAS, RAF1	3.44
9	Bladder cancer	Enrichment	EGFR, HRAS	3.34
10	Noonan syndrome 5	Enrichment	RAF1	2.96
11	Hypomagnesemia 4, renal	Enrichment	EGF	2.96
12	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.96
13	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.96
14	Noonan syndrome 13	Enrichment	MAPK1	2.96
15	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.96
16	Leopard syndrome 2	Enrichment	RAF1	2.96
17	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.96
18	Lopes-maciel-rodan syndrome	Enrichment	HTT	2.96
19	Spinocerebellar ataxia 44	Enrichment	GRM1	2.96
20	Trigonitis	Enrichment	RAF1	2.96
21	Juvenile huntington disease	Enrichment	HTT	2.96
22	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.96
23	Chondromyxoid fibroma	Enrichment	GRM1	2.96
24	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.96
25	Costello syndrome	Enrichment	HRAS	2.66
26	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.66
27	Wooly hair nevus	Enrichment	HRAS	2.66
28	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.48
29	Large congenital melanocytic nevus	Enrichment	HRAS	2.48
30	Spermatocytoma	Enrichment	HRAS	2.48
31	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.48
32	Melanoma of soft tissue	Enrichment	CREB1	2.48
33	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.35
34	Huntington disease	Enrichment	HTT	2.35
35	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.35
36	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.35
37	Epidermolytic nevus	Enrichment	HRAS	2.35
38	Cowden syndrome 1	Enrichment	EGFR	2.18
39	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	2.18
40	Lung squamous cell carcinoma	Enrichment	EGFR	2.18
41	Nevus, epidermal	Enrichment	HRAS	2.11
42	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	2.11
43	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.11
44	Follicular thyroid carcinoma	Enrichment	HRAS	2.11
45	Arteriovenous malformation	Enrichment	HRAS	2.00
46	Adult hepatocellular carcinoma	Enrichment	EGF	2.00
47	Congenital central hypoventilation syndrome	Enrichment	BDNF	2.00
48	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.96
49	Specific learning disability	Enrichment	MAPK1	1.92
50	Lung cancer susceptibility 3	Enrichment	EGFR	1.81
51	Rhabdomyosarcoma	Enrichment	HRAS	1.76
52	Gliosarcoma	Enrichment	EGFR	1.76
53	Giant cell glioblastoma	Enrichment	EGFR	1.73
54	Heart, malformation of	Enrichment	MAPK1	1.70
55	Arteriovenous malformations of the brain	Enrichment	EGFR	1.68
56	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.58
57	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.55
58	Differentiated thyroid carcinoma	Enrichment	HRAS	1.50
59	Non-immune hydrops fetalis	Enrichment	HRAS	1.47
60	Lung cancer	Enrichment	EGFR	1.46
61	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.44
62	Left ventricular noncompaction	Enrichment	RAF1	1.42
63	West syndrome	Enrichment	NTRK2	1.32
64	Body mass index quantitative trait locus 11	Enrichment	BDNF	1.27
65	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.24
66	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	1.22
67	Dilated cardiomyopathy	Enrichment	RAF1	1.07
68	Ovarian cancer	Enrichment	EGFR	0.97
69	Microcephaly	Enrichment	MAPK1	0.89
70	Complex neurodevelopmental disorder	Enrichment	HTT	0.89
71	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ERK pathway in Huntington's disease

Pathway Network for ERK pathway in Huntington's disease

Member Pathways for ERK pathway in Huntington's disease

Pathways in the ERK pathway in Huntington's disease SuperPath

Associated Genes for ERK pathway in Huntington's disease

Associated Disorders for ERK pathway in Huntington's disease

Disorders associated with ERK pathway in Huntington's disease SuperPath

STRING Interaction Network for ERK pathway in Huntington's disease

Sources for ERK pathway in Huntington's disease