ESR-mediated signaling

Pathway network for the ESR-mediated signaling SuperPath

Sources:

Reactome

Pathways in the ESR-mediated signaling SuperPath

#	Name	Source	Genes
1	ESR-mediated signaling	Reactome	AGO1 AGO2 AGO3 AGO4 AKT1 AKT2 AKT3 AREG ATF2 AXIN1 BCL2 BTC CALM1 CALM2 CALM3 CARM1 CAV1 CAV2 CBFB CCND1 CCNT1 CDK9 CDKN1B CHD1 CITED1 CREB1 CREBBP CTSD CXCL12 CXXC5 DDX5 EBAG9 EGF EGFR ELK1 EP300 EPGN ERBB4 EREG ESR1 ESR2 FKBP4 FKBP5 FOS FOSB FOXA1 FOXO3 GATA3 GNAI1 GNAI2 GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPAM GREB1 GTF2A1 GTF2A2 GTF2F1 GTF2F2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HBEGF HDAC1 HRAS HSP90AA1 HSP90AB1 HSPB1 IGF1R JUN JUND KANK1 KAT2B KAT5 KCTD6 KDM1A KDM4B KPNA2 KRAS MAPK1 MAPK3 MED1 MMP2 MMP3 MMP7 MMP9 MOV10 MYB MYC NCOA1 NCOA2 NCOA3 NOS3 NR5A2 NRAS NRIP1 PDPK1 PGR PIK3CA PIK3R1 PIK3R2 PIK3R3 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU2F1 PPID PPP5C PRKCZ PRMT1 PTGES3 PTK2 RAD21 RUNX1 S1PR3 SHC1 SMC1A SMC3 SP1 SPHK1 SRC SRF STAG1 STAG2 STRN TBP TFF1 TFF3 TGFA TLE3 TNRC6A TNRC6B TNRC6C UHMK1 USF1 USF2 XPO1 YY1 ZDHHC21 ZDHHC7 ZNF217 (see all 222) (see less)
2	Signaling by Nuclear Receptors	Reactome	ABCA1 ABCG1 ABCG5 ABCG8 ADH1A ADH1C ADH4 AGO1 AGO2 AGO3 AGO4 AKR1C3 AKT1 AKT2 AKT3 ALDH1A1 ALDH1A2 ALDH1A3 ALDH8A1 ANGPTL3 APOC1 APOC2 APOC4 APOD APOE AREG ARL4C ATF2 AXIN1 BCL2 BTC CALM1 CALM2 CALM3 CARM1 CAV1 CAV2 CBFB CCND1 CCNT1 CDK9 CDKN1B CETP CHD1 CITED1 CRABP1 CRABP2 CREB1 CREBBP CTSD CXCL12 CXXC5 CYP26A1 CYP26B1 CYP26C1 DDX5 DHRS3 DHRS4 DHRS9 DLAT DLD EBAG9 EEPD1 EGF EGFR ELK1 EP300 EPGN ERBB4 EREG ESR1 ESR2 FABP5 FABP6 FASN FKBP4 FKBP5 FOS FOSB FOXA1 FOXO3 GATA3 GNAI1 GNAI2 GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPAM GPS2 GREB1 GTF2A1 GTF2A2 GTF2F1 GTF2F2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HBEGF HDAC1 HDAC3 HRAS HSP90AA1 HSP90AB1 HSPB1 IGF1R JUN JUND KANK1 KAT2B KAT5 KCTD6 KDM1A KDM1B KDM3A KDM4A KDM4B KPNA2 KRAS MAPK1 MAPK3 MED1 MMP2 MMP3 MMP7 MMP9 MOV10 MYB MYC MYLIP NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NOS3 NR1H2 NR1H3 NR5A2 NRAS NRIP1 PCK1 PDHA1 PDHA2 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDPK1 PGR PIK3CA PIK3R1 PIK3R2 PIK3R3 PLIN1 PLTP POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU2F1 PPARD PPID PPP5C PRKCZ PRMT1 PTGES3 PTK2 RAD21 RARA RARB RARG RDH10 RDH11 RDH13 RDH14 RDH16 RDH5 RUNX1 RXRA RXRB RXRG S1PR3 SCD SDR16C5 SHC1 SMC1A SMC3 SP1 SPHK1 SRC SREBF1 SRF STAG1 STAG2 STRN TBL1X TBL1XR1 TBP TFF1 TFF3 TGFA TLE3 TNRC6A TNRC6B TNRC6C UGT1A3 UHMK1 USF1 USF2 XPO1 YY1 ZDHHC21 ZDHHC7 ZNF217 (see all 296) (see less)
3	Estrogen-dependent gene expression	Reactome	AGO1 AGO2 AGO3 AGO4 ATF2 AXIN1 BCL2 CARM1 CBFB CCND1 CCNT1 CDK9 CHD1 CITED1 CREBBP CTSD CXCL12 CXXC5 DDX5 EBAG9 EP300 ERBB4 ESR1 FKBP4 FOS FOSB FOXA1 GATA3 GPAM GREB1 GTF2A1 GTF2A2 GTF2F1 GTF2F2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HSP90AA1 HSP90AB1 JUN JUND KANK1 KAT2B KAT5 KCTD6 KDM1A KDM4B KPNA2 MED1 MOV10 MYB MYC NCOA1 NCOA2 NCOA3 NR5A2 NRIP1 PGR POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU2F1 PRMT1 PTGES3 RAD21 RUNX1 SMC1A SMC3 SP1 STAG1 STAG2 TBP TFF1 TFF3 TGFA TLE3 TNRC6A TNRC6B TNRC6C USF1 USF2 YY1 ZNF217 (see all 149) (see less)
4	RUNX1 regulates estrogen receptor mediated transcription	Reactome	AXIN1 CBFB ESR1 GPAM KCTD6 RUNX1 (see all 6) (see less)

Gene overlap in member pathways for ESR-mediated signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KCTD6	Potassium Channel Tetramerization Domain Containing 6	Protein Coding	4
2	ESR1	Estrogen Receptor 1	Protein Coding	4
3	GPAM	Glycerol-3-Phosphate Acyltransferase, Mitochondrial	Protein Coding	4
4	AXIN1	Axin 1	Protein Coding	4
5	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	4
6	CBFB	Core-Binding Factor Subunit Beta	Protein Coding	4
7	CDK9	Cyclin Dependent Kinase 9	Protein Coding	3
8	STAG1	STAG1 Cohesin Complex Component	Protein Coding	3
9	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	3
10	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	3
11	KAT5	Lysine Acetyltransferase 5	Protein Coding	3
12	PTGES3	Prostaglandin E Synthase 3	Protein Coding	3
13	STAG2	STAG2 Cohesin Complex Component	Protein Coding	3
14	CHD1	Chromodomain Helicase DNA Binding Protein 1	Protein Coding	3
15	H4C16	H4 Histone 16	Protein Coding	3
16	H3C14	H3 Clustered Histone 14	Protein Coding	3
17	H2BC26	H2B Clustered Histone 26	Protein Coding	3
18	ATF2	Activating Transcription Factor 2	Protein Coding	3
19	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	3
20	CTSD	Cathepsin D	Protein Coding	3
21	DDX5	DEAD-Box Helicase 5	Protein Coding	3
22	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	3
23	AGO4	Argonaute RISC Component 4	Protein Coding	3
24	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
25	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	3
26	FKBP4	FKBP Prolyl Isomerase 4	Protein Coding	3
27	KDM1A	Lysine Demethylase 1A	Protein Coding	3
28	KDM4B	Lysine Demethylase 4B	Protein Coding	3
29	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	3
30	KANK1	KN Motif And Ankyrin Repeat Domains 1	Protein Coding	3
31	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
32	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
33	NR5A2	Nuclear Receptor Subfamily 5 Group A Member 2	Protein Coding	3
34	H2BC1	H2B Clustered Histone 1	Protein Coding	3
35	GATA3	GATA Binding Protein 3	Protein Coding	3
36	AGO1	Argonaute RISC Component 1	Protein Coding	3
37	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	3
38	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	3
39	GTF2A1	General Transcription Factor IIA Subunit 1	Protein Coding	3
40	GTF2A2	General Transcription Factor IIA Subunit 2	Protein Coding	3
41	GTF2F1	General Transcription Factor IIF Subunit 1	Protein Coding	3
42	GTF2F2	General Transcription Factor IIF Subunit 2	Protein Coding	3
43	H2AC8	H2A Clustered Histone 8	Protein Coding	3
44	H2AC7	H2A Clustered Histone 7	Protein Coding	3
45	H2AX	H2A.X Variant Histone	Protein Coding	3
46	H2BC5	H2B Clustered Histone 5	Protein Coding	3
47	H2BC3	H2B Clustered Histone 3	Protein Coding	3
48	H3-3A	H3.3 Histone A	Protein Coding	3
49	H3-3B	H3.3 Histone B	Protein Coding	3
50	HDAC1	Histone Deacetylase 1	Protein Coding	3
51	FOXA1	Forkhead Box A1	Protein Coding	3
52	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	3
53	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	3
54	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	3
55	H3C15	H3 Clustered Histone 15	Protein Coding	3
56	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
57	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
58	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	3
59	MOV10	Mov10 RNA Helicase	Protein Coding	3
60	CITED1	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1	Protein Coding	3
61	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	3
62	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	3
63	H2AB1	H2A.B Variant Histone 1	Protein Coding	3
64	CXXC5	CXXC Finger Protein 5	Protein Coding	3
65	PGR	Progesterone Receptor	Protein Coding	3
66	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	3
67	POLR2A	RNA Polymerase II Subunit A	Protein Coding	3
68	POLR2B	RNA Polymerase II Subunit B	Protein Coding	3
69	POLR2C	RNA Polymerase II Subunit C	Protein Coding	3
70	POLR2D	RNA Polymerase II Subunit D	Protein Coding	3
71	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	3
72	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	3
73	POLR2G	RNA Polymerase II Subunit G	Protein Coding	3
74	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	3
75	POLR2I	RNA Polymerase II Subunit I	Protein Coding	3
76	POLR2J	RNA Polymerase II Subunit J	Protein Coding	3
77	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	3
78	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	3
79	POU2F1	POU Class 2 Homeobox 1	Protein Coding	3
80	MED1	Mediator Complex Subunit 1	Protein Coding	3
81	H4C15	H4 Clustered Histone 15	Protein Coding	3
82	H2AJ	H2A.J Histone	Protein Coding	3
83	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	3
84	RAD21	RAD21 Cohesin Complex Component	Protein Coding	3
85	CCND1	Cyclin D1	Protein Coding	3
86	BCL2	BCL2 Apoptosis Regulator	Protein Coding	3
87	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	3
88	H3C13	H3 Clustered Histone 13	Protein Coding	3
89	SP1	Sp1 Transcription Factor	Protein Coding	3
90	TBP	TATA-Box Binding Protein	Protein Coding	3
91	TFF1	Trefoil Factor 1	Protein Coding	3
92	TFF3	Trefoil Factor 3	Protein Coding	3
93	TGFA	Transforming Growth Factor Alpha	Protein Coding	3
94	TLE3	TLE Family Member 3, Transcriptional Corepressor	Protein Coding	3
95	H2AC19	H2A Clustered Histone 19	Protein Coding	3
96	USF1	Upstream Transcription Factor 1	Protein Coding	3
97	USF2	Upstream Transcription Factor 2, C-Fos Interacting	Protein Coding	3
98	YY1	YY1 Transcription Factor	Protein Coding	3
99	ZNF217	Zinc Finger Protein 217	Protein Coding	3
100	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	3
101	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	3
102	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	3
103	H4C9	H4 Clustered Histone 9	Protein Coding	3
104	H2AC14	H2A Clustered Histone 14	Protein Coding	3
105	H2AC6	H2A Clustered Histone 6	Protein Coding	3
106	H2AC4	H2A Clustered Histone 4	Protein Coding	3
107	H2AC18	H2A Clustered Histone 18	Protein Coding	3
108	H2AC20	H2A Clustered Histone 20	Protein Coding	3
109	H2BC8	H2B Clustered Histone 8	Protein Coding	3
110	H2BC13	H2B Clustered Histone 13	Protein Coding	3
111	H2BC15	H2B Clustered Histone 15	Protein Coding	3
112	H2BC14	H2B Clustered Histone 14	Protein Coding	3
113	H2BC7	H2B Clustered Histone 7	Protein Coding	3
114	H2BC6	H2B Clustered Histone 6	Protein Coding	3
115	H2BC9	H2B Clustered Histone 9	Protein Coding	3
116	H2BC10	H2B Clustered Histone 10	Protein Coding	3
117	H2BC4	H2B Clustered Histone 4	Protein Coding	3
118	H2BC17	H2B Clustered Histone 17	Protein Coding	3
119	H2BC21	H2B Clustered Histone 21	Protein Coding	3
120	H3C1	H3 Clustered Histone 1	Protein Coding	3
121	H3C4	H3 Clustered Histone 4	Protein Coding	3
122	H3C3	H3 Clustered Histone 3	Protein Coding	3
123	H3C6	H3 Clustered Histone 6	Protein Coding	3
124	H3C11	H3 Clustered Histone 11	Protein Coding	3
125	H3C8	H3 Clustered Histone 8	Protein Coding	3
126	H3C12	H3 Clustered Histone 12	Protein Coding	3
127	H3C10	H3 Clustered Histone 10	Protein Coding	3
128	H3C2	H3 Clustered Histone 2	Protein Coding	3
129	H4C1	H4 Clustered Histone 1	Protein Coding	3
130	H4C4	H4 Clustered Histone 4	Protein Coding	3
131	H4C6	H4 Clustered Histone 6	Protein Coding	3
132	H4C12	H4 Clustered Histone 12	Protein Coding	3
133	H4C11	H4 Clustered Histone 11	Protein Coding	3
134	H4C3	H4 Clustered Histone 3	Protein Coding	3
135	H4C8	H4 Clustered Histone 8	Protein Coding	3
136	H4C2	H4 Clustered Histone 2	Protein Coding	3
137	H4C5	H4 Clustered Histone 5	Protein Coding	3
138	H4C13	H4 Clustered Histone 13	Protein Coding	3
139	H4C14	H4 Clustered Histone 14	Protein Coding	3
140	H2BC12	H2B Clustered Histone 12	Protein Coding	3
141	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	3
142	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	3
143	H3C7	H3 Clustered Histone 7	Protein Coding	3
144	H2BC11	H2B Clustered Histone 11	Protein Coding	3
145	CCNT1	Cyclin T1	Protein Coding	3
146	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	3
147	EBAG9	Estrogen Receptor Binding Site Associated Antigen 9	Protein Coding	3
148	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	3
149	GREB1	Growth Regulating Estrogen Receptor Binding 1	Protein Coding	3
150	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
151	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	2
152	GNB5	G Protein Subunit Beta 5	Protein Coding	2
153	UHMK1	U2AF Homology Motif Kinase 1	Protein Coding	2
154	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
155	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	2
156	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	2
157	EGF	Epidermal Growth Factor	Protein Coding	2
158	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2
159	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
160	EREG	Epiregulin	Protein Coding	2
161	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
162	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
163	ESR2	Estrogen Receptor 2	Protein Coding	2
164	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	2
165	FOXO3	Forkhead Box O3	Protein Coding	2
166	EPGN	Epithelial Mitogen	Protein Coding	2
167	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
168	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
169	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
170	GNB1	G Protein Subunit Beta 1	Protein Coding	2
171	GNB2	G Protein Subunit Beta 2	Protein Coding	2
172	GNB3	G Protein Subunit Beta 3	Protein Coding	2
173	GNG3	G Protein Subunit Gamma 3	Protein Coding	2
174	GNG4	G Protein Subunit Gamma 4	Protein Coding	2
175	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
176	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
177	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
178	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
179	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
180	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
181	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
182	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	2
183	ZDHHC21	ZDHHC Palmitoyltransferase 21	Protein Coding	2
184	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	2
185	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	2
186	AREG	Amphiregulin	Protein Coding	2
187	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
188	MMP2	Matrix Metallopeptidase 2	Protein Coding	2
189	MMP3	Matrix Metallopeptidase 3	Protein Coding	2
190	MMP7	Matrix Metallopeptidase 7	Protein Coding	2
191	MMP9	Matrix Metallopeptidase 9	Protein Coding	2
192	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
193	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
194	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
195	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
196	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
197	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
198	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
199	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
200	PPID	Peptidylprolyl Isomerase D	Protein Coding	2
201	PPP5C	Protein Phosphatase 5 Catalytic Subunit	Protein Coding	2
202	ZDHHC7	ZDHHC Palmitoyltransferase 7	Protein Coding	2
203	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
204	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
205	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
206	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
207	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
208	GNB4	G Protein Subunit Beta 4	Protein Coding	2
209	SHC1	SHC Adaptor Protein 1	Protein Coding	2
210	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
211	SRF	Serum Response Factor	Protein Coding	2
212	STRN	Striatin	Protein Coding	2
213	BTC	Betacellulin	Protein Coding	2
214	XPO1	Exportin 1	Protein Coding	2
215	CALM1	Calmodulin 1	Protein Coding	2
216	CALM2	Calmodulin 2	Protein Coding	2
217	CALM3	Calmodulin 3	Protein Coding	2
218	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
219	CAV1	Caveolin 1	Protein Coding	2
220	CAV2	Caveolin 2	Protein Coding	2
221	SPHK1	Sphingosine Kinase 1	Protein Coding	2
222	GNG8	G Protein Subunit Gamma 8	Protein Coding	2
223	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
224	ARL4C	ARF Like GTPase 4C	Protein Coding	1
225	DHRS9	Dehydrogenase/Reductase 9	Protein Coding	1
226	CETP	Cholesteryl Ester Transfer Protein	Protein Coding	1
227	DHRS4	Dehydrogenase/Reductase 4	Protein Coding	1
228	RDH13	Retinol Dehydrogenase 13	Protein Coding	1
229	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	1
230	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	1
231	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	1
232	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	1
233	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	1
234	RDH10	Retinol Dehydrogenase 10	Protein Coding	1
235	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	1
236	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	1
237	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	1
238	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	1
239	SDR16C5	Short Chain Dehydrogenase/Reductase Family 16C Member 5	Protein Coding	1
240	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
241	FABP5	Fatty Acid Binding Protein 5	Protein Coding	1
242	FABP6	Fatty Acid Binding Protein 6	Protein Coding	1
243	FASN	Fatty Acid Synthase	Protein Coding	1
244	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	1
245	KDM1B	Lysine Demethylase 1B	Protein Coding	1
246	ANGPTL3	Angiopoietin Like 3	Protein Coding	1
247	GPS2	G Protein Pathway Suppressor 2	Protein Coding	1
248	MYLIP	Myosin Regulatory Light Chain Interacting Protein	Protein Coding	1
249	CYP26C1	Cytochrome P450 Family 26 Subfamily C Member 1	Protein Coding	1
250	APOC1	Apolipoprotein C1	Protein Coding	1
251	APOC2	Apolipoprotein C2	Protein Coding	1
252	APOC4	Apolipoprotein C4	Protein Coding	1
253	APOD	Apolipoprotein D	Protein Coding	1
254	APOE	Apolipoprotein E	Protein Coding	1
255	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	1
256	RDH11	Retinol Dehydrogenase 11	Protein Coding	1
257	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
258	PDHA2	Pyruvate Dehydrogenase E1 Subunit Alpha 2	Protein Coding	1
259	PDHB	Pyruvate Dehydrogenase E1 Subunit Beta	Protein Coding	1
260	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
261	PDK2	Pyruvate Dehydrogenase Kinase 2	Protein Coding	1
262	PDK3	Pyruvate Dehydrogenase Kinase 3	Protein Coding	1
263	PDK4	Pyruvate Dehydrogenase Kinase 4	Protein Coding	1
264	PLIN1	Perilipin 1	Protein Coding	1
265	PLTP	Phospholipid Transfer Protein	Protein Coding	1
266	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	1
267	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
268	KDM3A	Lysine Demethylase 3A	Protein Coding	1
269	CYP26B1	Cytochrome P450 Family 26 Subfamily B Member 1	Protein Coding	1
270	RDH14	Retinol Dehydrogenase 14	Protein Coding	1
271	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
272	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
273	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
274	RDH5	Retinol Dehydrogenase 5	Protein Coding	1
275	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
276	RXRB	Retinoid X Receptor Beta	Protein Coding	1
277	RXRG	Retinoid X Receptor Gamma	Protein Coding	1
278	SCD	Stearoyl-CoA Desaturase	Protein Coding	1
279	ABCG5	ATP Binding Cassette Subfamily G Member 5	Protein Coding	1
280	ABCG8	ATP Binding Cassette Subfamily G Member 8	Protein Coding	1
281	ALDH8A1	Aldehyde Dehydrogenase 8 Family Member A1	Protein Coding	1
282	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
283	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	1
284	NR1H2	Nuclear Receptor Subfamily 1 Group H Member 2	Protein Coding	1
285	TBL1XR1	TBL1X/Y Related 1	Protein Coding	1
286	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	1
287	EEPD1	Endonuclease/Exonuclease/Phosphatase Family Domain Containing 1	Protein Coding	1
288	RDH16	Retinol Dehydrogenase 16	Protein Coding	1
289	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	1
290	HDAC3	Histone Deacetylase 3	Protein Coding	1
291	ALDH1A2	Aldehyde Dehydrogenase 1 Family Member A2	Protein Coding	1
292	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	1
293	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
294	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
295	ABCG1	ATP Binding Cassette Subfamily G Member 1	Protein Coding	1
296	KDM4A	Lysine Demethylase 4A	Protein Coding	1

Disorders associated with ESR-mediated signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS, PIK3CA	6.32
2	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	5.89
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	5.63
4	Lipid metabolism disorder	Enrichment	ABCG5, ABCG8, APOE, CETP	5.49
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	4.77
6	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	4.77
7	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	4.08
8	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	4.08
9	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	3.98
10	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	3.98
11	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	3.92
12	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	3.92
13	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	3.92
14	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS, RUNX1	3.84
15	Myeloma, multiple	Enrichment	CCND1, CREBBP, H3C1, KRAS, NCOR2, PIK3R2, RXRA	3.69
16	Breast cancer	Enrichment	AKT1, ESR1, GNG3, JUN, KRAS, PIK3CA, SHC1	3.66
17	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	3.64
18	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.57
19	Adult hepatocellular carcinoma	Enrichment	AXIN1, EGF, PIK3CA	3.47
20	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.45
21	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	3.45
22	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, H4C3, H4C5, H4C9, KDM4B, TNRC6B	3.36
23	Caudal duplication anomaly	Enrichment	AXIN1	3.35
24	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	3.35
25	Gallbladder disease 4	Enrichment	ABCG5, ABCG8	3.32
26	Colorectal cancer	Enrichment	AKT1, CCND1, EP300, NRAS, PIK3CA, PIK3R1, SRC	3.26
27	Coronary heart disease 5	Enrichment	ABCA1, ABCG5, ABCG8	3.11
28	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.10
29	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.10
30	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	3.07
31	Storage pool platelet disease	Enrichment	RUNX1	3.05
32	Cleidocranial dysplasia 2	Enrichment	CBFB	3.05
33	Tafro syndrome	Enrichment	RUNX1	3.05
34	Histiocytoid hemangioma	Enrichment	FOS, FOSB	2.93
35	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, PIK3CA	2.92
36	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	2.88
37	Estrogen resistance	Enrichment	ESR1	2.88
38	Migraine without aura	Enrichment	ESR1	2.88
39	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	2.88
40	Sitosterolemia 1	Enrichment	ABCG5, ABCG8	2.85
41	Sitosterolemia	Enrichment	ABCG5, ABCG8	2.85
42	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	2.81
43	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	2.81
44	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	2.77
45	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.76
46	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	2.76
47	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.76
48	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.75
49	Blood platelet disease	Enrichment	RUNX1	2.75
50	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	CBFB	2.75
51	Aggressive systemic mastocytosis	Enrichment	RUNX1	2.66
52	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	RUNX1	2.66
53	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	2.59
54	Pancytopenia	Enrichment	RUNX1	2.58
55	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1, PDHX	2.56
56	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	2.49
57	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	2.42
58	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	2.40
59	Alzheimer disease 2	Enrichment	APOE, NOS3	2.34
60	Migraine with or without aura 1	Enrichment	ESR1	2.31
61	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.28
62	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	2.28
63	Noonan syndrome 3	Enrichment	HRAS, KRAS	2.28
64	Gallbladder cancer	Enrichment	KRAS, PIK3CA	2.28
65	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.28
66	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, KRAS, PIK3CA	2.25
67	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	2.22
68	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	2.16
69	Rasopathy	Enrichment	HRAS, KRAS, NRAS	2.07
70	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	2.05
71	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.05
72	Hepatocellular carcinoma	Enrichment	AXIN1	2.01
73	Myocardial infarction	Enrichment	ESR1	2.01
74	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	1.96
75	Hyperlipidemia, familial combined, 1	Enrichment	USF1	1.96
76	Holoprosencephaly 13, x-linked	Enrichment	STAG2	1.96
77	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	1.96
78	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	1.96
79	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	1.96
80	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	1.96
81	Mullegama-klein-martinez syndrome	Enrichment	STAG2	1.96
82	Progesterone resistance	Enrichment	PGR	1.96
83	Intellectual developmental disorder, autosomal dominant 47	Enrichment	STAG1	1.96
84	Mungan syndrome	Enrichment	RAD21	1.96
85	Cerebral palsy, spastic quadriplegic, 2	Enrichment	KANK1	1.96
86	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	1.96
87	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	1.96
88	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	1.96
89	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	1.96
90	Xq25 microduplication syndrome	Enrichment	STAG2	1.96
91	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	1.96
92	Menke-hennekam syndrome 1	Enrichment	CREBBP	1.96
93	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	1.96
94	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	1.96
95	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	1.96
96	Menke-hennekam syndrome	Enrichment	CREBBP	1.96
97	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	1.96
98	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	1.94
99	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	1.94
100	Homozygous familial hypercholesterolemia	Enrichment	ABCG5, ABCG8	1.91
101	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	1.90
102	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	1.82
103	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	1.80
104	Meningioma	Enrichment	AKT1, PIK3CA	1.80
105	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	1.79
106	Macrodactyly	Enrichment	PIK3CA	1.79
107	Proteus syndrome	Enrichment	AKT1	1.79
108	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.79
109	Oculoectodermal syndrome	Enrichment	KRAS	1.79
110	Hypomagnesemia 4, renal	Enrichment	EGF	1.79
111	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	1.79
112	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.79
113	Cowden syndrome 5	Enrichment	PIK3CA	1.79
114	Melanosis, neurocutaneous	Enrichment	NRAS	1.79
115	Noonan syndrome 6	Enrichment	NRAS	1.79
116	Pulmonary hypertension, primary, 3	Enrichment	CAV1	1.79
117	Ventricular tachycardia, familial	Enrichment	GNAI2	1.79
118	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.79
119	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.79
120	Noonan syndrome 13	Enrichment	MAPK1	1.79
121	Short syndrome	Enrichment	PIK3R1	1.79
122	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	1.79
123	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	1.79
124	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.79
125	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.79
126	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.79
127	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.79
128	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.79
129	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	1.79
130	Ovarian dysgenesis 8	Enrichment	ESR2	1.79
131	Neuroendocrine tumor	Enrichment	CDKN1B	1.79
132	Coronary heart disease 6	Enrichment	MMP3	1.79
133	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.79
134	Long qt syndrome 16	Enrichment	CALM3	1.79
135	Cowden syndrome 6	Enrichment	AKT1	1.79
136	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.79
137	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.79
138	Thrombocytopenia 6	Enrichment	SRC	1.79
139	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.79
140	Sick sinus syndrome 4	Enrichment	GNB2	1.79
141	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.79
142	Long qt syndrome 15	Enrichment	CALM2	1.79
143	Hypospadias	Enrichment	PIK3CA	1.79
144	Capillary hemangioma	Enrichment	AKT3	1.79
145	Congenital pulmonary airway malformation	Enrichment	KRAS	1.79
146	Rare venous malformation	Enrichment	PIK3CA	1.79
147	Diaphragmatic eventration	Enrichment	PIK3CA	1.79
148	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.79
149	Rare combined vascular malformation	Enrichment	PIK3CA	1.79
150	Cavernous lymphangioma	Enrichment	PIK3CA	1.79
151	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.79
152	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.79
153	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.79
154	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.79
155	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.79
156	Macrodactyly of toe	Enrichment	PIK3CA	1.79
157	Neurocutaneous melanocytosis	Enrichment	NRAS	1.79
158	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.79
159	Leukemia, acute myeloid	Enrichment	RUNX1	1.76
160	Nk-cell enteropathy	Enrichment	ERBB4, IGF1R	1.73
161	Thrombocytopenia	Enrichment	RUNX1	1.68
162	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	1.67
163	Sea-blue histiocyte disease	Enrichment	APOE	1.66
164	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	1.66
165	Charcot-marie-tooth disease, x-linked dominant, 6	Enrichment	PDK3	1.66
166	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	1.66
167	Lipoprotein glomerulopathy	Enrichment	APOE	1.66
168	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	1.66
169	Ifap syndrome 2	Enrichment	SREBF1	1.66
170	Diaphragmatic hernia 4, with cardiovascular defects	Enrichment	ALDH1A2	1.66
171	Radiohumeral fusions with other skeletal and craniofacial anomalies	Enrichment	CYP26B1	1.66
172	Focal facial dermal dysplasia 4	Enrichment	CYP26C1	1.66
173	Microphthalmia, syndromic 12	Enrichment	RARB	1.66
174	Spermatogenic failure 70	Enrichment	PDHA2	1.66
175	Lethal occipital encephalocele-skeletal dysplasia syndrome	Enrichment	CYP26B1	1.66
176	Hypoalphalipoproteinemia	Enrichment	ABCA1	1.66
177	Burkitt lymphoma	Enrichment	MYC	1.66
178	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.66
179	Thumb deformity	Enrichment	CREBBP	1.66
180	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.66
181	Spinocerebellar ataxia 17	Enrichment	TBP	1.66
182	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.66
183	Premature ovarian failure 3	Enrichment	AGO2	1.66
184	Gabriele-de vries syndrome	Enrichment	YY1	1.66
185	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.66
186	Intellectual developmental disorder, autosomal dominant 65	Enrichment	KDM4B	1.66
187	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.66
188	Menke-hennekam syndrome 2	Enrichment	EP300	1.66
189	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.66
190	Acute basophilic leukemia	Enrichment	MYB	1.66
191	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.66
192	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.66
193	Angiocentric glioma	Enrichment	MYB	1.66
194	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.66
195	Insulinoma	Enrichment	YY1	1.66
196	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.66
197	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.66
198	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.66
199	Lynch syndrome	Enrichment	KRAS, PIK3CA	1.61
200	Ovarian cancer	Enrichment	AKT1, CDKN1B, EGFR, KRAS, PIK3CA	1.60
201	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB, MYC	1.58
202	Hypertension, essential	Enrichment	GNB3, NOS3	1.51
203	Acute promyelocytic leukemia	Enrichment	RARA, TBL1XR1	1.50
204	Costello syndrome	Enrichment	HRAS	1.49
205	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.49
206	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.49
207	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.49
208	Keratosis, seborrheic	Enrichment	PIK3CA	1.49
209	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.49
210	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.49
211	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.49
212	Noonan syndrome 8	Enrichment	PIK3CA	1.49
213	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.49
214	Long qt syndrome 14	Enrichment	CALM1	1.49
215	Senior-loken syndrome 7	Enrichment	AKT3	1.49
216	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.49
217	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.49
218	Bardet-biedl syndrome 16	Enrichment	AKT3	1.49
219	Hypopituitarism	Enrichment	GNAI2	1.49
220	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.49
221	Metaphyseal anadysplasia	Enrichment	MMP9	1.49
222	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.49
223	Cerebral visual impairment	Enrichment	GNB1	1.49
224	Wooly hair nevus	Enrichment	HRAS	1.49
225	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.49
226	Pilarowski-bjornsson syndrome	Enrichment	CHD1	1.49
227	Tethered spinal cord syndrome	Enrichment	CREBBP	1.49
228	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.49
229	End stage renal disease	Enrichment	GATA3	1.49
230	Adenoid cystic carcinoma	Enrichment	MYB	1.49
231	Lessel-kreienkamp syndrome	Enrichment	AGO2	1.49
232	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.49
233	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	1.42
234	Apolipoprotein c-ii deficiency	Enrichment	APOC2	1.36
235	Tangier disease	Enrichment	ABCA1	1.36
236	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	1.36
237	Alzheimer disease 3	Enrichment	APOE	1.36
238	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	1.36
239	Pyruvate dehydrogenase e2 deficiency	Enrichment	DLAT	1.36
240	Retinal dystrophy, juvenile cataracts, and short stature syndrome	Enrichment	RDH11	1.36
241	Pyruvate dehydrogenase e1-beta deficiency	Enrichment	PDHB	1.36
242	Pyruvate dehydrogenase e3-binding protein deficiency	Enrichment	PDHX	1.36
243	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	1.36
244	Sitosterolemia 2	Enrichment	ABCG5	1.36
245	Hyperlipoproteinemia, type iii	Enrichment	APOE	1.36
246	Microphthalmia, isolated 8	Enrichment	ALDH1A3	1.36
247	Familial apolipoprotein c-ii deficiency	Enrichment	APOC2	1.36
248	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	ABCG5	1.36
249	Hypobetalipoproteinemia, familial, 2	Enrichment	ANGPTL3	1.36
250	Developmental and epileptic encephalopathy 23	Enrichment	ANGPTL3	1.36
251	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	1.36
252	Congenital generalized lipodystrophy	Enrichment	FOS	1.36
253	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.36
254	Mantle cell lymphoma	Enrichment	CCND1	1.36
255	Spastic quadriplegic cerebral palsy	Enrichment	KANK1	1.36
256	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.36
257	Thyroid carcinoma, familial medullary	Enrichment	ESR2	1.32
258	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.32
259	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.32
260	Langerhans cell histiocytosis	Enrichment	NRAS	1.32
261	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.32
262	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.32
263	Immunodeficiency 14	Enrichment	PIK3R1	1.32
264	Spermatocytoma	Enrichment	HRAS	1.32
265	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.32
266	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.32
267	Melanoma of soft tissue	Enrichment	CREB1	1.32
268	Keratoacanthoma	Enrichment	PIK3CA	1.32
269	Microcephaly	Enrichment	EP300, GNB1, IGF1R, MAPK1, SMC1A	1.29
270	Alzheimer disease, familial, 1	Enrichment	APOE, NOS3	1.28
271	Sudden infant death syndrome	Enrichment	CALM2, PDHA1	1.28
272	Cakut	Enrichment	GATA3, NRIP1	1.27
273	Hyperlipidemia, familial combined, 3	Enrichment	USF1	1.27
274	Von hippel-lindau syndrome	Enrichment	CCND1	1.27
275	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.27
276	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.27
277	Follicular lymphoma	Enrichment	BCL2	1.27
278	Inherited cancer-predisposing syndrome	Enrichment	RUNX1	1.24
279	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TBL1XR1	1.20
280	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.19
281	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.19
282	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.19
283	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.19
284	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.19
285	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.19
286	Achromatopsia 4	Enrichment	GNAI3	1.19
287	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.19
288	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.19
289	Cerebrovascular disease	Enrichment	PIK3CA	1.19
290	Pilocytic astrocytoma	Enrichment	KRAS	1.19
291	Epidermolytic nevus	Enrichment	HRAS	1.19
292	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.19
293	Primary hyperparathyroidism	Enrichment	CDKN1B	1.19
294	Familial sick sinus syndrome	Enrichment	GNB2	1.19
295	Hyperalphalipoproteinemia 1	Enrichment	CETP	1.19
296	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	1.19
297	Pierpont syndrome	Enrichment	TBL1XR1	1.19
298	Alzheimer disease 4	Enrichment	APOE	1.19
299	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	1.19
300	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1	1.19
301	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.19
302	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1	1.19
303	Isolated anophthalmia-microphthalmia syndrome	Enrichment	ALDH1A3	1.19
304	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.19
305	Hypertrichosis	Enrichment	CREBBP	1.19
306	Waardenburg syndrome	Enrichment	POLR2F	1.19
307	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.13
308	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.13
309	Capillary malformations, congenital	Enrichment	PIK3CA	1.10
310	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.10
311	Major depressive disorder	Enrichment	FKBP5	1.10
312	Insulin-like growth factor i	Enrichment	IGF1R	1.10
313	Pre-eclampsia	Enrichment	NOS3	1.10
314	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.10
315	Microphthalmia	Enrichment	ALDH1A3, RARB	1.08
316	Macular degeneration, age-related, 1	Enrichment	APOE	1.07
317	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1	1.07
318	Parkinson disease, mitochondrial	Enrichment	ADH1C	1.07
319	Spermatogenic failure 1	Enrichment	PDHA2	1.07
320	Rett syndrome, congenital variant	Enrichment	SMC1A	1.07
321	Congenital stationary night blindness	Enrichment	GNB3, RDH5	1.05
322	Long qt syndrome	Enrichment	CALM1, CALM2	1.04
323	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.04
324	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.03
325	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.03
326	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.03
327	Limited scleroderma	Enrichment	CAV1	1.03
328	Charge syndrome	Enrichment	EP300	1.02
329	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.02
330	Parkinson disease, late-onset	Enrichment	ADH1C, TBP	1.02
331	Leukemia, chronic lymphocytic	Enrichment	CCND1	0.98
332	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	0.96
333	Myelofibrosis	Enrichment	SRC	0.96
334	Squamous cell carcinoma, head and neck	Enrichment	EGFR	0.96
335	Pilomyxoid astrocytoma	Enrichment	KRAS	0.96
336	Megacolon	Enrichment	AKT3	0.96
337	Overgrowth syndrome	Enrichment	PIK3R1	0.96
338	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	0.91
339	Hypothyroidism	Enrichment	GNB1	0.91
340	Alcohol dependence	Enrichment	ADH1C	0.91
341	Hirschsprung disease 1	Enrichment	POLR2F, SREBF1	0.88
342	Fundus albipunctatus	Enrichment	RDH5	0.84
343	Heart disease	Enrichment	CREBBP	0.84
344	Stroke, ischemic	Enrichment	NOS3	0.82
345	Polymicrogyria	Enrichment	AKT3	0.82
346	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	0.82
347	Polydactyly, postaxial, type a1	Enrichment	EP300	0.82
348	Corpus callosum, agenesis of	Enrichment	CREBBP	0.82
349	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	0.82
350	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.82
351	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.82
352	Gastric cancer	Enrichment	KRAS, PIK3CA	0.81
353	Asthma	Enrichment	FKBP5	0.78
354	Leukemia, acute lymphoblastic	Enrichment	GNB1	0.78
355	Myelodysplastic syndrome	Enrichment	GNB1	0.78
356	Heritable pulmonary arterial hypertension	Enrichment	CAV1	0.78
357	Specific learning disability	Enrichment	MAPK1	0.78
358	Alobar holoprosencephaly	Enrichment	STAG2	0.77
359	Human immunodeficiency virus type 1	Enrichment	CXCL12	0.74
360	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	0.72
361	Parkinson's disease	Enrichment	TBP	0.72
362	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.71
363	Protein-deficiency anemia	Enrichment	NRAS	0.71
364	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4, GNB1	0.71
365	Crigler-najjar syndrome, type i	Enrichment	UGT1A3	0.70
366	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A3	0.70
367	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A3	0.70
368	Crigler-najjar syndrome, type ii	Enrichment	UGT1A3	0.70
369	Osteoporosis	Enrichment	SRC	0.69
370	Gilbert syndrome	Enrichment	UGT1A3	0.67
371	Nanophthalmos	Enrichment	ALDH1A3	0.67
372	Bilirubin metabolic disorder	Enrichment	UGT1A3	0.67
373	Tooth agenesis	Enrichment	TGFA	0.67
374	Kallmann syndrome	Enrichment	POLR2F	0.65
375	Rhabdomyosarcoma	Enrichment	HRAS	0.63
376	Gliosarcoma	Enrichment	EGFR	0.63
377	Lactic acidosis	Enrichment	DLD	0.63
378	Scoliosis	Enrichment	CREBBP	0.63
379	Cleft palate, isolated	Enrichment	GNB1	0.61
380	Giant cell glioblastoma	Enrichment	EGFR	0.61
381	Microphthalmia/coloboma 12	Enrichment	RARB	0.60
382	Alzheimer's disease	Enrichment	APOE	0.60
383	Congenital nervous system abnormality	Enrichment	CREBBP, GNB5, SMC1A	0.60
384	Nervous system disease	Enrichment	CREBBP, GNB5, SMC1A	0.60
385	Primary ovarian insufficiency	Enrichment	NOS3, NR5A2	0.60
386	Heart, malformation of	Enrichment	MAPK1	0.59
387	Autism spectrum disorder	Enrichment	GNB1, SMC3, TNRC6B	0.58
388	Multiple sclerosis	Enrichment	NR1H3	0.58
389	Coloboma of macula	Enrichment	RARB	0.55
390	Familial hypercholesterolemia	Enrichment	APOE	0.55
391	Endometrial cancer	Enrichment	PIK3CA	0.53
392	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.52
393	Pancreatic cancer	Enrichment	KRAS	0.47
394	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.46
395	Macs syndrome	Enrichment	ALDH1A3	0.45
396	Azoospermia	Enrichment	PDHA2	0.45
397	Strabismus	Enrichment	GNB1	0.44
398	Prostate cancer	Enrichment	PIK3CA	0.42
399	Dystonia	Enrichment	GNB1	0.36
400	Autism	Enrichment	ALDH1A3, CREBBP	0.33
401	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	0.32
402	Cerebral palsy	Enrichment	GNB1	0.32
403	Charcot-marie-tooth disease	Enrichment	HSPB1	0.31
404	Type 2 diabetes mellitus	Enrichment	AKT2	0.30
405	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	ABCG5	0.29
406	Hypertelorism	Enrichment	PIK3CA	0.24
407	Rare genetic deafness	Enrichment	POLR2F	0.23
408	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.22
409	Optic atrophy plus syndrome	Enrichment	RDH5	0.21
410	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PDHA2	0.15
411	Mitochondrial disease	Enrichment	PDHX	0.07
412	Hereditary retinal dystrophy	Enrichment	RDH11, RDH5	0.01
413	Fundus dystrophy	Enrichment	RDH11, RDH5	0.01
414	Retinitis pigmentosa	Enrichment	RDH5	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ESR-mediated signaling

Pathway Network for ESR-mediated signaling

Pathway network for the ESR-mediated signaling SuperPath

Member Pathways for ESR-mediated signaling

Pathways in the ESR-mediated signaling SuperPath

Gene overlap in member pathways for ESR-mediated signaling SuperPath

Associated Genes for ESR-mediated signaling

Associated Disorders for ESR-mediated signaling

Disorders associated with ESR-mediated signaling SuperPath

STRING Interaction Network for ESR-mediated signaling

Sources for ESR-mediated signaling